An Evaluation of Nitric Oxide, Folate, Homocysteine Levels and Lipid Peroxidation in Postmenopausal Osteoporosis

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Date

2013

Journal Title

Journal ISSN

Volume Title

Publisher

Wroclaw Medical Univ

Access Rights

info:eu-repo/semantics/closedAccess

Abstract

Objectives. In the current study, the risk coefficients of nitric oxide (NO), folate, homocysteine levels and lipid peroxidation in postmenopausal osteoporotic women were determined. Material and Methods. Bone mineral density was determined by dual-energy X-ray absorptiometry. The levels of serum lipid peroxidation products such as the thiobarbituric acid adduct of malondialdehyde (MDA) were measured spectrophotometrically. Plasma folate and homocysteine (Hcy) levels were measured by enzyme chemiluminescence immunoassay. Plasma nitrite levels were measured with the Griess reaction Results. The odds ratios and 95% Confidence Intervals (CI) of the variables MDA, folate, NO, body-mass index (BMI), menopause age and age were found significant. MDA, NO and folate variables were found statistically significant in the analysis of receiver operating charecteristic (ROCs). The areas under the curve (AUCs, 95% CI) of MDA, NO and folate were found to be statistically significant. Conclusions. The current study indicates that NO, MDA and folate are risk variables for postmenopausal osteoporosis

Description

Keywords

Nitric Oxide, Folate, Malondialdehyde, Homocysteine, Osteoporosis

Journal or Series

Advances in Clinical and Experimental Medicine

WoS Q Value

Q4

Scopus Q Value

Q1

Volume

22

Issue

3

Citation