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Öğe Effect of fish oil on indometacin-induced gastric lesions in rats(1995) Guzel C.; Ulak G.; Sermet A.; Cicek R.; Ulak M.The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats. After indometacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. The ulcer index was found to be decreased to 2.1 ± 1.8 mm with fish oil, 13.7 ± 5.4 mm with olive oil, and 14.6 ± 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indometacin and significantly enhanced the mucus content of the mucosa (p < 0.05).Öğe Effect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonists(1995) Sermet A.; Aybak M.; Ulak G.; Guzel C.; Denli O.Effect of vitamin B6 (pyridoxine-HCl, CAS 58-56-0) on platelet aggregation, plasma lipids and serum zinc level was investigated. The trial comprised 24 healthy male volunteers, aged between 19-24 years. The subjects were randomized in two groups of 12 and treated for 4 weeks by a single daily oral dose of 5 mg/kg vitamin B6 or placebo. Pyridoxine inhibited ADP- or epinephrine-induced aggregation by 48% and 41% (p < 0.001), respectively, whereas there was no change in control group. No significant effect on either, bleeding time, coagulation time or on platelet count was demonstrated in subjects given placebo. Pyridoxine prolonged both bleeding and coagulation time but not over the physiological limits. It had no effect on platelet count. These observations strongly suggest that vitamin B6, with no effect on platelet count, not only inhibits platelet aggregation but also prelongs clotting time. Pyridoxine significantly reduced total plasma lipid and cholesterol levels, whereas it enhanced HDL-cholesterol level. Serum zinc level was also significantly increased by pyridoxine (p < 0.001). These findings suggest that oral vitamin B6 inhibits platelet aggregation in normal subjects.Öğe Effect of vitamin B6 intake on tissue zinc levels in the rat(1995) Sermet A.; Atmaca M.; Ulak G.; Diken H.; Ulak M.Effect of vitamin B6 intake on tissue zinc (Zn) concentrations was investigated in weanling, male Wistar albino rats (100-120 g). The animals were divided into two groups (n = 9) and treated for 4 weeks by intraperitoneal 5 mg/kg/day pyridoxine-HCl or placebo. The Zn content of the liver, spleen, right kidney and right femur were determined. Increases in weight gain in the control and Pyridoxine-treated group were 29.20 ± 1.43% and 51.20 ± 4.53%, respectively (P < 0.001). Dried weights of liver, kidney and femur were significantly higher than those of control group (p < 0.01; p < 0.02; p < 0.001, respectively). No significant difference was observed between the serum Zn concentrations of the experimental and control group (P > 0.05). The Zn content of the liver, spleen, kidney and femur for both total and dry weight per gram of organ weight were significantly higher in the experimental group compared to controls. These findings suggested that pyridoxine affects Zn metabolism in young rats.Öğe Influence of zinc on imipenem susceptibility of Pseudomonas aeruginosa(1996) Atmaca S.; Gul K.; Ulak G.; Cicek R.; Atmaca M.The influence of zinc on imipenem susceptibility of Pseudomonas aeruginosa was investigated. In this study, two different amounts of zinc containing media were used, the first of which was Oxoid MHA containing 0.45 ?g/ml zinc, and the second Oxoid MHA supplemented with zinc-acetate, 64 times as much zinc as the first media. The percentage of P. aeruginosa isolates resistant to imipenem significantly increased (P < 0.001) in zinc-supplemented media, whereas the activity of ceftazidime against P. aeruginosa isolates was similar in both media.Öğe Omeprazole, nitrendipine, famotidine and stress-induced ulcers(1997) Inaloz S.S.; Canberk Y.; Ozaydin M.; Sari I.; Yenilmez E.; Ulak G.; Goral V.Background: Omeprazole inhibits gastric acid secretion by blocking the proton pomp of the gastric parietal cell. Nitrendipine is a derivative of dihydropyridine group of calcium channel blockers and administrated for angina and hypertension. Famotidine is one of the newer histamine H2 receptor antagonists and heals gastric and duodenal ulcers by reducing gastric acid output. Objectives: The healing effects of omeprazole, nitrendipine and famotidine on stress-induced gastric ulcers were investigated in rate. Methods: Forty male Wistar-albino rats were separated into five groups (n=8), a control (non-stress) and four experimental (stress) groups. Experimental rats were treated with omeprazole, nitrendipine, famotidine or a placebo after the stresses of starvation and cold-restraint. Results: Macroscopically, the mean area of the affected lesional mucosa was 1/4 of the total gastric mucosa in the famotidine treated group and 1/5 of the total gastric mucosa in the nitrendipine treated group. A considerably decrease was observed in the omeprazole treated group in which the mean area of the lesional mucosa was only in 1/8 of the total gastric mucosa. On microscopic examination, congestive vessels and chronic inflammatory cell infiltrates were significantly reduced in the omeprazole treated group. Tissue regeneration was more prominent in the omeprazole group than me other groups. Conclusion: Omeprazole was found to be superior in terms of the effect on the healing process to nitrendipine and famotidine. Although therapeutic effects of nitrendipine and famotodine were observed, those were less than omeprazole.Öğe Preventive action of omeprazole, famotidine or nitrendipine against stress ulcer formation in rats(1994) Canoruc N.; Ulak G.; Guzel C.; Kaya H.; Cicek R.The effects of H+/K+-ATP ase inhibitor, omeprazole, the H2-receptor antagonist, famotodine, and the calcium channel antagonist, nitrendipine, on gastric ulcers, gastric mucosal barrier and gastrin release were investigated in cold-restraint stress-induced rats. Omeprazole (30 mg/kg i.g.) famotidine (1 mg/kg, i.g.) and nitrendipine (16 mg/kg, i.p.) significantly prevented gastric ulceration. Nitrendipine reduced the mucus secretion and exhibited no important change in phospholipid content; thus, it failed to restore the damage in the gastric mucosal barrier due to cold-restraint stress. Omeprazole increased mucus secretion and phospholipid content of gastric mucosal barrier whereas famotidine tended to cause an increase in mucus and phospholipid levels; however, this difference did not attain statistical significance. Serum gastrin levels revealed lower values in the nitrendipine group as compared with controls; whereas it increased in omeprazole and famotidine groups, but more significantly in the omeprazole treated group.Öğe Protective effect of fish oil against stress-induced gastric injury in rats(1995) Ulak G.; Cicek B.; Sermet A.; Guzel C.; Ulak M.; Denli O.The effect of fish oil and olive oil on the gastric mucosal damage induced by cold-restraint stress was investigated in rats. The oils were dietary supplemented for 3 weeks. The results demonstrate that a diet containing fish oil, when ingested for 3 weeks before exposure to stress, protected from gastric ulceration significantly (p < 0.01) and led to a statistically significant increase both in mucus and phospholipid content of the gastric mucosal barrier (p < 0.02 and p < 0.001, resp.) in cold-restraint stress-induced gastric injury in rats. However, further studies are required to determine the role of dietary fish oils in the prophylaxis and treatment of peptic ulcer.
