An Evaluation of Nitric Oxide, Folate, Homocysteine Levels and Lipid Peroxidation in Postmenopausal Osteoporosis

[ X ]

Tarih

2013

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Wroclaw Medical Univ

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Objectives. In the current study, the risk coefficients of nitric oxide (NO), folate, homocysteine levels and lipid peroxidation in postmenopausal osteoporotic women were determined. Material and Methods. Bone mineral density was determined by dual-energy X-ray absorptiometry. The levels of serum lipid peroxidation products such as the thiobarbituric acid adduct of malondialdehyde (MDA) were measured spectrophotometrically. Plasma folate and homocysteine (Hcy) levels were measured by enzyme chemiluminescence immunoassay. Plasma nitrite levels were measured with the Griess reaction Results. The odds ratios and 95% Confidence Intervals (CI) of the variables MDA, folate, NO, body-mass index (BMI), menopause age and age were found significant. MDA, NO and folate variables were found statistically significant in the analysis of receiver operating charecteristic (ROCs). The areas under the curve (AUCs, 95% CI) of MDA, NO and folate were found to be statistically significant. Conclusions. The current study indicates that NO, MDA and folate are risk variables for postmenopausal osteoporosis

Açıklama

Anahtar Kelimeler

Nitric Oxide, Folate, Malondialdehyde, Homocysteine, Osteoporosis

Kaynak

Advances in Clinical and Experimental Medicine

WoS Q Değeri

Q4

Scopus Q Değeri

Q1

Cilt

22

Sayı

3

Künye