Investigating the effect of the poly(adp-ribose) polymerase inhibitor 5-aminoisoquinolinone and the na+-h+ exchanger inhibitor zoniporide on isolated perfused rat hearts during ischemia-reperfusion injury

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dc.contributor.authorAkkoç, Hasan
dc.contributor.authorGürkan, Ahmet
dc.contributor.authorKelle, İlker
dc.contributor.authorHekimoǧlu, Aşkın Taş
dc.contributor.authorErdi̇nç, Meral
dc.date.accessioned2024-04-24T17:56:14Z
dc.date.available2024-04-24T17:56:14Z
dc.date.issued2013
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractThe goal of this study was to investigate whether the combination of the Poly(ADP-ribose) polymerase inhibitor 5-aminoisoquinolinone (5-AIQ) and the Na+-H+ exchanger inhibitor zoniporide (ZN) provides increased protection against ischemia-reperfusion (I/R) injury. Rats were separated into 5 groups (n=8): Group 1: Control group, Group 2: I/R, Group 3: 5-AIQ, Group 4: ZN and Group 5: Mix (5-AIQ+ZN). Isolated rat hearts were subjected to 30 min of global ischemia, followed by 120 min of reperfusion using Langendorff's apparatus. In groups 3, 4 and 5, 5-AIO (7.5 ?M/L) and ZN (50 nM/L) were added to Tyrode Solution after a stabilization period. The level of lactate dehydrogenase (LDH) was determined in the sample perfusate. Myocardial infarct size was determined using the triphenyltetrazolium chloride method. Heart tissues were stored to determine the malondialdehyde (MDA) content, total oxidant status (TOS) and total antioxidant status (TAS). Compared to the 5-AIQ and ZN groups, there was no notable difference in the LDH, MDA, TOS, TAS and hemodynamic parameters of the 5-AIQ+ZN group, but myocardial infarct size decreased significantly, as determined by volume and weight measurements. These results show that the combined use of Zoniporide and 5-Aminoisoquinolinone provides increased protection against I/R injury by reducing myocardial infarct size.en_US
dc.identifier.citationAkkoç, H., Gürkan, A., Kelle, İ., Hekimoǧlu, A. T. ve Erdi̇nç, M. (2013). Investigating the effect of the poly(adp-ribose) polymerase inhibitor 5-aminoisoquinolinone and the na+-h+ exchanger inhibitor zoniporide on isolated perfused rat hearts during ischemia-reperfusion injury. Drug Research, 63(10), 521-526.
dc.identifier.doi10.1055/s-0033-1347241
dc.identifier.endpage526en_US
dc.identifier.issn2194-9379
dc.identifier.issue10en_US
dc.identifier.pmid23756954
dc.identifier.scopus2-s2.0-84886945857
dc.identifier.scopusqualityQ3
dc.identifier.startpage521en_US
dc.identifier.urihttps://doi.org/10.1055/s-0033-1347241
dc.identifier.urihttps://hdl.handle.net/11468/23390
dc.identifier.volume63en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofDrug Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5-Aminoisoquinolinoneen_US
dc.subjectİschemia-Reperfusion injuryen_US
dc.subjectLangendorffen_US
dc.subjectNa+-H+ Exchanger (Nhe) inhibitoren_US
dc.subjectPoly(Adp-Ribose) Polymerase (Parp)en_US
dc.subjectZoniporideen_US
dc.titleInvestigating the effect of the poly(adp-ribose) polymerase inhibitor 5-aminoisoquinolinone and the na+-h+ exchanger inhibitor zoniporide on isolated perfused rat hearts during ischemia-reperfusion injuryen_US
dc.titleInvestigating the effect of the poly(adp-ribose) polymerase inhibitor 5-aminoisoquinolinone and the na+-h+ exchanger inhibitor zoniporide on isolated perfused rat hearts during ischemia-reperfusion injury
dc.typeArticleen_US

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