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Öğe Association Between the Rh Blood Group and the Covid-19 Susceptibility(Akad Doktorlar Yayinevi, 2020) Arac, Esref; Solmaz, Ihsan; Akkoc, Hasan; Donmezdil, Suleyman; Karahan, Zulkuf; Kaya, Safak; Mertsoy, YilmazWe aimed to investigate whether there is a predisposition to COVID-19 with ABO and Rh blood group systems. This study was a retrospective study that investigate the patients admitted to our hospital between March 16 -May 20 due to Covid-19 pandemic and conducted with data revealed from the hospital Information Management System A total of 392 patients were included in this study, including 227 PCR test positive patients with blood group information in the system and 165 possible patients with CT findings in favor of Covid-19. Data from a blood group study conducted with 127091 people in our province in 2019 were used as a control group. In our study, a significant increase was observed in the blood group A in patients diagnosed with Covid-19, and a decrease was found in the blood groups B, AB and especially O. However, statistical analysis showed no significant difference between Covid-19 patients and healthy individuals in terms of ABO blood group system. When analyzed in terms of Rh blood group system, it was found that Rh positivity was statistically significantly higher in patients with Covid-19 (p= 0.000). Our study suggests that the Rh (-) blood group is protective and the Rh (+) blood group is predisposed to Covid 19 significantly. We think that it is valuable because it is the first study to reveal the relationship between Covid-19 and blood type in our country and the only one to reveal the relationship between Covid-19 and Rh (+) in the world literature.Öğe The Effects of Ethyl Pyruvate on Behavioral and BiochemicalParameters in Immobilization Stress-Induced Mice(2021) Akkoc, Hasan; Uyar, Emre; Abul, Mihrab; Dönmezdil, SüleymanObjective: Ethyl pyruvate (EP) is a molecule with antioxidant, anti-inflammatory, and anti-apoptotic features. The present study investigates EP's effects on behavioral and biochemical alterations induced by immobilization (IM) stress. Methods: In this outcome, 45 male BALB/c mice were separated into five groups [CONT (control), IM, IM+EP, EP, IM+F (fluoxetine)]. IM applied groups had 6 hours of immobilization stress procedure a day for a week. EP (50 mg/day) and fluoxetine (5 mg/day) were applied to the mice intraperitoneally. After the stress induction protocol, passive avoidance, open field (OF), and forced swimming tests (FST) were executed. After behavioral tests, brain tissues were obtained for biochemical investigations. Results: Immobilization application increased immobility times in the FST and decreased the total distance moved and the center time in the OF test. Immobile times were reduced with fluoxetine and EP applied groups compared with the IM group due to decreased learned helplessness. The IM group had decreased brain-derived neurotrophic factor (BDNF), superoxide dismutase, and glutathione peroxidase levels, which were increased with EP applications.Conclusion: These results show that EP generates antidepressant-like effects with decreasing oxidation and increasing BDNF levels.Öğe The effects of intravenous immunoglobulin on cerebral ischemia in rats: An experimental study(Sage Publications Inc, 2016) Tunik, Selcuk; Aluclu, Mehmet Ufuk; Acar, Abdullah; Akkoc, Hasan; Guzel, Aslan; Alabalik, Ulas; Akkus, MuratStroke is one of the major reasons of death in the United States and related to adult disability. Despite aggressive research, the treatment approaches of stroke still remains a major clinical problem. Intravenous immunoglobulin (IVIg) is a polyspecific Ig G preparation obtained from plasma of several thousand healthy people (donors). IVIg is an important treatment approach and used for several disorders. The aim of this study was to investigate the potentially beneficial effects of IVIg therapy in experimentally induced ischemia in middle cerebral artery occlusion (MCAo) models of rats. A total of 30 adult male Sprague Dawley rats were used. The rats were divided into two equal groups, each consisting of 15 randomly selected rats: control group (n = 15) and IVIg group (n = 15). Intraluminal filament method was used for establishment of cerebral ischemia. Intraluminal filament was withdrawn after 2 h of MCAo and reperfusion started again and passed to therapeutic stages for all the groups. Physiologic saline solution of 0.5 ml/kg was administered to the control group and 400 mg/kg IVIg was given to the IVIg group rats intravenously. In neurological evaluation, the worst score was determined as 3 and the best score as 0. After routine process, the brain tissue was prepared histopathological investigation. The IVIg group showed significantly better recovery with respect to the control group by neurological examination. The observation of specimens obtained from IVIg groups showed that findings correlate with grade 1 and -2 histopathologically. Nevertheless, ischemic amendments were observed to comply with grade 3 in ischemic areas in control group. IVIg therapy can be used in the treatment of ischemic stroke patients.Öğe The effects of spinosad on antioxidant system and cognitive performance of mice(Taylor & Francis Ltd, 2021) Acar, Abdullah; Akkoc, Hasan; Erdinc, MeralIntroduction: There are few studies examining the effect of spinosad on cognitive functions in the literature. Methods: In this study, we applied spinosad 3 weeks in different doses to mice and examined their effects on antioxidant system and cognitive performance. Results: In the open field test, we observed a significant decrease (p < .05) in the total distance travelled and the time spent in the central area in all subjects who underwent spinosad. In the novel object recognition test, we observed decreases in the time spent with new and old objects. From the biochemical point of view, while BDNF and NGF levels were significantly lower in the spinosad applied group (p < .05), there was no difference in GPx and SOD levels (p > .05). Conclusions: These results show that spinosad disrupts cognitive functions at the doses we used in our study and this negative effect may be related to the decrease in neurotrophic factors.Öğe Effects of Sublethal Doses of Thiacloprid, a Neonicotinoid Insecticide, on Learning and Memory Performance of Mice(Asian Network Scientific Information-Ansinet, 2020) Akkoc, Hasan; Acar, Abdullah; Toprak, Gulten; Uyar, EmreBackground and Objective: Thiacloprid (THI), a neonicotinoid insecticide, currently one of the most preferred insecticides worldwide. Although they are claimed to be less hazardous on mammals, late studies revealed the harmful effects of this kind of insecticides. However, there are few studies examining the effect of THI on learning and memory performance in the literature. This study was conducted to investigate the effects of sublethal doses of THI on learning and memory functions and to determine the effect of the protocol on biochemical parameters. Materials and Methods: In this outcome, 50, 100 and 200 mg kg(-1) THI were administered by oral gavage for 3 weeks in mice (n:7). At the end of this process, a novel object recognition (NOR) and passive avoidance (PA) tests were conducted to measure learning and memory functions. Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) levels were measured biochemically. Results: In the NOR test, reductions in the discrimination index values were observed with THI applications. The step-through latencies of the mice to enter the dark compartment in the retention trial of the PA test was reduced similarly in THI applied groups. The biochemical investigations revealed that BDNF and GPx levels in the brain tissue were significantly reduced in all groups compared to the control group, while a significant reduction in NGF levels was observed only in 200 mg kg(-1) applied group. There was no significant difference in SOD and CAT levels between test groups. Conclusion: These results indicated that sublethal, chronic THI application degenerates the learning and memory functions with affecting BDNF, NGF and GPx levels.Öğe Ethyl Pyruvate Prevents Ischemia Reperfusion Injury in Isolated Perfused Rat Heart(Colegio Farmaceuticos Provincia De Buenos Aires, 2013) Akkoc, Hasan; Tunik, Selcuk; Kelle, Ilker; Gurkan, Ahmet; Erdogmus, Zeynep; Simsek, Selda; Erdinc, MeralThe aim of the present study was to investigate the protective effect of ethyl pyruvate (EP) against ischemia reperfusion (I/R) injury in isolated rat heart. Male Sprague-Dawley rats were divided into three groups (n = 8); Group 1: Control group, Group 2: I/R, Group 3: I/R+EP. Ischemia was produced for 30 min by blocking the perfusion with Krebs Henseleit solution and it was followed by reperfusion for 60 min. In group 3, EP (2 mmol/L) was added into Krebs Henseleit solution after stabilization period. EP did not change the number of a-smooth muscle actin positive vessels and expression of Bcl-2 and desmin. Treatment with EP significantly reduced I/R induced extension in infarct size (p < 0.001) and release of lactate dehidrogenase (p < 0.001) and creatine phosphokinase (p < 0.05). Myocardial I/R injury significantly increased oxidative stress index and malondialdehyde, total oxidant status levels and significantly decreased paraoxonase actvity and total antioxidant status (p < 0.05). On the other hand, alterations in these biochemical indices due to I/R injury were attenuated by EP treatment (p < 0.01). These results show that ethyl pyruvate prevents ischemia reperfusion injury in isolated perfused rat heart.Öğe FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey(Hindawi Publishing Corporation, 2010) Balkan, Mahmut; Gedik, Abdullah; Akkoc, Hasan; Ay, Ozlem Izci; Erdal, M. Emin; Isi, Hilmi; Budak, TurgayThe influence of FSH receptor (FSHR) variants on male infertility is not completely understood. The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey. The SNPs in codon 680 and at position -29 of the FSHR gene were analyzed by PCR-RFLP technique in 240 men with proven fathers, and 270 infertile men (150 nonobstructive azoospermic and 120 severe oligozoospermic). The separate analysis for SNP at nucleotide position -29 did not show any difference in genotypic frequencies and serum FSH levels. The genotype distribution of SNP at position 680 was different but does not influence serum FSH levels. Together the two SNPs form four discrete haplotypes (A-Thr-Asn, G-Thr-Asn, A-Ala-Ser, and G-Ala-Ser) occurring in 10 combinations. A statistically significant difference in the allelic distribution of G-Asn/G-Ser and G-Ser/G-Ser genotype between proven fathers and infertile men but there were not any statistically significant difference in the overall frequency of the four FSHR haplotypes. We conclude that the FSHR haplotype does not associate with different serum FSH levels but it is differently distributed in proven fathers and infertile men.Öğe Impact of N-acetylcysteine and Etodolac Treatment on Systolic and Diastolic Function in a Rat Model of Myocardial Steatosis Induced by High-Fat-Diet(Bentham Science Publ Ltd, 2014) Topal, Askin Ender; Akkoc, Hasan; Kelle, Ilker; Yilmaz, Sedat; Topal, Derya; Akkus, MuratObjectives: Obesity is a worldwide problem, leading to cardiomyopathy. Oxidative stress and inflammation have been reported to play significant roles in developing obesity cardiomyopathy. N-acetylcysteine is a glutathione prodrug that preserves liver against steatosis via constraining the production of reactive oxygen species. Etodolac is a nonsteroidal anti-inflammatory drug which has been demonstrated to protect liver against fibrosis. The aim of the present study was to evaluate and compare the effects of N-acetylcysteine and etodolac on impaired cardiac functions due to high-fat-diet (HFD) induced myocardial steatosis in rats. Material and Methods: Thirty-two male Sprague-Dawley rats were randomly divided into four groups. Control group was maintained on standard-rat-basic-diet (SD) for 20 weeks, while HFD was given to three study groups for 20 weeks. Then N-acetylcysteine was given to one of the study groups (HFD+NAC), and etodolac to another group (HFD+ETD) as a supplement for 4 weeks while all groups were continued on SD. At the end of the study periods, hearts were examined by Langendorff technique and rat livers were evaluated histologically. Results: HFD and HFD+ETD groups presented with significantly higher steatosis and fibrosis in liver compared to other groups. HFD+NAC preserved diastolic functions. Also HFD+NAC and HFD+ETD groups had significantly better systolic funtions than HFD group. Conclusions: Obesity is associated with diastolic dysfunction rather than systolic dysfunction. NAC may protect the heart against diastolic dysfunction due to obesity. NAC and etodolac treatment improve systolic function, even in the absence of systolic dysfunction.Öğe Investigating the Effects of Trolox on Behaviour and Biochemical Parameters in Mice Exposed to Immobilization Stress(Asian Network Scientific Information-Ansinet, 2019) Toprak, Gulten; Akkoc, Hasan; Uyar, EmreBackground and Objective: Stress is known to play a causal role in several neuropsychiatric disorders. Trolox has been reported to show potent antioxidant activity against reactive oxygen species. The aim of this study was to investigate the effect of trolox on the behaviour and biochemical parameters of mice exposed to immobilization stress. Materials and Methods: The mice were subjected to 6 h of immobilization stress daily for 7 consecutive days. The 48 mice were randomly divided into 6 groups with 8 mice each: (I) Control, (II) Immobilization (IM), (III) Immobilization+Trolox (IM+T), (IV) Immobilization+Fluoxetine (IM+F), (V) Immobilization+Trolox+Fluoxetine (IM+T+F) and (VI) Trolox (T). At the end of day 7, open field test (OFT) and forced swimming test (FST) were performed to assess the locomotor activity and anxiety-like behaviour in mice. After the completion of these tests, brain tissue samples were removed for biochemical analysis. Results:The OFT and FST results indicated that the incidences of anxiety-like and depression-like behaviour were significantly lower in the IM+T group compared to the IM group. A significant improvement was observed in the groups treated with trolox for the catalase, total oxidant status, total antioxidant status and oxidative stress index values deteriorated by immobilization. Conclusion:The results implicated that antioxidant molecules such as trolox can lead to favourable outcomes in the treatment of oxidative damage either in isolation or in combination with classic treatment methods.Öğe Investigation into the effect of neoadjuvant therapy and tumor regression grade on the shrinkage of distal surgical margin in rectal cancer: A prospective case-control study(Wolters Kluwer Medknow Publications, 2022) Aday, Ulas; Kilicarslan, Ahmet; Boyuk, Abdullah; Akkoc, HasanBackground: The present study aimed to explore the effect of neoadjuvant therapy and tumor regression grade (TRG) on the shrinkage in the distal surgical margin ( DSM) induced by formalin fixation in rectal cancer. Materials and Methods: In this prospective study, the DSM of resected 61 specimens of rectal and rectosigmoid junction adenocarcinoma were measured following fresh and formalin fixation. The measurements were performed within the first 15 min after resection and at 24 h after formalin fixation without pinning and were compared with regard to neoadjuvant treatment status and TRG. Results: In the patients that received neoadjuvant therapy, the fresh and postfixation DSM values were 32.2 mm and 22.7 mm, respectively, and the mean shrinkage rate was 34.7% (P. 0.001). In the patients that did not receive neoadjuvant therapy, the fresh and postfixation DSM values were 54.03 mm and 41.9 mm, respectively, and the mean shrinkage rate was 23.7% (P. 0.001). The mean shrinkage rate was 41.9% in TRG 1, 29.4% in TRG 2, and 31.9 in TRG 3 specimens. The mean shrinkage rate was higher in specimens with a DSM of =20 mm compared to specimens with a DSM of >20 mm (46.2% vs. 24.9%). Conclusion: A complete or near-complete tumor regression in patients with rectal cancer undergoing neoadjuvant therapy increases the shrinkage of DSM. Moreover, this shrinkage rate is likely to be higher and the pathological DSM is likely to be closer than expected in cases that present a better clinical response to neoadjuvant therapy, particularly in distal rectal cancer.Öğe Metformin HCl has curative effect on rebuilding of ventricular diastolic functions in high-fat-diet fed rats(Univ Karachi, 2017) Topal, Askin Ender; Kelle, Ilker; Akkoc, Hasan; Yilmaz, Sedat; Akkus, MuratMyocardial lipid accumulation due to diabetes and/or obesity plays a role in the progression of left ventricular diastolic dysfunction. Our aims were to exhibit the correlation between histopathologic stage of the liver and cardiac functions, and to evaluate the effects of metformin HC1 and rosiglitazone on myocardial functions. Thirty-two male Sprague-Dawley rats were divided into four groups to exhibit the correlation between histopathologic stage of the liver and cardiac functions and to determine whether metformin HC1 and rosiglitazone have effects on cardiac functions. For 20 weeks, one group was fed standard rat basic diet, whereas the other groups were on high-fat-diet. During the last 4 weeks, metformin HC1 was given to the third group, rosiglitazone to the fourth group. Histological evaluation of rat livers yielded significantly higher steatosis grade in high-fat-diet group and different fibrosis stages among groups. Also, there was significant correlation between diastolic functions and steatosis grade/fibrosis stage of rat liver. Electrophysiological study of hearts via Langendorff technique showed better coronary perfusion pressures and diastolic functions in standard -diet and metformin HC1 groups compared to other groups. Metformin HC1 improves LV diastolic dysfunction and coronary perfusion pressures.Öğe Oxytocin Ameliorates Remote Liver Injury Induced by Renal Ischemia-Reperfusion in Rats(Korean Journal Of Physiology & Pharmacology, 2013) Hekimoglu, Askm Tas; Toprak, Gulten; Akkoc, Hasan; Evliyaoglu, Osman; Ozekinci, Selver; Kelle, IlkerRenal ischemia-reperfusion (IR) causes remote liver damage. Oxytocin has anti-inflammatory and antioxidant effects. The main purpose of this study was to evaluate the protective function of oxytocin (OT) in remote liver damage triggered by renal IR in rats. Twenty four rats were randomly divided into four different groups, each containing 8 rats. The groups were as follows: (1) Sham operated group; (2) Sham operated+OT group (3) Renal IR group; (4) Renal IR+OT group. OT (500 mu g/kg) was administered subcutaneously 12 and 24 hours before and immediately after ischemia. At the end of experimental procedure, the rats were sacrificed, and liver specimens were taken for histological assessment or determination of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON-1) activity and nitric oxide (NO). The results showed that renal IR injury constituted a notable elevation in MDA, TOS, Oxidative stress index (OSI) and significantly decreased TAS, PON-1 actvity and NO in liver tissue (p<0.05). Additionally renal IR provoked significant augmentation in hepatic microscopic damage scores. However, alterations in these biochemical and histopathological indices due to IR injury were attenuated by OT treatment (p<0.05). These findings show that OT ameliorates remote liver damage triggered by renal ischemia-reperfusion and this preservation involves suppression of inflammation and regulation of oxidant-antioxidant status.Öğe Phenotypical examination of the macrolide-lincosamide-streptogramin B resistance in Staphylococcus isolates(Academic Journals, 2012) Ozbek, Erdal; Temiz, Hakan; Tekay, Fikret; Kalayci, Raike; Akkoc, HasanThe aim of the present study was to evaluate the phenotypic characteristics of the macrolide-lincosamide-streptogramin B (MLSB) resistance in Staphylococcus aureus and coagulase-negative staphylococci (CNS) strains isolated from various clinical samples in our hospital. The study was conducted on 516 Staphylococcus isolates isolated from various clinical samples in Microbiology Laboratory of Diyarbakir State Hospital between January, 2009 and December, 2009. After the identification of microorganisms via conventional methods and the evaluation of their methicillin resistance profile, disk approximation test was performed using erythromycin (15 mu g) and clindamycin (2 mu g) disks in order to determine MLSB resistance phenotypes. Of 516 Staphylococcus isolates, 208 were determined to be S. aureus and 308 were CNS. The MLSB resistance of isolates was 56.2%, whereas the resistance due to the efflux pump was determined to be 3.5%. The MLSB resistance phenotype was determined in 38% of S. aureus strains and 68.5% of CNS strains. The presence of MLSB resistance was determined to be higher in methicillin-resistant group (74.7%) compared to the methicillin-susceptible group (23.9%). While constitutive MLSB resistance (cMLS(B)) and inducible MLSB resistance (iMLS(B)) were determined in 48.9 and 19.1% of methicillin-resistant S. aureus strains, respectively, these rates were 2.6 and 10.5% for methicillin-susceptible strains, respectively. The rate of constitutive resistance was determined to be 41.5% in methicillin resistant CNS, whereas the rate of inducible resistance was determined to be 35.9%. In methicillin-susceptible CNS group, cMLS(B) and iMLS(B) resistances were determined to be 17.6 and 23%, respectively. The cMLS(B) phenotype was more common among methicillin-resistant S. aureus and CNS group, whereas iMLS(B) phenotype was more common among methicillin-susceptible S. aureus strains. In conclusion, we suggest that the determination and reporting of the presence of inducible resistance is of great importance regarding the success of therapy; therefore, it would be beneficial to use D test in routine antibiogram studies.Öğe THE POTENTIAL BENEFICIAL EFFECTS OF ETHYL PYRUVATE ON DIABETIC NEPHROPATHY: AN EXPERIMENTAL AND ULTRASTRUCTURAL STUDY(Vesalius Univ Medical Publ, 2016) Bahadir, Mehmet Veysi; Yildirim, Yasar; Baran, Ozlem Pamukcu; Polat, Sait; Akkoc, Hasan; Tunik, SelcukOxidative stress is one of the main causes of diabetic nephropathy, which is a complication of diabetes mellitus (DM). The aim of this study was to investigate the possible role of ethyl pyruvate (EP) in streptozotocin-induced diabetic rats' kidney. Four groups (n = 8) of male Wistar albino rats were used as follows: control group rats received only sodium citrate buffer solution intraperitoneally (ip). The EP group was given 50 mg/kg EP ip. In the DM group, diabetes was induced by streptozotocin. The DM + EP group received 50 mg/kg EP ip. All animals received daily treatment for 14 days, and at the end of the study the kidneys were removed: the left kidney of the rats was used for malondialdehyde (MDA) analysis and the right kidney for histological examination. There was normal appearance of the kidney tissues in the control and the EP-administered groups. In the DM group, there was evident basement membrane thickening and enlargement of mesangial matrix; swelling in some tubular epithelial cells was also noticeable. In the DM+EP administered group, nearly the same appearance as the control group and relative thickening in the glomerular basal membrane were observed. The antioxidant effect of ethyl pyruvate improved the renal structures in the DM + EP group.Öğe The Prophylactic Effects of Folic Acid and Vitamin E against Valproic Acid During Fetal Thymus Development: an Ultrastructural Study(Soc Chilena Anatomia, 2011) Baran, Ozlem Pamukcu; Tunik, Selcuk; Akkoc, Hasan; Devieci, Engin; Ayaz, Ercan; Soker, Sevda; Tas, Sevgi KalkanliTo evaluate histopathologic differences in the thymus of Wistar Albino rat fetuses prenatally exposed to valproic acid (VPA), folic acid (FA) and vitamin E (Vit-E). VPA (400 mg/kg), FA (400 mcg/kg) and Vit -E (250 mg/kg) were administered to rats on each of gestation days 8,9 and 10. The fetuses (n:24) were divided into four groups: control, VPA, VPA+Vit-E and VPA+FA groups. On the 20th day of gestation, all pregnant rats were sacrificed and the fetuses were extracted. Thin sections from thymus of live fetuses were stained with uranyl acetate-lead citrate and were examined under transmission electron microscope. The histopathological findings of control group was normal. In VPA group, it showed extensive degenerative changes by VPA were on all tissue compartments when compared to controls. In VPA-FA group, vacuoles, mitochondrial cristalysis and swelling were decreased in cytoplasm. In VPA-Vit-E group, lipid storage and vacuolization were observed. Mitochondrial cristalysis decreased. Our aim in the present study is to analyze histopathological changes which may occur in a high risk experimental model after giving of VPA. In addition, protective roles of the administration of FA and Vit-E are assessed.Öğe Protective effects of ethyl pyruvate in cisplatin-induced nephrotoxicity(Taylor & Francis Ltd, 2014) Kelle, Ilker; Akkoc, Hasan; Tunik, Selcuk; Nergiz, Yusuf; Erdinc, Meral; Erdinc, LeventThis study was performed to investigate the effect of ethyl pyruvate on changes in renal functions and oxidative stress related renal injury caused by cisplatin (cis-dichlorodiammine platinum-II; CDDP). Male Wistar albino rats were divided into four groups (n = 8): (1) control group (1ml Ringer's lactate solution i.p.); (2) ethyl pyruvate (EP) group (50mg/kg Ringer's EP solution (REPS) i.p.); (3) cisplatin group (a single dose of cisplatin (5mg/kg, i.p.); and (4) cisplatin + EP group (a single dose of cisplatin (5mg/kg, i.p.) + REPS 50mg/kg/day, i.p.) for five days. At the sixth day, kidneys of rats were mounted to a Langendorff apparatus. Renal perfusion pressures were recorded. Blood samples were taken for serum urea, creatinine, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stres index (OSI) evaluations. Kidney tissues were obtained for malondialdehyde (MDA) analyses and histopathological examination. Perfusion pressures, serum urea, creatinine, TOS, OSI and tissue MDA levels were found significantly higher, whereas TAS was notably lower in cisplatin group. Histopathological examination showed apparent renal paranchymal injury in cisplatin group. In cisplatin + REPS group, perfusion pressures, serum urea, creatinine and tissue MDA levels were decreased. Moreover, EP co-administration provided less inflammatory cell infiltration, tubular dilatation, whereas TOS, TAS and OSI improved significantly versus cisplatin group. These findings show that EP has protective effects against cisplatin nephrotoxicity.Öğe Relation between seizure duration, apllied electrical dose and response speed to electroconvulsive therapy for patients with depression: a retrospective study(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2009) Essizoglu, Altan; Yasan, Aziz; Bulbul, Israfil; Akkoc, Hasan; Yildirim, Ejder Akguen; Ozkan, MustafaObjective: The aim of this study was to determine the relationship between speed of clinical response and both applied dose to produce seizure and seizure duration in inpatients with depression who underwent electroconvulsive therapy (ECT) in Dicle University Faculty of Medicine Psychiatry Service between 1st June 2006 and 1st June 2008. Methods: The sociodemodemographic and diagnostic features of 48 inpatients who underwent ECT in our clinic between 1st June 2006 and 1st June 2008 were examined retrospectively. In order to establish correlations between applied dose and seizure duration on the one hand and speed of clinical response during ECT treatment on the other, data of 21 inpatients with depression whose cure was completed in spite of adequate clinical response were analyzed using chi-square and Mann Whitney U tests. Results: In our study, 87 (16.3%) of the 533 inpatients were diagnosed with depression, 48 (9.0%) of all inpatients received ECT, 32 (66.7%) of ECT recipients were diagnosed with depression, 21 (65.6%) of those 32 recipients had adequate clinical response and completed the cure. 57.1% of the patients with depression who completed the cure received ECT with the indication of suicide attempt/suicidal ideation. Among patients who had adequate clinical response; our analyses indicated that patients received six and less ECT treatments needed lower dose and had longer seizure duration than patients received seven and more ECT treatment. Conclusion: The results of our study show that beginning from the first ECT treatment the droopiness of the applied dose to produce seizure and the length of seizure duration may predict that patients with depression will have more rapid clinical response during ECT treatment. However, further research which includes more patients is needed about this issue. (Anatolian Journal of Psychiatry 2009; 10: 286-292)
