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Öğe Can long-term exposure to chromium improve insulin sensitivity in chromium mine workers?(Wiley-Liss, 2004) Tuzcu, Alpaslan; Bahçeci, Mithat; Dursun, Mehmet Emin; Parmaksız, Y.; Ertem, Melikşah; Dalgıç, A.; Turgut, Cengiz; Kale, EbruThe purpose of this work was to evaluate insulin sensitivity in chromium mine workers exposed to chromium chronically. Body mass index, waist circumference, fat mass and percent, lipid levels, serum glucose, insulin, leptin and chromium levels, HOMA (%S), and HOMA (%B) values were measured in 93 male workers and 94 age- and body mass index-matched healthy controls. Fat mass and fat percent of workers were higher than control subjects (P < 0;01 and P < 0.0001, respectively). Mean insulin level of the workers was lower than control subjects (6.2 +/- 4.9 muU/mL and 9.38 +/- 5, respectively, P < 0.0001). Mean serum leptin levels was also lower than the control group (8.47 +/- 6.5 ng/mL and 19.0 +/- 10.8, respectively, P < 0.0001). Serum chromium was higher than the control subjects (407.7 +/- 224.2 nmol/L and 4.45 +/- 3.9, respectively, P < 0.00001). Mean HOMA (%S) index of workers was higher than control subjects (114.4 +/- 55.6 and 55.7 +/- 40.6, P < 0.001). Serum high-density lipoprotein cholesterol levels of the workers were significantly higher than the control group (P < 0.02). In conclusion, long-term exposure to chromium may improve insulin sensitivity and beta-cell function. This improvement appears to be a result of low body fat mass and fat percent in body composition. In addition chromium usage may have useful effects in the insulin sensitivity and therefore in development of type 2 diabetes mellitus.Öğe Çeşitli koma örneklerinde prolaktin düzeyi ve octreotidin etkisi(2018) Bahçeci, Mithat; Aydın, İsmetDiabetik-metabolik,serebrovasküler ve kafa trauması nedeniyle gelişen koma koşullarında serebral dopaminerjik sistemde değişimler ortaya çıkmaktadır.Bu değişimler ise hipotalamo hipofizer düzeyde etkiyle ön hipofizin hormon salınımı üzerinde çeşitli farklılıklara yol açmaktadır.Çalışma çeşitli koma örneklerinde PRL değişimlerini irdelemek amacıyla£ndokrinoloji,Nöroşirürji ve Nöroloji kliniklerinde yatırılarak tedavi edilen hastalarda yapıldı.. On'u kontrol, 10'u diabetik,10'u Traumatik ve 10 tanesi de nörolojik komalı toplam 40 erkek şahıs çalışma kapsamına alındı.Araştırma kapsamına alman hastalara bazal kan örnekleri alındıktan sonra 100 mikrogram uzun etkili somatostatin analogu olan octreotid asetat (Sandostatin) subkutan uygulandı.Uygulamadan sonraki 30,60 ve 120. dakikalarda PRL ölçümleri için kan örnekleri alındı.Prolaktin düzeyleri enzimimmunassay yöntemiyle belirlendi.Bazal prolaktin değerleri kontrol,diabetik ve nörolojik komalı hastalarda anlamlı fark göstremezken kafa traumalı hasta kesiminde anlamlı olarak (P<0,01) yüksek bulundu. Octreotid uygulamasından sonra yine kontrol,diabetik ve nörolojik komalı gurupta PRL değerlerinde anlamlı değişmeler olmamakla birlikte traumatik komalı hastalarda 60 ve 120. dakikadaki prolaktin düzeyleri istatistiksel anlamlılık ölçüsünde baskılandığı görüldü. Sonuç olarak: l)Normal koşullarda somatostatin analogu olan octreotid asetat prolaktin salınımı ile kan şekeri üzerine etkili değildir. 2)Diabetik komalı hastalarda serum prolaktin düzeyleri çoğunlukla yükselmemektedir.Diabetik metabolik değişimler de, dopaminerjik sistem üzerinden PRL salımmını etkilemekte, bazal salınımdan çok uyarılmış PRL tepkimesini baskıladığını düşündürmektedir.Ancak bu konularda daha ileri çalışmalara gereksinim vardır. 3)Traumatik komalı hastalarda prolaktin salınanında artış olması ve octreotid uygulamasıyla prolaktin düzeylerinin baskılanması bu kişilerdeki prolaktin artışından dopaminden başka diğer hormonların (GH,TRH,VİP,GRF) da sorumlu olabileceğini düşündürmektedir.4)Serebrovasküler bozukluklarda nöron hasarına bağlı olarak dopamin gibi nörotransmitterlerin salgılanmasının koma ağırlığıyla ilişkili olduğu,aynca denervasyon duyarlılığının olabileceği de söylenebilir.Öğe The effect of high-fat diet on the development of obesity and serum leptin level in rats(Springer International Publishing, 1999) Bahçeci, Mithat; Tuzcu, Alpaslan Kemal; Akkuş, Murat; Yaldız, Mehmet Sadık; Özbay, A.Ten male Wistar-albino rats were overfed with high-fat diet (margarine at the dose 40 g/kg body weight/day in addition to standard rat diet) during six months from the age of between 8-12 weeks. Ten male rats received a standard chow for the same period. The body weights of the overfed rats increased time dependently (basal 171.5±5, at sixth month 268±19 g), whereas those of the rats fed with standard chow did not increase significantly (basal 177±6.4, at sixth month 220±10 g). At the sixth month, mean body fat percentages were 36.3±6.7% and 24.2±5.4% respectively. Both total cholesterol-triglyceride levels and mean serum leptin levels were also higher than in the overfed rats (p<0.01 and p<0.05 respectively). The livers of all rats were histopathologically normal. Conclusion: high-fat diet resulting in an increased body fat percentage in rats is associated with hyperleptinemia, hypercholesterolemia and hypertriglyceridemia.Öğe Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome(2007) Bahçeci, Mithat; Aydemir, Mehmet; Tuzcu, Alpaslan Kemal; 0000-0002-1814-9773Objective: To evaluate serum lipid responses and insulin resistance to a high-fat content meal in patients with polycystic ovary syndrome (PCOS). Design: Controlled clinical study. Setting: Healthy volunteers and patients with PCOS in clincial research. Patient(s): Twenty women with PCOS (22.7 ± 4 years, body mass index [BMI]: 23.5 ± 2.6 kg/m2) and 20 age- and BMI-matched control women (22.8 ± 4, BMI: 23.1 ± 3.1 kg/m2) were included in the study. Waist circumference, BMI, fat mass, fat percent, and fat-free mass were measured. Intervention(s): A standard oral glucose tolerance test (75 g of glucose, 2 hours) was performed, and the area under the curve-glucose (AUCglu) and homeostasis model assessment of insulin resistance (HOMA-IR) were used for insulin resistance. An oral fat tolerance test (OFTT) with 500 mL standard fat meal (1493 kcal) was performed. With OFTT, both timely (at 0, second, fourth, sixth, and eighth hours) and AUCtriglyceride, AUCtotal-cholesterol, AUCVLDL-cholesterol, AUCHDL-cholesterol, AUCLDL-cholesterol, AUCinsulin, AUCglucose, AUChs-CRP, AUCLP(a), AUCApoA1, and AUCApoB responses were evaluated. Main Outcome Measure(s): Plasma lipid, insulin, and C-reactive protein levels. Result(s): Waist circumference, fat percent, and HOMA-IR values of PCOS patients were higher than those of control subjects. AUCglu values were also higher in patients with PCOS. After OFTT, AUCtriglyceride, AUCtotal cholesterol, and AUCVLDL values were higher in patients with PCOS. Conclusion(s): Patients with PCOS have insulin resistance and prolonged lipid response to OFTT. These exaggerated responses may cause early atherogenesis in these patients.
