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Öğe The effect of exogen glutathione administration on the gastric mucosal barrier in rats under stress(1998) Kanay Z.; Sert C.; Isik B.; Kurt D.; Guzel C.; Mete N.We investigated the effect of glutathione (GSH) on the gastric mucosal barrier of rats under stress. Twenty two swiss Albino rats weighing between 150-200 g were used and stress was induced by cold and immobilisation. GSH was administered in 300 mg/kg doses to the study group and oral saline was given to a control group. Mucus and phospholipid levels of the gastric mucosal barrier were then measured using come and Baur's methods. These important components of the gastric mucosal barrier were found to be decreased (p<0.05), but levels were higher in rats given GSH than in the control group (p<0.01, p<0.05 respectively). To conclude, GSH was found to be effective in preventing gastric mucosal barrier damage caused by stress.Öğe Effect of fish oil on indometacin-induced gastric lesions in rats(1995) Guzel C.; Ulak G.; Sermet A.; Cicek R.; Ulak M.The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats. After indometacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. The ulcer index was found to be decreased to 2.1 ± 1.8 mm with fish oil, 13.7 ± 5.4 mm with olive oil, and 14.6 ± 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indometacin and significantly enhanced the mucus content of the mucosa (p < 0.05).Öğe Effect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonists(1995) Sermet A.; Aybak M.; Ulak G.; Guzel C.; Denli O.Effect of vitamin B6 (pyridoxine-HCl, CAS 58-56-0) on platelet aggregation, plasma lipids and serum zinc level was investigated. The trial comprised 24 healthy male volunteers, aged between 19-24 years. The subjects were randomized in two groups of 12 and treated for 4 weeks by a single daily oral dose of 5 mg/kg vitamin B6 or placebo. Pyridoxine inhibited ADP- or epinephrine-induced aggregation by 48% and 41% (p < 0.001), respectively, whereas there was no change in control group. No significant effect on either, bleeding time, coagulation time or on platelet count was demonstrated in subjects given placebo. Pyridoxine prolonged both bleeding and coagulation time but not over the physiological limits. It had no effect on platelet count. These observations strongly suggest that vitamin B6, with no effect on platelet count, not only inhibits platelet aggregation but also prelongs clotting time. Pyridoxine significantly reduced total plasma lipid and cholesterol levels, whereas it enhanced HDL-cholesterol level. Serum zinc level was also significantly increased by pyridoxine (p < 0.001). These findings suggest that oral vitamin B6 inhibits platelet aggregation in normal subjects.Öğe The effects of octreotide on gastric lesions and gastric mucosal barrier in rats which applied stress(1999) Guzel C.; Kanay Z.; Onen A.; Kurt D.; Denli O.; Canoruc F.The aim of this research was to investigate the effects of octreatide on gastric lesions and mucosal barrier in rats exposed cold +immobilisation stress. Twenty four Swiss Albino rats (approx 150-200 g) were used for this study. Feeds were witheld from to rats for 24 hours, after which they were divided in to three groups. Each group consisted of seven rats; I (n=7) non/stress-induced control group, 2 (n=7): cold and immobilisation stress was induced, 3 (n=7): 100 ?g/kg octreatide was administered subcutaneously one hour prior to stress induction. The rats were then killed and their stomachs examined for ulcerative lesions and ulcer indexes considered. The amounts of mucus and phospholipid, important components of the gastric mucosal barrier, were then rated using Corn and Baur methods and were found to be significantly decreased (p<0.05, p>0.05) in rats exposed to stress. In the third group given sandostatin, it was found that gastric lesions had been prevented. Moreover, mucus and phospholipid levels were higher in this group than the stress exposed control group. (p<0.05, p<0.05 respectively). According to our findings, octreatide is effective in preventing acute hemorrhagic gastric lesions caused by stress and in maintaining gastric mucosal barrier parameters.Öğe Preventive action of omeprazole, famotidine or nitrendipine against stress ulcer formation in rats(1994) Canoruc N.; Ulak G.; Guzel C.; Kaya H.; Cicek R.The effects of H+/K+-ATP ase inhibitor, omeprazole, the H2-receptor antagonist, famotodine, and the calcium channel antagonist, nitrendipine, on gastric ulcers, gastric mucosal barrier and gastrin release were investigated in cold-restraint stress-induced rats. Omeprazole (30 mg/kg i.g.) famotidine (1 mg/kg, i.g.) and nitrendipine (16 mg/kg, i.p.) significantly prevented gastric ulceration. Nitrendipine reduced the mucus secretion and exhibited no important change in phospholipid content; thus, it failed to restore the damage in the gastric mucosal barrier due to cold-restraint stress. Omeprazole increased mucus secretion and phospholipid content of gastric mucosal barrier whereas famotidine tended to cause an increase in mucus and phospholipid levels; however, this difference did not attain statistical significance. Serum gastrin levels revealed lower values in the nitrendipine group as compared with controls; whereas it increased in omeprazole and famotidine groups, but more significantly in the omeprazole treated group.Öğe Protective effect of fish oil against stress-induced gastric injury in rats(1995) Ulak G.; Cicek B.; Sermet A.; Guzel C.; Ulak M.; Denli O.The effect of fish oil and olive oil on the gastric mucosal damage induced by cold-restraint stress was investigated in rats. The oils were dietary supplemented for 3 weeks. The results demonstrate that a diet containing fish oil, when ingested for 3 weeks before exposure to stress, protected from gastric ulceration significantly (p < 0.01) and led to a statistically significant increase both in mucus and phospholipid content of the gastric mucosal barrier (p < 0.02 and p < 0.001, resp.) in cold-restraint stress-induced gastric injury in rats. However, further studies are required to determine the role of dietary fish oils in the prophylaxis and treatment of peptic ulcer.
