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    Determination of antioxidant potential of Nepeta nuda subsp. lydiae
    (Taylor and Francis Ltd., 2016) Aras, Abdulmelik; Doğru, Mehmet; Bursal, Ercan
    The antioxidant activities of ethanol and water extracts of Nepeta nuda subsp. lydiae leaves were determined by different in vitro methods such as; DPPH, ABTS, FRAP and CUPRAC assays. The results were compared to BHA, BHT and ascorbic acid as standard antioxidant compounds. Both water and ethanol extracts presented high antioxidant potential on DPPH free radical scavenging assay and CUPRAC assay. Also, both extracts presented low level on ABTS and FRAP assays. In conclusion, leaves of N. nuda subsp. lydiae have some potential of antioxidant activities, so it could be a useful source for food industry as a food ingredient after analyzing other biological properties.
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    Enzyme inhibitory function and phytochemical profile of Inula discoidea using in vitro and in silico methods
    (Elsevier, 2021) Bursal, Ercan; Yılmaz, Mustafa Abdullah; İzol, Ebubekir; Türkan, Fikret; Atalar, Mehmet Nuri; Murahari, Manikanta; Aras, Abdulmelik; Ahmad, Mushtaq
    Many plant species have a large diversity of secondary metabolites with different biological activities. This study aims to assess the phenolic constituent, enzyme inhibitory and antioxidant activities of the aqueous (water) and methanol extracts of Inula discoidea. The enzyme assays showed effective enzyme inhibition of the methanol extract against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), glutathione S-transferase (GST), and alpha-glycosidase (alpha-Gly) enzymes. The IC50 values for AChE, BChE, GST, and alpha-Gly were found as 38.5 mg/mL, 34.65 mg/mL, 77.0 mg/mL, and 40.76 mg/mL, respectively. Antioxidant properties of the aqueous and methanol extracts of I. discoidea were determined by four well-known in vitro techniques (ABTS, CUPRAC, DPPH, and FRAP methods). The antioxidant values of both water and methanol extracts were found to be better than the standard antioxidants (BHA, BHT, ascorbic acid, and alpha-tocopherol) in ABTS and CUPRAC methods. According to an updated LC-MS/MS technique analysis, quinic acid (21.08 mg/g), protocatechuic acid (4.49 mg/g), and gallic acid (0.48 mg/g) were found as major phenolic compounds of the plant extract. The binding interactions of major phenolic compounds of I. discoidea with the AChE, BChE, GST, and alpha-Gly enzymes were investigated by the molecular docking studies.
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    Identification of Bioactive Polyphenolic Compounds and Assessment of Antioxidant Activity of Origanum acutidens
    (Scipress Ltd, 2017) Aras, Abdulmelik; Silinsin, Muzaffer; Bingol, Muhammed Nuri; Bursal, Ercan
    The main objective of the current work is to search the antioxidant activities of Origanum acutidens leaves by using DPPH, FRAP and CUPRAC methods severally. Three well known antioxidant compounds (BHA, BHT and ascorbic acid) were used as standards for comparing the extracts. Also, phenolic compounds of Origanum acutidens leaves were identified by UHPLC-ESIMS/MS. The high concentrations of rosmarinic acid (11158.99 ppb) quinic acid (3200.84 ppb) and naringenin (1238.45 ppb) were detected quantitatively.
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    Polyphenolic Content, Antioxidant Potential and Antimicrobial Activity of Satureja boissieri
    (Jihad Daneshgahi, 2018) Aras, Abdulmelik; Bursal, Ercan; Alan, Yusuf; Turkan, Fikret; Alkan, Huseyin; Kilic, Omer
    Antioxidant activities of Satureja boissieri extracts were detected by using specific in vitro techniques. Standard antioxidant compounds such as ascorbic acid, BHA (Butylated Hydroxyanisole) and BHT (Butylated Hydroxytoluene) were used to compare with the results obtained from ethanol and water extracts of the plant samples. Both extracts presented high antioxidant actions on ABTS cation radical and DPPH free radical scavenging methods. Furthermore, the antimicrobial activity of S. boissieri was defined by using three fungi species, three Gram-positive and four Gram-negative bacteria species. The reducing power antioxidant activities of samples were measured by CUPRAC and FRAP techniques. Also, phenolic compounds of S. boissieri leaves were identified by UHPLC-ESI-MS/MS. The high concentration of hesperidin (5051 +/- 247 ppb) and rosmarinic acid (4364 +/- 214 ppb) was characterized quantitatively. According to the results, high phenolic content can be thought of as one of the responsible parameters for effective biological activity. Also, its flavonoid and phenolic contents are good natural sources for using in the food industry and pharmacological process.