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Öğe Chemical profiling and total thickness-excised wound-healing activity of Pistacia lentiscus L. fruits growing in Algeria(Taylor & Francis As, 2016) Boukeloua, Ahmed; Belkhiri, Abdelmalik; Yilmaz, Mustafa Abdullah; Temel, HamdiThe aim of this study was to determine the chemical characterization and to assess full-thickness-excised wound-healing activity of the oil of Pistacia lentiscus L. fruits grown in Algeria. The fatty acid composition of P. lentiscus L. extracts were analyzed by GC-MS and their total protein amounts were determined by elemental analysis. Total thickness-excised wound-healing activity of hexane extract was carried out on rabbits; comparing oil and wax effects. The results showed that P. lentiscus L. fruits contain considerable levels of oil and protein. Additionally, oleic (46.91 +/- 1.03, 48.34 +/- 0.07) in hexane and cold pressure extracts, respectively, palmitic (25.75 +/- 0.82, 25.44 +/- 0.65) and linoleic (20.59 +/- 0.03, 20.27 +/- 0.81) acids were the major fatty acids. Wound-healing activity was significantly higher in P. lentiscus L. fatty oil compared to the wax, therefore, fats refining is wildly recommended.Öğe A comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss)(Elsevier Ltd, 2024) Boukeloua, Ahmed; Leila, Soudani; Bendif, Hamdi; Elkadeem, Ahmed Mustafa; Boğa, Mehmet; Serralheiro, Maria Luísa; Yılmaz, Mustafa Abdullah; Yener, İsmailThe study aimed to analyse the chemical and biological composition of Azadirachta indica (A. Juss) (A. indica) leaves. Minerals were quantified using inductively coupled plasma-mass spectrometry (ICP-MS). Phenolic compounds and water-soluble vitamins were identified via LC-MS/MS. Antioxidant activity was assessed using ABTS cation radicals and cupric reducing antioxidant capacity (CUPRAC), while anticholinesterase effect was tested against butyrylcholinesterase (BChE) and Acetylcholinesterase (AChE). Results revealed significant levels of major elements (e.g., Zn, Cu) making it a promising source. Predominant phenolic acids included tannic and salicylic acid, with major flavonoids being hyperoside, kaempferol, and quercetin. Main water-soluble vitamins were nicotinic acid, nicotinamide, and pantothenic acid, followed by pyridoxine, thiamine, and riboflavin. Ethanol extract exhibited moderate antioxidant activity (30.02 % inhibition of ABTS radicals; IC50 0.918 ?g/mL for CUPRAC and low inhibition of BChE and AChE (2.29 % and 3.17 % respectively). These findings highlight A. indica as a valuable natural source of nutritionally significant compounds and antioxidants. © 2024 Phytochemical Society of EuropeÖğe Determination of anticholinesterase and antioxidant activities of methanol and water extracts of leaves and fruits of Chamaerops humilis L.(Applied and Natural Science Foundation, 2019) Bouhafsoun, Aicha; Boğa, Mehmet; Boukeloua, Ahmed; Temel, Hamdi; Kaid-Harche, MeriemThe present study was carried out to investigate the antioxidant activity of the water and methanol extracts of leaves and fruits extracts of Chamaerops humilis L. by using ABTS cation radicals and cupric reducing antioxidant capacity (CUPRAC). Anticholinesterase effect of the extracts was tested against both AChE and BChE using a microplate-reader assay based on the Ellman method. The methanol extracts of C. humilis leaves contained relatively higher content of flavonoids and total phenolics than those of fruits. All the extracts were found to have different levels of antioxidant activity in the systems tested. The leave extract showed the highest value of antioxidant activity, based on ABTS radical-scavenging activity, while the fruit water extract showed the highest value (0.53±0.50 µg/ mL) of cupric reducing antioxidant activity. Our data indicates that both methanol and water fruit extract were active for BChE inhibition (31.65 ± 0.37 and 30.19 ± 0.56%) respectively, whereas, all leave extracts did not show any activity against BChE. The present study demonstrated that the methanol and water extracts fractions of C. humilis have different responses with different antioxidant methods. Our results suggest that the C. humilis could be used as a source of antioxidant agents and may be beneficial in the AD treatment.Öğe Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC-ESI-MS/MS(Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA, 2018) Bouhafsoun, Aicha; Yılmaz, Mustafa Abdullah; Boukeloua, Ahmed; Temel, Hamdi; Kaid, Meriem HarcheIn this study, heated reflux extraction method has been used to identify the phenolic compounds from C. humilis var. argentea leaflets, rachis and fruits. Extractions were performed in both ultrapure water and 80% methanol solvents. The efficiency of procedures was determined in terms of the quality and quantity of phenolic acids and flavonoids identified. Chamaerops extracts have been characterized by high concentrations of phenolic compounds, which play a crucial role in protection against various diseases. LC-MS/MS was used to determine the chemical profile of various extracts obtained from Chamaerops. The results showed that the major components in leaflets and fruits extracts were quinic, malic and chlorogenic acids. In addition, nine minor acidic components were identified. On the other hand, rutin and hesperidin were found to be the major flavonoids. The methanol extract was shown as being the most efficient to identify phenolic compounds in C. humilis.
