Yazar "ULAK, G" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • [ X ]
    Öğe
    EFFECT OF FISH-OIL ON INDOMETHACIN-INDUCED GASTRIC-LESIONS IN RATS
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1995) GUZEL, C; ULAK, G; SERMET, A; CICEK, R; ULAK, M
    The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats, After indometacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. Thr ulcer index was found to be decreased to 2.1 +/- 1.8 mm with fish oil 13.7 +/- 5.4 mm with olive oil, and 14.6 +/- 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indometacin anti significantly, enhanced the mucus content of the mucosa (p < 0.05).
  • [ X ]
    Öğe
    THE EFFECT OF OFLOXACIN ON PENTOBARBITAL-INDUCED SLEEP IN MICE
    (Pergamon-Elsevier Science Ltd, 1991) ENGINAR, N; EROGLU, L; ULAK, G
    There have been several reports that insomnia occurs in some patients who receive ofloxacin. Since almost no experimental data on ofloxacin-induced insomnia were available, this study was conducted for the evaluation of ofloxacin effects on sleep parameters in mice. In Experiment 1, mice were pretreated with ofloxacin (20 or 40 mg/kg IP) or saline 15 minutes before sodium pentobarbital (35 mg/kg IP). Experiment 2 was carried out in two days. On the first day mice were treated twice, in the morning and in the evening, with ofloxacin (20 or 80 mg/kg IP) or saline. On the second morning, mice were pretreated with the same doses of ofloxacin or saline 15 minutes before sodium pentobarbital (35 mg/kg IP). Sleep latency and sleeping time were recorded in each experiment. Results showed that ofloxacin had no apparent effect on sleep latency, but caused a shortening in sleeping time. However, this effect was significant only in the 40 and 80 mg/kg ofloxacin-treated groups.
  • [ X ]
    Öğe
    EFFECT OF ORAL PYRIDOXINE HYDROCHLORIDE SUPPLEMENTATION ON IN-VITRO PLATELET SENSITIVITY TO DIFFERENT AGONISTS
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1995) SERMET, A; AYBAK, M; ULAK, G; GUZEL, C; DENLI, O
    Effect of vitamin B-6 (pyridoxine-HCl, CAS 58-56-0) on platelet aggregation, plasma lipids and serum zinc level was investigated. The trial comprised 24 healthy male volunteers, aged between 19-24 years. The subjects were randomized in two groups 12 and treated for 4 weeks by a single daily oral dose of 5 mg/kg vitamin B-6 or placebo. Pyridoxine inhibited ADP- or epinephrine-induced aggregation by 48% and 41% (p < 0.001), respectively, whereas there was no change in control group. No significant effect on either, bleeding time, coagulation time or on platelet count was demonstrated in subjects given placebo. Pyridoxine prolonged both bleeding and coagulation time but not over the physiological limits. It had no effect on platelet count. These observations strongly suggest that vitamin B-6, with no effect on platelet count, not only inhibits platelet aggregation but also prolongs clotting time. Pyridoxine significantly reduced total plasma lipid and cholesterol levels, whereas it enhanced HDL-cholesterol level. Serum zinc level was also significantly increased by pyridoxine (p < 0.001). These findings suggest that oral vitamin B-6 inhibits platelet aggregation in normal subjects.
  • [ X ]
    Öğe
    GASTROPROTECTIVE EFFECT OF NITRENDIPINE ON STRESS-INDUCED GASTRIC-LESIONS IN RATS
    (Karger, 1991) ULAK, G; CINGI, MI; EROL, K
    The effects of nitrendipine on stress-induced acute gastric lesions were investigated in rats. Intraperitoneally injected nitrendipine (8, 16, or 32 mg/kg) given 30 min before stress, dose-dependently prevented gastric glandular ulceration. The anti-ulcer effects of nitrendipine were not reversible by indometacin or dexamethasone. These results suggest that calcium is important in gastric pathophysiology and that the proof of gastroprotective effects of calcium channel blockers is of great value in the development of new and improved therapies for treatment and prevention of gastric ulcers in humans.
  • [ X ]
    Öğe
    PROTECTIVE EFFECT OF FISH-OIL AGAINST STRESS-INDUCED GASTRIC INJURY IN RATS
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1995) ULAK, G; CICEK, R; SERMET, A; GUZEL, C; ULAK, M; DENLI, O
    The effect of fish oil and olive oil on the gastric mucosal damage induced by cold-restraint str ess !:as investigated in rats. The oils were dietary supplemented for 3 weeks. The results demonstrate that a diet containing fish oil when ingested for 3 weeks before exposure to stress, protected from gastric ulceration significantly (p < 0.01) and led to a statistically significant increase both in mucus and phospholipid con tent of the gastric mucosal barrier (p < 0.02 and p < 0.001, resp.) in cold-restraint stress-induced gastric injury in rats. However; further studies are required to determine the role of dietary fish oils in the prophylaxis and treatment of peptic ulcer.