The role of sialoadenectomy and epidermal growth factor (EGF) in skin development

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dc.contributor.authorKaradede, Mehmet Irfan
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorAktas, Ayfer
dc.date.accessioned2024-04-24T17:39:58Z
dc.date.available2024-04-24T17:39:58Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, the effect of epidermal growth factor (EGF) on skin development was investigated. A total of 24 adult female Spraque-Dawley rats were used in the study. The rats were divided into 3 equal groups as control, sialoadenectomy (SX) and sialoadenectomy+epidermal growth factor (SX+EGF). Sialoadenectomy was performed on the other groups except control. After a 21-day recovery period, subjects were made to mate. SX+EGF group rats were also given 12.5 mu g/day EGF for each animal orally in the 16, 17th, 18th and 19th days of pregnancy. After pregnancy, the offsprings obtained were grown until the 28th day. All 28-day-old offsprings in all groups were weighed and sacrificed. Skin samples from interscapular region were examined under light and electron microscope. In light and electron microscopy, skin sections of SX group, atrophy in epiderm, hyperkeratosis, decrease in hair follicles and sebaceous glands, along with local thinning of basal membrane, hemidesmosome loss and necrotic cells were seen. In skin sections of SX+EGF group, the view was similar to controls. As a result, epidermal growth factor was concluded to have an important role in skin development.en_US
dc.identifier.endpage2955en_US
dc.identifier.issn1684-5315
dc.identifier.issue20en_US
dc.identifier.scopus2-s2.0-77952950326
dc.identifier.scopusqualityN/A
dc.identifier.startpage2949en_US
dc.identifier.urihttps://hdl.handle.net/11468/21481
dc.identifier.volume9en_US
dc.identifier.wosWOS:000277849800020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal Growth Factoren_US
dc.subjectRat Skinen_US
dc.subjectSialoadenectomyen_US
dc.titleThe role of sialoadenectomy and epidermal growth factor (EGF) in skin developmenten_US
dc.titleThe role of sialoadenectomy and epidermal growth factor (EGF) in skin development
dc.typeArticleen_US

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