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    Antioxidative effects of alpha-lipoic acid in spinal cord injury an experimental rat model
    (Edizioni Luigi Pozzi, 2021) Ercan S.; Aktaş A.; Kemaloglu M.S.
    BACKGROUND: Traumatic and ischemic injuries of the spinal cord are effective in the development of neurological dysfunction of tissue damage caused by primary and secondary mechanisms. Free radical changes are effective in the development of early ischemia and progressive tissue ischemia is the main cause of secondary damage. Delaying ischemia is the basis of treatment. In this study, we aimed to demonstrate the presence of neuroprotective effects of alpha-lipoic acid in comparison with methylprednisolone. METHODS: 50 Sprague Dawley rats were divided into 5 groups (n = 10) and spinal cord trauma was created by the method, described by Rivlin and Tator. Group 1: Laminectomy group, Group 2: Laminectomy + spinal cord injury (SCI), Group 3: Laminectomy + SCI + alpha-lipoic acid (ALA) (100 mg / kg), Group 4: Laminectomy + SCl + Methyl-prednisolone (30 mg / kg), Group 5: Laminectomy + SCl + ALA + Methyl-prednisolone. RESULTS AND DISCUSSION: Rats with spinal cord injury were found to be paraplegic. There was no significant change in motor function between the groups. When the antioxidant values were compared in the groups, there was a statistically significant difference between Group 2 and Group 3. Oxygen radicals decreased significantly between ALA and Methylprednisolone. The most striking difference was between the monotherapy group and the combined treatment group. CONCLUSION: Our results showed that alpha lipoic acid given after spinal cord trauma in rats decreases anti-oxidant formation. © 2021, Edizioni Luigi Pozzi. All rights reserved.
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    Biochemical and histopathological investigation of resveratrol, gliclazide, and losartan protective effects on renal damage in a diabetic rat model
    (Science Printers and Publishers Inc., 2015) Ezel T.; Kocyigit Y.; Deveci E.; Atamer Y.; Sermet A.; Uysal E.; Aktaş A.
    OBJECTIVE: To compare the protective effects of resveratrol, gliclazide, and losartan, at biochemical and histopathological levels, on the rat kidney with experimentally induced type 1 diabetes. STUDY DESIGN: A total of 35 adult male Wistar rats were divided into control, diabetic, diabetic gliclazide, diabetic resveratrol, and diabetic losartan groups. For biochemical analysis, based on one of the kidneys, superoxide dismutase, malondialdehyde, and catalase were used for measurement. The other kidney was stained for histochemical and immunohistochemical markers and examined by light microscopy. RESULTS: Nephropathy due to diabetes was developed at the end of the third week in the diabetic group: in the glomeruli, contraction from Bowman distance, diffuse mesangial matrix increasing and tubular dilation, and cytoplasmic vacuolar changes were observed. In tubulointerstitial areas, some tubular structures, an increased expression of VEGF was observed. CONCLUSION: As a result, in diabetic rats, the effects of gliclazide, resveratrol, and losartan cure were equivalent to each other according to the parameters which were followed. Resveratrol, gliclazide, and losartan significantly protected renal glomeruli and the proximal and distal tubules. © Science Printers and Publishers, Inc.
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    The effect of valproic acid on rat ovarium and the protective role of vitamin E and folic acid: An ultrastructural study
    (2010) Aktaş A.; Nergiz Y.; Akkuş M.
    This study was undertaken to investigate the effect of valproic acid and protective effects of vitamin E and folic acid on rat ovary ultrastructural changes. Twenty-four Wistar rats were used. Animals were divided into four groups. The first group of rats was used as control. The second group was injected valproic acid. The third group was injected valproic acid + folic acid and the fourth group was given valproic acid + vitamin E. At the end of the study, ovarium tissues were taken under anesthesia. Tissues were prepared and examined by transmission electron microscopy. Microscopically, the groups are cited as follows: Control group (in which the ovarium tissue was normal), valproic acid group (which showed increase in lipid content plus mitochondrial crystalysis seen in folliculer and theca interna cells of rat ovarium), valproic acid + folic acid group (in which the theca interna and granulosa cells of rat ovarium had normal appearance) and valproic acid + vitamin E group (where all the organelles of theca interna and granulosa cells of rat ovarium were observed to be normal). Vitamin E and folic acid have protective effects against valproic acid-induced tissue damage in rat ovaries. © 2010 Academic Journals.
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    The immunohistochemical and ultrastructural evaluation of pericytes in human full term placentas of gestasyonal diabetes mellitus
    (Acta Medica Mediterranea, 2013) Deveci E.; Söker S.; Turgut A.; Aktaş A.; Ayaz E.; Sak S.; Şeker U.
    Pericytes, vessel wall plays a stabilizing role in the regulation of blood flow in the microcirculation. The purpose of this study is based on non-diabetic pregnancies complicated by gestational diabetes pregnancies to investigate the morphological structure of pericyte cells. In this study, as a control group human placental tissues from normotensive pregnancies was collected from diabetic wome at 28-35 weeks of gestation. Pericytes with smooth alpha-actin positive cells, endothelial cells, and painted like a belt was surrounded. Pericytes, capillary plexus and endothelial cells of large vessels in the mesenchyme around the middle shows desmin positive reaction. Placental microvessels examined by transmission electron microscopy showed many pericytes. Placentas of gestational diabetes group, heterochromatin nucleus hypertrophy, dilatation of endoplasmic reticulum, mitochondria cristae in length, shortening was observed thickening of the filamentary structure. The contractile function of the barrier formed by endothelial cells, pericytes and can increase the contractions were considered.
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    Light microscope evaluation of iron accumulation in term placentas of subjects with preeclampsia
    (Acta Medica Mediterranea, 2014) Nasir Y.; Nergiz Y.; Aktaş A.; Akdeniz N.
    Aims: In this study, the aim was to investigate if the the use of placental iron storages detection could be used. Materials and Methods: This study was performed on 30 placentas, 20 preeclamptic and 10 normal gestations, of 36 weeks or more. Paraffin sections of preeclamptic and normotensive placental tissues were stained with Hematoxylin and Eosin, Masson's Trichrome, and Prussian Blue. Results: Evaluation of preeclampsia group placentas showed as most common findings: increased syncytial node in villus, cytotrophoblast proliferation, increased volume and number of fetal capillary, and increased fibrinoid accumulation. Among preeclampsia group placental tissue samples, Prussian Blue staining was observed most commonly in fetal central cross-sections. In most prominently Prussian Blue stained villus, presence of syncytial nodes and close neighboring between iron accumulation and syncytial kodes ere interesting findings. Statistical analysis of data was made by SPSS software using Mann Whitney U test and p values under 0.05 ere accepted as statistically significant. Conclusion: Studies of placental light microscopy are important in the clarification of preeclampsia etiopathogenesis and more studies with wider scope are needed.