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Öğe Effect of omeprazole, clarithromycin and amoxicillin therapy on duodenal ulcer and Helicobacter pylori eradication(1997) Goral V.; Tas M.; Gul K.; Canoruc F.Helicobacter pylori (H. pylori) is the most important factor in the pathogenesis of duodenal ulcer (DU). Eradication of H. pylori does lower the recurrence rate of DU. The aim of this study was to evaluate the efficacy, tolerability and compliance of a triple therapy with omeprazole and amoxicillin plus clarithromycin. 24 patients (22 males, 2 females, age range 21-27) with duodenal ulcer were treated for 2 weeks with omeprazole 20 mgr b.i.d. 28 plus amoxicillin 1 g b.i.d. plus daintromycin 250 mg. b.i.d. H. pylori (+) duodenal ulcer cases which were treated for 2 weeks with omeprazole 20 mgr b.i.d. plus amoxicillin 1 gr b.i.d., using as control groups. Diagnosis was made by upper G.I. endoscopy and by obtaining multiple biopsies from antral mucosa. Standard H.E., Giemsa stains and rapid urease test were performed for the diagnosis of H. pylori infection. Patients were endoscoped before and at the end of therapy and 1 month after completion of therapy. Eradication was defined as all tests were negative at the final evaluation. In the third endoscopy H. pylori positivity was found as 8%. The eradication was therefore reached in 22 patients (92%). At the control group, the eradication rate was calculated as 79% (p<0.05). It is concluded that a 2 weeks trial of triple therapy with omeprazole, clarithromycin and amoxicillin is very effective and well tolerated for the eradication of H. pylori infection.Öğe The effect of vitamin E on small intestine damage of ischemia- reperfusion in young rats(1998) Deveci E.; Goral V.; Yilmaz F.; Tacar O.; Demirant A.; Canoruc F.The effect of antioxidant agents on ischemia-reperfusion is well known. In this study 300 mg/kg of vitamin E was administered I.M to young rats for three consecutive. On day three, the mesenteric superior artery was held with atraumatic clamps for 30 minutes to create ischemia, and then exposed to 45 minutes of reperfusion. We took sections from the jejunum for histological examination, then observed the negative effect of ischemia reperfusion and protective effect of vitamin E.Öğe The effects of octreotide on gastric lesions and gastric mucosal barrier in rats which applied stress(1999) Guzel C.; Kanay Z.; Onen A.; Kurt D.; Denli O.; Canoruc F.The aim of this research was to investigate the effects of octreatide on gastric lesions and mucosal barrier in rats exposed cold +immobilisation stress. Twenty four Swiss Albino rats (approx 150-200 g) were used for this study. Feeds were witheld from to rats for 24 hours, after which they were divided in to three groups. Each group consisted of seven rats; I (n=7) non/stress-induced control group, 2 (n=7): cold and immobilisation stress was induced, 3 (n=7): 100 ?g/kg octreatide was administered subcutaneously one hour prior to stress induction. The rats were then killed and their stomachs examined for ulcerative lesions and ulcer indexes considered. The amounts of mucus and phospholipid, important components of the gastric mucosal barrier, were then rated using Corn and Baur methods and were found to be significantly decreased (p<0.05, p>0.05) in rats exposed to stress. In the third group given sandostatin, it was found that gastric lesions had been prevented. Moreover, mucus and phospholipid levels were higher in this group than the stress exposed control group. (p<0.05, p<0.05 respectively). According to our findings, octreatide is effective in preventing acute hemorrhagic gastric lesions caused by stress and in maintaining gastric mucosal barrier parameters.Öğe The efficacy of flumazenil in subclinical to mild hepatic encephalopathic ambulatory patients: A prospective, randomised, double-blind, placebo-controlled study(SMW supporting association, 2003) Dursun M.; Caliskan M.; Canoruc F.; Aluclu U.; Canoruc N.; Tuzcu A.; Yilmaz S.Hepatic encephalopathy (HE) is a neuropsychiatric syndrome associated with fulminant hepatic failure and chronic liver disease. Its pathogenesis is unclear. One of the factors implicated is enhanced GABA-ergic tone, which is probably related to increased concentrations of cerebral benzodiazepine (BNZ). In the present study, we tested flumazenil, a cerebral BNZ antagonist, in cirrhosis patients with hepatic encephalopathy. Methods: Out of 47 patients, 7 were excluded prior to randomization for various reasons. Twenty patients were included in the flumazenil group and 20 in the placebo group in a prospective, randomized, double-blind, placebo-controlled study. Patients were given flumazenil (1 mg/h, continuous IV infusion) or an equal volume of saline solution for 5 hours. Before and after treatment, portosystemic encephalopathy (PSE) stage and number connection test (NCT) scores were checked every half hour for 5 hours. EEG was recorded 15 minutes before and 1 hour after treatment. Results: While significant improvements were determined in PSE stage and NCT score in the flumazenil group, there were no such improvements in the placebo group. There was no statistically significant difference between pre- and post-treatment EEGs in either group. Conclusion: It was concluded that continuous IV infusion of flumazenil had beneficial and safe effects in the treatment of hepatic encephalopathy patients.Öğe Histopathological changes in liver of young rats treated with cadmium chloride during pregnancy(1998) Deveci E.; Goral V.; Tacar O.; Yaldiz M.; Canoruc F.In this study, cadmium chloride injection (I.V.) was administered to 17- 21 day pregnant Wistar Albino rats. The weight and liver histology of rats were then investigated. This short time administration of cadmium caused decrease in body weight and degeneration of liver structure in pregnant rats.Öğe Intraabdominal front wall hematoma as a rare complication of an uremic patient presenting as a rapidly developing large abdominal mass(1996) Yazanel O.; Canoruc F.; Aban N.In this case report, large spontaneously occurring abdominal wall hematoma as a rare complication of uremia in a patient on chronic hemodialysis is reported.Öğe Poor immune response to hepatitis B vaccination in hemodialysis patients(1996) Yazanel O.; Canoruc F.; Isikoglu B.For active immunization against infection caused by hepatitis B virus, 25 hemodialysis patients (13 men, 12 women, 15-62 years old range) were vaccinated with the close of 20-40 microgram recombinant DNA vaccine, three times one month apart. At the first evaluation 2 months after the last vaccination, we were able to include in the study 24 hemodialysis patients and 27 healthy relatives. Of 24 hemodialysis patients, 14 (58.3%) and of 27 healthy relatives, 25 (93%) developed anti-HBs antibody. Six months after the last vaccination (second evaluation), two men more had anti-HBs antibody. Thus, totally 16 hemodialysis patients responded to hepatitis B vaccination (66.6%). Immune reactivity seems to correlate with the uremic (p<0.05) and nutritional status. Women were more likely (75%) to be responder than men (50%), and the younger patients (<40 years old) correlated significantly with the antibody response. In conclusion, since these patients had a poor antibody response to standard vaccination, alternative hepatitis B vaccination regimens may have to be planned in this particular group of patients.Öğe Portal colopathy findings in patients with liver cirrhosis(1999) Goral V.; Kizilay E.; Yukselen V.; Dursun M.; Aras N.; Canoruc F.; Buyukbayram H.Portal hypertension diffusely affects the gastrointestinal (GI) tract. Portal colopathy is a new clinical entity with liver cirrhosis but the frequency and profile of distinct colonic mucosal lesions (portal colopathy) and rectal varices has been little studied in patients with liver cirrhosis. In this study, colonoscopic findings, upper GI endoscopy, portal system colored Doppler ultrasonographic results and the degree of liver dysfunction were prospectively investigated among 25 haemodynamically stable patients with postviral cirrhosis without a history of bleeding. We found the incidence of esophageal varices to be 96%, congestive gastropathy 20% and portal colopathy excluding anorectal varices and hemorrhoids 92% in our patients. Portal colopathic lesions were occasionally localized in the rectosigmoid area, ascending colon, anal canal and transverse colon. The degree of esophageal varices was associated with congestive colopathy but not with anorectal varices and hemorrhoids. While congestive gastropathy had no significant relationship with esophageal varices, congestive colopathy was present in all patients with congestive gastropathy. However, no association was evident between these lesions and the degree of disease severity. Additional studies are required not only to determine the frequency of this entity, but also to understand the pathophysiology of these lesions. Since the colonic lesions, although usually asymptomatic and clinically insignificant, are a potential source of acute or chronic lower GI bleeding, further investigation is needed to reduce the risk of bleeding and offer alternative treatment models.Öğe Randomized, comparative study of cefotaxime 2 versus 4 grams in spontaneous bacterial peritonitis [5](2007) Ozmen S.; Dursun M.; Y?lmaz S.; Ozmen C.A.; Canoruc F.[No abstract available]
