Yazar "Cevik, Mehmet Ugur" seçeneğine göre listele
Listeleniyor 1 - 18 / 18
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe ACUTE TOXIC EFFECTS OF METHYL ALCOHOL ON THE RAT BRAIN: THE PROTECTIVE EFFECTS OF CAFFEIC ACID PHENETHYL ESTER(Carbone Editore, 2014) Cevik, Mehmet Ugur; Varol, Sefer; Yucel, Yavuz; Akil, Esref; Uzar, E.; Kaplan, I; Can, Yazgan UmitBackground: Efficiency of caffeic acid phenethyl ester (CAPE) in reducing free radicals generated by oxidative stress has been previously reported. In the present study, the protective effect of CAPE on methyl alcohol (MeOH) induced oxidative damages on rat brain were presented. Methods: The rats were randomly divided into four groups as follows: Control, methotrexate (MTX) alone, MTX+MeOH, and MTX+MeOH+CAPE (CAPE treatment). All animals except the control group were treated with MTX for 7 days. MTX was diluted in sterile saline and administered (0.3 mg/kg/day) intraperitoneally (ip). At the eighth day, MeOH was administered (3gm/Kg) (ip) in MeOH+MTX and CAPE treatment groups. Four hours after MeOH administration in the CAPE group rats were treated with 10 mu mol/kg CAPE (ip), serum physiologic (i.p.) in MeOH+MTX group. After eight hours, rats were anaesthetized and sacrificed. Malondialdehyde (MDA) levels, paraoxonase-1 (PON-1) activity were measured on the cerebral tissue. Results: MTX+MeOH group compared to the MTX alone group; a statistically significant increase in MDA levels (p = 0.042) were detected. In addition, MTX+MeOH group than MTX MTX alone group in led to a statistically significant decrease in PON-I activity (p = 0.018). CAPE treatment, significantly decrease in MDA levels was compared with MeOH+MTX (p = 0.001). However, CAPE treatment caused an increase on PON-I activity in MeOH group, which was statistically significant (p = 0.009). Conclusion: Consequently, it was demonstrated for the first time that CAPE prevents acute MeOH intoxication induced brain injury by reducing the increase in lipid peroxidation, and elevating the decrease in PON-1 activity.Öğe Changes in serum albumin levels and neutrophil-lymphocyte ratio in patients with convulsive status epilepticus(Taylor & Francis Ltd, 2017) Ozdemir, Hasan H.; Akil, Esref; Acar, Abdullah; Tamam, Yusuf; Varol, Sefer; Cevik, Mehmet Ugur; Arikanoglu, AdaletAim: Inflammation may be involved in the ictogenesis and development of some partial epilepsies. Serum albumin levels and the neutrophil-lymphocyte ratio (NLR) are markers of inflammation. The aim of this study was to investigate the ability of serum albumin levels and NLR to predict inflammation in patients with convulsive status epilepticus (CSE). Methods: This retrospective study was conducted on 58 patients who were diagnosed with CSE and control group comprised of 58 healthy individuals. Albumin levels and NLR were evaluated during both the acute and subacute periods of CSE. Results: The average serum albumin levels were 3.27 +/- 0.62 g/dL during the acute period and 3.4 +/- 0.67 g/dL in the subacute period in the patient group and 3.92 +/- 0.52 g/dL in the control group. Neutrophil counts were higher in patients in the acute phase of CSE, but lymphocyte counts were lower compared to the control group and the subacute phase. The average NLR values were 4.83 +/- 5.1 in the acute period, 3.07 +/- 3.02 during the subacute period and 1.98 +/- 0.42 in the control group. Serum albumin and NLR levels were significantly different between the patients in the subacute and acute periods of CSE and the control group (p < 0.05). There were significant negative correlational relationships between serum albumin and NLR levels (p < 0.05). Conclusion: We found serum albumin levels were significantly lower and the NLR was significantly higher in the acute period of CSE. Neutrophil-mediated inflammation may be important in the aetiopathogenesis of CSE.Öğe Diagnostic value of F-wave inversion in patients with early carpal tunnel syndrome(Elsevier Ireland Ltd, 2012) Cevik, Mehmet Ugur; Altun, Yasar; Uzar, Ertugrul; Acar, Abdullah; Yucel, Yavuz; Arikanoglu, Adalet; Varol, SeferRoutine electrophysiological studies usually give normal results in patients with early stage carpal tunnel syndrome (CTS). Diagnostic significance of the F-wave inversion (the median of F-wave minimal latencies (FWML) exceeds a normal ipsilateral ulnar FWML by 1 ms) has not been previously reported in early stage CTS. In this study, our primary aim was to investigate the diagnostic value of F-wave inversion in early stage CTS. Additionally, we aimed to demonstrate any possible relationship between F-wave inversion and symptom scores of the Boston questionnaire and functional capacity in early stage CTS. The study included 60 early stage CTS patients who presented with a median sensory nerve conduction velocity of >= 50 m/s. The symptom severity and functional status of the patients were assessed by using the Boston questionnaire. The control group consisted of 45 healthy volunteers. We compared early stage CTS patients and healthy control subjects in terms of the results obtained from median-ulnar FWML. Existence of F-wave inversion was found in 32 (53.3%) of the early stage CTS patients and in 3 (8.7%) of the healthy controls (p = 0.001). It was also found to be positively correlated with the Boston questionnaire scores (p = 0.001, r = 0.41) and functional capacity scores (p = 0.001, r = 0.41). The sensitivity and specificity of F-wave inversion for the diagnosis of early stage CTS were calculated as 53.3% and 93.3%, respectively. The addition of F-wave inversion measurement to the set of the routine nerve conduction studies can increase the reliability of the electrophysiological studies in patients with early stage CTS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.Öğe Double Filtration Plasmapheresis in the Treatment of a Case with Acute Disseminated Encephalomyelitis(Turkish Neurological Soc, 2013) Cevik, Mehmet Ugur; Cetincakmak, Mehmet Guli; Varol, Sefer; Akil, EsrefAcute disseminated encephalomyelitis (ADEM), is a monophasic autoimmune demyelinating disease of the central nervous system. Although high-dose steroid management has been considered the mainstay of treatment for ADEM, some patients are unresponsive to steroid therapy. We report the case of a 44-year-old woman with ADEM who did not respond to steroid therapy, but who showed a noticeable improvement with double filtration plasmapheresis (DFPP). To the best of our knowledge, this is the first case report of ADEM in literature treated with DFPP.Öğe Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats(Springer-Verlag Italia Srl, 2012) Uzar, Ertugrul; Alp, Harun; Cevik, Mehmet Ugur; Firat, Ugur; Evliyaoglu, Osman; Tufek, Adnan; Altun, YasarThe aim of this study was to investigate the possible effects of ellagic acid in brain and sciatic nerve tissues of diabetic rats. Also, the impact of ellagic acid on catalase and paraoxonase (PON-1) activities, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and nitric oxide (NO) were examined. The rats were randomly divided into four groups, with eight rats each: Normal controls (not diabetic), only ellagic acid treated (ellagic acid controls, not diabetic), Diabetic controls (streptozotocin, diabetic), ellagic acid-treated diabetic (streptozotocin + ellagic acid). After a 4 week experiment, rats were sacrificed, and biomarkers for oxidative stress in the brain and sciatic nerve tissues of the rats were measured. There was significant depletion in the PON-1, catalase, and TAS levels in the brain and sciatic nerve tissues compared to the control groups (for both parameters, p < 0.05). The values of catalase, PON-1 and TAS reversed back to normal levels in ellagic acid-treated diabetic rats compared to untreated diabetic rats (for both parameters, p < 0.05). The levels of MDA, TOS, NO and, OSI in the brain and sciatic nerve tissues were higher in untreated diabetic rats compared to control group (for both parameters p < 0.05). However, MDA, TOS, OSI, and NO levels were found to be significantly reduced in the ellagic acid-treated diabetic group compared to the untreated diabetic group in these tissues (for both parameters, p < 0.05). In conclusion, the results of the present study suggested that ellagic acid exhibits neuroprotective effects against oxidative damage in diabetic rats.Öğe The Increase of The Mean Platelet Volume in Patients With Intracerebral Haemorrhage(Galenos Publ House, 2012) Arikanoglu, Adalet; Cevik, Mehmet Ugur; Uzar, Ertugrul; Acar, Abdullah; Akil, Esref; Ekici, Faysal; Tasdemir, NebahatObjective: The mean platelet volume (MPV) is a biomarker of platelet function and activity. The influence of platelet function disorders on the aetiology of intracerebral haemorrhages (ICH) and mortality is not clear yet. The purpose of this study is to investigate the change in the MPV values in patients with ICH and to observe its influence on mortality in a retrospective manner. Material and Method: Sixty-six patients with intracerebral haemorrhage (32 males, 34 females; mean age: 61.9 +/- 16.9) were enrolled in the study. Patients with ICH were divided into two groups as those who died within the first 10 days and those who survived. The MPV values and the haematoma volumes were compared between the groups. Also, the MPV values and platelet counts of the patients with ICH were compared with the values of healthy volunteers from similar age and sex groups (27 males, 17 females; mean age: 59.9 +/- 3.2). Results: The MPV values of the patients with ICH measured within 24 hours following the intracerebral haemorrhage (8.33 +/- 1.27 fl) were statistically significantly higher than the MPV values of the control group (7.76 +/- 1.14 fl) (p=0.018). The platelet counts of the patients with ICH also measured with in the first 24 hours (235.8 +/- 94.9 x 10(3)/mL) were statistically significantly lower than the platelet counts of the control group (279.1 +/- 94.9 x 10(3)/mL) (p=0.022). No statistically significant difference in terms of the MPV values and platelet counts was observed between the patients with ICH who died within the first 10 days and those who survived (p>0.05). However, the difference observed in the haematoma volume between the patients with ICH who died within the first 10 days (31.1 +/- 33.7 ml) and those who survived (8.7 +/- 13.4 ml) was statistically significant (p<0.001). No correlation was found between the haematoma volume and the MPV value in the patients with ICH. Discussion: The increase, observed in the mean platelet volume in patients with ICH, may point to a disorder in the platelet function. No relationship was found between the increase in the MPV and the mortality rates.Öğe Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine(Bmc, 2011) Uzar, Ertugrul; Evliyaoglu, Osman; Toprak, Guelten; Acar, Abdullah; Yucel, Yavuz; Calisir, Tugba; Cevik, Mehmet UgurAsymmetric dimethylarginine (ADMA) has been found as correlated with endothelial dysfunction and oxidative stress. There are few studies regarding ADMA and nitric oxide (NO) levels in patients with migraine and alterations of ADMA and NO levels during migraine attack are not well-known. Therefore, in present study, we aimed to measure NO and ADMA levels in patients with migraine and compare them with the control group to investigate the correlation between migraine, oxidative stress and endothelial dysfunction. The migraine group consisted of 59 patients, including 22 suffering from migraine with aura and 37 suffering from migraine without aura. The control group consisted of 31 healthy volunteers without headache. The patients in migraine group were divided into subgroups based on whether attack period was present or not and whether it was migraine with or without aura. Plasma ADMA levels were measured using an enzyme-linked immunosorbent assay method. Migraine patients had higher concentrations of NO (35.6 +/- A 7.7, 31.0 +/- A 6.2 mu mol/L, respectively, p = 0.005) and ADMA (0.409 +/- A 0.028, 0.381 +/- A 0.044 mu mol/L, respectively, p = 0.001) levels when compared with the healthy controls. During migraine attack, NO and ADMA levels were found to be significantly higher in migraine group as compared to control group (respectively, p = 0.015, p = 0.014). Similarly, NO and ADMA levels in the patients with migraine in the interictal period were found to be significantly higher as compared to control group (p = 0.011, p = 0.003). In conclusion, higher ADMA and NO levels of patients with migraine supported that oxidative stress and endothelial dysfunction may have a role in migraine pathogenesis.Öğe Investigation of Mean Platelet Volume and Platelet Count in the Blood of Patients with Migraine(Turkish Neurological Soc, 2013) Varol, Sefer; Akil, Esref; Cevik, Mehmet Ugur; Celepkolu, Tahsin; Yucel, Yavuz; Tanriverdi, Mehmet Halis; Aluclu, Mehmet UfukObjective: Mean platelet volume (MPV) is an indicator for platelet function and activation. Studies researching MPV and platelet level on the patients with migraine are insufficient. In this study, we aimed to find a difference in MPV and platelet count in individuals with migraine compared to healthy controls, which are indicators for platelet activation. Material and Method: We recruited 193 patients (female/male: 128/65, average age: 31.66 +/- 9.01) who are referred to the Neurology Clinic of Dicle University, Faculty of Medicine between January 2010 and January 2012 and have been diagnosed with migraine according to 2004 diagnostic criteria of International Headache Society (IHS) and 119 healthy individuals (female/male: 73/46, averge age: 32.27 +/- 9.88) who are referred to the Family Practice Clinic and Blood Bank. We compared MPV and platelet counts between the patients with migraine and healthy controls. Both groups were similar in terms of age and gender. Results: A statistically insignificant increase was found in MPV in patients with migraine (7.98 +/- 1.34 fL) when compared to the control group (7.85 +/- 0.96 fL) (p=0.34). Platelet levels were significantly lower in patients with migraine (367.6 +/- 74.2) than the platelet levels of the control group (286.9 +/- 68.3) (p=0.02). Discussion: We found lower platelet levels in the patients with migraine compared to the control group. There was also statistically insignificant increase in MPV in patients with migraine, suggesting that these findings may indicate an insignificant platelet activation in patients with migraine. New prospective studies are needed on this subject.Öğe Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment(Dove Medical Press Ltd, 2016) Donmezdil, Nilufer; Cevik, Mehmet Ugur; Ozdemir, Hasan Huseyin; Tasin, MuhteremPurpose: There are many studies dedicated to researching the etiopathogenesis of epilepsy. In such research, oxidative and antioxidant indicators of etiopathogenesis have also been examined under the scope. Drawing on a group of patients with epilepsy who were receiving no treatment, we have tried to evaluate whether or not an increase in oxidative indicators is linked directly with the disorder, independent of epileptic medicaments. Methods: Thirty people in good health and 30 newly diagnosed with epilepsy and who received ambulatory treatment in the polyclinic of the Neurology Department took part in the study. The tests relating to serum malondialdehyde (MDA) levels and paraoxonase 1 (PON1) activity were carried out in the biochemistry laboratory. Results: Even though the levels of MDA in the patient group (14.34 +/- 3.59 nmol/mL) were found to be high compared to those of the control group, which consisted of people in good health (13.53 +/- 3.56 nmol/mL), there was no statistically significant difference. PON1 activity in the serum taken from people in the patient group (0.65 +/- 0.17) was lower in comparison to that observed in the serum of the control group (0.71 +/- 0.17 U/L). Nonetheless, it was not so low as to have significance from a statistical point of view. Conclusion: We conclude that such a high level of oxidative parameters should have been related to the disease and that statistically significant findings that emerged in some other studies could have been related to an antiepileptic treatment.Öğe Investigation of Total Oxidants/Antioxidants in Patients with Intracerebral Haemorrhage(Turkish Neurological Soc, 2013) Cevik, Mehmet Ugur; Acar, Abdullah; Yucel, Yavuz; Varol, Sefer; Akil, Esref; Arikanoglu, Adalet; Yuksel, HaticeObjective: Although there are numerous studies about oxidants and antioxidants in patients with ischemic stroke, the number of studies on this subject in patients with intracerebral hemorrhage (ICH) is limited. Malondialdehyde (MDA) is an oxidant parameter investigated in patients with ICH, and total oxidant status (TOS) has not been investigated so far. We aimed to investigate in blood samples the oxidant parameters MDA and TOS, and the total antioxidant status (TAS) in patients with ICH. Material and Method: A total of 30 patients with ICH, admitted and treated at the Neurology Clinic in the Faculty of Medicine, University of Dicle and 30 control who had no stroke or any systemic disorders were included in the study. Peripheral vein blood samples taken from patients and controls were included in the first 24 hours after stroke. Serum TAS, TOS values were measured with the Erel method, a specific, fully automatic and colorimetric method, and serum level of MDA was measured with method of Ohkawa. Results: Compared to the control group, the serum levels of TAS, TOS and MDA were significantly higher in the ICH patients (p < 0.05). However, there was no correlation between serum TOS, TAS and MDA levels and Glasgow Coma Scale (GCS) total scores and hematoma volumes (p> 0.05). Discussion: The increase in the serum levels of MDA, TOS, and TAS in ICH patients may demonstrate that there is an increase in oxidative stress and this supports the fact that that oxidative stress may play a significant role in the pathogenesis of the ICH. However, the increase of these parameters was not found to be associated with hematoma volume and GCS in patients with ICH.Öğe Primary Sjogren's Syndrome with Sensory Ganglionopathy and Painful Legs and Moving Toes Syndrome(Turkish Neurological Soc, 2014) Cevik, Mehmet Ugur; Varol, Sefer; Akil, Esref; Arikanoglu, Adalet; Batmaz, Ibrahim; Alabalik, UlasSjogren's syndrome is characterized by the sicca syndrome, with dryness of the mouth (xerostomia) and the eyes (xerophthalmia). Sjogren's syndrome is the only connective tissue disease that is associated with sensory neuronopathy. The syndrome of painful legs and moving toes presents with pain in the lower limbs with spontaneous movements of the toes or feet. The co-occurence of Sjogren's syndrome and painful legs and moving toes syndrome is a rare condition.Öğe Protective effects of L-glutamine against toxicity of deltamethrin in the cerebral tissue(Dove Medical Press Ltd, 2016) Varol, Sefer; Ozdemir, Hasan Huseyin; Cevik, Mehmet Ugur; Altun, Yasar; Ibiloglu, Ibrahim; Ekinci, Aysun; Ibiloglu, Aslihan OkanBackground: Deltamethrin (DLM) is a broad-spectrum synthetic dibromo-pyrethroid pesticide that is widely used for agricultural and veterinary purposes. However, human exposure to the pesticide leads to neurotoxicity. Glutamine is one of the principal, free intracellular amino acids and may also be an antioxidant. This study was undertaken in order to examine the neuroprotective and antioxidant potential of L-glutamine against DLM toxicity in female Wistar albino rats. Materials and methods: The rats were divided into the following groups (n=10): Group I: control (distilled water; 10 mL/kg, po one dose), Group II: L-glutamine (1.5 g/kg, po one dose), Group III: DLM (35 mg/kg, po one dose), and Group IV: DLM (35 mg/kg, po one dose) and L-glutamine (1.5 g/kg, po one dose after 4 hours). Total oxidant status (TOS), total antioxidant status (TAS), tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6 levels and apoptosis were evaluated in brain tissue. Results: DLM-treated animals had a significant increase in brain biochemical parameters, as well as TOS and TAS. Furthermore, the histopathological examination showed neuronal cell degeneration in the cerebral tissue. L-Glutamine treatment decreased the elevated brain levels of TOS and neuronal cell degeneration. There was no difference in tumor necrosis factor-a, IL-1 beta, and IL-6 levels between the groups. Conclusion: L-Glutamine may reduce the toxic effects of DLM in the cerebral tissue through antioxidant properties.Öğe Relation between electrophysiological findings and diffusion weighted magnetic resonance imaging in ulnar neuropathy at the elbow(Masson Editeur, 2013) Altun, Yasar; Aygun, Murat Serhat; Cevik, Mehmet Ugur; Acar, Abdullah; Varol, Sefer; Arikanoglu, Adalet; Onder, HakanAim: As only a limited number of studies have used diffusion-weighted imaging (DWI) and conventional magnetic resonance imaging (MRI) in patients with ulnar neuropathy at the elbow (UNE), the present study aimed to investigate the diagnostic value of the non-invasive DWI technique in patients with UNE. Methods: A total of 26 elbows in 19 healthy controls (age range: 22-56 years) with no symptoms and 24 elbows in 21 symptomatic patients (age range: 21-46 years) with cubital tunnel syndrome underwent DWI. The electrophysiological and clinical criteria for the diagnosis of UNE were examined. Results: No pathological signal from the ulnar nerve was detected in the healthy controls, whereas there was an increase in signals on DWI in all patients with UNE. On T2-weighted (T2W) imaging, there was increased signal intensity in 20 elbows, while low signal intensity was observed in the remaining four. A positive correlation was found between disease duration and presence of hyperintensity (P = 0.044, r = 0.42) on T2W images. Conclusion: DWI can be used together with electrophysiological methods for the diagnosis of UNE. Furthermore, DWI might be preferred in some cases, as it is non-invasive compared with the electrophysiological method for UNE diagnosis. (C) 2013 Elsevier Masson SAS. All rights reserved.Öğe Relationship of cognitive performance with prolidase and oxidative stress in Alzheimer disease(Springer-Verlag Italia Srl, 2013) Arikanoglu, Adalet; Akil, Esref; Varol, Sefer; Yucel, Yavuz; Yuksel, Hatice; Cevik, Mehmet Ugur; Palanci, YilmazGlutamate excitotoxicity and oxidative stress are held responsible for the pathogenesis of Alzheimer's disease (AD). Prolidase is known to have a crucial part in the recycling of proline for collagen synthesis. Elevated proline levels have been shown to increase glutamate concentration. To our knowledge, prolidase activity in AD has not yet been studied. In this study, we aimed to reveal the relationship of AD with oxidative stress and collagen turnover by comparing AD patients and healthy control group with regard to total antioxidant status (TAS), total oxidant status (TOS), and prolidase levels. Fifty patients (mean age, 72.5 +/- A 8.9 years) diagnosed with AD and a control group comprised of 39 healthy individuals (mean age, 69.1 +/- A 7.1 years) were compared relative to serum TAS, TOS, and prolidase levels. The relationship of cognitive performance with prolidase, TAS, and TOS was evaluated by Mini mental state examination (MMSE). Alzheimer's disease group demonstrated statistically significantly higher prolidase and TOS levels as compared to the control group (p = 0.01, p = 0.018, respectively). Total antioxidant status level was significantly lower in the dementia group than in the control group (p = 0.032). MMSE manifested a negative correlation with prolidase and TOS levels (p = 0.001, r = -0.33; p = 0.002, r = -0.32, respectively), while displaying a positive correlation with TAS levels (p = 0.002, r = 0.32). In conclusion, elevated prolidase and TOS levels along with reduced TAS concentrations suggest that oxidative stress and collagen breakdown are involved in the cognitive impairment in AD.Öğe Serum Asymmetric Dimethylarginine and Nitric Oxide Levels in Patients with Diabetic Neuropathy(Galenos Yayincilik, 2012) Tamam, Yusuf; Uzar, Ertugrul; Evliyaoglu, Osman; Tay, Arzu; Kilinc, Faruk; Cevik, Mehmet UgurObjective: Asymmetric dimethylarginine (ADMA) is a novel marker of endothelial dysfunction. ADMA is an endothelial nitric oxide synthase inhibitor. Due to scarcity of studies on the role of ADMA in pathogenesis of diabetic neuropathy, it remains to be determined whether blood ADMA and nitric oxide (NO) levels are associated with diabetic neuropathy. In this case control study, we aimed to evaluate the relationship between serum NO and ADMA levels among diabetic neuropathy cases Methods: 48 patients with diabetic neuropathy and 34 healthy subjects were included in the study. All type 2 diabetic patients underwent electrophysiological and neurological examination. NO levels were determined using the Griess method. Serum ADMA levels were determined by using the ELISA method. Results: The serum ADMA levels in diabetic neuropathy patients were found to be statistically significantly lower than those of the control group (p=0.005). However, a statistically significant increase was observed in serum NO levels in patients with diabetic neuropathy compared with those in the control group (p=0.009). A negative correlation was found between NO levels and ADMA levels (p=0.041, r=-0.23). Discussion: Changes in NO and ADMA levels in the blood of diabetic neuropathy patients may indicate oxidative stress and endothelial dysfunction in the pathogenesis of diabetic neuropathy. (Archives of Neuropsychiatry 2012; 49: 183-187)Öğe Serum Levels of Calcification Inhibitors in Patients With Intracerebral Hemorrhage(Taylor & Francis Ltd, 2012) Acar, Abdullah; Cevik, Mehmet Ugur; Arikanoglu, Adalet; Evliyaoglu, Osman; Basarili, Mustafa Kemal; Uzar, Ertugrul; Ekici, FaysalThe vascular calcification regulators and inflammatory markers including fetuin-A, osteopontin (OPN), and matrix Gla protein (MGP) may play an important role in the development of intracerebral hemorrhages (ICHs). So far, the relationship between these parameters and ICH has not been studied. Therefore, this study was designed to elucidate whether fetuin-A, MGP, and OPN are involved in the pathophysiology of ICH. The ICH group consisted of 27 consecutive patients with spontaneous ICH evaluated in the neurology intensive care unit within the first 24 hours from the onset of the stroke. The serum OPN levels were significantly increased in patients with ICH compared to the controls. On the other hand, the serum MGP and fetuin-A levels were significantly decreased in the patients with ICH in comparison to the controls. In the patients with ICH, the serum MGP levels of the nonsurvivors were statistically significantly lower than the MGP levels of the survivors. In conclusion, the change in serum fetuin-A, MGP, and OPN levels after ICH indicates that these parameters play a role in the pathophysiological processes leading to an ICH. Measurement of the serum MGP levels may also be of value to estimate mortality.Öğe Serum Vitamin B12, Folic Acid and Ferritin Levels in Patients with Migraine(Turkish Neurological Soc, 2011) Acar, Abdullah; Evliyaoglu, Osman; Uzar, Ertugrul; Yucel, Yavuz; Cevik, Mehmet Ugur; Guzel, Isil; Colpan, LeylaObjective: It has been reported that disability due to migraine may be reduced with homocysteine-lowering treatment including folic acid and vitamin B12. In addition, periaqueductal gray matter iron deposits have been found recently to be increased in migraine patients. There are few studies regarding vitamin B12, folic acid, ferritin, and transferrin levels in patients with migraine. The aim of this study was to measure vitamin B12, folic acid, ferritin, and transferrin levels in patients with migraine and to compare them with the control group. Patients and Methods: Fifty-one consecutive newly diagnosed migraine patients who did not receive any vitamin supplement medication were enrolled. The study group consisted of 51 patients suffering from migraine with aura (n= 23) and migraine without aura (n= 28). The control group consisted of 28 healthy participants without history of headache, anemia or vitamin supplement. Serum vitamin B12, folic acid, ferritin, and transferrin levels were measured using a chemiluminescence method. Results: Migraine patients had significantly lower concentrations of vitamin B12 and folic acid compared with the healthy controls (for vitamin B12: 215.6 +/- 133.7 pg/mL vs. 289.9 +/- 12 pg/mL, respectively, p= 0.005; for folic acid: 6.74 (+/-) 4.31 pg/mL vs. 8.47 +/- 1.85 pg/mL, respectively, p= 0.048). The vitamin B12 levels were found to be significantly lower during attacks in migraine patients than in interictal periods (177.3 +/- 139.2 pg/mL vs. 252.5 +/- 119.5 pg/mL, p= 0.043). There were no differences in folic acid, and transferrin levels during attacks versus in the interictal period in patients with migraine (p>0.05). The ferritin levels were found to be significantly lower during attacks in migraine patients than in interictal periods (43.4 +/- 41.1 mg/mL vs. 75.4 +/- 51.7 mg/mL, respectively, p= 0.018). Conclusion: Migraine patients had lower serum vitamin B12 and folic acid levels than healthy subjects. These findings support that vitamin B12 and folic acid may have a role in migraine pathogenesis and may be included in migraine prophylaxis. Further, this study indicated that iron homeostasis is disturbed in migraine attacks.Öğe Toxic Effects of Isoniazid and Rifampicin on Rat Brain Tissue: The Preventive Role of Caffeic Acid Phenethyl Ester(Asian Network Scientific Information-Ansinet, 2012) Cevik, Mehmet Ugur; Acar, Abdullah; Tanriverdi, Halis; Varol, Sefer; Arikanoglu, Adalet; Yucel, Yavuz; Akil, EsrefTo the best of present knowledge, the possible protective effects of Caffeic Acid Phenethyl Ester (CAPE), on possible Isoniazid (INH) and Rifampicin (RIF) induced neurotoxic effects in brain tissue have not been investigated yet. As such, the purpose of this experimental study was to investigate the effects of CAPE, on INH and RIF induced neurotoxicity in rat brain tissue. We measured Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD) activities, Malondialdehyde (MDA) and nitric oxide (NO) levels in the brain tissue of rats. Male Sprague-Dawley rats were divided into eight experimental groups, with ten animals in each group. These groups are consist of control group, INH-treated group, RIF-treated group, INH+RIF treated group, INH+CAPE treated group, RIF+CAPE treated group, INH+RIF+CAPE treated group and CAPE treated group. MDA and SOD levels in brain tissue were significantly higher and TAC levels were lower in the INH, RIF and INH+RIF treated groups (p<0.05) and TAC levels were lower in the INH, RIF and INH+RIF groups than in the control group (p<0.05). CAPE plus INH and/or RIF treatment caused a significant decrease in MDA levels in brain tissue (p<0.05). In addition, CAPE plus INH and/or RIF treatment caused a significant increase in TAC levels (p<0.05). In conclusion, we have shown that administration of INH and RIF is accompanied by increased lipid peroxidation and oxidants in rat brain tissue. CAPE may protect against INH and RIF-induced neurotoxicity. Therefore, CAPE supplementation may be used as a potential neuroprotective drug for antituberculosis therapy with INH and/or RIF.
