The Effects of Pegylated Interferon Alpha-2a and Alpha-2b Therapy on Chromosomal Aberrations and Mitotic Index in Patients with Chronic Hepatitis B

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dc.contributor.authorAkbas, Halit
dc.contributor.authorYalcin, Kendal
dc.contributor.authorIsi, Hilmi
dc.contributor.authorSimsek, Selda
dc.contributor.authorAtay, Ahmet Engin
dc.contributor.authorBudak, Turgay
dc.date.accessioned2024-04-24T17:27:37Z
dc.date.available2024-04-24T17:27:37Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: We aimed to prospectively evaluate the effects of pegylated interferon alpha-2a and alpha-2b therapy on chromosomal aberrations and mitotic index in patients with chronic hepatitis B. Material and Methods: Fifty patients with chronic hepatitis B who underwent pegylated interferon alpha-2a or 2b therapy were evaluated for chromosomal aberrations and mitotic index before the treatment and at the end of 6 months of therapy. Results: Cytogenetic examinations revealed out that there was no significant difference between pre- and post-treatment frequencies of mitotic index and chromosomal aberrations. Conclusion: Interferon alpha-2a and alpha-2b therapy which is associated with common hematologic adverse effects has no significant cytogenetic effect.en_US
dc.identifier.doi10.5336/medsci.2011-26395
dc.identifier.endpage1559en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84868317546
dc.identifier.scopusqualityQ4
dc.identifier.startpage1554en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2011-26395
dc.identifier.urihttps://hdl.handle.net/11468/20091
dc.identifier.volume32en_US
dc.identifier.wosWOS:000314145000009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis Ben_US
dc.subjectInterferon Alfa-2aen_US
dc.subjectInterferon Alfa-2ben_US
dc.subjectChromosome Aberrationsen_US
dc.subjectMitotic Indexen_US
dc.titleThe Effects of Pegylated Interferon Alpha-2a and Alpha-2b Therapy on Chromosomal Aberrations and Mitotic Index in Patients with Chronic Hepatitis Ben_US
dc.titleThe Effects of Pegylated Interferon Alpha-2a and Alpha-2b Therapy on Chromosomal Aberrations and Mitotic Index in Patients with Chronic Hepatitis B
dc.typeArticleen_US

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