Evaluation of Serum Levels of Progranulin and Bone Morphogenetic Protein-4 in Female Patients with Knee Osteoarthritis
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kuwait Medical Assoc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To investigate serum bone morphogenetic protein-4 (BMP-4) and progranulin (PGRN) levels in patients with osteoarthritis (OA) and to present a new evidence of pathogenesis OA disease Design: Prospective study Setting: Dicle University Medical Faculty Hospital Subjects: Thirty-eight female knee osteoarthritis patients and thirty-eight healthy female volunteers were enrolled from January 2016 to April 2016. Intervention: Family histories, clinical histories and examinations, and radiological examinations were obtained from the hospital data system. Blood samples were obtained from the antecubital vein of all participants after overnight fasting. Main outcome measures: Se-rum PGRN and BMP4 concentrations were measured using enzyme-linked immunosorbent assay. Body mass index, erythrocyte sedimentation rate, white blood cells and neutrophil lymphocyte ratio were also assessed. Results: Mean BMP-4 levels were significantly lower in OA women compared to controls (p < 0.001). Mean PGRN levels were found to be significantly lower in OA women compared to controls (p < 0.001). There was a significant positive correlation between BMP-4 and PGRN in patients with OA. Conclusions: BMP-4 and PGRN levels may play a role in the pathogenesis of knee OA and could be a useful biomarker of knee OA, as well as a potential therapeutic target for the management of knee OA.
Açıklama
Anahtar Kelimeler
Bone Morphogenetic Protein-4, Osteoarthritis, Progranulin
Kaynak
Kuwait Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
50
Sayı
2
