A cross-sectional measurement of endogenous oxidative stress marker levels in obsessive compulsive disorder

Basit Öğe Kaydı
dc.authorid0000-0003-3718-0458en_US
dc.authorid0000-0003-1091-5602en_US
dc.authorid0000-0002-9202-4944en_US
dc.authorid0000-0001-9313-4056en_US
dc.authorid0000-0003-3300-3665en_US
dc.contributor.authorKuruhan, Faruk
dc.contributor.authorKamış, Gülsüm Zuhal
dc.contributor.authorAlp, Hamit Hakan
dc.contributor.authorÇim, Emine Füsun Akyüz
dc.contributor.authorAtlı, Abdullah
dc.date.accessioned2023-07-24T10:03:04Z
dc.date.available2023-07-24T10:03:04Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: There is a correlation between the increase in reactive oxygen radicals and the presence of specific mental illnesses. In this context, the objective of this study is to investigate the relationship between obsessive-compulsive disorder and the variations in the levels of several endogenous oxidative stress markers. Methods: Thirty obsessive-compulsive disorder patients were included in the study as the patient group, and 30 healthy volunteers of matching demographic characteristics were included in the study as the control group. Accordingly, the patient group consisted of 10 females and 20 males with a mean age of 29.5 ± 6.1 years, and the control group consisted of 15 females and 15 males with a mean age of 31.9±5.6 years. The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were compared using the independent samples t-test. The relationships between the serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were analyzed using the Pearson’s correlation coefficient. Results: The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the patient group were statistically significantly higher than those of the control group (P < .001). Statistically significant positive correlations were detected between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and nicotinamide adenine dinucleotide phosphate oxidase-4 levels (r=0.692, P=.001) and between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and malondialdehyde levels (r=0.563, P=.001). Conclusion: The results of this study indicated that oxidative stress and lipid peroxidation levels were higher in obsessive-compulsive disorder patients. Based on this finding, NOX-2 and NOX-4 levels can be used as indicators of endogenous oxidative stress in obsessive-compulsive disorder patients.en_US
dc.identifier.citationKurhan, F., Kamış, G. Z., Alp, H. H., Çim, E. F. A. ve Atlı, A. (2022). A cross-sectional measurement of endogenous oxidative stress marker levels in obsessive compulsive disorder. Psychiatry and Clinical Psychopharmacology, 32(3), 215-221.en_US
dc.identifier.doi10.5152/pcp.2022.21318
dc.identifier.endpage221en_US
dc.identifier.issn2475-0581
dc.identifier.issue3en_US
dc.identifier.startpage215en_US
dc.identifier.trdizinid1176644
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1176644
dc.identifier.urihttps://hdl.handle.net/11468/12228
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1176644
dc.identifier.volume32en_US
dc.identifier.wosWOS:000865985700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAtlı, Abdullah
dc.language.isoenen_US
dc.publisherAves Yayıncılıken_US
dc.relation.ispartofPsychiatry and Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObsessivecompulsive disorderen_US
dc.subjectOxidative stressen_US
dc.subjectOxidative damageen_US
dc.subjectNADPH oxidase 2en_US
dc.subjectNADPH oxidase 4en_US
dc.subjectMalondialdehydeen_US
dc.titleA cross-sectional measurement of endogenous oxidative stress marker levels in obsessive compulsive disorderen_US
dc.titleA cross-sectional measurement of endogenous oxidative stress marker levels in obsessive compulsive disorder
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
A Cross-Sectional Measurement of Endogenous Oxidative Stress Marker Levels.pdf
Boyut:
1.16 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Dahili Tıp Bilimleri Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu