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Öğe Evaluation of catalase, myeloperoxidase and ferroxidase values in pregnant women with hyperemesis gravidarum(Via Medica, 2019) Ege, Serhat; Bademkıran, Muhammed Hanifi; Peker, Nurullah; Erdem, Selami; Bağlı, İhsan; Köçeroǧlu, Ruşen; Kahveci, Bekir; Yıldızhan, Recep; Erel, Özcan; Araç, EşrefObjectives: To investigate maternal serum catalase, myeloperoxidase and ferroxidase levels in pregnant women with Hyperemesis Gravidarum and to compare the results with healthy pregnancies. Material and methods: In this study, 60 female patients admitted to the Health Sciences University, Gazi Yasargil Training and Research Hospital, Gynecology and Obstetrics Department were evaluated. The patients were divided into two groups: Group 1 included 30 pregnant women with hyperemesis gravidarum; Group 2 included 30 healthy pregnant women. Pregnancies over 14 weeks were excluded from the study. Results: The laboratory and laboratory characteristics of both groups are shown in Table 1. No significant differences were found between the groups in terms of the maternal age, gestational age, gravidity, parity, fasting glucose level, and BMI. The maternal blood CAT levels were significantly higher in the HG group (219.6 ± 111.3 kU/L) when compared to the control group (71.5 ± 52.5 kU/L) (p < 0.001). The maternal blood MPO levels were lower in the control group (121.5 ± 36.3 U/L) than in the study group (90.9 ± 56.4 U/L) (p = 0.016). However, the ferroxidase levels were similar between the two groups. The independent variables BMI, age, parity, gravidity and gestational week effects were adjusted according to the logistic regression method with groups. Significant differences were observed between the two groups in the levels of CAT (0.001), MPO (0.005) values. Conclusions: This study suggests that antioxidants in response to oxidative stress gave different reactions with different mechanisms; Also, we believe that insufficient food intake suppresses the immune system and this has an important role on antioxidants.Öğe Iron deficiency, anemia and intestinal parasitic infection in children with pica(Türkiye Klinikleri, 1999) Koç, Ahmet; Erel, Özcan; Kösecik, Mustafa; Ataş, Ali; Haspolat, Yusuf KenanPikası olan okul öncesi dönemi çocuklarda demir eksikliği, anemi ve bağırsak parazitleri sıklığım tespit amacıyla 1-6 yaşları arasında (ortalama yaş 29.54 ± 12.73 ay) olan 107 çocuk incelendi. Kontrol grubu olarak aynı yaş grubunda ve pika hikayesi olmayan 60 çocuk alındı. En sık yenilen maddeler; toprak (%85.9), duvar sıvaları (%15.9), kömür (%9.3), taş parçaları ve kum (%7.5), ve kül (%5.6 vakada) olarak bulundu. Vakaların %21 inin birden fazla madde yediği tesbit edildi. Pikalı çocukların %57sinde anemi, %76.6sında demir eksikliği bulunurken, kontrol grubunda anemi %21.7, demir eksikliği %35.0 oranlarında görüldü. İki grup arasındaki bu farklılıklar anlamlıydı (p<0.01 ve p<0.01). Pika ve anemisi olan çocuklarda demir eksikliği ise %85.2 oranında bulundu. Çocukların %62sinde bağırsak paraziti görüldü ve poliparazitizm oranı %27.5 idi. Demir eksikliği ve aneminin ağırlığı ile pika süresi ve poliparazitizm arasında önemli bir ilişki bulundu. Demir eksikliği olan çocukların %,79unda demir preparatları ile tedaviden sonra pika kayboldu. Bu çalışma, okul öncesi pikalı çocuklarda demir eksikliği ve aneminin oldukça yaygın bulunduğunu ve belki de pikanın en önemli sebebi olduğunu, fakat tek sebebi olmadığını göstermiştir.Öğe Oxidative and antioxidative responses in submandibular and parotid glands of rats exposed to long-term extremely low frequency magnetic field(Modestum Publishing Ltd., 2014) Akdağ, Mehmet; Akdağ, Mehmet Zülküf; Daşdağ, Süleyman; Erel, ÖzcanObjective: Some epidemiologic and laboratory studies have suggested a possible associations between exposure to extremely low frequency magnetic field (ELF-MF) and cancer. However, it is not known underlying mechanisms of this interaction. The aim of the study was to investigate the possible oxidative damage induced by longterm ELF-MF exposure on submandibular and parotid glands of rats.Methods: Rats in the experimental group were exposed to 100 and 500 µT ELF-MF (2 h/day, 7 days/week, for 10 months) corresponding to exposure levels that are considered safe for humans. The same experimental procedures were applied to the sham group, but the ELF generator was turned off. The levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were measured in rat submandibular and parotid gland.Results: Although some oxidative and antioxidative parameters of submandibular gland were altered by ELF100 and ELF-500 exposure groups, these changes were not statistically significant (p >0.05). However, a decrease observed in CAT levels of parotid gland in both the ELF100 and ELF-500 exposure groups (p<0.05, p<0.01). No significant alterations was found in other endpoints related to parotid gland (p>0.05).Conclusion: Our results showed that long-term ELF-MF exposure did not alter oxidative, antioxidative processes and lipid peroxidation in submandibular gland of rats. However, 100 µT and 500 µT ELF-MF exposure decreased CAT activity in parotid gland.Öğe Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia(Wolters Kluwer Medknow Publications, 2022) Ebik, Berat; Aslan, Nihat; Ekin, Nazım; Bacaksız, Ferhat; Arpa, Medeni; Neşelioǧlu, Salim; Erel, Özcan; Uçmak, FeyzullahBackground: To investigage the thiol and disulphide levels in Helicobacter pylori-positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy. Methods: This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia according to Rome IV criteria were included in the study. First, blood samples were drawn from patients to determine their serum thiol and disulphide levels. Endoscopic biopsy was performed on all patients and the biopsy specimens obtained were examined pathologically. Patients positive for H. pylori were administered eradication therapy. Blood samples were drawn from these patients for the second time, and their serum thiol and disulphide levels were measured. The thiol-disulfide levels of the patients who were successful in H. pylori eradication treatment, with those who were not, were compared before and after the treatment. Results: The mean plasma disulphide level decreased significantly from 14.0 ± 6.6 to 10.9 ± 5.9 μmol/L in H. pylori-positive patients that responded to the H. pylori eradication treatment (P = 0.033). On the other hand, there was an insignificant increase in the mean serum thiol level (341.4 ± 30.5 vs. 342.6 ± 29.8 μmol/L; P = 0.273) and an insignificant decrease in the mean serum disulphide level (15.2 ± 2.5 vs. 14.8 ± 2.3 μmol/L; P = 0.163) in H. pylori-positive patients that did not respond to the H. pylori eradication treatment. Conclusion: The inflammation caused by H. pylori shifted the thiol-disulphide equilibrium in the cell redox system towards the direction of disulphide. The study findings suggest that the restoration of the said hemostatic balance with eradication therapy relieved the organism from oxidative stress.Öğe The relationship of oxidative metabolism to treatment response in major depression: A biological basis for treatment duration(2012) Selek, Salih; Dalkılıç, Alican; Kaya, Mehmet Cemal; Savaş, Haluk Asuman; Bez, Yasin; Çelik, Hakim; Erel, Özcan; 0000-0001-5197-5682; 0000-0002-2996-3236; 0000-0003-4357-8809Background: We aimed to determine the relationship between antidepressant treatment and oxidative metabolism in patients with major depression. Materials and methods: Two groups, the patients diagnosed with depression (N = 21), and healthy controls (N = 40), were enrolled in the study. The patients received naturalistic antidepressant treatment. Serum samples were collected prior to treatment and at the end of the 8 weeks of antidepressant treatment. Those participants in the control group were sampled only once. The total antioxidant status (TAS) and total oxidant status (TOS) were measured and oxidative stress index (OSI) was calculated. Severity of depression in patients was also measured both prior to and after 8 weeks of antidepressant treatment. Results: In terms of TAS, TOS, and OSI there were significant differences between the groups both at the baseline. Baseline and final HAM-D scores of the patient group differed significantly. The baseline TAS, TOS, and OSI levels of patients did not change significantly after antidepressant treatment. The duration of illness was not correlated with baseline serum levels of TAS, TOS, and OSI. Patients who were deemed to be unresponsive to the antidepressant treatment differed significantly from the controls both at the baseline and at the final visit for TAS, TOS, and OSI. Additionally, treatment responsive patients did not show any similar difference in terms of TOS and OSI levels. Discussion: Chronic increase in anti-oxidant and oxidant levels in patients with major depression may be related to the elevation of anti-oxidant defenses that were developed in response to increased oxidative metabolism.Öğe The Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome(2018) Turgut, Abdulkadir; Erel, Özcan; Oral, Hilmi Baha; Köroğlu, Nadiye; Ergin, Merve; Tola, Esra NurBackground: Oxidative stress has been proposed as a potentialtrigger in the etiopathogenesis of polycystic ovary syndromerelatedinfertility. Thiol/disulphide homeostasis, a recently identifiedoxidative stress marker, is one of the antioxidant mechanism inhumans with critical roles in folliculogenesis and ovulation.Aims: To investigate follicular fluid thiol/disulphide homeostasis inthe etiopathogenesis of polycystic ovary syndrome and to determine itsassociation with in vitro fertilization outcome. The study procedureswere approved by the local ethics committee.Study Design: Cross-sectional study.Methods: Follicular fluid from 22 women with polycystic ovarysyndrome and 20 ovulatory controls undergoing in vitro fertilizationtreatment was sampled. Thiol/disulphide homeostasis was analyzedvia a novel spectrophotometric method.Results: Follicular native thiol levels, as well as the native thiol/total thiol ratio, were lower in the polycystic ovary syndrome groupthan in the non-polycystic ovary syndrome group (p=0.041 andp<0.0001, respectively). Disulphide levels, disulphide/native thiol,and disulphide/total thiol ratios were increased in the polycysticovary syndrome group (p<0.0001). A positive correlation betweenthe fertilization rate and native thiol (p=0.01, r=0.53) and totalthiol (p=0.01, r=0.052) among polycystic ovary syndrome patientswas found. A positive predictive effect of native thiol level on thefertilization rate in the polycystic ovary syndrome group was alsofound (p=0.03, ?=0.45, 95% CI= 0.031-0.643).Conclusion: Deterioration of thiol/disulphide homeostasis, especiallyelevated disulphide levels, could be one of the etiopathogeneticmechanisms in polycystic ovary syndrome. Increased native thiollevels are related to the fertilization rate among polycystic ovarysyndrome patients and are positive predictors of the fertilizationrate among polycystic ovary syndrome patients. Improvement ofthiol/disulphide homeostasis could be important in the treatment ofpolycystic ovary syndrome to increase in vitro fertilization success.Öğe The thiol/disulfide balance in ketone positive and ketone negative pregnant women with nausea and vomiting - A prospective study in a tertiary center(GIPOA, 2020) Ege, Serhat; Peker, Nurullah; Bademkıran, Muhammed Hanifi; Köçeroǧlu, Ruşen; Erel, Özcan; Erdem, Selami; Özgökçe, Çaǧdaş; Yıldızhan, RecepObjectives: We aimed to investigate the thiol/disulfide balance in ketone positive (hyperemesis gravidarum) and ketone negative pregnant women with nausea and vomiting. Material and methods: A total of 60 patients under the 14th week of pregnancy were included in this study, and they were divided into two groups. Group 1 included 30 pregnant women with ketone positive, group 2 included 30 ketone negative pregnant women with nausea, and vomiting. Results: The native thiol, disulfide, and total thiol concentrations were measured using an automated method and compared among the two groups. There were also three indexes that are derived from disulfide, native and total thiol (Index 1 = 100 x disulfide/native thiol); (Index 2 = 100 x disulfide/total thiol); (Index 3 = 100 x native thiol/total thiol). When compared with Group 1 and Group 2, total thiol was high, native thiol was low but not statistically significant. Disulphide (p = 0.046), index 1 (p = 0.036) and index 3 (p = 0.034) were statistically significant. Conclusions: Patients with ketone positive are shifting to OS direction due to lack of nutrients and electrolytes. This study emphasizes the therapeutic potential of antioxidant supplementation, which is becoming an increasingly used approach in treating the symptoms of women with ketone positive.
