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Öğe Apolipoprotein E Genotype in Patients with Cerebrovascular Diseases and its Effect on the Disease Outcome(Taylor & Francis Ltd, 2009) Tamam, Yusuf; Tasdemir, Nebahat; Toprak, Recep; Tamam, Banu; Iltumur, KenanA total of 100 hospitalized stroke patients and 30 healthy controls were included in a study aiming to determine the predictive role of ApoE genotype polymorphism for stroke outcome in the Turkish population. The most frequent ApoE genotype was 3/3 reflecting Asian population polymorphic distribution. ApoE polymorphism in the Eastern Turkish population was found to be independent of stroke type, OSCP subtypes of infarction, localization of hemorrhage, severity of carotid artery stenosis, and resultant stroke outcome. Distinct polymorphic results in populations from nearby regions suggest a multifactorial pathogenesis and presence of very complex genetic factors in the development of stroke and stroke outcome.Öğe The Association Between Apolipoprotein E Genetic Polymorphisms and Multiple Sclerosis(Aves, 2013) Tasdemir, Nebahat; Tamam, Yusuf; Yalman, MedihaBackground: Although the etiology of multiple sclerosis (MS) has not yet been clearly elucidated, MS is a chronic inflammatory disease, in which genetic and environmental factors are involved. The association between apolipoprotein E (APOE) genetic polymorphisms and various neurodegenerative diseases, including MS, is controversial. In the current study, specific APOE genotypes were investigated in patients with MS. Methods: Fifty patients clinically diagnosed with MS and 30 healthy volunteers were included in the study. The APOE genotype was identified via the polymerase chain reaction (PCR) method. The patient and control groups were compared in terms of the frequency of APOE genotypes. Results: The APOE genotype distribution in the patient group was as follows: epsilon 3/epsilon 3, 82.0%; epsilon 3/epsilon 4, 12.0%; and epsilon 2/epsilon 3, 6.0%. There were no significant differences between the patient and control groups with respect to the frequency of APOE genotypes, and APOE epsilon 4 allele carriage (p=0.56). However, the frequency of APOE epsilon 4 allele carriers were significantly higher among male patients (p=0.007). Conclusion: These findings suggest that the APOE genotype has no effect on susceptibility to MS. Further studies with larger sample sizes to be able to include all APOE genotypes are warranted. Identification of genetic factors that may have a role in the etiology of MS will make a substantial contribution to the knowledge of the prevention and treatment of MS.Öğe Association of apolipoprotein e genotype and cerebrovascular disease risk factors in a Turkish population(Taylor & Francis Ltd, 2008) Tasdemir, Nebahat; Tamam, Yusuf; Toprak, Recep; Tamam, Banu; Tasdemir, M. SerhanThe purpose of the present study was to investigate the predictive role of apolipoprotein E genotypes for stroke-related risk factors in the Turkish population. Among 100 stroke patients and 30 healthy subjects included in the study, most frequent Apo E genotype was epsilon 3/3, compatible with polymorphic distribution of Asian population. VLDL and triglyceride levels in epsilon 2/4(+) subjects were higher than in epsilon 2/4(-) patients. HDL and homocysteine levels were higher in epsilon 4/4 (+) subjects than in epsilon 4/4 (-) stroke patients. These results suggest that ApoE polymorphism in this population was not associated with any other demographic or clinical variables except for lipid profiles and homocysteine levels.Öğe Cervical intramedullary granuloma of Brucella: a case report and review of the literature(Springer, 2007) Nas, Kemal; Tasdemir, Nebahat; Cakmak, Erkan; Kemaloglu, Mustafa Serdar; Bukte, Yasar; Geyik, Mehmet FarukThe aim of this study was to present a unique case of intramedullary brucellar granuloma (IBG) and to discuss the diagnosis and management. To our knowledge, only one case of thoracic IBG has been reported previously, and our case is the first in cervical spine. A 35-year-old female patient was admitted with headache, pain and weakness in her four extremities. She had no gastrointestinal symptoms and fever. She had been diagnosed with Brucella meningitis 3 months ago and a triple therapy of doxycyclin, rifampicin and trimetoprim/sulfametoxazol (TMP/SMZ) had been started. Medical history revealed that she had ingested raw cheese and taken her medication improperly. Loss of strength was detected in her four extremities, which led us to assume the formation of a mass lesion at cervical level. Therefore, we performed a magnetic resonance imaging scan and found enhancement of an intramedullary mass lesion at cervical 1-2 level. Diagnosis of neurobrucellosis was confirmed by titer of > 1/160 Brucella antibodies both in blood and cerebrospinal fluid. Based on these findings, brucellar granuloma of cervical spine was diagnosed and a combination therapy of doxycyclin, TMP/SMZ and rifampicin was administered for additional 6 months. At the ninth month of treatment, the patient recovered both radiologically and clinically. Our case is unique, in terms of cervical IBG formation. The excellent response to antimicrobial therapy in our patient suggests that, a trial of medical treatment for 6 months may be effective in such cases.Öğe Childhood dermatomiyositis(Pergamon-Elsevier Science Ltd, 2006) Tasdemir, Nebahat; Akcicek, Ali; Tasdemir, M. Serhan[Abstract Not Available]Öğe Early response to medical treatment in a case of brucellar spondylodiscitis with medullary compression(Ios Press, 2008) Nas, Kemal; Tasdemir, Nebahat; Kemaloglu, Mustafa Serdar; Buekte, Yasar; Guer, Ali; Tasdemir, Mehmet SerhanWe have presented a patient with brucellar spondylodiscitis who developed paraparezi secondary to spinal cord compression, and responded well to the medical treatment. A 55 year-old male farmer presented with a 7-day history headache, urinary retention, weakness in his lower extremities and a 3-month history of back pain. Blood brucella Wright antibody titer was 1/160 and Rose Bengal test was positive. Our case did not need a surgical intervention and gave a good response to medical treatment and rehabilitation. Thus, we suggest that in cased with brucella spondylitis, medical treatment should be considered at first, even in cases with spinal cord compression due to prevertebral abscess.Öğe The effect of venlafaxine HCl on painful peripheral diabetic neuropathy in patients with type 2 diabetes mellitus(Elsevier Science Inc, 2008) Kadiroglu, Ali Kemal; Sit, Dede; Kayabasi, Hasan; Tuzcu, Alpaslan Kemal; Tasdemir, Nebahat; Yilmaz, M. EminObjective: The objective of this study was to evaluate the efficacy of venlafaxine HCl in the symptomatic treatment of painful peripheral diabetic neuropathy (PPDN) among patients with type 2 diabetes mellitus (DM). Design: This study was designed as a prospective, randomized, and controlled trial. Setting: This study was conducted at the Dicle University Medical Faculty (Diyarbakir, Turkey). Patients: Sixty type 2 DM outpatients (47 females and 13 males) with PPDN who had a minimum visual analog scale (VAS) score of 40 mm were enrolled in this study. Interventions: Patients randomized to the treatment group (n=30) received venlafaxine HCl, whereas those randomized to the control group (n=30) received a combination of vitamins B-1 and B-6 tablets. Measures: Severity of pain was measured by VAS, Short-Form McGill Pain Questionnaire, and numerical analog scale scores at admission and at the second, fourth, and eighth weeks of the study. Polyneuropathy was supported by electromyelography. Outcome: In the treatment group, severity of pain was measured as 70.0+/-13.0 in the VAS, as 24.9+/-6.2 in the Short-Form McGill Pain Questionnaire, and as 7.2+/-1.1 in the numerical analog scale. In the control group, it was measured as 73.0+/-8.0 in the VAS, as 26.8+/-6.2 in the Short-Form McGill Pain Questionnaire, and as 7.4+/-0.8 in the numerical analog scale (P>.05). Results: The most common form of PPDN was distal symmetrical sensorimotor polyneuropathy in both groups (46.8% vs. 50.0%). At the end of the study, there was a significant difference in severity of pain between the groups. In the treatment group, scores were 8.5+/-5.2 and 3.1+/-1.6 in the Short-Form McGill Pain Questionnaire and numerical analog scale, respectively; in the control group, these were 20.5+/-7.0 and 5.5+/-1.6, respectively (P<.001). Conclusions: Venlafaxine HCl is a safe and well-tolerable analgesic drug in the symptomatic treatment of PPDN; however, it has minimal adverse effects. It showed its efficacy markedly in the second week of therapy. (C) 2008 Elsevier Inc. All rights reserved.Öğe Evaluation of serum transforming growth factor ?1 and C-reactive protein levels in migraine patients(Via Medica, 2013) Guzel, Isil; Tasdemir, Nebahat; Celik, YusufBackground and purpose: Migraine is a frequent form of headache. Although many mechanisms describing onset of migraine with and without visual aura have been suggested, the aetiology of migraine headaches is still not clear. Neurogenic inflammation may play a key role in the development of migraine headaches. We evaluated the discriminative power of serum levels of C-reactive protein (CRP) and transforming growth factor beta 1 (TGF-beta 1) in patients who presented to our clinic with migraine headaches with or without visual aura. Material and methods: We designed a prospective case-control study of 51 patients with migraine (27 with migraine with aura and 24 with migraine without aura; all had headache) and compared them with 27 healthy subjects during the study period. Demographic and clinical characteristics recorded were age, sex, marital status, occupation, characteristics of headache, laboratory values, and serum CRP and TGF-beta 1 levels. Statistical analyses used Student t-test, the chi(2) test, and AN OVA followed by the post-hoc Bonferroni test for multiple comparisons. Receiver operator characteristic (ROC)-curve analysis for CRP and TGF-beta 1 was also conducted. Result: There was no difference between the groups in terms of demographic characteristics, marital status, and socioeconomic status. Statistically, white blood cell levels, serum glucose levels, triglyceride levels, high-density lipoprotein levels, and serum CRP and TGF-beta 1 were significantly higher in patients with migraine (p < 0.05). The ROC curve results in this study identified that CRP and TGF-beta 1 may discriminate patients who have different types of migraine headache. Conclusions: This study suggests that serum CRP and TGF-beta 1 levels may be diagnostic factors to differentiate migraine patients with and without aura. These findings show that neurogenic inflammation may have a role in the aetiology of migraines.Öğe Immunological Parameters in Migraine Patients(Ortadogu Ad Pres & Publ Co, 2009) Tasdemir, Nebahat; Ulug, Nuray Can; Dogan, Bahar BurtanObjective: In this study, we aimed to investigate by measuring differences between the levels of plasma cytokines interleukin-1 beta (IL-1 beta), IL-2 receptor, IL-6, IL-8, IL-10, turnout necrotizing factor alpha (TNF-alpha), compleman 3 (Q) and 4 (C4); immunoglobulins G (IgG), IgA, IgM, IgE during migraine attacks and headache-free periods. Material and Methods: Seventy-two patients and 41 age and sex matched healthy people were enrolled in the study. The diagnosis was made according to the International Classification of Headache Disorders (ICHD-II) criteria. Thirty patients out of 72 were in a migraine status while 42 were headache-free. The plasma levels of the cytokines such as IL-10, IL-2 receptor, IL-6, IL-8, IL-10, TNF-alpha, complements (C3, C4) and immunoglobulins were measured in all patients and the controls. Results: The level of TNF-alpha was higher during the attack and the headache-free period in migraine patients than in the healthy control group. The level of C3 was higher during a headache-free period than in the healthy control group. There were significant differences between groups regarding IL-1 beta, IL-6, IL-10 and IgG levels. Conclusion: Immunologic alterations and activity of proinflammatory markers were present during the migraine attack and headache free period in migraine patients.Öğe The Increase of The Mean Platelet Volume in Patients With Intracerebral Haemorrhage(Galenos Publ House, 2012) Arikanoglu, Adalet; Cevik, Mehmet Ugur; Uzar, Ertugrul; Acar, Abdullah; Akil, Esref; Ekici, Faysal; Tasdemir, NebahatObjective: The mean platelet volume (MPV) is a biomarker of platelet function and activity. The influence of platelet function disorders on the aetiology of intracerebral haemorrhages (ICH) and mortality is not clear yet. The purpose of this study is to investigate the change in the MPV values in patients with ICH and to observe its influence on mortality in a retrospective manner. Material and Method: Sixty-six patients with intracerebral haemorrhage (32 males, 34 females; mean age: 61.9 +/- 16.9) were enrolled in the study. Patients with ICH were divided into two groups as those who died within the first 10 days and those who survived. The MPV values and the haematoma volumes were compared between the groups. Also, the MPV values and platelet counts of the patients with ICH were compared with the values of healthy volunteers from similar age and sex groups (27 males, 17 females; mean age: 59.9 +/- 3.2). Results: The MPV values of the patients with ICH measured within 24 hours following the intracerebral haemorrhage (8.33 +/- 1.27 fl) were statistically significantly higher than the MPV values of the control group (7.76 +/- 1.14 fl) (p=0.018). The platelet counts of the patients with ICH also measured with in the first 24 hours (235.8 +/- 94.9 x 10(3)/mL) were statistically significantly lower than the platelet counts of the control group (279.1 +/- 94.9 x 10(3)/mL) (p=0.022). No statistically significant difference in terms of the MPV values and platelet counts was observed between the patients with ICH who died within the first 10 days and those who survived (p>0.05). However, the difference observed in the haematoma volume between the patients with ICH who died within the first 10 days (31.1 +/- 33.7 ml) and those who survived (8.7 +/- 13.4 ml) was statistically significant (p<0.001). No correlation was found between the haematoma volume and the MPV value in the patients with ICH. Discussion: The increase, observed in the mean platelet volume in patients with ICH, may point to a disorder in the platelet function. No relationship was found between the increase in the MPV and the mortality rates.Öğe Investigation of Mean Platelet Volume in Patients with Multiple Sclerosis(Turkish Neurological Soc, 2011) Uzar, Ertugrul; Arikanoglu, Adalet; Yucel, Yavuz; Aydin, Birsen; Tanriverdi, Mehmet Halis; Tasdemir, NebahatObjective: Alterations in platelet function have been observed in patients with multiple sclerosis. Mean platelet volume is a marker of the platelet activity and is reported to be increased in vascular diseases. The aim of this retrospective study was to investigate the correlation between mean platelet volume and multiple sclerosis. Materials and Methods: The patient group consisted of 46 multiple sclerosis patients who were presented with multiple sclerosis attacks (males/females: 10/36, mean age: 34.3 +/- 9.4 year). In the multiple sclerosis patients, mean platelet volume values during the attack were compared with the mean platelet volume value after attack. Mean platelet volume values of patients were also compared with those of 38 age/sex-matched healthy individuals (males/females: 14/24, mean age: 36.4 +/- 10.4). Results: No difference was found in mean platelet volume values during the multiple sclerosis attack (8.0 +/- 1.2) versus after the multiple sclerosis attack (7.9 +/- 1.2), and no relation was found between mean platelet volume and Expanded Disability Status Scale (EDSS) parameters (p> 0.05). No difference was found in mean platelet volume values between the multiple sclerosis group (8.1 +/- 1.3) and control group (8.1 +/- 1.1) (p> 0.05). Conclusion: No significant change in mean platelet volume values was seen during the multiple sclerosis attack versus after the multiple sclerosis attack. This finding supports that platelet activation does not play an important role in the multiple sclerosis pathogenesis. However, the relation between multiple sclerosis and mean platelet volume should be investigated prospectively.Öğe Pseudotumor cerebri due to Behcet's disease increased fluid in the perioptic nerve sheath on cranial magnetic resonance imaging(Aves Press Ltd, 2011) Uzar, Ertugrul; Ekici, Faysal; Sahin, Alparslan; Tamam, Yusuf; Acar, Abdullah; Tasdemir, NebahatPseudotumor cerebri is a rare condition of Behcet's disease. Enlargement of optic nerve sheath and increased subarachnoid fluid around the optic nerve are uncommon magnetic resonance (MR) findings of the patients with pseudotumor cerebri. To the best of our knowledge, these findings were not reported in pseudotumor cerebri due to Behcet's disease. Lumboperitoneal shunting surgery may be performed in cases which have visual symptoms and refractory to the medical treatment. In this paper, the relevant clinical and radiological findings were discussed, and a brief overview of therapeutic management was provided.
