High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?

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dc.contributor.authorOnat, Altan
dc.contributor.authorAydin, Mesut
dc.contributor.authorCan, Gunay
dc.contributor.authorKoroglu, Bayram
dc.contributor.authorKaragoz, Ahmet
dc.contributor.authorAltay, Servet
dc.date.accessioned2024-04-24T17:24:22Z
dc.date.available2024-04-24T17:24:22Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome. METHODS: Middle-aged adults representative of a general population with baseline circulating adiponectin measurements (n = 1224) were analyzed prospectively at a mean of 3.8 years' follow-up, using continuous values or sex-specific tertiles. Total adiponectin was assayed by an ELISA kit. Type-2 diabetes was identified by criteria of the American Diabetes Association. Hypertension was defined as a blood pressure >= 140 mmHg and/or >= 90 mmHg and/or use of antihypertensive medication. Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders. RESULTS: In models of multiple linear regression, sex hormone-binding globulin, fasting insulin (inverse) and, in men, age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine. Cox regression analyses for incident coronary heart disease (CHD), adjusted for sex, age, non-HDL cholesterol, waist circumference and C-reactive protein, revealed significant inverse association with adiponectin tertiles in men but not women (HR = 0.66; 95% CI: 0.32-1.38 for highest tertile). Cox regression for type-2 diabetes in a similar model (wherein glucose replaced non-HDL cholesterol), adiponectin tertiles appeared to protect in each gender. HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles (P -trend = 0.67). CONCLUSION: High adiponectin levels failed to protect against the development of hypertension and, in women, against CHD, presumably paralleling impairment in renal function as well. Involvement of adiponectin in autoimmune complex with loss of antioxidative- antiatherogenic properties may be underlying. (C) 2013 Baishideng. All rights reserved.en_US
dc.description.sponsorshipTurkish Society of Cardiologyen_US
dc.description.sponsorshipSupported by The Turkish Society of Cardiologyen_US
dc.identifier.doi10.4239/wjd.v4.i5.219
dc.identifier.endpage226en_US
dc.identifier.issn1948-9358
dc.identifier.issue5en_US
dc.identifier.pmid24147206
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.4239/wjd.v4.i5.219
dc.identifier.urihttps://hdl.handle.net/11468/19639
dc.identifier.volume4en_US
dc.identifier.wosWOS:000219105900008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Diabetes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdiponectinen_US
dc.subjectAntioxidative Functionen_US
dc.subjectCoronary Heart Diseaseen_US
dc.subjectCreatinineen_US
dc.subjectType-2 Diabetesen_US
dc.subjectHypertensionen_US
dc.titleHigh adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?en_US
dc.titleHigh adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?
dc.typeArticleen_US

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