Yazar "Dursun, Mehmet Emin" seçeneğine göre listele
Listeleniyor 1 - 20 / 30
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Amblyopia and Refractive Errors Among School-Aged Children With Low Socioeconomic Status in Southeastern Turkey(Slack Inc, 2013) Caca, Ihsan; Cingu, Abdullah Kursat; Sahin, Alparslan; Ari, Seyhmus; Dursun, Mehmet Emin; Dag, Umut; Balsak, SelahattinPurpose: To investigate the prevalence of refractive errors and other eye diseases, incidence and types of amblyopia in school-aged children, and their relation to gender, age, parental education, and socioeconomic factors. Methods: A total of 21,062 children 6 to 14 years old were screened. The examination included visual acuity measurements and ocular motility evaluation. Autorefraction under cycloplegia and examination of the external eye, anterior segment, media, and fundus were performed. Results: There were 11,118 females and 9,944 males. The average age was 10.56 +/- 3.59 years. When all of the children were evaluated, 3.2% had myopia and 5.9% had hyperopia. Astigmatism 0.50 D or greater was present in 14.3% of children. Myopia was associated with older age, female gender, and higher parental education. Hyperopia was inversely proportional with older age. Spectacles were needed in 4,476 (22.7%) children with refractive errors, and 10.6% of children were unaware of their spectacle needs. Amblyopia was detected in 2.6% of all children. The most common causes of amblyopia were anisometropia (1.2%) and strabismus (0.9%). Conclusion: Visual impairment is a common disorder in school-aged children. Eye health screening programs are beneficial in early detection and proper treatment of refractive errors. [J Pediatr Ophthalmol Strabismus 2013;50:37-43.]Öğe Autonomic dysfunction detection by an automatic pupillometer as a non?invasive test in patients recovered from COVID?19(Springer, 2021) Karahan, Mine; Demirtaş, Atılım Armağan; Hazar, Leyla; Erdem, Seyfettin; Ava, Sedat; Dursun, Mehmet Emin; Keklikçi, UğurPurpose To recognize dysfunctions in the autonomic nervous system (ANS) with changes in dynamic and static pupillary responses in patients who recovered from coronavirus disease-2019 (COVID-19) Methods One month after recovery from COVID-19, patients were subjected to eye examinations. Pupillary responses were measured using a pupillometry system. Dynamic pupil parameters (i.e., pupil contraction amplitude, pupil dilatation latency, pupil contraction latency, pupil dilatation duration, pupil dilatation velocity, pupil contraction duration, pupil contraction velocity, resting pupil diameter [PD]) and static pupil parameters (i.e., mesopic PD, scotopic PD, high photopic PD, and low photopic PD) were registered. Results Although high photopic and scotopic PDs were significantly higher in patients recovering from COVID-19 than in healthy controls (P = 0.04 and P = 0.002), no statistically significant difference was found in mesopic and low photopic PD (P = 0.19 and P = 0.41). Regarding dynamic pupillometry parameters, resting PD and pupil contraction velocity (P = 0.04 and P = 0.02, respectively) were significantly higher in patients recovering from COVID-19 than in healthy controls (P < 0.001 and P < 0.001, respectively), whereas pupil dilatation latency and pupil contraction duration were lower in these patients than in healthy controls (P = 0.01 and P = 0.008, respectively). No significant differences in pupil contraction amplitude, pupil dilatation duration, pupil contraction latency, and pupil dilatation velocity were found between the study groups (P = 0.93, P = 0.91, P = 0.42, and P = 0.48, respectively). Conclusion Pupil responses, which are controlled by the ANS, were impaired in patients recovering from COVID-19. Pupillometry shows promise as a non-invasive, easy-to-apply diagnostic technology for detecting autonomic dysfunction in patients recovering from COVID-19.Öğe Bilateral central retinal artery occlusion secondary to SARS-CoV-2 infection in the early and late periods: A case report(Georg Thieme Verlag KG, 2021) Karahan, Mine; Erdem, Seyfettin; Hazar, Leyla; Dursun, Mehmet Emin; Ava, Sedat; Emek, Hüseyin; Keklikçi, UğurThe causative agent of coronavirus disease (COVID-19) is a new virus termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the coronavirus family. It was first detected in China in December 2019 and spread rapidly around the world. COVID-19 is highly contagious and mainly transmitted through contact with infected patients or droplets. The most common symptoms are fever, cough, weakness, muscle pain, and shortness of breath [1]. SARS-CoV-2 infects host cells through the renin angiotensin-converting enzyme 2 (ACE2) receptors. The ACE2 receptor is widely expressed in many organs, including the retina, and plays a role in the pathogenesis of systemic vascular diseases, which can lead to ocular symptoms such as diabetic and hypertensive retinopathy [2], [3]. SARS-COV-2 has been reported to be associated with neurological symptoms, including stroke, thromboembolism (e.g., pulmonary embolism), and myocardial infarction. Hypercoagulation associated with COVID-19 has been described as “sepsis-induced coagulopathy” and may predispose patients to the spectrum of thromboembolic events [4], [5], [6]. We present here the first case of bilateral central retinal artery occlusion (CRAO) that developed in the early and late stages secondary to the SARS-CoV-2 infection.Öğe Can dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome?(Springer, 2021) Erdem, Seyfettin; Yılmaz, Süreyya; Karahan, Mine; Dursun, Mehmet Emin; Ava, Sedat; Alakuş, Mehmet Fuat; Keklikçi, UğurPurpose We aimed to reveal whether static and dynamic pupillary responses can be used for the detection of autonomic nervous system (ANS) dysfunction in patients with obstructive sleep apnea syndrome (OSAS). Methods We included in this study patients with OSAS, who were divided into three groups according to the apnea-hypopnea index (AHI) (group 1, mild [n = 20]; group 2, moderate [n = 20]; and group 3, severe [n = 20]), and healthy controls (group 4, n = 20). Pupillary responses were measured using a pupillometry system. Results Static (mesopic PD, P = 0.0019; low photopic PD, P = 0.001) and dynamic pupil responses (resting diameter, P = 0.004; amplitude of pupil contraction, P < 0.001; duration of pupil contraction, P = 0.022; velocity of pupil contraction, P = 0.001; and velocity of pupil dilation, P = 0.012) were affected in patients with different OSAS severities. Also, AHI was negatively correlated with mesopic PD (P = 0.008), low photopic PD (P = 0.003), resting diameter (P = 0.001), amplitude of pupil contraction (P < 0.001), duration of pupil contraction (P = 0.011), velocity of pupil contraction (P < 0.001), and velocity of pupil dilation (P = 0.001). Conclusion We detected pupil responses innervated by the ANS were affected in the OSAS patients. This effect was more significant in the severe OSAS patients. Therefore, the pupillometry system can be an easily applicable, noninvasive method to detect ANS dysfunction in the OSA patients.Öğe Can long-term exposure to chromium improve insulin sensitivity in chromium mine workers?(Wiley-Liss, 2004) Tuzcu, Alpaslan; Bahçeci, Mithat; Dursun, Mehmet Emin; Parmaksız, Y.; Ertem, Melikşah; Dalgıç, A.; Turgut, Cengiz; Kale, EbruThe purpose of this work was to evaluate insulin sensitivity in chromium mine workers exposed to chromium chronically. Body mass index, waist circumference, fat mass and percent, lipid levels, serum glucose, insulin, leptin and chromium levels, HOMA (%S), and HOMA (%B) values were measured in 93 male workers and 94 age- and body mass index-matched healthy controls. Fat mass and fat percent of workers were higher than control subjects (P < 0;01 and P < 0.0001, respectively). Mean insulin level of the workers was lower than control subjects (6.2 +/- 4.9 muU/mL and 9.38 +/- 5, respectively, P < 0.0001). Mean serum leptin levels was also lower than the control group (8.47 +/- 6.5 ng/mL and 19.0 +/- 10.8, respectively, P < 0.0001). Serum chromium was higher than the control subjects (407.7 +/- 224.2 nmol/L and 4.45 +/- 3.9, respectively, P < 0.00001). Mean HOMA (%S) index of workers was higher than control subjects (114.4 +/- 55.6 and 55.7 +/- 40.6, P < 0.001). Serum high-density lipoprotein cholesterol levels of the workers were significantly higher than the control group (P < 0.02). In conclusion, long-term exposure to chromium may improve insulin sensitivity and beta-cell function. This improvement appears to be a result of low body fat mass and fat percent in body composition. In addition chromium usage may have useful effects in the insulin sensitivity and therefore in development of type 2 diabetes mellitus.Öğe Evaluation of anterior segment parameters with Pentacam in children with poorly-controlled type 1 Diabetes Mellitus without diabetic retinopathy(Elsevier, 2021) Karahan, Mine; Demirtaş, Atılım Armağan; Erdem, Seyfettin; Ava, Sedat; Dursun, Mehmet Emin; Beştaş, Aslı; Haspolat, Yusuf Kenan; Keklikçi, Uğururpose: To determine the effect of abnormal glucose metabolism on the cornea, lens, anterior chamber volume (ACV), and anterior chamber depth (ACD) in children with poorly-controlled type 1 diabetes mellitus (DM) without diabetic retinopathy (DR). Methods: After the complete ophthalmologic examination of children with poorly-controlled (glycosylated hemoglobin [HbA1c] >7.0 %) type 1 DM without DR and age-matched healthy subjects (control group), the central corneal thickness (CCT), keratometry (K) values (Kmean front and back, and Kmax), radius (R) values (Rmin front and back), corneal volume (CV), ACD, ACV, pupil diameter, mean lens density (MLD), lens density standard deviation (LD SD), and maximum lens density (LD max) were measured using Pentacam High Resolution. Endothelial cell density was measured using a specular microscope. The results were assessed and compared between the two groups. Results: There were 60 patients (38 boys and 22 girls) in the DM group and 30 (14 boys, 16 girls) in the control group. There were considerable differences between the groups in terms of CCT, CV, ACD, MLD, LD SD and LD max, and Kmean back. Further, there was a positive correlation between HbA1c and MLD, LD SD, CV, and CCT in patients with DM. Conclusion: The results of our study demonstrate that poorly-controlled type 1 DM without DR affects the cornea, ACD, and LD based on anterior segment measurements taken with a Scheimpflug camera. CCT, CV, LD SD, and MLD values may be parameters that can be used to follow-up patients with type 1 DM.Öğe Evaluation of blood inflammatory parameters of infants with premature retinopathy treated with intravitreal anti vascular endothelial growth factor(Gazi Göz Vakfı, 2022) Ava, Sedat; Hazar, Leyla; Karahan, Mine; Erdem, Seyfettin; Dursun, Mehmet Emin; Keklikçi, UğurPurpose: This study compared the blood inflammatory parameters between early preterm infants with retinopathy of prematurity (ROP) who were treated with intravitreal anti-vascular endothelial growth factor (VEGF)) and those who did not need treatment. Materials and Methods: One hundred and six infants were included in the study. Early preterm infants with a gestational age (GA) ≤ 32 weeks and birth weight (BW) ≤ 1500 gm were included. These infants were divided into three groups: infants without ROP (group 1), infants with ROP who did not require treatment (group 2) and infants with ROP who were treated with intravitreal anti-VEGF (group 3). In the first week, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) of the groups were calculated and compared. Results: Of 106 infants, 38 (35.8%) were in group 1, 30 (28.3%) were in group 2 and 38 (35.8%) were in group 3. GA was 24.89 ± 1.48 weeks, and BW was significantly lower in group 3, 775.21 ± 175.11 gm. (p < 0.001). There was no significant difference between the groups in terms of NLR, MLR and PLR (p = 0.833, p = 0.918 and p = 0.082, respectively). Logistic regression analysis was performed; BW was a statistically significant independent risk factor (OR: 0,999 %CI: 0,992-0,999 p = 0.022) associated with ROP that required treatment. Conclusion: It was shown that systemic inflammation parameters, including NLR, MLR and PLR, are not a reliable marker in the diagnosis and prognosis of ROP.Öğe Evaluation of choroidal thickness in patients who have recovered from COVID-19(Springer, 2022) Erdem, Seyfettin; Karahan, Mine; Ava, Sedat; Dursun, Mehmet Emin; Dursun, Birgul; Hazar, Leyla; Bozarslan Senol, BerivanPurpose We aimed to evaluate choroidal thickness (CT) in patients who have recovered from COVID-19 by using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods We included fifty-eight patients who have recovered from COVID-19 (group 1) and fifty healthy control subjects (group 2) in this prospective study. Best corrected visual acuity, anterior segment and posterior segment examinations of all subjects were performed. CT scan and measurements were taken with the EDI mode of the Spectral Domain OCT device. Results Of the 108 subjects included in this study, 57 were female and 51 were male. The mean age was similar in both groups (36.10 +/- 7.12 and 35.58 +/- 7.29, respectively, p = 0.276). Group 1 had the following characteristics: the mean time since diagnosis was 53.18 +/- 2.84; it had been 38.48 +/- 4.07 days since the PCR test was negative; and all subjects were outpatients. It was detected that the CT of the patients in group 1 decreased in all areas compared to group 2, and this decrease was significant in subfoveal, temporal and inferior areas (257.48 +/- 32.79, 273.62 +/- 45.04, p = 0.04; 232.96 +/- 41.79, 252.76 +/- 46.09, p = 0.02, and 245.22 +/- 44.58, 271.54 +/- 55.07, p = 0.01, respectively). In the retinal nerve fiber layer analysis for group 1, thickening was detected in all areas, although it was not statistically significant, except in the temporal area where it was (superotemporal, superonasal, nasal, inferonasal, inferotemporal, temporal, and global [p = 0 .08, p = 0.45, p = 0.73, p = 0.64, p = 0.74, p = 0.02, and p = 0.10, respectively]). Conclusion For individuals who had recovered from COVID-19, it was found that CT decreased in all areas in these patients. Therefore, this study in which we have demonstrated the decrease in the thickness of the choroidal tissue, a tissue with high blood flow, may contribute to the understanding of the systemic microvascular waste of this disease.Öğe Evaluation of parafoveal and peripapillary vascular densities using optical coherence tomography angiography in children with thalassemia major(SAGE Publications Ltd., 2023) Dursun, Mehmet Emin; Hazar, Leyla; Karahan, Mine; Erdem, Seyfettin; Ava, Sedat; Üzel, Veysiye Hülya; Dursun, Birgül; Keklikçi, UğurBackground: Thalassemia major (TM) is an inherited anaemia caused by faulty haemoglobin synthesis. Reducing serum iron levels using iron chelating agents is an important step in the treatment of TM, and the effects on the eye of both the disease and these agents can be determined by regular eye examination. Objectives: We evaluated macular and optic nerve vascular densities in children with TM and compared the results with healthy controls using optical coherence tomography angiography (OCTA). Design: This is a prospective study. Methods: A total of 30 children with TM and 30 healthy controls were included in the study. The area of the foveal avascular zone (FAZ) and the vascular densities (VD) of the optic nerve head (ONH), radial peripapillary capillary (RPC) and deep and superficial retinal vascular networks were measured using OCTA. Results: A statistically significant decrease in VD was observed in the whole image and the parafovea, superior hemi, superior and inferior parts of the superficial capillary plexus and in the whole image and the superior regions of the deep capillary plexus in the TM patient group compared with the control group (p < 0.05). A significant decrease in VD was also observed in the whole image and the inside disc, peripapillary, nasal, inferonasal and temporal regions of the ONH and in the whole image and the inside disc, peripapillary and inferonasal regions of the RPC network in patients with TM (p < 0.05). A significant positive correlation was observed between both serum ferritin levels and deferasirox dosage, on one hand, and both the superficial (p = 0.023 and p = 0.002, respectively) and deep FAZs (p = 0.015 and p = 0.045, respectively), on the other hand. A negative correlation was also found between the deferasirox dosage and the VDs of the superficial (p = 0.010) and deep (p = 0.001) foveal plexuses. Conclusion: Retinal VD and FAZ are affected in patients with TM. OCTA, which can noninvasively measure retinal VD in patients with TM, may be a useful tool for the early detection of retinal microvascular changes that may occur during the course of the disease.Öğe Evaluation of parafoveal vascular density using optical coherence tomography angiography in patients with central serous chorioretinopathy(Springer London Ltd, 2022) Dursun, Mehmet Emin; Erdem, Seyfettin; Karahan, Mine; Ava, Sedat; Hazar, Leyla; Dursun, Birgul; Keklikci, UgurUsing optical coherence tomography angiography (OCTA), we sought to evaluate parafoveal vascular density (VD) in patients with central serous chorioretinopathy (CSCR). Our study included 43 patients with a diagnosis of CSCR and 40 healthy controls. Ophthalmologic examination findings and OCTA measurements of the participants were retrospectively analysed. Of the 43 patients with CSCR, 31 were males (72%) and 12 were females (28%); the control group was 30 males (75%) and 10 females (25%) (p = 0.657). There were significant differences between affected eyes, unaffected eyes and healthy control eyes for all parameters in the superficial capillary plexus (SCP) VD and deep capillary plexus (DCP) VD (p < 0.05 for all values). It was also determined that the affected eyes had lower SCP-VD and DCP-VD than the unaffected eyes and that the unaffected eyes had lower SCP-VD and DCP-VD than the healthy control eyes (p < 0.05 for all values). While there were no significant differences in the deep foveal avascular zone (FAZ) area, the superficial FAZ area was larger in affected eyes than in both unaffected eyes and healthy control eyes (p < 0.05). In most areas, the SCP-VD and DCP-VD values were lower and the FAZ larger in the chronic group than in the acute group (p < 0.05). Retinal vascular changes were found in patients with both acute and chronic CSCR, and the fellow eyes of these patients were also affected. OCTA can therefore be considered an easily applicable, non-invasive screening option for evaluating the microvascular structure in these patients.Öğe Evaluation of plasma inflammatory markers in patients with nonarteritic retinal artery occlusion(2023) Karahan, Mine; Ava, Sedat; Erdem, Seyfettin; Keklikçi, Uğur; Dursun, Mehmet Emin; Hazar, Leyla; Vural, EsraPurpose: To examine the clinical characteristics, comorbid status and laboratory parameters of patients followed up with a diagnosis of retinal artery occlusion (RAO) and to compare blood inflammation parameters with control subjects. Methods: The medical records of 49 patients who were followed up for RAO at Dicle University Medical Faculty between 2017 and 2020 were retrospectively analysed. The occlusion type was divided into two groups, central retinal artery occlusion (CRAO) and branch retinal artery occlusion (BRAO). The demographic characteristics and clinical and laboratory tests of the groups were compared. The blood WBC, neutrophil, lymphocyte, monocyte and platelet counts of the patients were also recorded, and the neutrophil/lymphocyte, monocyte/lymphocyte and platelet/lymphocyte counts were calculated by simple division and compared with 41 age- and gender-matched controls. Results: There was no difference in age and gender between the CRAO and BRAO groups (p = 0.220 and p = 0.303 respectively). Heart disease was significantly more common in CRAO patients (p = 0.004), and hypertension was observed more often, although not significantly (p = 0.084). WBC, neutrophil and monocyte values were found to be significantly higher in those with RAO than in the controls (p = 0.005, p < 0.001, p = 0.035 respectively). The neutrophil-lymphocyte ratio (NLR) was found to be significantly higher in those with RAO (p = 0.007). Conclusion: RAO is associated with significant elevation in WBC and NLR. The association of CRAO with cardiovascular disease is prominent.Öğe Evaluation of Retinal Microvascular Perfusion Changes in Patients with Celiac Disease(Taylor & Francis Inc, 2022) Erdem, Seyfettin; Ucmak, Feyzullah; Karahan, Mine; Ava, Sedat; Dursun, Mehmet Emin; Dursun, Birgul; Hazar, LeylaPurpose We aimed to determine whether there are retinal microvascular changes in patients with celiac disease (CD). Methods A total of 30 patients with CD (group 1) and 30 healthy controls (group 2) were included in this study. AngioVue optical coherence tomography angiography (OCTA) device was used to evaluate the retinal microvascular structure. Results Some of the values of both optic nerve head (ONH) vessel density (VD) and radial peripapillary capillary VDs were found to be significantly lower in group 1 than in group 2. These 2 groups were similar except for one of the parameters of superficial capillary plexus VD (SCP-VD), whereas it was found that deep capillary plexus VD (DCP-VD) was lower in group 1 than in group 2 except for the foveal area. Conclusion It was determined that some VDs obtained from the ONH and DCP-VD obtained from most areas of the macular region were significantly lower.Öğe Evaluation of the effect of obstructive sleep apnea syndrome on retinal microvascularity by optical coherence tomography angiography(Elsevier, 2022) Ava, Sedat; Erdem, Seyfettin; Karahan, Mine; Dursun, Mehmet Emin; Hazar, Leyla; Şen, Hadice Selimoğlu; Keklikçi, UğurPurpose: Using optical coherence tomography angiography (OCTA), we sought to determine whether there are retinal microvascular changes in patients with obstructive sleep apnea syndrome (OSAS). Method: The study included 56 patients diagnosed with OSAS by polysomnography [21 patients with mild OSAS (group 1), 14 with moderate OSAS (group 2) and 21 with severe OSAS (group 3)], and 26 healthy individuals as a control group (group 4). The vascular densities of the superficial capillary plexus and deep capillary plexus of the retinal segmentations, together with the foveal avascular zone (FAZ) width, were measured for all participants, using OCTA.Result: Compared with the control group, vascular densitiy in whole image of superficial capillary plexus were found to be significantly lower in group 2. In addition, vascular densitiy in fovea region of superficial capillary plexus was significantly lower in group 1 than the control group. In deep capillary plexus, vascular densitiy of whole image, superior hemi and nasal regions were found to be significantly lower in group 2 and group 3 compared with the control group. Parafoveal region in group 3 had significantly lower vascular densities than the controls. A significantly larger FAZ was also found in group 1 and group 3 in the deep capillary plexus, compared with the controls. Conclusion: We detected smaller vascular densities in both the superficial capillary plexus and deep capillary plexus and a larger deep capillary plexus FAZ in OSAS patients. Therefore, OCTA may be useful as a non-invasive method to understand the systemic effects of OSAS.Öğe Examination of the effects of COVID 19 on corneal endothelium(Springer, 2021) Erdem, Seyfettin; Karahan, Mine; Ava, Sedat; Dursun, Mehmet Emin; Hazar, Leyla; Keklikçi, UğurPurpose To demonstrate the efects of the disease on the corneal endothelium in individuals recovering from COVID-19 through specular microscopy. Methods Eighty individuals recovering from COVID-19 (group 1) and 72 healthy controls (group 2) were included in this prospective study. After examining visual acuity, refractive defect detection, anterior and posterior segment examinations, and specular microscopy measurements were calculated from images with at least 100 cells. The mean cell density (CD), mean coefcient of variation (CV), mean hexagonal cell percentage, mean cell area (AVG), and central corneal thickness (CCT) were evaluated. Results The mean time from diagnosis of the disease in group 1 was 54.25±6.36 days. The mean time elapsed since the PCR test became negative was 38.45±6.87 days. Only four were treated in the hospital. Specular microscopy data showed that the CD was 2713.56±246.25 and 2845.80±299.27 in groups 1 and 2, respectively (p=0.003). The CV values were 42.92±6.79 and 40.16±5.97, respectively (p=0.009). The hexagonality were 46.51±7.35 and 49.12±6.87, respectively (p=0.024). The AVG was 371.60±34.64 and 353.16±35.29, respectively (p=0.007). The CCT values were 553.00±73.2, and 526.84±33.57, respectively (p=0.005). Conclusion A decrease in the number of endothelial cells and hexagonal cells (polymorphism) as well as an increase in the cell area change coefcient (polymegatism) and the average cell area were observed from corneal specular microscopic examination of individuals recovering from COVID-19 in the early period of the disease. These results may be important in understanding the systemic efects of the diseaseÖğe İntravitreal Bevacizumab ile Tedavi Edilen Prematüre RetinopatiliBebeklerde Risk Faktörlerinin Değerlendirilmesi(2021) Keklikçi, Uğur; Ava, Sedat; Hazar, Leyla; Karahan, Mine; Erdem, Seyfettin; Vural, Esra; Dursun, Mehmet EminAmaç: Prematüre retinopatisi (PR) olgularında retinopatinin şiddeti ile anne ve bebekteki risk faktörlerinin ilişkisini analiz etmekYöntemler: Haziran 2017- Ekim 2020 yılları arasında Dicle Üniversitesi Tıp Fakültesinde prematüre retinopatisi nedeniyle takip edilen bebeklerin verileri retrospektif olarak değerlendirildi. Prematüre bebeklerin, doğum yaşı, doğum ağırlığı, takip süresince eşlik eden komorbid hastalıklar, annenin gebelik problemleri kaydedildi. Tedavisiz takip edilenler (grup 1) ve intravitreal bevacizumab tedavisi uygulananlar (grup 2) karşılaştırıldı.Sonuçlar: Çalışmaya 167 prematüre bebek alındı. Prematüre bebeklerin 99’unda (%60) tedavi gerektirmeyen PR vardı (grup 1), 68’ine (%40) intravitreal bevacizumab (grup 2) uygulandı. Grup 2’nin gestasyonel yaşı ve doğum ağırlığı grup 1’den anlamlı olarak düşük iken (p<0.001 ve p<0.001) cinsiyet dağılımları açısından fark yoktu (p=0.387). İkizden ikize transfüzyon, Rh uyumsuzluğu, korioamnionit, erken membran rüptürü oranları iki grupta benzer bulundu (p>0.05). Grup 2’de Respiratuar Distress Sendromu (RDS) anlamlı olarak daha yaygın görüldü (p=0.010). Lojistik regresyon analizinde doğum ağırlığı anlamlı bağımsız risk faktörü olarak bulundu (p=0.048; %95 GA, 0.993-1.00). Tartışma: Tedavi gerektiren PR’ li bebeklerde düşük doğum ağırlığı bağımsız bir risk faktörüdür. Eşlik eden komorbid durumların etkisini daha iyi ortaya koymak için büyük ölçekli, çok merkezli çalışmalara ihtiyaç vardır.Öğe Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?(SAGE Publications Ltd, 2021) Karahan, Mine; Hazar, Leyla; Erdem, Seyfettin; Ava, Sedat; Dursun, Mehmet Emin; Demirtaş, Atılım Armaǧan; Keklikçi, UğurPurpose: We aimed to analyze blood inflammation parameters in patients with age-related macular degeneration (AMD). Methods: In this retrospective study, patients were divided into three groups: wet-type AMD (n = 60), dry-type AMD (n = 60), and healthy controls (n = 71). The laboratory and demographic data of the patients were analyzed. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated manually. Results: The mean NLR was 2.26 ± 1.42 in the dry-type AMD group, 3.90 ± 1.65 in the wet-type AMD group, and 1.84 ± 0.61 in the control group (p < 0.001). The mean MLR was 0.30 ± 0.20 in the dry-type AMD group, 0.47 ± 0.31 in the wet-type AMD group, and 0.28 ± 0.14 in the control group (p < 0.001). The mean PLR was 129.31 ± 79.82 in the dry-type AMD group, 156.67 ± 83.99 in the wet-type AMD group, and 135.59 ± 58.68 in the control group (p = 0.101). Receiver operating characteristic (ROC) curve analyses revealed that the area under the curve (AUC) for NLR and MLR was 0.920 and 0.717, respectively, for wet-type AMD. The sensitivity and specificity of NLR for wet-type AMD were 64% and 93%, respectively, whereas MLR was 63% and 75%, respectively. Conclusion: Simple blood tests revealed that NLR and MLR were significantly higher in patients with wet-type AMD than in patients with dry-type AMD and healthy controls, which implies low-grade inflammation.Öğe Konjenital katarakt operasyonu sonrası refraktif hata değişikliklerini biyometrik formüllerle saptamak(2016) Dursun, Mehmet Emin; Çaça, İhsanAmaç: Konjenital katarakt operasyonu sonrası oluşan refraktif hata değişiklerini SRK, SRK-T, SRK-II, Binkhorst-II ve HoIIaday-1 formüllerini kullanarak saptamak. Metod ve Materyal: Dicle üniversitesi Tıp Fakültesi Hastanesi Göz Hastalıkları Kliniği'nde Eylül 2006-Mart 2009 tarihleri arasında konjenital katarakt nedeniyle katarakt ekstraksiyonu ile birlikte göz içi lens implantasyonu yapılan 46 hastanın 82 gözü çalışmaya alındı. Olgular aksiyel uzunluğuna göre; Grup 1: 22 mm'den küçük aksiyel uzunlukta kısa gözler. Grup 2: 22- 24 mm arası aksiyel uzunlukta olan normal gözler. Grup 3: 24 mm'den büyük aksiyel uzunluğa sahip uzun gözler olarak üç gruba ayrıldı. Operasyon sonrası refraktif hatalar sferik değere silindirik değerin yarısı (sferik eşdeğer) eklenerek hesaplandı. Her bir formülle hesaplamadan sonra beklenen refraktif hatadan operasyondan sonraki gerçek hata çıkarılarak mutlak refraktif hata hesaplandı. Her hasta için 1.ay, 3.ay, 6.ay ve 12.ayda mutlak refraktif hata değeri ölçüldü. Bulgular: Operasyon sonrası tüm olgularda 1.ay,3.ay,6.ay ve 12.ayda refraksiyon hatalarında formüller arasında istatistiksel olarak anlamlı fark olmadığını tespit ettik. Alt grupları incelediğimizde normalden kısa gözlerde de normal gözlerde olduğu gibi formüller arasında farklılık saptamadık. Mutlak refraktif hata değerleri açısından formülleri değerlendirdiğimiz zaman normalden uzun gözlerde Binhorst-II ve Holladay-1 formülleri SRK, SRK-II ve SRK-T’ye göre daha düşük hata değerleri vermektedir. Ayrıca olgularımızda 1.aydan 12.aya doğru gidildikçe erken yaşta daha fazla olmak üzere miyopiye doğru kayma saptadık. Sonuç: Konjenital katarakt operasyonu sonrası mutlak refraktif hata açısından uzun aksiyel uzunluktaki olgularda Binkhorst-II ve Holladay-1 formülleri daha güvenilirdir.Öğe Macular vessel density in patients recovered from COVID 19(Elsevier, 2021) Hazar, Leyla; Karahan, Mine; Vural, Esra; Ava, Sedat; Erdem, Seyfettin; Dursun, Mehmet Emin; Keklikci, UgurPurpose: The purpose is to evaluate macular vascular densities (VDs) using optical coherence tomography angiography (OCTA) in patients effected by coronavirus disease-2019 (COVID-19). Methods: The superficial (SF) and deep macular VD of 50 patients with SARS CoV2 pneumonia who had positive polymerase chain reaction (PCR) tests and who recovered after receiving treatment and 55 healthy age- and gender-matched controls were compared using OCTA. Blood inflammation parameters were also recorded. Results: There was no statistically significant difference between the two groups in terms of age and gender (p = 0.147 and p = 0.504, respectively). Nor was there a difference with respect to smokers between the two groups (p = 0.231). In COVID-19 patients, the VDs in superior hemi quadrant, superior quadrant and inferior quadrant, were significantly lower (p = 0.033, p = 0.029 and p = 0.042, respectively) in superficial plexus. It was also significantly lower in parafovea, superior hemi and superior quadrants (p = 0.026, p < 0.001 and p = 0.004, respectively) in deep plexus. In addition, white blood cell and neutrophil counts were significantly negatively correlated with the VD of the deep parafovea, deep superior quadrant and deep superior hemi quadrant (p < 0.05). There was no difference between the patient and control groups in both superficial and deep foveal avascular zone (FAZ) (p = 0.101 and p = 0.691 respectively). Conclusion: In COVID-19 disease, VD is low in some sectors in both SF and deep layers, but no change in FAZ. The effect of COVID 19 disease on the retina and whether it makes the retina sensitive to damage can only be understood with long-term follow-up.Öğe Maküla damar yoğunluğunun ve foveal avasküler zon genişliğinin miyopi şiddeti ile ilişkisi(Medical Network, 2022) Ava, Sedat; Hazar, Leyla; Karahan, Mine; Erdem, Seyfettin; Dursun, Mehmet Emin; Keklikçi, UğurAmaç: Miyopi şiddetinin maküla damar yoğunluğuna, foveal avasküler zon genişliğine ve foveal avasküler zondaki foveal damar yoğunluğuna etkisini optik koherans tomografi anjiyografi ile değerlendirmektir. Gereç ve Yöntem: Çalışmaya hafif miyop olan 50 göz (grup 1), orta miyop olan 50 göz (grup 2) ve yüksek miyop olan 50 göz (grup 3) olmak üzere toplam 150 miyop göz dahil edildi. Katılımcıların optik koherans tomografi anjiyografi ile maküler yüzeyel kapiller pleksus ve derin kapiller pleksus damar yoğunluğu, foveal avasküler zon genişliği, foveal avasküler zon foveal damar yoğunluğu ölçümleri yapıldı. Optik biyometri ile aksiyel uzunluk ölçümleri de yapıldı. Bulgular: Yüzeyel kapiller pleksus ve derin kapiller pleksusun damar yoğunluğu ve foveal avasküler zon foveal damar yoğunluğu grup 3’te anlamlı olarak daha düşük iken (p<0,05), foveal avasküler zon genişliğinde gruplar arasında anlamlı fark saptanmadı (p >0,05). Aksiyel uzunluk ile yüzeyel kapiller pleksus damar yoğunluğu ve foveal avasküler zon foveal damar yoğunluğu arasında negatif korelasyon saptanırken aksiyel uzunluk ile derin kapiller pleksusun damar yoğunluğu ve foveal avasküler zon genişliği arasında herhangi korelasyon saptanmadı (p>0,05). Sonuç: Miyopi şiddetinin artışı ile yüzeyel kapiller pleksus ve derin kapiller pleksus damar yoğunluğu, foveal avasküler zon foveal damar yoğunluğu azalmakta ancak foveal avasküler zon boyutu etkilenmemektedir. Miyopi ile ilişkili komplikasyonların daha iyi anlaşılabilmesi için geniş ölçekli daha fazla çalışmaya ihtiyaç vardır.Öğe Multimodal imaging of unilateral acute idiopathic maculopathy in a child patient(Wolters Kluwer Health, 2023) Ava, Sedat; Hazar, Leyla; Karahan, Mine; Erdem, Seyfettin; Dursun, Mehmet EminPurpose:To report a case of the clinical manifestation of unilateral acute idiopathic maculopathy in a child patient.Methods:Case report.Results:An 11-year-old male patient complaining of visual impairment in the left eye that had persisted for 3 weeks was admitted to the Dicle University Ophthalmology Clinic. Fundus examination, optical coherence tomography (OCT), enhanced depth imaging OCT, fundus autofluorescence, and fundus fluorescence angiography examinations were conducted. During the fundus examination, a yellowish gray area of swelling with yellowish granules spanning approximately half the diameter of the disk was found on the left macula. Optical coherence tomography revealed serous detachment and hyperreflective debris, OCT angiography showed hyperreflective spots on the outer retina, enhanced depth imaging OCT revealed an increase in choroidal thickness, fundus autofluorescence showed hyperreflective spots, and fundus fluorescence angiography revealed late-phase hyperfluorescence accumulation. Acute idiopathic maculopathy was diagnosed from these findings.Conclusion:Acute idiopathic maculopathy should be considered in the differential diagnosis of children presenting with a complaint of unilateral low vision.
