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Öğe Aniline based aminophosphine and cationic bis phosphino amine Ru II complexes: Investigation of catalytic activity in transfer hydrogenation of ketones(Dicle Üniversitesi, 2013) Kayan, Cezmi; Meriç, Nermin; Aydemir, Murat; Baysal, Akın; Temel, HamdiHydrogen transfer reduction processes are attracting increasing interest from synthetic chemists in viewof their operational simplicity. For this aim, a series of Ru II complexes with the NPP and NHP ligandswere synthesized starting from the complex [Ru ?6-p-simen µ-Cl Cl]2. The complexes were fullycharacterized by analytical and spectroscopic methods. Complexes 1-4 catalyze the transfer hydrogenationof a variety of simple alkyl and aryl alkyl ketones to secondary alcohols in the presence of iso-PrOH as thehydrogen source. Notably 3 acts as an excellent catalyst giving the corresponding alcohols in excellentconversions up to 99% TOF:198 h-1Öğe Antibacterial effect of Some New Metal Complexes with Schiff Base Ligands on Gram-positive Bacteria (Staphylococcus aureus) and Gram-negative Bacteria (Pseudomonas aeruginosa)(Dicle Üniversitesi Fen Bilimleri Estitüsü, 2012) Akbolat, Nezahat; Yıldız, Abdulnasır; Temel, Hamdi; Paşa, Salih; Yeşil, Ö. Faruk; Gül, Kadri[Özet Yok]Öğe Antibacterial effect of some new metal complexes with schiff base ligans on gram-pozitive bacteria (Staphlococcus aureus) and gram-negative bacteria (Pseudomonas aeruginosa)(Dicle Üniversitesi, 2012) Akbolat, Nezahat; Yıldız, Abdulnasır; Temel, Hamdi; Paşa, Salih; Yeşil, Ömer Faruk; Gül, Kadri[Abstract Not Available]Öğe The application of novel boron complexes in asymmetric transfer hydrogenation of aromatic ketones(Pergamon-Elsevier Science Ltd, 2015) Temel, Hamdi; Pasa, Salih; Aydemir, MuratAsymmetric transfer hydrogenation using iso-PrOH as a hydrogen source offers an attractive route for reducing simple unsymmetrical functionalized ketones to chiral alcohols. The combined use of organometallic and coordination chemistry has produced a number of new and powerful synthetic methods for important classes of compounds in general and for optically active substances in particular. For this aim, the (S,Z)-1-((1-hydroxy butane-2-yl imino)methyl)naphthalene-2-ol chiral ligand was chosen to obtain boron complexes. Boronic derivative compounds such as phenylboronic acid, 6-methoxynaphthalen-2-ylboronic acid, 4-methyl-3-nitrophenylboronic acid and 1,4-phenylenediboronic acid were applied to obtain complexation with chiral based ligands. The structures of these ligands and their complexes have been elucidated by a combination of multinuclear NMR spectroscopy, LC MS/MS, TGA/DTA, UV Vis., elemental analysis, XRD, SEM, and FTIR. These boron complexes have also been tested as catalysts in the enantioselective transfer hydrogenation of acetophenone derivatives to afford the corresponding product, (S)-1-phenylethanol with high conversions (up to 99%) and modest enantioselectivities (up to 70% ee). The substituents on the backbone of the ligands had a significant effect on both the activity and % ee. (C) 2015 Elsevier Ltd. All rights reserved.Öğe Bazı Salvia (Ada Çayı) Türlerinin HPLC-IT-TOF-MS ile Taranması, Sekonder Metabolitlerinin Saflaştırılması ve Antikanser Özelliklerinin Belirlenmesi(2018) Yılmaz, Mustafa Abdullah; Yener, İsmail; Ertaş, Abdulselam; Temel, Hamdi; Topçu, Gülaçtı; Kandemir, Sevgi İrtegün; Kolak, UfukArazi çalışmaları sonucu toplanan 6 Salvia türünün ön biyolojik aktivite deneylerinde kullanılmak üzere kloroform ve etanol ekstreleri hazırlandı. Bu 12 ekstreden aktif çıkan etanol ekstrelerinden saf madde izolasyonuna gidilmiştir. Özellikle izolasyon çalışmaları için klorofil ve türevleri çok ciddi problemlere yol açmaktadır. En azından kök ksımlarının ekstreleri hazırlanarak izolasyon çalışmalarında klorofil ve türevlerinin neden olacağı problemlerin önüne geçilmesi düşünülmüştür. Toplanan türlerin LC-MS/MS ile fenolik içeriklerinin tespiti için çeşitli kısımlarının etanol ekstreleri hazırlanmıştır. Ayrıca bu türlerin yağ asidi bileşimini GC-MS ile belirlemek için petrol eteri ekstreleri hazırlandı. Bunlara ilaveten 3 yıl boyunca toplanan örneklerin uçucu yağı elde edilmiştir. 3 yıl boyunca toplanan örneklerin GC-MS ile uçucu yağ ve aroma içerikleri belirlenmiştir. Çalışılan türlerin uçucu yağ verimlerinin, aroma ve uçucu yağ içeriklerinin yıllara bağlı olarak çok değişmediği tespit edilmiştir. Ayrıca aroma ve uçucu yağ içeriklerinin daha çok monoterpenler bakımından zengin olduğu saptanmıştır. Yine GC-MS ile belirlenen yağ asidi içeriğinin de yıllara bağlı olarak çok değişmediği belirlenmiştir. Ayrıca Salvia türlerine özgü 19 bileşik ile yeni bir metot geliştirilerek valide edilmiştir. Üç yıl toplanan örneklerin bu bileşikler bakımından içerik tayinleri yine LC-MS/MS ile tespit edilmiştir. Çalışılan Salvia türlerinin çeşitli kısımlarının farklı ekstrelerinin toplam fenolik ve toplam flavonoit miktarları belirlenmiştir. Hazırlanan tüm ekstrelerin 4 farklı yöntemle antioksidan aktiviteleri belirlenmiştir. Çalışılan 6 Salvia türünün aktivite sonuçlarına baktığımızda genel olarak petrol eteri ekstrelerinin daha çok sadece ?-Karoten-linoleik asit yönteminde etanol ekstrelerinin ise kullanılan 4 yöntemde de aktif olduğu tespit edilmiştir. Çalıştığımız 6 Salvia türünün kloroform ve etanol ekstrelerinin sitotoksik aktivitesi MTT metoduna göre 3 hücre serisine karşı belirlenmiştir. Çalışılan 12 ekstrenin sonuçları genel olarak değerlendirildiğinde ancak yüksek konsantrasyonlarda HT29 ve MCF7 hücre serilerine karşı sitotoksik etki gösterdiği belirlenmiştir. Ekstrelerin sitotoksik etkilerinin düşük antioksidan etkilerinin yüksek çıkmasından dolayı izolasyon çalışmalarının antiokisdan kontrolü ile yapılmasına karar verilmiştir. Etanol ekstrelerinin kloroform ekstrelerine göre daha yüksek antioksidan aktivite göstermelerinden dolayı saf madde izolasyonuna bu ekstrelerden gidilmiştir. 5 Türden (Toprak üstü ve kök olmak üzere) hazırlanan 10 ekstre kolon kromatografisi ile fraksiyonlara ayrılmıştır. Bu fraksiyonlardan antioksidan aktiviteleri yüksek çıkanlardan izolasyon çalışmaları yapılmıştır. İzolasyon çalışmalarında 4?ü yeni olmak üzere toplam 52 bileşik elde edilmiştir. İzole edilen maddelerin antioksidan ve sitotoksik aktiviteleri tespit edilmiştir. Genel olarak preperatif HPLC ile elde edilen maddelerin çok yüksek bir antiokidan kapasitye sahip olduğu belirlenmiştir. Özellikle yüksek miktarda elde edilen 6,7-dehidroroyleanon bileşiğinin ve türevi olan asetil royleanon bileşiklerinin elde edilen terpenler içinde en yüksek antioksidan aktiviteye sahip olduğu tespit edilmiştir. Yapısı bilinen maddelerden triterpen yapısında olan ursolik asit ve diterpen yapısında olan 6,7-dehidroroyleanon, asetil royleanon, ferruginol ve kriptanol bileşiklerinin yüksek bir sitotoksik potansiyele sahip olduğu belirlenmiştir. Ayrıca ilk defa tarafımızdan saflaştırılıp yapısı tayin edilen 5 bileşik ise orta derece antioksidan aktivite gösterirken çok yüksek sitotoksik etki gösterdikleri belirlenmiştir. Western Blot sonuçlarına göre çalışılan 5 türün de majör bileşiği olan rozmarinik asidin MCF-7 ve HT-29 hücre serisi üzerinde, metot validasyonu için standart olarak alınan kriptotanşinon bileşiğinin ise kanserli MCF-7 hücre serisi üzerinde umut verici sonuçlar verdiği görülmektedir.Öğe Biological activities of some transition metal complexes derived from N,N -bis salicylidene -1,2-bis- o - and p - aminophenoxy ethan(Dicle Üniversitesi, 2013) Temel, Hamdi; Uçmak, Hasan; Paşa, Salih; Yılmaz, Mustafa A.; Hoşoğlu, SalihThe Schiff base ligands N,N -bis salicylidene -1,2-bis- o-aminophenoxy ethane L1 and N,N -bis salicylidene 1,2-bis- p-aminophenoxy ethane L2 were synthesized for this study. The Cu II , Ni II , Zn II complexesof L1 and the Cu II , Co II , Zn II complexes of L2 were obtained with various transition metal salts.These compounds were evaluated against to the common infectious bacteria in human such as E. coli,Pseudomonas, Acinetobacter and Staphylococcus strains. The copper complexes of both L1 and L2 were foundeffective against Staphylococcus strains. Staphylococcus strains are common pathogens in hospital environment.Thus, their copper complexes L1-Cu and L2-Cu may be useful in hospital hygieneÖğe Boronic modified quercetin molecules: Synthesis and biological investigations with molecular docking verification(Elsevier B.V., 2023) Temel, Hamdi; Paşa, Salih; Atlan, Metin; Türkmenoğlu, Burçin; Ertaş, AbdulselamQuercetin is an essential compound belonging to the flavanol group, which is a derivative of bioflavonoids found in fruits and vegetables. Quercetin has various pharmacological properties such as anticancer, antioxidant, anti-inflammatory, antiviral, antihistamine, and antitumor. Based on these important properties, the quercetin compound was modified with various boronic acids and new types of quercetin-based boronic (QB) compounds were synthesized. In the current study, we have synthesized quercetin-based boronic compounds to obtain more effective molecules by doping the biological activity properties of quercetin naturally in its structure. In this purpose, 6‑methoxy naphthalene boronic acid, 1,4-phenyl diboronic acid, 4‑methoxy phenylboronic acid, 6‑methoxy-3-pyridinylboronic acid, 3-formyl-4-methoxyphenyl boronic acid compounds were used. The synthesized compounds were structurally enlightened by mass, 13C NMR, 1H NMR, and FTIR spectroscopy. Then, the antioxidant, anticholinesterase, antiurease, antityrosinase and toxic-cytotoxic effects of these molecules were tested. QB compounds synthesized and examined in vitro in the study were also analyzed by molecular docking. Molecular docking, one of the structure-based drug design methods, has been applied to support experimental data. It was determined that QB compounds showed more significant efficacy than the reference substance employed in antioxidant and enzyme activity studies. As a result of molecular docking analysis, the binding energy parameter values and active binding site amino acid residues of the compounds were determined. Obtained novel boronic compounds might be associated as drug candidate due to consistent results both in experimental and molecular docking results.Öğe The chemical absorption of sulfur dioxide in aqueous suspension of limestone and DTA studies(2002) Temel, Hamdi; 0000-0001-9225-7425In this study, the interaction of sulfur dioxide with limestone was investigated in aqueous suspension. Sulfur dioxide taken from gas cylinder was passed through the mixture of reactive limestone and water, iodine solution. The absorbed and unabsorbed amount of sulfur dioxide on solid and liquid phases and the concentration of Ca2+ and Mg2+ ions were determined by means of iodometric and complexometric respectively. The effects of contact time, the activated temperatures of absorbent and equilibrium pH on the chemical absorption of SO2 were examined. For calcite the maximum amount of absorbed SO2 in the liquid phase was found to be 8.9 g (activated at 600°C), for 10 g absorbent/250 mL water, and in the solid phase, it was found to be 7.5 g (activated at 1000°C). The reaction products were also characterized by the differential thermal analysis (DTA) technique.Öğe Chemical Compositions by Using LC-MS/MS and GC-MS and Biological Activities of Sedum sediforme (Jacq.) Pau(Amer Chemical Soc, 2014) Ertas, Abdulselam; Boga, Mehmet; Yilmaz, Mustafa Abdullah; Yesil, Yeter; Hasimi, Nesrin; Kaya, Meryem Seyda; Temel, HamdiIn this research, the chemical composition and biological activities of various extracts obtained from whole parts of Sedum sediforme (Jacq.) Pau were compared. The amounts of total phenolic and flavonoid components in crude extracts were determined by expression as pyrocatechol and quercetin equivalents, respectively. All of the extracts (petroleum ether, acetone, methanol, and water) obtained from S. sediforme showed strong antioxidant activity in four tested methods. Particularly, the IC50 values of the methanol extract, which was the richest in terms of total phenolic and flavonoid contents, were found to be lower than those of alpha-tocopherol and BHT in beta-carotene bleaching (9.78 +/- 0.06 mu g/mL), DPPH free radical scavenging (9.07 +/- 0.07 mu g/mL), and ABTS cation radical scavenging (5.87 +/- 0.03 mu g/mL) methods. Furthermore, the methanol extract of S. sediforme showed higher inhibition activity than galanthamine against acetyl- and butyryl-cholinesterase enzymes. Also, acetone and methanol extracts exhibited moderate antimicrobial activity against Candida albicans. The main constituents of fatty acid and essential oil were identified as palmitic acid (C16:0) (28.8%) and alpha-selinene (20.4%), respectively, by GC-MS. In the methanol extract of S. sediforme, quercetin, rutin, naringenin, and protocatechuic, p-coumaric, caffeic, and chlorogenic acids were detected and quantified by LC-MS/MS. Results of the current study showed that the methanol extract of S. sediforme may also be used as a food supplement.Öğe Chemical Profile and Biological Activities of Two Edible Plants: Chemical Investigation and Quantitative Analysis Using Liquid Chromatography Tandem Mass Spectrometry and Gas Chromatography Mass Spectrometry(Taylor & Francis Inc, 2016) Ertas, Abdulselam; Yilmaz, Mustafa Abdullah; Boga, Mehmet; Hasimi, Nesrin; Yesil, Yeter; Goren, Ahmet C.; Temel, HamdiThe objectives of this study were to define the phenolic and fatty acid profiles, anticholinesterase, antioxidant, antimicrobial activities, and total phenolic-flavonoid contents of Lycopsis orientalis and Tragopogon latifolius var. angustifolius which have been used as food source and food supplement in Anatolia and have never been examined before. Rosmarinic and quinic acids (21.11 and 11.46 mg g(-1) extract, respectively) were found to be the most abundant constituents in L. orientalis and T. latifolius var. angustifolius among the studied 27 compounds by liquid chromatography tandem mass spectrometry. In the fatty acid compositions of L. orientalis and T. latifolius var. angustifolius that were determined by gas chromatography mass spectrometry, oleic (29.1%) and palmitic (28.7%) acids were identified as the major components, respectively. The high antioxidant activity of the methanol extract of L. orientalis shows parallelism to its rosmarinic acid content. Besides, this extract showed medium anticholinesterase activity. The results of the present study proves that the L. orientalis might also be used as a food source due to its high phenolic acid content and strong antioxidant property.Öğe Chemical profiling and total thickness-excised wound-healing activity of Pistacia lentiscus L. fruits growing in Algeria(Taylor & Francis As, 2016) Boukeloua, Ahmed; Belkhiri, Abdelmalik; Yilmaz, Mustafa Abdullah; Temel, HamdiThe aim of this study was to determine the chemical characterization and to assess full-thickness-excised wound-healing activity of the oil of Pistacia lentiscus L. fruits grown in Algeria. The fatty acid composition of P. lentiscus L. extracts were analyzed by GC-MS and their total protein amounts were determined by elemental analysis. Total thickness-excised wound-healing activity of hexane extract was carried out on rabbits; comparing oil and wax effects. The results showed that P. lentiscus L. fruits contain considerable levels of oil and protein. Additionally, oleic (46.91 +/- 1.03, 48.34 +/- 0.07) in hexane and cold pressure extracts, respectively, palmitic (25.75 +/- 0.82, 25.44 +/- 0.65) and linoleic (20.59 +/- 0.03, 20.27 +/- 0.81) acids were the major fatty acids. Wound-healing activity was significantly higher in P. lentiscus L. fatty oil compared to the wax, therefore, fats refining is wildly recommended.Öğe Comparative sorption capacity of Pb(II) and Cd(II) by natural zeolite in phosphoric acid medium(Taylor & Francis Inc, 2016) Kussainova, Marzhan Zhan; Pasa, Salih; Zhumasilovich, Dzhusipbekov Umirzak; Chernyakova, Reisa Mixailovna; Atlan, Metin; Temel, HamdiZeolite, a well-known inorganic compound, was used for Pb(II) and Cd(II) sorption. For this purpose, the model system composed with H3PO4-Pb2+-Cd2+ medium was selected and applied with various amounts of both heavy metal salts. The results revealed that sorption capacity of the sorbent was higher for Pb2+ cation than in the diluted phosphoric acid (20% H3PO4) for all periods. The absorption of toxic metal ions was measured by atomic absorption spectroscopy. Different physical and chemical analysis techniques such as Fourier Transform infrared, scanning electron microscope, DTA, and XRD showed that natural state of zeolite in a diluted phosphoric acid (20% H3PO4) system underwent protonation and hydroxylation to produce additional OH- groups that are active in the sorption process and no destruction was observed in the structure.Öğe Comparative Studies on Phenolic Composition, Antioxidant, Wound Healing and Cytotoxic Activities of Selected Achillea L. Species Growing in Turkey(Mdpi, 2015) Agar, Osman Tuncay; Dikmen, Miris; Ozturk, Nilgun; Yilmaz, Mustafa Abdullah; Temel, Hamdi; Turkmenoglu, Fatma PinarTurkey is one of the most important centers of diversity for the genus Achillea L. in the world. Keeping in mind the immense medicinal importance of phenols, in this study, three species growing in Turkey, A. coarctata Poir. (AC), A. kotschyi Boiss. subsp. kotschyi (AK) and A. lycaonica Boiss. & Heldr. (AL) were evaluated for their phenolic compositions, total phenolic contents (TPC), antioxidant properties, wound healing potencies on NIH-3T3 fibroblasts and cytotoxic effects on MCF-7 human breast cancer cells. Comprehensive LC-MS/MS analysis revealed that AK was distinctively rich in chlorogenic acid, hyperoside, apigenin, hesperidin, rutin, kaempferol and luteolin (2890.6, 987.3, 797.0, 422.5, 188.1, 159.4 and 121.2 mu g analyte/g extract, respectively). The findings exhibited a strong correlation between TPC and both free radical scavenging activity and total antioxidant capacity (TAC). Among studied species, the highest TPC (148.00 mg GAE/g extract) and TAC (2.080 UAE), the strongest radical scavenging (EC50 = 32.63 g/mL), the most prominent wound healing and most abundant cytotoxic activities were observed with AK. The results suggested that AK is a valuable source of flavonoids and chlorogenic acid with important antioxidant, wound healing and cytotoxic activities. These findings warrant further studies to assess the potential of AK as a bioactive source that could be exploited in pharmaceutical, cosmetics and food industries.Öğe Complexation ability of modified Na-Humate and its application in removal of toxic metals from water(Taylor & Francis Inc, 2016) Sabirjanovna, Taubayeva Aliya; Pasa, Salih; Zhumasilovich, Dzhusipbekov Umirzak; Temel, Hamdi; Oryntayevna, Nurgalieva GulzipaEfficiency of an amine modified Na-Humate (Na-Hum), which was isolated from coal mine in Karaganda/Kazakhstan, was explored as a sorbent for removal of toxic metal ions from water. Na-Hum was immobilized with ethylene diamine to get a suitable adsorbent called modified humate (Mod-Hum). Pseudo-first-order and pseudo-second-order kinetic models gave the best correlation at the suitable pH. The experimental results were calculated according to the related adsorption formulas, which were then depicted in tables and graphics. The amount of toxic metal ions remained in the solution after treating with Mod-Hum was measured by atomic absorption spectroscopy. The process parameters such as mixing time, temperature, and pH during the adsorption were investigated to find optimum sorption capacity. The results after adsorption were compared to determine the differences between natural (Na-Hum) and the modified matter (Mod-Hum). The complexation ability of compounds by exchange of Na-Hum and Mod-Hum with several metal ions such as Cu(CH3COO)(2)center dot H2O, Co(CH3COO)(2)center dot 4H(2)O, Ni(CH3COO)(2)center dot 4H(2)O, and Cd(CH3COO)(2)center dot 2H(2)O was also investigated. All obtained compounds were characterized by several techniques such as FTIR, TGA/DTA, and SEM-EDAX, elemental analysis and XRD. The adsorption studies with both Na-Hum and Mod-Hum clearly demonstrated that Na-Humate treated with amine is a more efficient adsorbent than the natural form. In addition, Mod-Hum fitted better with pseudo-first-order model and removed water contaminants such as Cu, Co, Ni, and Cd more effectively, which was attributed to higher reactivity of N and O donor sites of the adsorbent toward toxic metals.Öğe Complexation studies of some newly synthesized precursors for substituted dibenzo and dibenzodiaza crown ethers(John Wiley & Sons Inc, 2004) Çakır, Ümit; Uğraş, Halil İbrahim; Temel, Hamdi; Topal, Giray; 0000-0002-7056-3912; 0000-0001-9225-7425; 0000-0002-9430-4069This study represents the synthesis of dibenzo and dibenzodiaza crown ether precursors with various functional groups in good yield by employing four different methods using polar protic and aprotic solvents with high boiling points. Also the complexation abilities of all synthesized ligands with Cu2+, Zn2+, and Ag+ were studied by conductometry; thus the conductometric behavior of Cu(NO3)(2), ZnCI2, and AgNO3 in 80% dioxane-water mixture was investigated in the presence of these ligands. The order of formation constant for complexes of the ligands with Cu2+, Zn2+, and Ag+ ions was found to be: Cu2+ > Zn2+ > Ag+ for the ligands of VI, VIL XI, and XII; Cu2+ > Ag+ > Zn2+ for the ligands of III and VIII; and Zn2+ > Cu2+ > Ag+ for the ligands of I, II, IV, V, IX, and X. (C) 2003 Wiley Periodicals, Inc.Öğe Cream production and biological in vivo/in vitro activity assessment of a novel boron-based compound derived from quercetin and phenyl boronic acid(Elsevier GmbH, 2022) Temel, Hamdi; Atlan, Metin; Ertaş, Abdulselam; Yener, İsmail; Akdeniz, Mehmet; Yazan, Zehra; Yılmaz, Mustafa AbdullahBoronic acids constitute an important class of synthetic intermediates due to their high chemical stability, ease of use, moderate organic Lewis acid properties, reduced reactivity profiles and numerous biological activities such as antibacterial and antioxidant. The present study documents the synthesis and characterization of a novel boronic ester compound (3,5,7-trihydroxy-2- (2-phenyl benzo [d] [1,3,2] dioxaborol-5-yl) −4H-chromen-4-a) which was derived from phenyl boronic acid and quercetin. The new boron-based compound was used in the cream formulation after evaluating its antioxidant, antibacterial, anti-enzyme, anticancer activities and electrochemical oxidation behaviour. Furthermore, the cream has been dermatologically and microbiologically tested. Also, histological evaluation of the agent was estimated on multiple rat organs by hematoxylin-eosin staining method. Antioxidant potential of the new compound was tested by ABTS cation radical (IC50: 0.11 ± 0.01 µg/mL), DPPH free radical scavenging (IC50: 0.14 ± 0.01 µg/mL), and CUPRAC (A0.5: 1.73 ± 0.16 µg/mL) methods, respectively. The compound determined to have a dominant antioxidant activity. In addition, the synthesized compound had no toxic effect on the healthy cell line (PDF), while having a very high (IC50: 18.76 ± 0.62 µg/mL) cytotoxic effect on the cancerous cell line (MCF-7). In general, the compound showed moderate acetylcholinesterase enzyme activity (IC50: 115.63 ± 1.16 µg/mL), high butyrylcholinesterase (IC50: 3.12 ± 0.04 µg/mL), antiurease (IC50: 1.10 ± 0.06 µg/mL), and antithyrosinase (IC50: 11.52 ± 0.46 µg/mL) enzyme activities. In addition, the compound was found to be effective against Escherichia coli (ATCC 25922) bacteria studied at concentrations of 6.50 mg/mL. Moreover, the test results of the boronic ester compound used in the cream formulation demonstrated that it was microbiologically and dermatologically appropriate. Histologic analysis showed that the control group and experimental group were at similar properties without significant change. The phenyl boronic acid derivative compound synthesized from quercetin may have higher biological activity potential than quercetin. Due to the high biological activity potential of the synthesized compound, it has the potential to be used in food, feed, pharmaceutical and cosmetic industries.Öğe Cross-coupling reactions in water using ionic liquid-based palladium(II)-phosphinite complexes as outstanding catalysts(Wiley, 2014) Meriç, Nermin; Aydemir, Murat; Işık, Uğur; Ocak, Yusuf Selim; Rafikova, Khadichakhan; Paşa, Salih; Kayan, Cezmi; Durap, Feyyaz; Temel, Hamdi; Zazybin, Alexey G.; 0000-0003-0899-1948; 0000-0002-6244-9327; 0000-0002-4792-8821Two new phosphinite ligands based on ionic liquids [(Ph2PO)C7H14N2Cl]Cl (1) and [(Cy2PO)C7H14N2Cl]Cl (2) were synthesized by reaction of 1-(3-chloro-2-hydoxypropyl)-3-methylimidazolium chloride, [C7H15N2OCl]Cl, with one equivalent of chlorodiphenylphosphine or chlorodicyclohexylphosphine, respectively, in anhydrous CH2Cl2 and under argon atmosphere. The reactions of 1 and 2 with MCl2(cod) (M=Pd, Pt; cod=1,5-cyclooctadiene) yield complexes cis-[M([(Ph2PO)C7H14N2Cl]Cl)(2)Cl-2] and cis-[M(Cy2PO)C7H14N2Cl]Cl)(2)Cl-2], respectively. All complexes were isolated as analytically pure substances and characterized using multi-nuclear NMR and infrared spectroscopies and elemental analysis. The catalytic activity of palladium complexes based on ionic liquid phosphinite ligands 1 and 2 was investigated in Suzuki cross-coupling. They show outstanding catalytic activity in coupling of a series of aryl bromides or aryl iodides with phenylboronic acid under the optimized reaction conditions in water. The complexes provide turnover frequencies of 57 600 and 232 800h(-1) in Suzuki coupling reactions of phenylboronic acid with p-bromoacetophenone or p-iodoacetophenone, respectively, which are the highest values ever reported among similar complexes for Suzuki coupling reactions in water as sole solvent in homogeneous catalysis. Furthermore, the palladium complexes were also found to be highly active catalysts in the Heck reaction affording trans-stilbenes. Copyright (c) 2014 John Wiley & Sons, Ltd.Öğe A detailed chemical and biological investigation of twelve allium species from Eastern Anatolia with chemometric studies(Wiley-V C H Verlag Gmbh, 2021) İzol, Ebubekir; Temel, Hamdi; Yılmaz, Mustafa Abdullah; Yener, İsmail; Ölmez, Özge Tokul; Kaplaner, Erhan; Fırat, Mehmet; Ertaş, Abdülselam; 0000-0002-4090-7227; 0000-0001-9225-7425; 0000-0002-0988-9462; 0000-0002-2093-4949; 0000-0002-2193-8386Allium species are widely consumed as food all over the world. The phenolic profile of ethanol extracts of aerial parts and roots of 12 Allium species, collected from five different Eastern Anatolia regions, were studied using LC-MS/MS. In vitro antioxidant, anticholinesterase, cytotoxic and antimicrobial activities were also tested. The multivariate analyses were performed using principal component and hierarchical cluster analyses. Seventeen of 27 standard compounds were detected in all Allium species. The major components were mainly identified as quinic acid, malic acid, vanillin, and p-coumaric acid. The aerial parts possessed better antioxidant activity than roots. Aerial parts of A. atroviolaceum, A. chrysantherum, A. kharputense, and A. shirnakiense exhibited high cytotoxic activity against DLD-1 colon cancer cell lines (IC50 12.5 mu g/mL). A. shatakiense and A. vineale demonstrated good antimicrobial activity against S. aureus and E. coli (MIC 75 mu g/mL). According to chemometric analysis, differences were detected between aerial parts and the roots. The aerial parts of A. atroviolaceum, A. chrysantherum, A. kharputense, and A. shirnakiense could be potent in the pharmaceutical industry while A. shatakiense and A. vineale in the food industry after further investigations.Öğe A detailed study on the chemical and biological profiles of essential oil and methanol extract of Thymus nummularius (Anzer tea): Rosmarinic acid(Elsevier, 2015) Ertas, Abdulselam; Boga, Mehmet; Yilmaz, Mustafa Abdullah; Yesil, Yeter; Tel, Gulsen; Temel, Hamdi; Hasimi, NesrinThe aim of this study was to determine the chemical profile of Thymus nummularius by LC-MS/MS and GC/MS. Additionally, the methanol extract, essential oil and some individual main compounds of Thymus nummularius were tested for antioxidant, anticholinesterase and antimicrobial activities. Besides, HPLC-FLD was used to determine total aflatoxin in the plant material. Among the twenty-seven compounds studied by LC-MS/MS, rosmarinic acid (131,898.9 +/- 6463.0 mu g/g dry-extract) was found to be the most abundant compound in the methanol extract. On the other hand, thymol (60.38%) and terpinyl-acetate (10.49%) were found to be the major compounds of the essential oil. Both the essential oil and the methanol extract of T. nummularius exhibited strong antioxidant activity in the four tested methods. Furthermore, the essential oil showed high inhibitory activity against acetyl-,butyryl-cholinesterase enzymes and very strong antimicrobial activity against all tested microorganisms. Besides, T. nummularius can be used both as rosmarinic acid source and as food supplement due to its non-aflatoxin content and high antioxidant, anticholinesterase and antimicrobial activities. (C) 2015 Elsevier B.V. All rights reserved.Öğe Determination of anticholinesterase and antioxidant activities of methanol and water extracts of leaves and fruits of Chamaerops humilis L.(Applied and Natural Science Foundation, 2019) Bouhafsoun, Aicha; Boğa, Mehmet; Boukeloua, Ahmed; Temel, Hamdi; Kaid-Harche, MeriemThe present study was carried out to investigate the antioxidant activity of the water and methanol extracts of leaves and fruits extracts of Chamaerops humilis L. by using ABTS cation radicals and cupric reducing antioxidant capacity (CUPRAC). Anticholinesterase effect of the extracts was tested against both AChE and BChE using a microplate-reader assay based on the Ellman method. The methanol extracts of C. humilis leaves contained relatively higher content of flavonoids and total phenolics than those of fruits. All the extracts were found to have different levels of antioxidant activity in the systems tested. The leave extract showed the highest value of antioxidant activity, based on ABTS radical-scavenging activity, while the fruit water extract showed the highest value (0.53±0.50 µg/ mL) of cupric reducing antioxidant activity. Our data indicates that both methanol and water fruit extract were active for BChE inhibition (31.65 ± 0.37 and 30.19 ± 0.56%) respectively, whereas, all leave extracts did not show any activity against BChE. The present study demonstrated that the methanol and water extracts fractions of C. humilis have different responses with different antioxidant methods. Our results suggest that the C. humilis could be used as a source of antioxidant agents and may be beneficial in the AD treatment.
