Correlations between whole body volumetric parameters of 68Ga-PSMA PET/CT and biochemical-histopathological parameters in castration-naive and resistant prostate cancer patients

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dc.contributor.authorYildirim, Ozgen Ahmet
dc.contributor.authorGundogan, Cihan
dc.contributor.authorCan, Canan
dc.contributor.authorPoyraz, Kerem
dc.contributor.authorErdur, Erkan
dc.contributor.authorKomek, Halil
dc.date.accessioned2024-04-24T16:02:43Z
dc.date.available2024-04-24T16:02:43Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective To evaluate the relationship between whole body volumetric (Wbv) results of Ga-68-PSMA PET/CT with biochemical and histopathological parameters. Methods One hundred twenty-one prostate cancer patients who underwent Ga-68-PSMA PET/CT between January 2018 and December 2019 were included. Imaging was conducted for staging upon new diagnosis with moderate- and high-risk disease and for confirming the progression of castration resistance. The relationships between the Wbv Ga-68-PSMA PET/CT parameters and prostate-specific antigen (PSA) levels, PSA doubling time and Gleason score (GS) were evaluated. Results The median GS and mean PSA levels were similar between the castration-naive and resistant patients. The PSA levels were positively correlated with MTVwb (p: 0.009, r: 0.286) and TLPwb (p: 0.002, r: 0.344). Gleason scores were positively correlated with MTVwb (p: 0.050, r: 0.216), TLPwb (p: 0.007, r: 0.296) and highest standard uptake value (HSUV) max (p: 0.047, r: 0.220). In the castration-naive group, Gleason scores (from p < 0.001 to p = 0.04 and r = 0.331 to 0.549) and PSA levels (from p = 0.002 to p = 0.045 and from r = 0.323 to 0.473) correlated with all Ga-68-PSMA-PET/CT parameters. PSA doubling time was negatively correlated with whole-body metabolic tumour volume (MTVwb) (p: 0.050, r: 0.232) and whole-body total lesion PSMA (TLPwb) (p: 0.026, r: 0.262). The MTVwb, TLPwb and HSUVpeak values of the patients with biochemical recurrence (BR) of 0-6 months (n = 18) were higher than those with BR > 2 years (n = 35) (p = 0.046, 0.047 and 0.042, respectively). Conclusions Wbv Ga-68-PSMA PET/CT results were correlated with PSA levels and Gleason scores. The correlation was relatively stronger in the castration-naive group. The prognostic accuracy of PSA in the resistant group may be weaker than in the naive group. The difference in volumetric parameters of patients with short BR compared to long BR supports the idea that Ga-68-PSMA PET/CT can distinguish patients with rapid relapse from others.en_US
dc.identifier.doi10.1007/s12149-021-01594-8
dc.identifier.endpage548en_US
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue5en_US
dc.identifier.pmid33586097
dc.identifier.startpage540en_US
dc.identifier.urihttps://doi.org/10.1007/s12149-021-01594-8
dc.identifier.urihttps://hdl.handle.net/11468/14893
dc.identifier.volume35en_US
dc.identifier.wosWOS:000617848000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Nuclear Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate Canceren_US
dc.subject(68)Ga-Psmaen_US
dc.subjectPeten_US
dc.subjectCten_US
dc.subjectProstate-Specific Antigenen_US
dc.subjectGleason Scoreen_US
dc.titleCorrelations between whole body volumetric parameters of 68Ga-PSMA PET/CT and biochemical-histopathological parameters in castration-naive and resistant prostate cancer patientsen_US
dc.titleCorrelations between whole body volumetric parameters of 68Ga-PSMA PET/CT and biochemical-histopathological parameters in castration-naive and resistant prostate cancer patients
dc.typeArticleen_US

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