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Öğe Automatic detection and localization of COVID-19 pneumonia using axial computed tomography images and deep convolutional neural networks(Wiley, 2021) Polat, Hasan; Özerdem, Mehmet Siraç; Ekici, Faysal; Akpolat, VeysiCOVID-19 was first reported as an unknown group of pneumonia in Wuhan City, Hubei province of China in late December of 2019. The rapid increase in the number of cases diagnosed with COVID-19 and the lack of experienced radiologists can cause diagnostic errors in the interpretation of the images along with the exceptional workload occurring in this process. Therefore, the urgent development of automated diagnostic systems that can scan radiological images quickly and accurately is important in combating the pandemic. With this motivation, a deep convolutional neural network (CNN)-based model that can automatically detect patterns related to lesions caused by COVID-19 from chest computed tomography (CT) images is proposed in this study. In this context, the image ground-truth regarding the COVID-19 lesions scanned by the radiologist was evaluated as the main criteria of the segmentation process. A total of 16 040 CT image segments were obtained by applying segmentation to the raw 102 CT images. Then, 10 420 CT image segments related to healthy lung regions were labeled as COVID-negative, and 5620 CT image segments, in which the findings related to the lesions were detected in various forms, were labeled as COVID-positive. With the proposed CNN architecture, 93.26% diagnostic accuracy performance was achieved. The sensitivity and specificity performance metrics for the proposed automatic diagnosis model were 93.27% and 93.24%, respectively. Additionally, it has been shown that by scanning the small regions of the lungs, COVID-19 pneumonia can be localized automatically with high resolution and the lesion densities can be successfully evaluated quantitatively.Öğe Bone mineral density in children with beta-thalassemia major in Diyarbakir(Elsevier, 2011) Pirinççioğlu, Ayfer Gözü; Akpolat, Veysi; Köksal, Orhan; Haspolat, Yusuf Kenan; Söker, MuratBone mineral status has extensively been investigated in adult thalassemics but less in thalassemic children. This study involves measurements of the bone mineral density (BMD), various demographic and biochemical parameters in 47 thalassemic children and 50 healthy controls with comparable age, sex, socioeconomic and regional distribution. Patients have significantly higher aspartate aminotransferase, alanine aminotransferase, phosphorous, osteocalcin, serum carboxy terminal teleopeptide fragment of type I collagen, intact parathyroid hormone (iPTH) and ferritin levels while they have significantly lower 25-hydroxy vitamin D (25OH-D), alkaline phosphatase and z-scores both at lumbar and femur compared to controls. Patients with high iPTH (30%) had significantly lower z-scores and 25OH-D while larger osteocalcin. We conclude that a significantly lower BMD in beta-thalassemic children compared with their healthy counterparts is a complex process and may partially attributed to their slower physical development, caused by iron overload and chelation therapy which may influence the liver as well as the endocrine tissues.Öğe Classification of Epilepsy Types from Electroencephalogram Time Series Using Continuous Wavelet Transform Scalogram-Based Convolutional Neural Network(Amer Soc Testing Materials, 2021) Turk, Omer; Akpolat, Veysi; Varol, Sefer; Aluclu, Mehmet Ufuk; Ozerdem, Mehmet SiracDuring the supervisory activities of the brain, the electrical activities of nerve cell clusters produce oscillations. These complex biopotential oscillations are called electroencephalogram (EEG) signals. Certain diseases, such as epilepsy, can be detected by measuring these signals. Epilepsy is a disease that manifests itself as seizures. These seizures manifest themselves in different characteristics. These different characteristics divide epilepsy seizure types into two main groups: generalized and partial epilepsy. This study aimed to classify different types of epilepsy from EEG signals. For this purpose, a scalogram-based, deep learning approach has been developed. The utilized classification process had the following main steps: the scalogram images were obtained by using the continuous wavelet transform (CWT) method. So, a one-dimension EEG time series was converted to a two-dimensional time-frequency data set in order to extract more features. Then, the increased dimension data set (CWT scalogram images) was applied to the convolutional neural network (CNN) as input patterns for classifying the images. The EEG signals were taken from Dicle University, Neurology Clinic of Medical School. This data consisted of four classes: healthy brain waves, generalized preseizure, generalized seizure, and partial epilepsy brain waves. With the proposed method, the average accuracy performance of three of the EEG records' classes (healthy, generalized preseizure, and generalized seizure), and that of all four classes of EEG records were 90.16 % (+/- 0.20) and 84.66 % (+/- 0.48). According to these results, regarding the specific accuracy ratings of the recordings, the healthy EEG records scored 91.29 %, generalized epileptic seizure records were at 96.50 %, partial seizure EEG records scored 89.63 %, and the preseizure EEG records had a 90.44 % rating. The results of the proposed method were compared to the results of both similar studies and conventional methods. As a result, the performance of the proposed method was found to be acceptable.Öğe Classification of Mental Task EEG Records Using Hjorth Parameters(Ieee, 2017) Turk, Omer; Seker, Mesut; Akpolat, Veysi; Ozerdem, Mchmet SiracThe effects of mental activities on brain dynamics is the main field that studied for a long time, but the results of studies have not reached the desired level. The aim of present study was to classify the mental task EEG records by using Hjorth parameters. hi this study, EEG signals that recorded from 9 subjects were used. EEG signals were recorded by applying a experimental paradigm which contains five stimuli related to different mental task. These stimuli are defined as condition word mental subtraction spatial navigation right hand motor imagery and feet motor imagery Wavelet packet transform was used to obtain sub bands of EEC signals. Statistical parameters that consist of mobility, complexity and Mahalanobis distance were applied to sub-bands. Feature vectors were classified by using artificial neural network. When classification performances related to mental activities were examined, the best classification accuracy was obtained as nearly 80% for 'condition word - mental subtraction', ('spatial navigation feet motor imagery;' and 'spatial navigation - condition word'. The lowest classification accuracy was obtained for 'mental subtraction - right hand motor imagery,', 'condition word - right hand motor imagery' and 'spatial navigation right hand motor imagery'. The classification accuracies related to all stimuli that classifed among themselves were obtained as 77,61%.Öğe Çok düşük frekanslı manyetik alanın ratlarda lens üzerine etkileri(Dicle Üniversitesi Tıp Fakültesi, 2008) Keklikçi, Uğur; Akpolat, Veysi; Özekinci, Selver; Ünlü, Kaan; Çelik, M. Salih; Tunik, SelçukBu çalışmanın amacı çok düşük frekanslı manyetik alanın (ELF MF) lens fibrilleri ve lens epitel hücreleri üzerine etkisini değerlendirmektir. Yirmi adet erişkin, dişi Spraque Dawley rat, her birisi 10 rattan oluşan 2 grupa ayrıldı. Deney grubu, günde 2 saat olmak üzere 7 gün ELF MF aldı. İkinci grup standart laboratuar şartlarına alınarak, kontrol grubu olarak kullanıldı. Materyaller lenste kataraktöz değişiklik ve lens epitel hücrelerinde histolojik değişiklikler yönünden değerlendirildi. Biomikroskopik muayenede lenste patoloji saptanmadı. Materyallerin mikroskopik incelemesinde, kontrol grubunda lens fibrilleri ve lens epitel hücrelerinde değişiklik saptanmadı. Deney grubunda ise yüzeyel epitel hücre konturlarında hafif pleomorfizm dışında patoloji saptanmadı. Çalışmada, ELF MF’nin lens fibrillerinde ve epitelinde belirgin bir histopatolojik değişikliğe yol açmayabileceği sonucuna varıldı.Öğe Comparison of Effects of Pulsed Electromagnetic Field Stimulation on Platelet-Rich Plasma and Bone Marrow Stromal Stem Cell Using Rat Zygomatic Bone Defect Model(Lippincott Williams & Wilkins, 2015) Kapi, Emin; Bozkurt, Mehmet; Selcuk, Caferi Tayyar; Celik, Mehmet Salih; Akpolat, Veysi; Isik, Fatma Birgul; Bozarslan, Beri HocaogluBackground Reconstruction of bone defects that occur because of certain reasons has an important place in plastic and reconstructive surgery. The objective of the treatments of these defects was to reinstate the continuity of tissues placed in the area in which the defect has occurred. In this experimental study, the effect of pulsed electromagnetic field stimulation on platelet-rich plasma (PRP) and bone marrow stromal cell, which propounded that they have positive impact on bone regeneration, was evaluated with the bone healing rate in the zygomatic bone defect model enwrapped with superficial temporal fascia. Methods After creating a 4-mm defect on the zygomatic bone of the experiments, the defect was encompassed with a superficial temporal fascial flap and a nonunion model was created. After surgery, different combinations of the PRP, bone marrow stromal cell, and electromagnetic field applications were implemented on the defective area. All the experiments were subjected to bone density measurement. Results The result revealed that the PRP and pulsed electromagnetic field implementation were rather a beneficial and an effective combination in terms of bone regeneration. Conclusions It was observed that the superficial temporal fascial flap used in the experiment was a good scaffold choice, providing an ideal bone regeneration area because of its autogenous, vascular, and 3-dimensional structures. As a result, it is presumed that this combination in the nonhealing bone defects is a rather useful treatment choice and can be used in a reliable way in clinical applications.Öğe Comparison of the effect of local microvibration and pulsed electromagnetic field application on bone fracture(Wiley-Blackwell, 2015) Bilgin, Hakki Murat; Celik, Ferhat; Akpolat, Veysi; Yildiz, Ismail; Ekinci, Aysun; Gem, Mehmet[Abstract Not Available]Öğe Determining the effect of an electromagnetic field generated by a high voltage power line on rat spermatogonia cells(Dicle Üniversitesi Tıp Fakültesi, 2018) Yavaş, Mehmet Cihan; Akpolat, Veysi; Deveci, Engin; Bilgin, Hakkı Murat; Kaplan, İbrahim; Şeker, Uğur; Yıldız, İsmail; Alkış, Mehmet Eşref; Çelik, Mustafa Salih; Akdağ, Mehmet ZülküfAbstract:Objective: Purpose of the study was to research the effect of an electromagnetic field created by a high voltage line onthe testes tissue and the serum biochemistry of Wistar albino male rats. At the same time, in the study also examinedthe protective effects of melatonin and ganoderma lucidum.Methods: In the study, 64 rats were divided into eight equal groups (n: 8). In experiments lasting 26 and 52 days, thefollowing groups were used: High voltage (HV), HV + Ganoderma lucidum (GI), HV + Melatonin (MEL), and Shamcontrol.MEL (10 mg/kg) was administered intraperitoneally and GI (20 mg/kg) as oral lavage. Extremely lowfrequency electric (80.3 V/m) and magnetic fields (2.48 µT) were applied for eight hours per day. Results: The biochemical results of the study show an increase in total oxidant status (TOS) and oxidative stress index(OSI) level and a decrease in total antioxidant status (TAS) level in the 26 and 52 day high voltage groups, comparedto the control group. In the high voltage groups, the nitric oxide (NO) value increased with the increase of theexposure period. Testicular mass (p>0.05), TAS, TOS, OSI and NO (p<0.05) were found at 26 days of comparison.Testicular weight, TAS, TOS, OSI (p<0.05), and NO (p>0.05) were found in 52 day comparisons. In routinehistopathology data, we detected effects on both the 26 and 52 day HV groups, such as degeneration in spermatic cellsand full structural deterioration and increasing hyalinisation. We also detected an step up in the ligament cell in thetubular field for the 52-day test groups. In melatonin added group, proliferating cell nuclear antigen (PCNA)-positivecells were more active. TUNEL assay analysis showed that there was no significant difference between the the 26 dayexperiment groups (p>0.05), but that there was a significant dissimilarity between the 52 day experiment groups(p<0.05).Conclusions: In our study, the oxidative effect of created by a high voltage results in changes in serum biochemistry ofrats and a number of degenerative deterioration in the histological structure of testes. Aslo, it is shown that theoxidative effect created by a high voltage has negative effects on the creation of spermatogonia. GI partly protectsagainst these effects, while melatonin is more effective in this regard.Öğe Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain(Taylor & Francis Inc, 2019) Alkis, Mehmet Esref; Bilgin, Hakki Murat; Akpolat, Veysi; Dasdag, Suleyman; Yegin, Korkut; Yavas, Mehmet Cihan; Akdag, Mehmet ZulkufUbiquitous and ever increasing use of mobile phones led to the growing concern about the effects of radiofrequency radiation (RFR) emitted by cell phones on biological systems. The aim of this study is to explore whether long-term RFR exposure at different frequencies affects DNA damage and oxidant-antioxidant parameters in the blood and brain tissue of rats. 28 male Sprague Dawley rats were randomly divided into four equal groups (n = 7). They were identified as Group 1: sham-control, Group 2: 900 MHz, Group 3: 1800 MHz, and Group 4: 2100 MHz. Experimental groups of rats were exposed to RFR 2 h/day for 6 months. The sham-control group of rats was subjected to the same experimental condition but generator was turned off. Specific absorption rates (SARs) at brain with 1 g average were calculated as 0.0845 W/kg, 0.04563 W/kg, and 0.03957, at 900 MHz, 1800 MHz, and 2100 MHz, respectively. Additionally, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), total antioxidant status (TAS), and total oxidant status (TOS) analyses were conducted in the brain tissue samples. Results of the study showed that DNA damage and oxidative stress indicators were found higher in the RFR exposure groups than in the sham-control group. In conclusion, 900-, 1800-, and 2100-MHz RFR emitted from mobile phones may cause oxidative damage, induce increase in lipid peroxidation, and increase oxidative DNA damage formation in the frontal lobe of the rat brain tissues. Furthermore, 2100-MHz RFR may cause formation of DNA single-strand breaks.Öğe Effect of a 50-Hz Sinusoidal Electromagnetic Field on the Integrity of Experimental Colonic Anastomoses Covered with Fibrin Glue(Wroclaw Medical Univ, 2009) Girgin, Sadullah; Ozturk, Hayrettin; Gedik, Ercan; Akpolat, Veysi; Kale, Ebru; Ozturk, HulyaBackground. Low-frequency magnetic fields have been shown to affect biological processes. In this article the effects of 50-Hz sinusoidal magnetic field (MF) stimulation and application of fibrin glue on the healing of experimental colonic anastomoses were investigated. Material and Methods. Twenty-eight rats were divided into four groups. Group 1 underwent 2-cm left colonic resection and primary anastomosis. Group 2 underwent normal resection anastomosis and the area was covered with fibrin glue. Group 3 underwent normal resection anastomosis and the rats were exposed to a 50-Hz sinusoidal MF. Group 4 underwent normal resection anastomosis, the anastomosis area was covered with fibrin glue, and the rats were exposed to a 50-Hz sinusoidal MF. Investigations included bursting pressure measurement, hydroxyproline content, and histopathological changes. Results. Tissue hydroxyproline levels and anastomotic bursting pressures of groups 2, 3, and 4 were significantly higher than in group 1. Collagen deposition and fibroblast infiltration in groups 2, 3, and 4 had higher scores than in group 1. Furthermore, these results were significantly higher in group 4 rats than in the other groups. Histopathological examination of the anastomosis revealed significantly better healing patterns for group 4 than for groups 1, 2, and 3. Conclusions. A50-Hz sinusoidal MF stimulation and application of fibrin glue provided a significant gain in anastomotic healing in the large intestine. A combination of a 50-Hz sinusoidal MF and fibrin glue has significantly favorable effects on healing of experimental colon anastomosis (Adv Clin Exp Med 2009, 18, 1, 13-18).Öğe The effect of extremely low frequency magnetic field on the conjunctiva and goblet cells(Taylor & Francis Inc, 2008) Keklikci, Ugur; Akpolat, Veysi; Ozekinci, Selver; Unlu, Kaan; Celik, M. SalihPurpose: The aim of this study was to examine the effects of extremely low frequency magnetic field (ELF MF) on the conjunctiva and goblet cells density. Methods: Thirty adult female Spraque Dawley rats were assigned to one of two groups, each containing 15 rats. The experimental group received magnetic field 4 hr/day for 7 days. The second group received standard laboratory care and served as a control. The specimens were evaluated by light microscopy for goblet cell density, conjunctival edema, inflammation, and fibroblast proliferation. Results: In ELF MF exposure group rats, the number of goblet cells was less than the control group. We also observed a significant difference between ELF MF exposure group and control group in terms of goblet cell density (p = 0.010). The ELF MF exposure group manifested conjunctival edema and inflammation compared to the control group (p < 0.001 and p = 0.003). There was no statistical difference between the groups for fibroblast proliferation (p = 0.422). Conclusion: This study suggests that ELF MF exposure leads to morphological alterations of the conjunctiva and reductions in the number of goblet cells. We believe that ELF MF may cause dry eye symptoms.Öğe The effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats(Turkish Assoc Trauma Emergency Surgery, 2014) Demirtas, Abdullah; Azboy, Ibrahim; Bulut, Mehmet; Ucar, Bekir Yavuz; Alemdar, Celil; Alabalik, Ulas; Akpolat, VeysiBACKGROUND: The aim of the present study was to investigate the effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats. METHODS: Thirty-two rats were divided as follows: nicotinized group (1), hyperbaric oxygen group (2), nicotinized + hyperbaric oxygen group (3), and control group (4). For 28 days, nicotine was administered in Groups 1 and 3. Then, a standard shaft fracture was induced in the left femur of rats. Groups 2 and 3 underwent hyperbaric oxygen therapy for 21 days. At the end of the experiment, fracture site, left femur and whole body bone mineral content and density were measured. RESULTS: The radiological and histopathological scores of Group 1 were statistically significantly lower compared to Groups 2, 3 and 4, and there was no statistically significant difference between the Groups 2, 3 and 4. In a comparison between the groups, no statistically significant difference was found in terms of bone mineral content and density values measured at the fracture site, left femur and whole body. CONCLUSION: The negative effects of nicotine on fracture healing are eliminated with hyperbaric oxygen therapy, but hyperbaric oxygen alone does not cause significant changes in healing (radiologically and histopathologically).Öğe Effects of Combined Pulse Electromagnetic Field Stimulation Plus Glutamine on the Healing of Colonic Anastomosis in Rats (vol 54, pg 745, 2009)(Springer, 2010) Girgin, Sadullah; Gedik, Ercan; Ozturk, Hayrettin; Akpolat, Veysi; Kale, Ebru; Buyukbayram, Huseyin; Celik, Salih[Abstract Not Available]Öğe Effects of local vibration and pulsed electromagnetic field on bone fracture: A comparative study(Wiley, 2017) Bilgin, Hakkı Murat; Çelik, Ferhat; Gem, Mehmet; Akpolat, Veysi; Yıldız, İsmail; Ekinci, Aysun; Özerdem, Mehmet Siraç; Tunik, Selçuk; 0000-0002-6040-9989; 0000-0003-2585-9981; 0000-0002-2435-7800; 0000-0002-0547-4139; 0000-0001-5505-838X; 0000-0002-9368-8902; 0000-0002-0549-8472The effectiveness of various therapeutic methods on bone fracture has been demonstrated in several studies. In the present study, we tried to evaluate the effect of local low-magnitude, high-frequency vibration (LMHFV) on rat tibia fracture in comparison with pulsed electromagnetic fields (PEMF) during the healing process. Mid-diaphysis tibiae fractures were induced in 30 Sprague-Dawley rats. The rats were assigned into groups such as control (CONT), LMHFV (15 min/day, 7 days/week), and PEMF (3.5 h/day, 7 days/week) for a three-week treatment. Nothing was applied to control group. Radiographs, serum osteocalcin levels, and stereological bone analyses of the three groups were compared. The X-rays of tibiae were taken 21 days after the end of the healing process. PEMF and LMHFV groups had more callus formation when compared to CONT group; however, the difference was not statistically significant (P = 0.375). Serum osteocalcin levels were elevated in the experimental groups compared to CONT (P <= 0.001). Stereological tests also showed higher osteogenic results in experimental groups, especially in LMHFV group. The results of the present study suggest that application of direct local LMHFV on fracture has promoted bone formation, showing great potential in improving fracture outcome. (C) 2017 Wiley Periodicals, Inc.Öğe The effects of long-term exposure to extremely low-frequency magnetic fields on bone formation in ovariectomized rats(Wiley, 2012) Çelik, Mustafa Salih; Gür, Ali; Akdağ, Zülküf; Akpolat, Veysi; Güven, Kemal; Çelik, Yusuf; Saraç, Aysegül Jale; Otçu, Selçuk; 0000-0002-2435-7800; 0000-0002-0181-3746; 0000-0003-2849-4033The effects of long-term extremely low-frequency magnetic field (ELF-MF) exposure on bone formation and biochemical markers were investigated in ovariectomized rats. Sixty mature female SpragueDawley rats were randomly divided into four different groups (n?=?15): (i) unexposed control (CTL); (ii) ovariectomized only (OVX); (iii) non-ovariectomized, exposed (SHAM?+?ELF-MF); and (iv) ovariectomized, exposed (OVX?+?ELF-MF). The third and fourth groups were exposed to 1.5?mT ELF-MF for 4?h a day for 6 months. Bone mineral density (BMD) was determined using dual energy X-ray absorption (DEXA) measurements. The formation and resorption of bone were evaluated using bone-specific alkaline phosphatase (BAP), osteocalcin, osteoprotogerin, and N-telopeptide. After 6 months of ELF-MF therapy, BMD values were significantly lower in the OVX group and higher in the OVX?+?ELF-MF and SHAM?+?ELF-MF groups than they were before therapy (P?Öğe Effects of Pulsed and Sinusoidal Electromagnetic Fields on MMP-2, MMP-9, Collagen Type IV and E-cadherin Expression Levels in the Rat Kidney An Immunohistochemical Study(Sci Printers & Publ Inc, 2013) Tunik, Selcuk; Ayaz, Ercan; Akpolat, Veysi; Nergiz, Yusuf; Isen, Kenan; Celik, M. Salih; Seker, UgurOBJECTIVE: To investigate the role of extremely low frequency pulsed and sinusoidal electromagnetic fields on kidney tissues. STUDY DESIGN: Twenty-seven male Wistar albino rats were used. The rats were divided into 3 groups (n = 9): control group, sinusoidal electromagnetic field (SEMF) group, and pulsed electromagnetic field (PEMF) group. The SEMF and PEMF groups (pulse time 25 mu sn, pulse frequency 50 Hz) were subjected to 1.5 mT, 50 Hz, exposure 6 hours a day, 5 days a week for 28 days in methacrylate boxes. Formalin-fixed, paraffin-embedded kidney tissue sections were stained with hematoxylin-eosin, Gomori and periodic acid-Schiff. In addition, matrix metalloproteinase-2 (MMP-2) and 9 (MMP-9), E-cadherin and collagen type IV expression levels were examined immunohistochemically. RESULTS: Thickening of glomerular basement membranes was evident in electromagnetic fields, especially in the SEMF group. In addition, expression levels of E-cadherin were decreased with electromagnetic field (EMF) exposure. The expression level of MMP-9 increased, and MMP-2 and collagen type IV expression levels were not altered with EMF exposure. CONCLUSION: Both EMFs changed the molecular component of the kidney adversely.Öğe Effects of Pulsed and Sinusoidal Electromagnetic Fields on Rat Testes(Sci Printers & Publ Inc, 2020) Tunik, Selcuk; Baran, Ozlem Pamukcu; Akpolat, Veysi; Ayaz, Ercan; Nergiz, Yusuf; Celik, M. Salih; Yumusak, OzkanOBJECTIVE: To investigate the role of 50-Hz extremely low frequency pulsed (PEMF) and sinusoidal (SEMF) electromagnetic fields on the testis using a rat model. STUDY DESIGN: Twenty-seven male Wistar albino rats were used. The rats were divided into three groups (n=9 each): sham group, SEMF group, and PEMF group. The SEMF and PEMF groups (pulse time: 20 milliseconds, pulse frequence: 50 Hz) were subjected to 1.5 mT, 50 Hz exposure 6 hours a day, 5 days a week for 28 days in methacrylate boxes. Formalin-fixed, paraffin-embedded tissue sections were stained with H-E and PAS. In addition, E-cadherin and type IV collagen expressions were examined immunohistochemically. RESULTS: Seminiferous tubule basement membranes decreased with EMFs, especially those treated with SEMF. In addition, expression levels of E-cadherin on seminiferous epithelium decreased in PEMF and SEMF groups. The expression level of type IV collagen was also decreased in perivascular and seminiferous tubule basement membrane as compared to that in the sham group. CONCLUSION: PEMF and SEMF have adverse effects on the testis at a histopathological level. EMF leads to a decrease in E-cadherin and type IV collagen expression levels.Öğe An Evaluation of Nitric Oxide, Folate, Homocysteine Levels and Lipid Peroxidation in Postmenopausal Osteoporosis(Wroclaw Medical Univ, 2013) Akpolat, Veysi; Bilgin, H. Murat; Celik, M. Yusuf; Erdemoglu, Mahmut; Isik, BirgulObjectives. In the current study, the risk coefficients of nitric oxide (NO), folate, homocysteine levels and lipid peroxidation in postmenopausal osteoporotic women were determined. Material and Methods. Bone mineral density was determined by dual-energy X-ray absorptiometry. The levels of serum lipid peroxidation products such as the thiobarbituric acid adduct of malondialdehyde (MDA) were measured spectrophotometrically. Plasma folate and homocysteine (Hcy) levels were measured by enzyme chemiluminescence immunoassay. Plasma nitrite levels were measured with the Griess reaction Results. The odds ratios and 95% Confidence Intervals (CI) of the variables MDA, folate, NO, body-mass index (BMI), menopause age and age were found significant. MDA, NO and folate variables were found statistically significant in the analysis of receiver operating charecteristic (ROCs). The areas under the curve (AUCs, 95% CI) of MDA, NO and folate were found to be statistically significant. Conclusions. The current study indicates that NO, MDA and folate are risk variables for postmenopausal osteoporosisÖğe Examination of extremely low frequency electromagnetic fields on orthodontic tooth movement in rats(Taylor & Francis Ltd, 2014) Dogru, Mehmet; Akpolat, Veysi; Dogru, Arzum Guler; Karadede, Beyza; Akkurt, Atilim; Karadede, M. IrfanThe purpose of this study was to evaluate whether 50 Hz extremely low frequency electromagnetic fields (ELF-EMFs) affect the amount of orthodontic tooth movement in rats. The experiments were performed on 18 male Sprague-Dawley rats. The rats were randomly divided into three groups (n = 6): cage-control (Cg-Cnt) group (n = 6); sinusoidal electromagnetic field (SEMF) group (n = 6); and pulsed electromagnetic field (PEMF) group (n = 6). In SEMF and PEMF groups, rats were subjected to 1.5 mT EMF exposure eight hours per day for eight days. In order to obtain tooth movement, holes were drilled on the right and left maxillary central incisors of the rats at a distance 1.5-2 mm away from the gingiva and 20 g of orthodontic forces were applied to the teeth. Generated linear model for repeated measures and Bonferroni tests were used to evaluate the differences between the groups. Interactions among groups by days were found by using Pillai's trace multivariate test. The results showed that significant differences were present among the groups (F = 5.035; p = 0.03) according to the extent of tooth movement. Significant differences between the amount of tooth movements were determined especially after the fifth day and the following days six, seven and eight (p < 0.001). Within the limitations, according to the results of the present study, the application of ELF-EMF accelerated the orthodontic tooth movement in rats.Öğe An experimental study on the effect of platelet-rich plasma application on skin graft healing(Ortadoğu Reklam Tanıtım Yayıncılık, 2022) Gülsün, Niyazi; Akkoç, Mehmet Fatih; Kapı, Emin; Selçuk, Caferi Tayyar; Bozkurt, Mehmet; Akpolat, Veysi; Çelik, Yusuf; Alabalık, Ulaş; Yıldız, İsmailObjective: There is new information increasingly added about wound healing, which is one of the most complex physiological processes. In this study, it is aimed to evaluate the effect of plateletrich plasma on the wound healing process in pursuit of creation of skin defect on the back skin of the rat and application of graft to it. Material and Methods: The study was planned on 30 randomly selected inbred Sprague-Dawley rats. In the rats in the experimental group, 3x2 cm full-thickness skin defect was created after the back area was shaved. The skin taken from the defected area was thinned and turned into a full-thickness skin graft and sutured again to the area where it was taken. Platelet-rich plasma was applied under the graft to the rats in the 1st group, and physiological saline was applied to the 2nd group. The 3rd group did not undergo any surgical procedure, and it was created as the control group. Results: Significant differences were observed in glucose, lactate, glycerol, and pyruvate values in the tissue in Group 1, compared to other groups. In the histopathological evaluation, a significant decrease was detected in the rate of inflammation and edema in the Group 1, in comparison with the other groups. Conclusion: Based on the data obtained from this study, it was taken into consideration by us that platelet-rich plasma application is a method that can be applied in addition to the classical wound care, especially in the cases with wound healing problems.
