Yazar "Tas, Mahmut" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Acute Appendicitis Together with Chylous Ascites: Is It a Coincidence?(Hindawi Ltd, 2010) Akbulut, Sami; Yilmaz, Davut; Bakir, Sule; Cucuk, Erdal; Tas, MahmutAcute chylous ascites is a rarely seen clinical picture, therefore, examination findings are often confused with acute appendicitis. To the best of our knowledge, there is no publication to date showing the occurrence of them together. This study presents the treatment plan for a 25-year-old male patient with both acute chylous ascites and appendicitis. Surgical findings were retrocaecal appendicitis, evident lymphangiectasia in the proximal segment of jejunum, and approximately 3 lt of chylous fluid. An appendectomy was performed and drainage was applied. Low-fat total parenteral nutrition (TPN) and octreotide treatment were administered for 7 days postoperatively. We also present a general review of some studies on chylous ascites, which have been published in the English language medical literature since 1910.Öğe The association between mean platelet volume and inflammation in geriatric patients with emergency hypertension(Emergency Medicine Association of Turkey, 2019) Gökdemir, Mehmet Tahir; Gökdemir, Gül Şahika; Tas, MahmutObjectives: We aimed to investigate the role of inflammation parameters and platelet activation in geriatric patients with hypertension. Therefore, we compared the levels of those parameters in patients with hypertensive urgency and emergency. We also investigated the potential relationship between those parameters. Methods: Ninety-six hypertensive (HT) patients (aged > 60) were included in the study in two groups: HT emergency (N = 48, group 1) and HT urgency (N = 48, group 2). Mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR) and high-sensitive C reactive protein (hs-CRP) were compared between those groups. Optimum cut-off levels of each parameter were determined by the use of Receiver operating characteristic (ROC) curve analysis. Pearson correlation test was used to examine the relationship between variables. Results: The mean MPV and hs-CRP levels were significantly higher in patients with HT emergencies (both P < 0.001). Mean NLR was also significantly different between the two groups (P = 0.011). Pearson correlation analysis revealed a positive but weak correlation between the MPV and NLR (r = 0.245, P = 0.016), the hs-CRP level (r = 0.394, P < 0.001), and the WBC count (r = 0.362, P < 0.001). Conclusion: Increased platelet activity and inflammation are associated with the end organ failure. Levels of MPV and other inflammatory parameters may be useful in the management of geriatric patients with HT. © 2018 The Emergency Medicine Association of TurkeyÖğe Demographic and clinical characteristics of traumatic shoulder dislocations in an urban city of Turkey: a retrospective analysis of 208 cases(Turkish Assoc Orthopaedics Traumatology, 2013) Tas, Mahmut; Canbora, M. Kerem; Kose, Ozkan; Egerci, Omer Faruk; Gem, MehmetObjective: The aim of this study was to investigate the demographic and clinical characteristics of traumatic shoulder dislocations in an urban city of Turkey. Methods: The digital patient database was reviewed to identify all patients with glenohumeral dislocation of the shoulder admitted to the emergency departments of the two hospitals in Diyarbakir between January 2008 and December 2010. Incidence, demographics, clinical characteristics, recurrence, associated injuries, and mechanism of injury were evaluated. Results: Two hundred and eight patients (163 male, 45 female; mean age: 37.2+/-21.3) experienced traumatic shoulder dislocation during the study period. The overall incidence of primary shoulder dislocations was 5.3 per 100,000 person-years. Age distribution peaked between 21 and 30 years (96.5% male) and between 61 and 70 years (66.7% female) Primary shoulder dislocation occurred in 172 patients (82.7%) and recurrent dislocations in 36 (17.3%). Patients with recurrent shoulder dislocations were younger than those with primary dislocations (mean age, 29.7+/-14.5 and 38.8+/-22.2, respectively; p=0.020). There were 195 (93.4%) anterior dislocations. The mechanism of injury was falls in 155 (74.5%) cases. Reduction was achieved in 165 patients (79.3%) in the emergency department. General anesthesia was used for 43 patients (20.7%). Conclusion: The 5.3 per 100,000 person-years incidence of traumatic shoulder dislocations in Turkey was much lower than previous studies. Demographic characteristics also showed various differences closely related to the population pyramid.Öğe The Effect of Losartan on Deformities Occurring in Brain Tissue Craniectomy(Sci Printers & Publ Inc, 2020) Avinca, Oner; Karakoc, Yenal; Tas, Mahmut; Deveci, EnginOBJECTIVE: Traumatic brain injury is a major problem in the disruption of the blood-brain barrier integrity of nerve cells and glial cells. We aimed to investigate the antioxidant effects of losartan, an AT1 receptor blocker, on cell apoptosis with changes in the blood-brain barrier after craniectomy in a rat model. STUDY DESIGN: Male Sprague Dawley rats were randomly divided into 3 groups consisting of 10 rats each. The groups were as follows: control group, trauma group, and trauma +losartan group. After traumatic brain injury, blood samples were taken from the animals and analyzed with various biochemical markers. TUNEL assays and glial fibrillary acidic protein (GFAP) expressions were evaluated immunohistochemically. RESULTS: With TUNEL staining, positive expression was observed in posttraumatic neurons and glial cells. GFAP reaction was positive in degenerative astrocyte processes in the trauma group. In the trauma +losartan group, positive expression in astrocytes with regular structure around the blood vessels was observed. CONCLUSION: Losartan may cause release of cytochrome c via the mitochondrial pathway; however, it also may decrease cellular apoptosis.Öğe Effects of thymoquinone on spinal cord injury in rats(Pisa Univ Press, 2022) Avinca, Oner; Tas, Mahmut; Karakoc, Yenal; Yavuz, Dilek; Deveci, EnginPurpose: Spinal cord injury (SCI) is a condition that causes disturbances in normal sensory, motor, and autonomic functions. During SCI, damages occur such as, contusion, compression, distraction. The aim of this study was to investigate effects of the antioxidative thymoquinone on neuron and glia cells in SCI biochemically, immunohistochemically and ultrastructurally. Methods: Male Sprague-Dawley rats were divided into Control, SCI and SCI + Thymoquinone groups. After T10 -T11 laminectomy was performed, a metal weight of 15 grams was left down the spinal tube for spinal damage. Immediately after the trauma, the muscles and skin incision were sutured. Thymoquinone was given to the rats by gavage as 30mg/kg/21days. Tissues fixed in 10% formaldehyde, embedded in paraffin wax and immunstained with Caspase-9 and phosphorylated signal transducer and activator of transcription 3 (pSTAT-3) antibodies. Remaining were stored at-80oC for biochemistry. Frozen spinal cord tissues were placed in a phosphate buffer solution and homogenized, centrifuged then used to measure malondialdehyde (MDA) levels, glutathione peroxidase (GSH) and Myeloperoxidase (MPO).Results: In the SCI group, MDA, MPO, neuronal degeneration, vascular dilatation, inflammation, apoptotic appearance in the nucleus, loss of membrane and cristae in mitochondria, and dilatation in the endoplasmic reticulum were observed due to degeneration in the neuron structure. In the electron microscopic examination of the trauma + thymoquinone group, the membranes of the nuclei of the glial cells were thick and euchromatin, and mitochondria were shortened in length. In the SCI group, pyknosis and apoptotic changes were observed in neuronal structures and nuclei of glia cells in the substantia grisea and substantia alba region, along with positive Caspase-9 activity. An increase in Caspase-9 activity was observed in endothelial cells in blood vessels. In the SCI + thymoquinone group, Caspase-9 expression was positive in some of the cells in the ependymal canal while the cuboidal cells showed a negative Caspase-9 reaction in the majority. A few degenerated neurons in the substantia grisea region showed a positive reaction with Caspase-9. In SCI group, pSTAT-3 expression was positive in degenerated ependymal cells, neuronal structures, and glia cells. pSTAT-3 expression was positive in the endothelium and surrounding aggregated cells of the enlarged blood vessels. In the SCI+ thymoquinone group, pSTAT-3 expression was negative in most of the bipolar and multipolar neuron structures and glial cells in ependymal cells, enlarged blood vessel endothelial cells.Conclusions: It has been thought that thymoquinone application in spinal cord injuries may be an antioxidant that can be recommended as an alternative treatment in suppressing the apoptosis of neural cells by significantly reducing the inflammation process.Öğe Factors Influencing Mortality in Pediatric Trauma Patients(Emergency Medicine Physicians Assoc Turkey, 2012) Tas, Mahmut; Guloglu, Cahfer; Orak, Murat; Ustundag, Mehmet; Aldemir, MustafaObjective: In our study, we aimed to research the factors we thought might be affect mortality in a pediatric age group (0-15 y) with multiple trauma. Materials and Methods: In our study of 1658 pediatric patients suffering from falling events, burns, cutting and perforating instrument injuries, gunshot injuries and vehicle accidents admitted to Dicle University. hospital ED between March 2003 and December 2006 were analyzed and included to the study consecutively. The patients were divided in two groups, the patients who survived were in group 1, and the patients who died were in group 2. Results: Of the 1658 patients, 70.5% (n= 1169) were male, 29.5% (n=489) were female and 107 patient died (6.46 %). Mean age was 6.75+-0.397 in group 2 (who died) and 7.00+-0.99 in group 1, (survived). Low RTS score (OR (odds ratio)= 1.565, CI=1.297-1.889, p<0.05). Falling down from height OR=0.637, CI=0.408- 0.995, p<0.05), postulated admission (OR=2.035 CI=1.267-3.267, p<0.05) and medical treatment (OR=0.451, CI=0.273-0.744, p<0.05) were found to be the effective factors in pediatric patients with multiple trauma. Conclusion: The falling events, abdominal and thoracic trauma with low ISS, RTS, TRISS and postulated admission to ED are the factors that affect the mortality in pediatric trauma patients.Öğe Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats(Soc Chilena Anatomia, 2016) Tas, Mahmut; Gok, Ertugrul; Ekinci, Cenap; Deveci, Engin; Deveci, SenayBone damage and accidents, traumas can alter people's normal life, and damage the soft tissues. In this study, we aimed to investigate in calvarial defects in rats depending on the severity of cerebral contusion injury occurring in the temporal region. The rats were randomly divided into two groups: group 1 (control group), critical size cranial model with no treatment (n=10); group 2 (14-day synthetic graft group given 7th day DEXA), critical size cranial model treated with Dexamethasone (0.05 mg/kg intramuscular injection) + Synthetic graft (n=10) One calvarium defect of 7 mm was made in the parietal bone of each animal under general anesthesia. Calvarial defect results in dilatation of blood vessels, hemorrhage and deterioration was observed in glial fibrillary structures. Additionally, the increase in vascular endothelial growth factor expression showed a positive reaction with glial fibrillary acid protein astrocytes extensions. Apoptotic glial cells stained positive with Bcl-2. Calvarial defects caused by mild brain injury, to be induced by inflammatory cytokines, interrupting glial fibrillary degeneration by affecting the blood brain barrier is thought to promote apoptotic changes.Öğe Ortalama Hava Sıcaklığının Hastalarda Üre, Kreatinin, eGFR, Sodyum ve Potasyum Düzeylerine Etkileri(Türkiye Acil Tıp Derneği, 2020) Tas, Mahmut; Şen, Abdullah; Avınca, Öner; Karakoç, YenalAmaç: Bu çalışmada acil servise başvuran hastalarda hava koşullarının mevsimsel etkilerinin elektrolit dengesizliği ile ilişkili olup olmadığını araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmaya 21 942 hasta dahil edildi ve bu hastalar iki gruba ayrıldı: Grup 1, havanın sıcak olduğu yaz aylarında acil servisimize başvuran 10953 hastadan, Grup 2 ise havanın soğuk olduğu kış aylarında acil servise başvuran 10989 hastadan oluşuyordu. Bulgular:Gruplar elektrolitler ve eGFR açısından birbirleriyle karşılaştırılmış ve Grup 1'de üre ve kreatinin değerleri daha yüksek, Sodyum, potasyum ve eGFR değerleri aynı grupta daha düşük olarak bulunmuştur (p <0.001). Hastaların günlük sıcaklık, yaş, üre, kreatinin, sodyum, potasyum ve eGFR'deki değişim arasında bir korelasyon olup olmadığını değerlendirmek için korelasyon analizi yapıldı. Günlük sıcaklıktaki değişikliklerin üre ve kreatinin ile pozitif, yaş, sodyum, potasyum ve eGFR ile negatif korelasyon gösterdiği gözlendi. Sonuç: Bu çalışmanın acil servise başvuran hastalarda mevsimsel sıcaklık değişikliklerinden kaynaklanan elektrolit dengesizlikleri arasındaki ilişkiyi göstermesi açısından anlamlı sonuçlar verdiğini düşünüyoruz.Öğe Pneumomediastinum and Pneumothorax After Blunt Neck Trauma(Emergency Medicine Physicians Assoc Turkey, 2010) Ozhasenekler, Ayhan; Gokhan, Servan; Yilmaz, Fevzi; Tas, Mahmut; Tan, Omer; Nasir, AhmetPneumomediastinum is air presence in mediastinum. It is spontaneously and traumatically divided into two. While spontaneous pneumomediastinum is generally found in healthy young men, traumatic pneumomediastinum may develop due to skull, neck, chest traumas and intraoral injuries. Pneumomediastinum is a clinical state with high morbidity and mortality due to complications it causes. It should be considered that it can improve and also accompanied by pneumothorax even without trachea and esophagus injury after blunt neck, face and eye traumas.Öğe Predictors of mortality in near hanging emergency department patients(Elsevier Science Bv, 2007) Ustundag, Mehmet; Orak, Murat; Guloglu, Cahfer; Sayhan, Mustafa Burak; Tas, MahmutObjectives: In this study, our purpose is to search the factors predicted to have influence on mortality in near-hanging patients. Materials and Methods: The records of near hanging patients presenting to our Emergency Department (ED) between March 2004 and January 2007 were found through computer and manual search of medical records, and examined retrospectively. The following data were extracted: age, gender, marital status, occupation, event zone, administration time, reason of event (homicide or suicide), vital findings, Glasgow Coma Score (GCS), electrocardiography, brain and cervical computed tomography findings, arterial blood gases, complete blood count and biochemical markers. Statistical analyses have been done. Results: In this study, 14 (50%) of 28 patients were men and the remaining 14 (50%) were women. And 11 (39.2%) of the patients who suffered near hanging became ex. There was no significant difference statistically between age and gender in terms of mortality ratios (p>0.05). Presence of low GCS at the time of admission (p=0.000), acidosis in arterial blood gases (p=0.041), elevated serum level lactic acid (p=0.000), hyoid and cervical vertebra fracture (p=0.016) and cerebral edema (p=0.018) were found as predicted factors on mortality of the patients with near hanging. Contrary, normal sinus rhythm was found as decreased factors on mortality of the patients with near hanging (p=0.002). Conclusion: Presence of low GCS at the time of admission, acidosis in arterial blood gases, elevated serum level lactic acid, hyoid and cervical vertebra fracture and cerebral edema were found as predicted factors on mortality of the patients with near hanging. Contrary, normal sinus rhythm was found as decreased factors on mortality of the patients with near hanging.Öğe Unusual histopathological findings in appendectomy specimens: A retrospective analysis and literature review(Baishideng Publishing Group Inc, 2011) Akbulut, Sami; Tas, Mahmut; Sogutcu, Nilgun; Arikanoglu, Zulfu; Basbug, Murat; Ulku, Abdullah; Semur, HeybetAIM: To document unusual findings in appendectomy specimens. METHODS: The clinicopathological data of 5262 patients who underwent appendectomies for presumed acute appendicitis from January 2006 to October 2010 were reviewed retrospectively. Appendectomies performed as incidental procedures during some other operation were excluded. We focused on 54 patients who had unusual findings in their appendectomy specimens. We conducted a literature review via the PubMed and Google Scholar databases of English language studies published between 2000 and 2010 on unusual findings in appendectomy specimens. RESULTS: Unusual findings were determined in 54 (1%) cases by histopathology. Thirty were male and 24 were female with ages ranging from 15 to 84 years (median, 32.2 +/- 15.1 years). Final pathology revealed 37 cases of enterobiasis, five cases of carcinoids, four mucinous cystadenomas, two eosinophilic infiltrations, two mucoceles, two tuberculosis, one goblet-cell carcinoid, and one neurogenic hyperplasia. While 52 patients underwent a standard appendectomy, two patients who were diagnosed with tuberculous appendicitis underwent a right hemicolectomy. All tumors were located at the distal part of the appendix with a mean diameter of 6.8 mm (range, 4-10 mm). All patients with tumors were alive and disease-free during a mean follow-up of 17.8 mo. A review of 1366 cases reported in the English literature is also discussed. CONCLUSION: Although unusual pathological findings are seldom seen during an appendectomy, all appendectomy specimens should be sent for routine histopathological examination. (C) 2011 Baishideng. All rights reserved.
