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    EVALUATION OF SERUM LEVELS OF OSTEOPONTIN AND BONE SIALOPROTEIN IN FEMALE PATIENTS WITH TENDINOPATHY
    (Derman Medical Publ, 2017) Hira, Serdar; Tamam, Cuneyt; Demirpek, Ugur; Gem, Mehmet
    Aim: The pathogenesis of tendinopathy remains unclear. Small integrin-binding ligand N-linked glycoproteins (SIBLING), a family of non-collagenous proteins including osteopontin (OPN) and bone sialoprotein (BSP), were initially thought to be limited to mineralized tissue, but recent studies have reported that they are more widely distributed and are expressed in non-mineralized tissues. The aim of this study was to investigate relationships between serum OPN and BSP levels and tendinopathy disease. Material and Method: 39 female tendinopathy patients and 39 female healthy volunteers were recruited for this prospective observational study. Serum OPN and BSP levels were measured using enzyme-linked immunosorbent assay. We also measured body mass index and erythrocyte sedimentation rate (ESR), white blood cells (WBC), and neutrophil-lymphocyte ratio (NLR). Results: There were no significant differences in serum BSP levels between the two groups (41.83 +/- 52.03 vs. 53.64 +/- 53.06 ng/mL, p=0.276). There were also no significant differences in serum OPN levels between the two groups (57.37 +/- 21.61 vs. 77.72 +/- 72.14 ng/mL, p=0.363). There were no significant differences in WBC, NLR, and ESR values between the two groups (p=0.897, p=0.795, p=0.405, respectively). There was no correlation between serum BSP levels and OPN, WBC, NLR, and ESR levels in the patient group. Patients with tendinopathy had a negative correlation between serum OPN levels and NLR levels. Discussion: The results of this study have indicated that BSP and OPN levels are not involved in the pathogenesis of tendinopathy.
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    Evaluation of Serum Levels of Progranulin and Bone Morphogenetic Protein-4 in Female Patients with Knee Osteoarthritis
    (Kuwait Medical Assoc, 2018) Hira, Serdar; Tamam, Cuneyt; Demirpek, Ugur; Gem, Mehmet
    Objective: To investigate serum bone morphogenetic protein-4 (BMP-4) and progranulin (PGRN) levels in patients with osteoarthritis (OA) and to present a new evidence of pathogenesis OA disease Design: Prospective study Setting: Dicle University Medical Faculty Hospital Subjects: Thirty-eight female knee osteoarthritis patients and thirty-eight healthy female volunteers were enrolled from January 2016 to April 2016. Intervention: Family histories, clinical histories and examinations, and radiological examinations were obtained from the hospital data system. Blood samples were obtained from the antecubital vein of all participants after overnight fasting. Main outcome measures: Se-rum PGRN and BMP4 concentrations were measured using enzyme-linked immunosorbent assay. Body mass index, erythrocyte sedimentation rate, white blood cells and neutrophil lymphocyte ratio were also assessed. Results: Mean BMP-4 levels were significantly lower in OA women compared to controls (p < 0.001). Mean PGRN levels were found to be significantly lower in OA women compared to controls (p < 0.001). There was a significant positive correlation between BMP-4 and PGRN in patients with OA. Conclusions: BMP-4 and PGRN levels may play a role in the pathogenesis of knee OA and could be a useful biomarker of knee OA, as well as a potential therapeutic target for the management of knee OA.