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Acil Serviste Kardiyopulmoner Resüsitasyon Yapılan Hastaların Değerlendirilmesi; Retrospektif Çalışma
(Bolu Abant İzzet Baysal Üniversitesi, 2021) Araç, Songül; Zengin, Yılmaz; İçer, Mustafa; Gündüz, Ercan; Dursun, Recep; Durgun, Hasan; Üstündağ, Mehmet
GİRİŞ ve AMAÇ: Kardiyak arrest tedavisinde yapılacak işlemlerin tamamı Kardiyopulmoner resüsitasyon (KPR) olarak adlandırılmaktadır. Tüm ölümlerin yaklaşık %20’si ani kardiyak arrest nedeniyle olmaktadır. Çalışmamızda hastane içi ve dışı kardiyak arestlerin özelliklerini tanımlamak ve sonuçlarımızı literatür ile karşılaştırmak amaçlandı. YÖNTEM ve GEREÇLER: Bu çalışmada 01.01.2013 ile 31.05.2015 tarihleri arasında acil servise başvuran tüm yaş gruplarında etyolojiden bağımsız olarak Kardiyopulmoner Resüsitasyon uygulanan hastalar retrospektif olarak incelendi. Tüm olgular yaş, cinsiyet, başvuru saati, komorbidite varlığı, biyokimyasal parametreler, kullanılan ilaçlar, hasta sonlanımı, yoğun bakım ihtiyacı, yatış sonrası hastanede kalış süreleri ve mortalite gibi sosyodemografik ve klinik özellikleri bakımından araştırıldı. TARTIŞMA ve SONUÇ: Tüm hastalarda HT varlığı sağ kalım lehine anlamlı iken, erkek cinsiyeti ve saat 06:01-12:00 arası başvuru mortalite lehine anlamlı bulundu. Hastane içi kardiyak arestte 21 dakika ve üzeri uygulanan KPR artmış mortalite ile ilşkili bulunmuştur. Kardiyopulmoner Resüsitasyonun kalitesini arttırmak amaçlı kayıt sistemlerinin ve standardizasyonun oluşturulması gerekliliği görülmektedir.
Acute Pancreatitis and Splenic Vein Thrombosis due to Hypertriglyceridemia
(Hindawi Ltd, 2015) Gunduz, Ercan; Dursun, Recep; Icer, Mustafa; Zengin, Yilmaz; Guloglu, Cahfer
Acute pancreatitis (AP) is a condition characterised by the activation of the normally inactive digestive enzymes due to an etiological factor and digestion of the pancreatic tissues, resulting in extensive inflammation and leading to local, regional, and systemic complications in the organism. It may vary from the mild edematous to the hemorrhagic and severely necrotising form. The most common causes are biliary stones and alcohol abuse. In this case study, we would like to present a patient with AP due to hypertriglyceridemia (HPTG), which is a rare cause of pancreatitis, and splenic vein thrombosis, which is a rare complication of pancreatitis.
Adult-Onset Still's Disease: Case Report
(Aves, 2014) Gunduz, Ercan; Gullu, Mehmet Nezir; Zengin, Yilmaz; Dursun, Recep; Icer, Mustafa; Ozhasenekler, Ayhan; Karakoc, Yenal
Introduction: Adult-onset Still's disease (ASD) is a systemic inflammatory disease of unknown etiology and pathogenesis. ASD, one of the most important causes of fever of unknown origin, is diagnosed after ruling out infection, malignancy, and rheumatologic diseases. It may also present with fever alone, without typical skin rash and articular manifestations. Case Report: There are no pathognomonic laboratory findings in ASD. In this paper, we report a case that presented to the emergency department with fever, malaise, and joint pain for 5 days and was subsequently diagnosed with ASD. Conclusion: In patients with prolonged fever combined with musculoskeletal symptoms and macular rash, the differential diagnosis should include ASD. Timely diagnosis and treatment of the disease can prevent complications and lead to a favorable prognosis
AFFECTING FACTORS ON EARLY MORTALITY IN ELDERLY PATIENTS DIAGNOSED WITH PULMONARY EMBOLISM IN EMERGENCY DEPARTMENT
(Gunes Kitabevi Ltd Sti, 2015) Zengin, Yilmaz; Gunduz, Ercan; Dursun, Recep; Icer, Mustafa; Durgun, Hasan Mansur; Taylan, Mahsuk; Guloglu, Cahfer
Introduction: The ratio of elderly people in Turkey is rapidly growing. It is known that pulmonary embolism and venous thrombolysis incidence increases with age. Despite the major advances in pulmonary embolism diagnosis and treatment, pulmonary embolism leads to higher mortality rates in the elderly. In the present study, evaluation of socio-demographic and clinical characteristics of elderly patients diagnosed with pulmonary embolism in the emergency department and determination of factors that affect early mortality have been targeted in order to decrease mortality. Materials and Method: Between January 1, 2009, and September 30, 2014, patients who were 65 years of age and older who had been admitted through the emergency department with suspected pulmonary embolism and whose pulmonary embolism diagnosis was finalized via computerized tomographic pulmonary angiography. Results: In the study, 87 (61.8%) were female and 52 (38.2%) were male. Thirteen patients (9.4%) died during the follow-up period. The analysis of the relationship between pulmonary embolism in elderly patients and early mortality revealed that there is a statistical correlation among immobility, syncope, tachycardia, hypotension, elevated Troponin-T, coronary arterial disease, cerebrovascular disease, pulmonary embolism with massive dimension, bilateral pulmonary embolism, Wells-likely pulmonary embolism, and modified Geneva-likely pulmonary embolism were statistically related factors(p values, respectively, were 0.002; 0.033; 0.000; 0.000; 0.000; 0.037; 0.011; 0.000; 0.030; 0.023; 0.018). Conclusion: Immobility, syncope, tachycardia, hypotension, elevated Troponin T, coronary arterial disease, cerebrovascular disease, pulmonary embolism with massive dimension, bilateral pulmonary embolism, Wells-likely pulmonary embolism, and modified Geneva-likely pulmonary embolism were determined as effective risk factors affecting the early mortality of elderly patients with pulmonary embolism.
AFFECTING FACTORS ON EARLY MORTALITY IN ELDERLY PATIENTS DIAGNOSED WITH PULMONARY EMBOLISM IN EMERGENCY DEPARTMENT
(2015) Zengin, Yılmaz; Gülolu, Cahfer; Dursun, Recep; İçer, Mustafa; Gündüz, Ercan; Taylan, Mahşuk; Durgun, Hasan Mansur
Giriş: Tüm dünyada olduğu gibi Türkiye'de de yaşlı nüfus oranı hızla artmaktadır. Pulmoneremboli ve venöz tromboli insidansının yaşla birlikte arttığı bilinmektedir. Pulmoner emboli tanı vetedavisindeki büyük ilerlemelere rağmen pulmoner emboli yaşlılarda daha yüksek oranda mortalite ile sonuçlanmaktadır. Bu çalışmada, acil serviste pulmoner emboli tanısı alan yaşlı hastalarınsosyodemografik ve klinik özelliklerini değerlendirmek ve mortalitenin azaltılabilmesi için erkenmortalite üzerindeki etkili faktörlerin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Bu çalışma 01.01.2009 tarihi ile 30.09.2014 tarihleri arasında acil servise başvuran 65 yaş ve üzeri olan ve pulmoner emboli şüphesi ile çekilen kompüterize tomografikpulmoner anjiografilerinde pulmoner emboli tanısı kesinleşen 139 hasta hastane bilgisayar kayıtsisteminden retrospektif olarak incelendi. Bulgular: Bu çalışmada hastaların 87'si (%61,8) kadın, 52'si (%38,2)'si erkekti. Hastaların takibinde 13 kişi (9,4%) yaşamını kaybetti. Çalışmada pulmoner embolili yaşlı hastalarının acil başvuru anındaki özellikleri ile erken mortalite arasındaki faktörlerin araştırıldığı analizde immobilite,bayılma, taşikardi, hipotansiyon, Troponin T yükselmesi, koroner arter hastalığı, serebrovaskülerhastalık, masif boyutlu pulmoner emboli olması, bilateral pulmoner emboli olması, Wells skorlamasında muhtemel pulmoner emboli olması ve Modifiye Genava skorlamasında muhtemel pulmoner emboli olmasının istatistiksel olarak ilişkili faktörler olduğu tespit edildi( p değerleri sırasıyla 0,002; 0,033; 0,000; 0,000; 0,006; 0,037; 0,011; 0,000; 0,030; 0,023; 0,018).Sonuç: İmmobilite, senkop, taşikardi, hipotansiyon, Troponin T yükselmesi, koroner arterhastalığı, serebrovasküler hastalık, masif boyutlu pulmoner emboli olması, bilateral pulmoner emboli olması, Wells skorlamasında muhtemel pulmoner emboli olması ve Modifiye Genava skorlamasında muhtemel pulmoner emboli olması yaşlı pulmoner embolili hastalarda erken mortaliteüzerine etkili faktörler olarak bulunmuştur
Assessment of adult patients with hypernatremia: A single center experience
(Dicle Üniversitesi Tıp Fakültesi, 2015) Gündüz, Ercan; Zengin, Yılmaz; İçer, Mustafa; Durgun, Hasan Mansur; Dursun, Recep; Gündüzalp, Ahmet; İpek, Mustafa; Güloğlu, Cahfer
Objective: In the present study, determination of symptoms, clinical characteristics, prevalence and recovery rates was aimed in patients who applied to the emergency service and diagnosed with hypernatremia. Methods: Patients who applied to Dicle University Medical School Emergency Service during January 2013-December 2014 and whose serum Na>148 mEq/L were included in the study. The study was conducted retrospectively. Results: Hypernatremia prevalence was determined as 0.21% in the cases who applied to the emergency service. The average age in all patients was 69±22 and the median age was 72 years. The average hospitalization period was 13.3±10.9 days. The mortality rate was 75.7% and male gender domination (56%) was determined in patients who developed mortality. When mortality and recovery groups were compared statistically; significant difference was determined (p<0.05) in terms of hospitalization period, glucose, urea, creatinine and calcium averages. The complaints of our patients who applied to the emergency service were changes in consciousness (92.7%), oral intake disorder (83.4%) and fever (48.6%) based on frequency order. The accompanying comorbid states were cerebrovascular illness (36.9%), Dementia/ Alzheimer (32.4%) and hypertension (28.9%) based on frequency order. Conclusion: Consequently, hypernatremia is a fluidelectrolyte disorder progressing with high mortality and could be observed in older patients and in patients whose oral intake is defective and who have cerebrovascular illness and dementia
A Bomb explosion in Diyarbakir: Clinical findings and management of emergency department
(Dicle Üniversitesi Tıp Fakültesi, 2016) İçer, Mustafa; Zengin, Yılmaz; Durgun, Hasan Mansur; Dursun, Recep; Arı, Baran; Ekinci, Mustafa; Üstündağ, Mehmet; Orak, Murat; Güloğlu, Cahfer
Objectives: In this study, we present management of emergency department, patients’ clinical findings and mortality analysis after a bomb explosion. Methods: Patients brought to Diyarbakır Dicle University Hospital emergency department after the explosion at 5 June 2015 were retrospectively examined. Patients’ age, gender, triage, system injuries, hypotension, blood transfusion, admission to the ICU, Intensive care unit surgical treatment, amputation and trauma scores (Glasgow Coma Score (GCS), Revised Trauma Score (RTS), Injury Severity Score (ISS), Trauma Score-Injury Severity Score (TRISS), Shock index) were studied. Factors affecting emergency department management and mortality were analyzed. Results: The mean age was found as 29.64±12.88 years in survivors and 36±19.98 years in deaths. GCS, ISS and shock index were found as the factors affecting mortality (p≤0.05). Wounded taken to the resuscitation room, hypotension, blood transfusion, intubation, treatment in ICU and amputation were correlated with mortality (p<0.05). Conclusion: A fast and effective triage system must be applied in EDs following a bomb explosion. The explosion of a bomb on the open areas are the most common injury to the lower extremity injury. Mortality is most often associated with lower limb amputations.
A Case of Uncorrected Tetralogy of Fallot Undiagnosed Until Adulthood and Presenting With Polycythemia
(Elmer Press Inc, 2014) Gunduz, Ercan; Gorgel, Ahmet; Dursun, Recep; Durgun, Hasan Mansur; Cil, Habip; Icer, Mustafa; Zengin, Yilmaz
Congenital heart defects with right-to-left shunt are one of the hypoxia-related causes of acquired secondary polycythemia (SP). Tetralogy of Fallot (ToF) is the most common congenital cyanotic heart disease in children. Cases of uncorrected ToF in adult ages are rare. This paper reports a woman detected with elevated hemoglobin level during routine tests performed for infertility therapy and subsequently diagnosed SP with related ToF.
COVID-19 Sürecinde Acil Servis, Hasta Değerlendirme ve Yönetimi
(2021) Türk, Mehmet; Guloglu, Cahfer; Dursun, Recep
Covid-19 pandemisi sırasında acil servisler hastane ve yerel bakımın ön saflarında yer almaktadır. Hem şüpheli COVID-19 vakalarını belirlemek ve yönetmek hem de diğer tıbbi acil durumları teşhis etmeye ve tedavi etmeye devam etmek için kritik öneme sahiptirler. Sonuç olarak, değişen ihtiyaçları karşılamak için acil servislerin yeniden gözden geçirilmesi gerekmektedir. Bu makalemizde COVID-19 pandemisi sırasında acil servis organizasyonu ve hasta yönetimi süreçlerine odaklanmayı amaçladık.
Demographic Analysis of Complications of Warfarin Treatment and Factors Affecting Mortality
(Aves, 2013) Orak, Murat; Dursun, Recep; Ustundag, Mehmet; Ozhasenekler, Ayhan; Durgun, Hasan Mansur; Guloglu, Cahfer
Objective: This study investigated the demographic analysis of complications of warfarin therapy and the factors affecting mortality. Material and Methods: The digital medical records of patients who applied to our Emergency Clinic with warfarin overdose between September 2007 and September 2010 were retrieved and patient files were assessed retrospectively. Cases were classified into two groups in terms of INR level and hemorrhagic complications; patients with an INR level greater than 3.5 and a hemorrhagic complication, and patients with an INR level greater than 3.5 and no hemorrhagic complication. Furthermore, cases with a hemorrhagic complication were divided into two subgroups as those who died and those who survived. Results: The study enrolled 151 cases presenting to our emergency clinic with warfarin overdose. Among these, 50.3% (n = 76) were males and 49.7% (n = 75) were females. Mean age was 60.80 +/- 16.11 years. There was no significant difference between the groups in terms of sex and age. Hemorrhagic complication was present in 66.89% (n = 101) while absent in 33.11% (n = 50). PT and INR levels were significantly higher in patients with hemorrhage compared to those without (for PT 90.98 +/- 26.52 vs. 55.51 +/- 12.70, respectively; p < 0.001; for INR 8.97 +/- 11.29 vs. 4.63 +/- 0.68, respectively; p = 0.042). In patients with a hemorrhagic complication who died, the PT level was significantly higher, and hematocrit and platelet levels were significantly lower than those of patients who survived a hemorrhagic complication (p < 0.001, p = 0.033, and p = 0.009, respectively). Conclusion: Education in warfarin use, regular follow-ups, self-monitorization, and increased distribution of home-type coagulometry devices will decrease the frequency of complications.
DEMOGRAPHIC PROPERTIES AND CLINICAL OUTCOMES OF ACUTE PANCREATITIS IN PREGNANCY: OUR EXPERIENCE OF 33 PATIENTS
(Carbone Editore, 2014) Gunduz, Ercan; Zengin, Yilmaz; Ulger, BurakVeli; Icer, Mustafa; Dursun, Recep; Gullu, Mehmet Nezir
Objective: In this study We aimed to examine the clinical, demographic properties, and outcome of acute pancreatitis in pregnancy. Materials and method: Our study included 33 patients with acute pancreatitis in pregnancy (APP) who were followed at the departments of Obstetrics and Gynecology and Internal Medicine at Dicle University Faculty of Medicine between January 2004 and June 2013. Patient information were obtained from the hospital records:. Age, gestational age, etiology, complications, laboratory results, diagnostic tests, treatment modalities, mode of delivery,(normal vaginal delivery or caesarean section (C/S)), duration of hospital stay, and maternal mortality and morbidity rates were recorded. Hypertriglyceridemia was recorded as the etiological factor when triglyceride level was more than 11.3 mmol/L (1000 mg/dl)and biliary pathology was recorded when there were biliary stones or bile mud. Patients who did not have a history of alcohol abuse or any condition responsible from pancreatitis were classified as idiopathic pancreatitis and grouped accordingly. Results: This study included a total of 33 patients with APP among a total of 85542 deliveries. Mean age of the study population was 34.8 +/- 7.15 (2346) years and mean gestational age was 25.75 +/- 7.49 weeks. The etiology of acute pancreatitis was a biliary pathology in 18 (545%) patients, hypertriglyceridemia in 11 (33.3%), and idiopathic APP in 4 (12.2%). Four (12.1%) maternal deaths occurred. Sixteen (48.5%) patients suffered from a maternal complication while 10 (33.3%) patients died. Twenty-nine patients were discharged With cure. All maternal deaths and 50% of maternal complications occurred in second trimester. Conclusion: In our study APP was most commonly observed in second trimester and it had a more complicated and fatal course during this period. Biliary pathologies were the most fatal etiological group.
Demographic Properties of Civilians with Blast Injuries in Southeastern Anatolia Region
(2015) Akdağ, Mehmet; Kaçmaz, Ömer; Dursun, Recep; Üstündağ, Mehmet; Durgun, Hasan Mansur; Gulloglu, Cahfer; Orak, Murat
ObjectivesThe present study conducted demographic analysis of blast injuries, with the authors aiming to guide the determination of groups and regions at risk, helping hospitals take preventive measures and providing information for accurate triage, rapid intervention, multidisciplinary approach, and lowering workforce losses.MethodsThis study retrospectively examined the demographic properties of civilians who presented to the Emergency Department of Dicle University after being injured in explosions of various origins between January 2005 and September 2013 in the Southeastern Anatolia Region of Turkey.ResultsOf the study population, 85.50% were male and 14.50% were female. The explosive responsible for injury was a mine in 20.51% of the cases, a bomb in 29.06%, a squib in 14.53%, dynamite in 7.69%, and some other explosive in the remaining 28.31%. Of those injured, 35.90% were students, 21.36% were farmers, 11.10% were shepherds or drivers, and 31.62% were from other occupational groups.ConclusionsIn conclusion, injuries resulting from explosions are associated with higher morbidity and mortality rates, making it necessary to increase the number of trauma centers and emergency action teams in that region, as well as demining the region and educating the native population about explosives
Demographic properties of civilians with blast injuries in Southeastern Anatolia Region
(Türkiye Acil Tıp Derneği, 2015) Kaçmaz, Ömer; Dursun, Recep; Durgun, Hasan Mansur; Akdağ, Mehmet; Orak, Murat; Üstündağ, Mehmet; Güloğlu, Cahfer
Objectives The present study conducted demographic analysis of blast injuries, with the authors aiming to guide the determination of groups and regions at risk, helping hospitals take preventive measures and providing information for accurate triage, rapid intervention, multidisciplinary approach, and lowering workforce losses. Methods This study retrospectively examined the demographic properties of civilians who presented to the Emergency Department of Dicle University after being injured in explosions of various origins between January 2005 and September 2013 in the Southeastern Anatolia Region of Turkey. Results Of the study population, 85.50% were male and 14.50% were female. The explosive responsible for injury was a mine in 20.51% of the cases, a bomb in 29.06%, a squib in 14.53%, dynamite in 7.69%, and some other explosive in the remaining 28.31%. Of those injured, 35.90% were students, 21.36% were farmers, 11.10% were shepherds or drivers, and 31.62% were from other occupational groups. Conclusions In conclusion, injuries resulting from explosions are associated with higher morbidity and mortality rates, making it necessary to increase the number of trauma centers and emergency action teams in that region, as well as demining the region and educating the native population about explosives.
Do Meteorological Changes Have an Effect on The Occurence of Spontaneous Pneumothorax?
(Bilimsel Tip Publishing House, 2016) Oruc, Menduh; Sahin, Atalay; Dursun, Recep; Taylan, Mahsuk; Erbey, Ahmet; Meteroglu, Fatih; Ozturk, Bulent
OBJECTIVES: Spontaneous pneumothorax refers to the leakage of air into the space between the parietal and the visceral layers of the pleura. It occurs with or without a known lung disease. We aimed to investigate the effects of atmospheric pressure, humidity, and temperature changes on the incidence of spontaneous pneumothorax (SP). MATERIAL AND METHODS: This study included 551 patients with spontaneous pneumothorax retrospectively screened between January 2009 and December 2013. The medical data of the patients were accessed via their medical records on the hospital automation system. The atmospheric pressure, temperature, humidity rate, amount of precipitation, and wind velocity on the day of spontaneous pneumothorax were obtained from the data provided by the general directorate of meteorology. The three consecutive days on which at least 2 cases of SP presented were collectively considered as a cluster. The study data were analyzed with the SPSS version 15 software package, using the Chi-square and the Student's t tests. A p value less than 0.05 was considered statistically significant. RESULTS: Of the 552 patients included in the study, 89.3% had primary spontaneous pneumothorax and 10.7% had secondary spontaneous pneumothorax. Ninety-two percent of the patients were male and 8% were female. The mean age was 24 years. Clustering was observed in 71.7% of the study population. No significant differences were observed between yearly and monthly SP incidences. There were, however, differences between the days with SP and the days without SP with respect to atmospheric pressure, ambient temperature, wind velocity, and humidity rate. The differences between the atmospheric pressures were not statistically significant, although the differences between the ambient temperature and the humidity rate were statistically significant (p=0.05). CONCLUSION: We determined that the changes in the ambient temperature and the humidity rate affected the rate of spontaneous pneumothorax by altering the meteorological conditions.
The effect of body mass index on trauma severity and prognosis in trauma patients
(Turkish Assoc Trauma Emergency Surgery, 2016) Durgun, Hasan Mansur; Dursun, Recep; Zengin, Yilmaz; Ozhasenekler, Ayhan; Orak, Murat; Ustundag, Mehmet; Guloglu, Cahfer
BACKGROUND: As in the rest of the world, the prevalence of obesity in Turkey has been increasing in recent years and has become a major public health issue. Although many trials have been conducted to study the effects of obesity on internal diseases, there are few studies investigating the effects of obesity on prognosis of trauma patients. The present study analyzed the effects of body mass index (BMI) on trauma severity and prognosis in trauma patients. METHODS: This study was prospectively conducted with trauma patients older than 15 years of age who presented at the Dicle University Faculty of Medicine emergency medicine department trauma unit between June I, 2013 and May 31, 2014. Patients were grouped into high-energy trauma and low-energy trauma groups based on trauma severity. In addition, 4 groups were made according to BMI value (kg/m(2)). Group I was defined as BMI <25 (normal weight). Group II patients had BMI of 25-29.9 (overweight). Group III had BMI of 30-34.9 (obese), and Group IV was made up of patients with BMI >= 35 (morbidly obese). RESULTS: Comparison of whole patient population for inter-group differences showed significant differences between rate of head injury, thoracic injury, extremity injury, multitrauma, clinic admission rate, and mortality rate (p<0.001). No significant difference was observed between groups in abdominal injury rate (p=0.347). CONCLUSION: Clinic admission rate, length of intensive care unit stay, mortality rate, multitrauma rate, and injury severity score increased in proportion to greater BMI.
Effects of Carvacrol on Experimental Testicular Torsion-Detorsion Model Investigation by Immunohistochemistry
(Sci Printers & Publ Inc, 2020) Dursun, Recep; Sen, Abdullah; Yaman, Mahmut; Durgun, Hasan Mansur; Asir, Firat
OBJECTIVE: To investigate the protective effects of carvacrol on an experimental testicular torsion-detorsion rat model. STUDY DESIGN: Wistar male rats (n=48) weighing 230-250 g were assigned to 4 groups (8 per group): control, torsion, torsion-detorsion, and torsion-detorsion + carvacrol-treated groups. Control group animals did not undergo any surgical operation. For the torsion group, the scrotum was opened (under general anesthesia) and the left testis twisted 720 degrees clockwise and in the last 30 minutes of 3-hour ischemia; i.p. saline was injected. In the torsion-detorsion group, after ischemia the left testis was reperfused for 2 hours. The torsion/ detorsion +carvacrol group protocol was similar to that of the torsion-detorsion group but in the last 30 minutes of 3-hour ischemia, i.p. 20 mg/kg carvacrol was administered. RESULTS: Malondialdehyde (MDA) was highest in the torsion-detorsion group (p <0.01). The lowest catalase (CAT) value was found in the torsion-detorsion group. Decrease in glutathione (GSH) levels of the torsion and torsion-detorsion groups as compared to those of control and carvacrol groups was significant (p<0.01). The highest superoxide dismutase (SOD) value was in the control and carvacrol groups. Increased apoptosis and degeneration of spermatogenic cells with hyperplasic nuclei were mainly observed in the torsion and torsion-detorsion groups. The torsion-detorsion + carvacrol group mostly showed regular histology, but Leydig cells were degenerated. ET-1 expression was increased in endothelial cells in the torsion and detorsion groups but negative in the carvacrol group. Bax expression was positive in luminal spermatogenic cells in the torsion group but negative in interstitial cells in both torsion and torsion-detorsion groups. In the carvacrol-treated group some luminal spermatogenic cells in seminiferous tubules showed positive Bax expression but weak in basal membrane cells and Leydig cells. CONCLUSION: Carvacrol influences spermatogenic cells with strong mitotic activity in basal membranes of seminiferous tubules and may prevent apoptotic development and signaling of these cells.
Erişkin Still Hastalığı: Olgu Sunumu
(Acil Tıp Uzmanları Derneği, 2014) Gündüz, Ercan; Güllü, Mehmet Nezir; Zengin, Yılmaz; Dursun, Recep; İçer, Mustafa; Özhasenekler, Ayhan; Karakoç, Yenal
Introduction: Adult-onset Still’s disease (ASD) is a systemic inflammatory disease of unknown etiology and pathogenesis. ASD, one of the most important causes of fever of unknown origin, is diagnosed after ruling out infection, malignancy, and rheumatologic diseases. It may also present with fever alone, without typical skin rash and articular manifestations. Case Report: There are no pathognomonic laboratory findings in ASD. In this paper, we report a case that presented to the emergency department with fever, malaise, and joint pain for 5 days and was subsequently diagnosed with ASD. Conclusion: In patients with prolonged fever combined with musculoskeletal symptoms and macular rash, the differential diagnosis should include ASD. Timely diagnosis and treatment of the disease can prevent complications and lead to a favorable prognosis
The Evaluation of Blood Alcohol Concentration of Drivers Involved in Traffic Accidents or Suspected for Alcohol in The Roadside Controls in Four Big Cities of Turkey
(2022) Karabağ, Gökmen; Duran, Latif; Sever, Demet; Asirdizer, Mahmut; Can, Hale Nur; Dursun, Recep; Bilge, Adnan
Objective: Previous studies have revealed a relationship between the driving under the influence of alcohol (DUIA) and/or driving under the influence drugs (DUID) and the increased risk of death and injury in traffic accidents. The aim of this study was to investigate of blood alcohol concentration (BAC) of drivers after involved in a traffic accident or for suspected for drunkenness in the roadside traffic control in the Turkey’s four major cities. Methods: In this study, we retrospectively reviewed the laboratory registrations in university hospitals in four big cities of Turkey (Van, Manisa, Diyarbakır and Samsun) for BAC for five years (from 1 January 2015 to 31 December 2019) of the drivers. Results: In 342 cases (7.1%), BACs were above the cut-off value (0.01 g/100 mL). Of the cases sent for alcohol determination, 11.3% were women and 88.7% were men, and their mean age was 35.3±13.1. In 342 alcohol positive cases, BACs were above 0.101% in 58.8% of cases. BAC positivity of the cases was 9.4% in Manisa, 6.3% in Van, 5.3% in Samsun, and 5% in Diyarbakır. BAC was found to be positive in 4.4% (n=24) of females and 7.4% (n=318) of males (p<0.05). Conclusion: This study is one of the limited number of multicentre studies in this field; it was concluded in the study that zero tolerance should be for drunk driving in traffic, the deterrence of fines should be increased, and roadside screening tests should be used more widely.
Evaluation of inflammatory and hematological parameters in patients diagnosed with COVID-19
(J Infection Developing Countries, 2022) Mermutluoglu, Cigdem; Dursun, Recep; Aktar, Fesih; Dayan, Saim; Celen, Mustafa Kemal; Kadiroglu, Ali Kemal; Inci, Erdal
Introduction: This study aims to research the effects of hematological and inflammatory parameters on the prognosis of COVID-19 disease and Methodology: One hundred and eighty-six patients with COVID-19 and a control group consisting of 187 healthy individuals were included in the study. Hematological variables and inflammatory parameters of the patients were recorded on the first and the fifth days of hospitalization. Results: White blood cell count, lymphocyte count, and platelet count were statistically lower, and mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) levels were higher in the patient group compared to the control group. It was observed that the neutrophil count and MPV level were lower, and the platelet count and ferritin level were statistically higher on the fifth day of follow-up compared to the admission day. In contrast, there was a significantly positive correlation between the duration of hospitalization and the fifth day D-dimer (r = 0.546, p < 0.001) and ferritin (r = 0.568, p < 0.001); in addition, there was a negative correlation between the duration of hospitalization and admission day lymphocyte count and the fifth-day lymphocyte count. Conclusions: Increased levels of ferritin and D-dimer, and decreased count of lymphocytes are among the important factors affecting the duration of hospitalization for COVID-19 patients. Furthermore, we think that neutrophil count and MPV levels are low, and platelet count and ferritin levels are high during the disease. Therefore, these parameters can be used as prognostic indicators of the disease.
Evaluation of pregnant patients admitted to the emergency department with suicide attempt
(Modestum Publishing Ltd., 2015) Zengin, Yılmaz; Gündüz, Ercan; Dursun, Recep; İçer, Mustafa; Durgun, Hasan Mansur; Kara, Ertuğrul; Gündüzalp, Ahmet; Güloğlu, Cahfer
Objective: In the pregnancy period, the incidence of suicide attempt is lower compared to other life-periods. However, according to the recent studies, suicide attempts may lead life-threatening consequences in high-risk pregnant women. The aim of this study is to compare pregnant patients admitted to the emergency department for suicide attempt in terms of their sociodemographic and clinical properties and suicide attempt methods. Methods: In this study, 56 patients admitted to the emergency department of university for suicide attempt between January 1, 2009, and December 31, 2014, were included and they were classified according to suicide attempt methods into 2 groups as violent ones. Group 1 included violent methods as hanging, jumping, shooting and Group 2 included non-violent method as drugs. The study was a retrospective cross-sectional study. The sociodemographic, psychiatric and clinical properties of the patients were identified by patient registry system and patient files, and inter-group differences were compared. Results: In this study, 15 (26.7%) patients in the violent suicide attempt group, and 41 (73.3%) patients in the non-violent suicide attempt group, totally 56 patients were included. In the non-violent suicide attempt group, cigarette smoking, suicide attempt due to boredom, and live birth was significantly higher as compared to violent group; hospitalization period and fetal death was lower (p=0.04; p=0.006; p=0.004; p=0.004, respectively). Conclusion: Most of our pregnant suicide attempt patients are in the non-violent group, however, violent suicide attempt increased hospitalization period and fetal mortality significantly. J Clin Exp Invest 2015; 6 (2): 115- 120.

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