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Öğe Coffee: Pharmacognosic review(Society of Pharmaceutical Sciences of Ankara (FABAD), 2018) Saltan F.Z.; Kaya H.Coffee with more than a hundred species belonging to the Rubiaceae family is an herbal product with its own aromatic scent with the roasting of seeds grown in small trees. Especially roasted coffee seeds are known to be used in wound healing and acute diarrhea, while green seeds are used to reduce rheumatism and kidney stones. Several scientific studies have revealed that melanoidin and quinic acid derivatives are formed during roasting, the amount of acrylamide is increased and the amounts of phenolic compounds are changed. These differences are mainly due to the variety of the coffee, the methods of processing and the degree of roasting. A number of epidemiological and clinical studies have been carried out mainly including antioxidant, anti-inflammatory, anticancer and antidiabetic effects of coffee. At the end of this review; it appears that the necessity of conscious consumption of the cup of coffee in terms of human health and the determination of emergence of clinical studies and mechanisms of action on many different coffee varieties due to the side effect of the caffeine it contains. In this way, the therapeutic importance of coffee and its composition as well as the economic value will be supported. © 2018 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.Öğe Effects of treatment regimens on survival in patients with malignant pleural mesothelioma.(2013) Abakay A.; Abakay O.; Tanrikulu A.C.; Sezgi C.; Sen H.; Kaya H.; Kucukoner M.In this study, we aimed to investigate the factors affecting the survival of patients with malignant pleural mesothelioma (MPM) according to their treatment regimens, including best supportive care (BSC), chemotherapy, surgical group and multimodality (MM) therapy. A retrospective analysis was performed on clinical data and treatment outcomes of 400 patients registered in our hospital with MPM between January 1989 and April 2010. Mean age (p < 0.001), presence of asbestos exposure (p = 0.0014), presence of smoking history (p < 0.001), Karnofsky performance status (p < 0.001), histological subtype (p = 0.034) and stage (p < 0.001) variables were found to be significantly different among the four treatment regimens. Mean survival time of all patients was 12.32 months. Mean survival time 10.5 months for the BSC group, 15.7 for the surgical group, 16.02 for the chemotherapy group, and 26.55 for the MM group. There were significant differences in mean survival time among the four treatment regimens. In addition, a significant difference was found in survival time between the two chemotherapy groups (p = 0.032). Mean survival time for cisplatin + gemcitabine was found to be 14.49 months and for cisplatin + pemetrexed, 18.34 months. The MM group had better survival rates than the other groups. The new chemotherapy combination, cisplatin + pemetrexed, can be helpful in improving survival time.Öğe The evaluation of relationship between plasma asymmetric dimethylarginine (ADMA) and aortic stiffness in patients with systemic sclerosis(2013) Aritürk Z.; Dağ Ş.; Ali Elbey M.; Kaya H.; Erta F.; Bozkurt M.; Çevik R.Objective: Endothelial dysfunction and vasculopathy are crucial pathogenic factors in systemic sclerosis. Increased concentrations of plasma asymmetric dimethylarginine (ADMA) may also contribute to endothelial dysfunction in patients with systemic sclerosis. We evaluated the relationship between ADMA and aortic elastic properties in patients with systemic sclerosis. Material and Method: Plasma ADMA levels were measured in 30 patients with systemic sclerosis (28 females, mean age 40.7±11.6) and 30 healthy subjects (27 females, mean age 40.6±13). Aortic stiffness was determined with echocardiography. Results: In patients with systemic sclerosis, the mean value of ADMA was 0.53±0.13?mol/l compared with 0.46±0.15 ?mol/l for control group. Systolic blood pressure, pulse pressure and aortic 'strain' were found to be higher in patients with systemic sclerosis (p=0.027, p=0.048, p=0.037, respectively), diyastolic blood pressure and aortic distensibility was found lower in systemic sclerosis (p=0.039, p=0.045, respectively). There was no significant correlations between ADMA and aortic 'strain'. Conclusion: ADMA serum levels were increased in patients with systemic sclerosis, but no significant correlation was found between ADMA and aort's elastic structure (aortic 'strain', distensibility, and aortic stiffness index).Öğe Factors associated with mortality among tuberculosis patients in southeast Turkey(A. CARBONE Editore, 2015) Yilmaz S.; Taylan M.; Sen H.S.; Abakay O.; Demir M.; Kaya H.; Yilmaz Z.Introduction: Tuberculosis (TB) is a disease caused by bacillus mycobacterium tuberculosis. Tuberculosis is a preventable and treatable disease that, despite the rapid advances in active therapy, continues to cause global mortality. In this study, we investigated the risk factors associated with mortality in patients undergoing treatment for TB. Materials and methods: Records of 2,450 tuberculosis patients who were followed-up with in tuberculosis dispensaries in the city of Diyarbakir, southeast Turkey, between January 2005 and December 2011 were reviewed retrospectively. Case definitions and treatment outcomes were classified according to WHO criteria. Results: Of the 2,450 registered TB patients, 1,339 were male (54.7%) and 1,111 were female (45.3%). Their mean age was 32.15±17.87 years, and 51 (2.1%) of them died. Mortality rates were higher in pulmonary TB (PTB) patients, males, relapse patients, category 2 patients, those >65 years old, TB meningitis patients, and patients who self-administered their therapy. According to Kaplan-Meier analysis, the mortality rates were significantly higher in patients aged >65 years, in those with Category II and in those TB meningitis. The significant independent risk factors for mortality during anti-TB treatment were advanced age, TB meningitis and gastrointestinal TB. Conclusion: Mortality was increased in the elderly, males, those with relapse, and in category II and extrapulmonary TB patients. Based on these data, we suggest that tuberculosis control programs should pay more attention to the high-risk groups determined in the current and previous studies. Treatment regimens for these risk groups should be considered for revision.Öğe Fibulin-3 as a diagnostic biomarker in patients with malignant mesothelioma(Asian Pacific Organization for Cancer Prevention, 2015) Kaya H.; Demir M.; Taylan M.; Sezgi C.; Tanrikulu A.C.; Yilmaz S.; Bayram M.Background: New tumour biomarkers are being intensely investigated for malignant mesothelioma (MM). Fibulin-3 is produced in MM but its role remains uncertain. The aim of this study was to evaluate the validity of measuring serum fibulin-3 in the diagnosis and prognosis of MM. Materials and Methods: This prospective study was performed on 43 patients and 40 healthy controls who were admitted to our hospital between January 2012 and January 2014. Data from MM patients, including demographic and clinical features, routine laboratory data, levels of serum fibulin-3, and treatment outcomes were defined as potential prognostic factors. The receiver operating characteristic (ROC) curve for fibulin-3 was used to detect the cut-off value with highest sensitivity and specificity. Univariate survival analysis was performed using the Kaplan-Meier method in patients with MM. Afterwards, the possible factors identified with univariate analyses were entered into the cox regression analysis. Results: Our results revealed that patients with MM had significantly higher serum levels of fibulin-3 than controls. The results showed that the best cut-off point was 36.6 ng/ml with an AUC (area under the curve)=0.976, sensitivity=93.0% and specificity=90.0. In our study, the initial significant poor prognostic factors were advanced stage, high white blood cell count, high platelet count, high C-reactive protein (p<0.05 for each variable). Later, according to multivariate analysis the results showed only advanced stage as significant parameter (p=0.040). Conclusions: We determined that real use for serum fibulin-3 was not for prognosis but for diagnosis in MM. Also advanced stage was associated with poor MM prognosis.Öğe Hormone levels of people occupationally exposed to radiofrequencies(1999) Dasdag S.; Balci K.; Kaya H.; Celik M.S.The present article intended to investigate some hormone levels of technicians in the radio-broadcasting, television (TV) and radio - link stations. The study was carried out on 43 technicians from 20 to 59 years age occupationally exposed to radiofrequency (RF) and microwave (MW) radiation. 20 unexposed and voluntary persons from 20 to 59 years age were accepted as a control group. We determined the levels of some hormones as triiodothyronine (T3), tetraiodothyronine (T4), thyroid stimulant hormone (TSH), free T4, estradiol, dehydroepiondrosterone sulfate (DHEA), testosterone, cortisol and progesterone in the technicians under investigation. The hormone levels of exposure groups were statistically compared with the unexposed control group. T3, T4, estradiol, testosterone and progesterone levels of technicians in the radio-link and TV transmitter stations were found to be significant (p < 0.05, p < 0.001). T3, T4, TSH, estradiol and progesterone levels of technicians in the broadcasting station were also found to be significant (p < 0.001). In conclusion some hormone levels of technicians under investigation were altered by RF/MW.Öğe An overview of thrombolytic treatment for pulmonary embolism: A single Centre experience(Acta Medica Mediterranea, 2014) Şen H.S.; Abakay Ö.; Sezgi C.; Yilmaz S.; Taylan M.; Kaya H.; Tanrikulu A.C.Introduction: A massive pulmonary embolism (MPE) has a poor prognosis and high mortality. Thrombolytic therapy is preferred in patients with life-threatening symptoms such as hypotension, cardiogenic shock, and right ventricular failure due to the risk of severe bleeding. Materials and methods: This is a retrospective analysis of patients who were hospitalized with the diagnosis of pulmonary embolism (PE) and given thrombolytic therapy in the chest diseases clinic of a tertiary university hospital between January 2008 and November 2013. Results: The subjects' mean age was 59.54 ± 13.76 years. Fourteen of 39 patients who were treated with thrombolytic therapy were male (35.89%) and 25 (64.10%) were female. The symptoms experienced by the patients included dyspnea in 39 patients, chest pain in 35 patients, hemoptysis in 6 patients, syncope in 13 patients and cough in 10 patients. Risk factors were advanced age (> 60 years) in 19, immobilization in 19, malignancy in 3, major surgery in 11 patients. The in-hospital mortality analysis showed that 32 patients were discharged and 7 patients died. Four patients died from their pulmonary embolism and 3 patients died because of a major bleeding complication. Conclusions: Pulmonary embolism is a disease that may lead to death within hours secondary to acute right heart failure. Early diagnosis and treatment can be life saving. Thrombolytic therapy has been shown to improve hemodynamic parameters in the early period post-PE. An increased risk of bleeding is one of the most important drawbacks of thrombolytic therapy. Nonetheless, it can be a life-saving therapy in properly selected patients.Öğe Preventive action of omeprazole, famotidine or nitrendipine against stress ulcer formation in rats(1994) Canoruc N.; Ulak G.; Guzel C.; Kaya H.; Cicek R.The effects of H+/K+-ATP ase inhibitor, omeprazole, the H2-receptor antagonist, famotodine, and the calcium channel antagonist, nitrendipine, on gastric ulcers, gastric mucosal barrier and gastrin release were investigated in cold-restraint stress-induced rats. Omeprazole (30 mg/kg i.g.) famotidine (1 mg/kg, i.g.) and nitrendipine (16 mg/kg, i.p.) significantly prevented gastric ulceration. Nitrendipine reduced the mucus secretion and exhibited no important change in phospholipid content; thus, it failed to restore the damage in the gastric mucosal barrier due to cold-restraint stress. Omeprazole increased mucus secretion and phospholipid content of gastric mucosal barrier whereas famotidine tended to cause an increase in mucus and phospholipid levels; however, this difference did not attain statistical significance. Serum gastrin levels revealed lower values in the nitrendipine group as compared with controls; whereas it increased in omeprazole and famotidine groups, but more significantly in the omeprazole treated group.Öğe Pulmonary findings in patients with fascioliasis(Acta Medica Mediterranea, 2013) Sezgi C.; Cicek M.; Sen H.S.; Kaya H.; Taylan M.; Abakay A.; Abakay O.Aim: Fasciola hepatica (FH) is sporadically found in the humans and causes disease by involving the bile ducts. However, it is rarely localized ectopically in the lungs; typical and atypical involvement of lung have been shown. The aim of this study is to investigate pulmonary findings for clinical, radiologic and laboratory in patients with fascioliasis. Materials and methods: All patients included in this study were diagnosed with fascioliasis. Diagnosis of fascioliasis was made by IgG antibody detection with ELISA, detection of parasite eggs with stool examination, radiologic images and clinical findings and laboratory parameters. Diseases involving in the differential diagnosis of lung involvement were individually evaluated when an abnormality was detected on chest radiography. Additional biochemical and microbiologic tests were performed. Thoracic computed tomography (CT), fiberoptic bronchoscopy and thoracentesis were performed. When other diseases were eliminated, the patient was diagnosed with fascioliasis. Results: Lung involvement was detected in 3 out of 56 patients (5.35%). The most prominent symptoms were right hypochondrial pain, chest pain, cough and dyspnea. Hepatomegaly and pulmonary rales were the most common physical examination findings. On radiologic imaging of the lung, ground-glass densities were detected in one patient, infiltration in one and pleural effusion was detected in the other. Conclusion: Although Fasciola hepatica may only affect the lungs rarely, the presence of respiratory symptoms and physical examination findings in the acute period of diagnosis should suggest lung abnormality.Öğe Spinal tuberculosis: A retrospective chart review(Acta Medica Mediterranea, 2014) Sezgi C.; Taylan M.; Kaya H.; Sen H.S.; Abakay O.; Bulut M.; Abakay A.Aims: Background and objectives: This study aimed to investigate the clinical characteristics, diagnostic methods, and therapeutic outcomes in patients with spinal tuberculosis (TB) in Southeastern Turkey Methods: Patients diagnosed with spinal TB at Dicle University Hospital, Diyarbakir, Turkey, between October 2005 to December 2010 were enrolled in the study retrospectively. Patients were evaluated for the following: Clinical presentation, underlying diseases, laboratory results, imaging findings, medical therapies, and treatment outcomes Results: A total of 23 patients including 14 men and 9 women with spinal TB, also known as Pott's disease, were enrolled. The study subjects' ages ranged from 17 to 69 years with a mean age of 38.4 years. Patients most often presented with back pain (69.5%, n=16) and fever (56.5%, n=13), and the most frequent physical finding was spinal tenderness (91.3%). Only 17.4% of the patients demonstrated neurological deficits and no paraplegia was observed. The time interval between onset of symptoms and treatment initiation was 3.2 months. Of all the patients, 47.8% exhibited Pott's disease in the thoracolumbar region while 34.8% only had thoracic involvement. On average, 2.5 vertebrae were diseased in this cohort. Furthermore, 82.6% of the patients had paraspinal and psoas abscesses. All patients were treated with anti-TB therapy. However, 26.1% required additional surgery, and one patient with miliary TB died. The mean treatment course lasted for 12.3 months. Conclusions: It may be possible to refine methods of spinal TB detection and diagnosis by studying thoracolumbar pathology in young adults with Pott's disease in endemic countries such as Turkey. By studying the clinical progression of this disease, the delay between symptom onset and diagnosis may be decreased so that complications such as paraplegia and surgical interventions are avoided.Öğe Statin therapy and increased coronary heart disease risk in primary prevention of people with enhanced low-grade inflammation(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2014) Onat A.; Aydin M.; Köro?lu B.; Can G.; Kaya H.; Ademo?lu E.Objective: We investigated whether statin treatment, associated with slightly increased risk of incident diabetes, confers elevated coronary heart disease (CHD) risk, and circumstances thereof.Material and Methods: Totally, 2959 participants 270 of whom were medicated with statins, and free of CHD at baseline, were analyzed at 7.9-years' follow-up using Cox regression.Results: Participants using statin at baseline-compared with remaining participants-had significantly higher values of metabolic syndrome (MetS) components, but lower apolipoprotein B, were fewer current smokers, and had similar HDL- and LDL-cholesterol levels. Women additionally had higher plasma fibrinogen and lipoprotein[Lp](a). Adjusted Lp(a) concentrations were significantly associated with statin medication, especially in men. In Kaplan-Meier analyses for 381 incident CHD cases (stratified to gender, age category and changed status of statin usage) demonstrated steadily separating curves in statin users, compared with non-users (Log rank <0.0001). Cox regression hazard ratio for developing incident CHD was 2.42 (95% CI 1.80; 3.25) in individuals using statin, after adjustment for traditional risk factors, in men irrespective of MetS-status.Conclusion: Appropriately instituted statin therapy in population subsets with MetS or enhanced inflammation may increase CHD risk in a primary prevention setting. Excess risk imparting may be attributed to a modifying effect of statins on Lp(a). Copyright © 2014 by Türkiye Klinik leri.Öğe The value of new inflammatory parameters in Malignant mesothelioma prognosis(Acta Medica Mediterranea, 2015) Tanrikulu A.C.; Hocanli I.; Yilmaz A.; Meteroglu F.; Taylan M.; Demir M.; Kaya H.Aim: Malignant mesothelioma (MM) has a poor prognosis. Inflammation is associated with MM prognosis and symptoms. Several inflammatory markers were investigated to estimate MM prognosis. We investigated the role of available inflammatory index and markers for MM prognosis. We developed the advanced mesothelioma index (AMI) to assess the degree of inflammation in MM. Materials and methods: We performed a retrospective study of 202 MM patients (116, male, 86 female) evaluated at Dicle University. Demographic parameters and laboratory data were collected. The AMI was calculated as Body Mass Index*serum albumin value (g/dl)/platelet-to-lymphocyte ratio. Results: The mean age of patients was 59.04 years. A total of 135 (66.8%) patients showed epithelial-type histopathological subtypes and 177 patients had pleural MM. The mean survival time was 13.1±11.5 months in the all MM patients. Twenty-four potential prognostic factors were associated with a poor outcome and then analyzed in the univariate analysis. Eighteen of them were definitely associated with a poor prognosis. These 18 potential prognostic factors were analyzed in the multivariate analysis. Based on the results of the multivariate analysis, only patients with an AMI<0.5 had an associated poor prognosis. An AMI<0.5 increased the mortality rate by 10.47. Furthermore, low AMI was associated with other bad inflammatory markers (such as high platelet count, high C reactive protein level, low Body Mass Index, low albumin and low hemoglobin). Conclusion: Our findings indicate that the AMI can be used to assess the degree of systemic inflammation.
