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Öğe Comparison of the effect of periodontal therapy and diode decontamination and periodontal therapy alone on the amount of TNF-alpha in systemically healthy chronic periodontitis patients a non-randomized clinical trial(SCI Printers & Publication INC, 2020) Doğru, Arzum Güler; Toprak, Ömer; Üner, Devrim Deniz; İzol, Bozan Serhat; Kaplan, İbrahim; Doğru, Mehmet; İpek, FikretAbstract OBJECTIVE: To evaluate the outcome of initial periodontal therapy and additional diode laser decontamination therapy on clinical parameters and the amount of tumor necrosis factor alpha (TNF-alpha) in gingival crevicular fluid (GCF) in patients with chronic periodontitis. STUDY DESIGN: The study included 22 patients who were diagnosed with chronic periodontitis and who had at least 1 (>= 5 mm) periodontal pocket in the posterior region of each upper left hemi-arcade. The study was designed as a split-mouth study involving mechanical therapy on the right side and nonsurgical periodontal therapy plus diode laser decontamination therapy on the left side. RESULTS: A statistically significant decrease was observed in clinical parameters at 3 months when compared to the values at baseline in both treatment areas. The change in clinical parameters at 3 months after therapy was not significantly different between the groups (p>0.05). The comparison of GCF TNF-alpha levels at baseline and at 3 months in the 2 treatment areas identified significant changes in the TNF-alpha levels in the hemi-arcade treated with laser diode contamination therapy, whereas the changes in the hemi-arcade treated with nonsurgical periodontal therapy were not significant (p>0.05). A between-group comparison revealed no statistically significant difference at 3 months post-therapy, while the difference at 1 month was found to be statistically significant. CONCLUSION: The study found that laser therapy in addition to nonsurgical periodontal therapy has a positive effect on the clinical parameters and proinflammatory TNF-alpha levels in the early period but makes no contribution in the long term.Öğe The effect of graft application and allopurinol treatmenon calvarial bone defect in rats(Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia, 2019) Laçin, Nihat; İzol, Bozan Serhat; Özkorkmaz, Ebru Gökalp; Deveci, Buşra; Tuncer, Cudi Mehmet;Purpose: To investigate the effects of allopurinol administration on osteoinductive reaction and bone development with graft material. Methods: Thirty-six Wistar albino rats were divided into 3 groups. In the control group, calvarial bone defect was only created without any treatment. In the Defect + Graft group, allograft treatment was performed by forming 8 mm calvarial bone defect. In the Defect + Graft + Allopurinol group, alloplastic bone graft was placed in the calvarial bone defect and then, allopurinol (50 mg/kg/day) treatment was intraperitoneally applied for 28 days. Results: Histopathological examination revealed inflammation, congestion in the vessels, and an increase in osteoclast cells in the defect area. We also observed that new osteocyte cells, increase in connective tissue fibers, and new bone trabeculae. Osteopontin expression was positive in osteoblast cells and lacunated osteocyte cells were located in the periphery of the new bone trabeculae. Osteopontin expression was also positive in osteoblasts and osteocytes cells of new bone trabeculae in the graft site. Conclusion: It has been shown that allopurinol treatment in rat calvaria defects may induce osteoblastic activity, matrix development, mature bone cell formation and new bone formation when used with autogenous graftsÖğe The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study(Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia, 2019) Laçin, Nihat; İzol, Bozan Serhat; Özkorkmaz, Ebru Gökalp; Deveci, Buşra; Tuncer, Cudi MehmetPurpose: To evaluate histologically and immunohistochemically the bone regeneration after application of simvastatin on tibial bone defects in rats. Methods: Sixty Wistar albino rats were divided into 3 groups as control (6 mm tibial bone defect), defect + graft (allograft treatment), and defect + graft + simvastatin (10 mg/kg/day) for 28 days. Results: Histopathological examination revealed inflammation in control group (defect group), congestion in blood vessels, and an increase in osteoclast cells. In defect + graft group, osteoclastic activity was observed and osteocyte cells were continued to develop. In defect + graft + simvastatin group, osteocytes and matrix formation were increased in the new bone trabeculae. Osteopontin and osteonectin expression were positive in the osteclast cells in the control group. Osteoblasts and some osteocytes showed a positive reaction of osteopontin and osteopontin. In defect + graft + simvastatin group, osteonectin and osteopontin expression were positive in osteoblast and osteocyte cells, and a positive expression in osteon formation was also seen in new bone trabeculae. Conclusion: The simvastatin application was thought to increase bone turnover by increasing the osteoinductive effect with graft and significantly affect the formation of new bone.Öğe Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats(Via Medica, 2020) Laçin, Nihat; İzol, Bozan Serhat; Gökalp Özkormaz, E.; Deveci, Buşra; Devecí, EnginBackground: This study presents the evaluation of the damage in the bone tissue resulting from a calvarial defect in rats and the efficiency of exposure to an ozone application with an alloplastic bone graft on the calvarial bone damage. Materials and methods: Wistar male rats (n = 56) were divided into four groups: a control group (n = 14), defect and ozone group (n = 14), defect and graft group (n = 14), and defect, graft, and ozone group (n = 14). Under anaesthesia, a circular full-thickness bone defect was created in all groups, and the experimental groups were further divided into two sub-groups, with 7 rats in each group sacrificed at the end of the 4th and 8th weeks. Bone samples were dissected, fixed in 10% formalin solution, and decalcified with 5% ethylene-diamine-tetraacetic acid (EDTA). After the routine follow-up on tissues, immunostaining of osteopontin and osteonectin antibodies was applied to sections and observed under a light microscope. Results: The control group exhibited osteopontin and osteonectin expression in fibroblasts and inflammatory cells at the end of the 4th week with an acceleration at the 8th week. Ozone administration elucidated new trabecular bone formation by increasing osteoblastic activity. Lastly, our observations underscore that a combination of allograft and ozone application increased the osteoblast, osteocyte, and bone matrix development at the 4th and 8th weeks. Conclusions: Exposure to an ozone application with an alloplastic bone graft on calvarial bone damage may induce osteoblastic activity, matrix development, mature bone cell formation, and new bone formation in rats. © 2020 Via MedicaÖğe Effects of formaldehyde on vascular endothelial growth factor, matrix metallopeptidase 2 and osteonectin levels in periodontal membrane and alveolar bone in rats(Via Medica, 2019) Laçin, Nihat; İzol, Bozan Serhat; Tuncer, Cudi Mehmet; Özkorkmaz, Ebru Gokalp; Deveci, Buşra; Deveci, Enginackground: The objective of this study was to investigate whether long term formaldehyde inhalation may affect periodontal membrane and alveolar bone loss leading to periodontitis. The negative effects of formaldehyde were described using vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP-2) and osteonectin antibodies involved in the extracellular matrix and angiogenetic development. Materials and methods: Thirty adult Wistar albino rats were used in this study. Rats were divided into two groups: a control group (n = 15) and formaldehyde administered group (n = 15). Formaldehyde group was exposed to inhalation of 10 ppm formaldehyde 8 hours a day, 5 days a week for 5 weeks. Maxillary bone regions were dissected under anaesthesia. After fixation in 10% formaldehyde solution, tissues were passed through graded ethanol series to obtain paraffin blocks. Five-micrometre histological sections were cut with RM2265 rotary microtome stained with Masson trichrome and VEGF, MMP-2 and osteonectin antibodies for examination under Olympus BH-2 light microscopy. Results: The present study revealed that congestion in blood vessels, degeneration of collagen fibres and alveolar matrix around alveolar bone were observed to be more significant in formaldehyde group than the control group (p ≤ 0.001). Interestingly, VEGF expression in the formaldehyde group was the most significant finding between the two groups (p < 0.001). When compared inflammation, MMP-2 and osteonectin expressions were significant (p < 0.01) in the formaldehyde group. Conclusions: It was suggested that formaldehyde toxicity decreased the expression of MMP-2 and in osteoblasts as well as affecting the retention of MMP levels in tooth cavity, which is very low in collagen fibres. But, vice versa for the expression of VEGF in dilated vascular endothelial cells and osteocytes in alveolar bone. As a conclusion, formaldehyde disrupts the periodontal membrane and may cause collagen fibres degeneration by affecting the alveolar bone matrix.Öğe Eroziv liken planusun oral bulguları: Bir olgu sunumu(Dicle Üniversitesi Tıp Fakültesi, 2007) Kaya, Filiz Acun; Sarıbaş, Ebru; Başkan, S. Zelal; İzol, Bozan Serhat; Kılınç, NihalEroziv liken planus, oral liken planusun hastaya en çok rahatsızlık veren formudur. Hastaların yeme, içme ve konuşma gibi fonksiyonları ciddi şekilde etkilenir. Deride ve mukozada lezyonlara neden olan hastalığın etiyolojisi çok iyi bilinmemekte ve otoimmünite suçlanmaktadır. Bu olgu sunumunda, Dicle Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalına başvuran 51 yaşındaki bir bayan hastanın oral bulguları rapor edilmiştir. Ekstraoral ve intraoral muayeneleri yapılmış, kesin tanı biyopsi ile konmuştur. Hastaya dermatoloji kliniğinde sistemik kortikosteroid tedavisi uygulanmıştır. Periodontal tedavileri yapıldıktan sonra da protetik restorasyonları yapılarak, fonksiyon, fonasyon ve estetik gereksinimler sağlanmıştır. Hastanın periyodik takiplerine devam edilmektedir.Öğe Evaluation of the effect of EDTA on root coverage at free gingival graft procedure(Uluslararası Diş Araştırmaları Birliği, 2018) İzol, Bozan Serhat; İpek, Fikret; Öner, Devrim Deniz; Arpağ, Osman FatihAim: The present study was designed to compare the effect of root surface biomodification with ethylenediaminetetraacetic acid (EDTA) for the treatment of buccal gingival recession using the free gingival graft (FGG) technique.Methodology: In this randomized controlled parallel clinical trial, 34 patients with 40 teeth with Miller Class I and Class II gingival recessions were treated using FGG. The 40 teeth with recessions were assigned randomly to receive FGG with or without the application of EDTA gel. On pre-treatment (Day 0) and at 3-months and 6-months post-treatment, the following parameters were measured: gingival recession height (GRH), gingival recession width (GRW), probing pocket depth (PD), clinical attachment level (CAL), and width of keratinized tissue (WKT).Results: In the FGG+EDTA group, statistically significant changes from baseline were found: GRH decreased from 4.71.5 mm to 1.31.2 and WKT increased from 0.90.9 mm to 5.51.8 mm. In the FGG group, GRH decreased from 4.61.3 mm to 1.31.2 mm and WKT increased from 0.90.7 mm to 5.41.5 mm. For the FGG and FGG+EDTA groups, averagerootcoveragewasfoundtobe74.14%and69.26%, respectively.Conclusions: Thedatademonstratedthattherootsurface biomodification agent, EDTA, had no beneficial effect on root coverage.Öğe Lokalize dişeti çekilmelerinin serbest dişeti grefti ile tedavisine ek olarak EDTA kullanımının klinik etkilerinin incelenmesi(2017) İzol, Bozan Serhat; İpek, FikretBu çalışmada amacımız kök yüzey biyomodifikasyonu olarak kullanılan EDTA’nın bukkal dişeti çekilmelerinin serbest dişeti grefti ile tedavisi üzerine olan etkisini araştırmaktır. Bu rasgele, kontrollü paralel klinik çalışmada, 34 hastadaki mevcut 40 adet dişteki Miller Sınıf I ve Sınıf II dişeti çekilmesi SDG ile tedavi edilmeye çalışıldı. 40 diş rasgele iki grubu ayrılarak bir gruptaki dişlere kök yüzeylerine EDTA diğer gruptaki dişlerin kök yüzeyine ise herhangi bir materyal uygulanmadı. Tedavi öncesi(0.gün) ve tedavi sonrası 3. ve 6. aylardaki DÇY, DÇG, SCD, KAS ve KDG ölçüldü. Tedavi sonrası ağrı düzeyleri, creeping ataşman seviyeleri ve kök kapanma yüzdeleri değerlendirildi. Tedavi sonrası EDTA uygulanan grupta DÇY 4.7?1.5 mm’den 1.3?1.2 mm’ye gerilerken, KDG ise 0.9?0.9 mm’den 5.5?1.8 mm’ye yükseldi. EDTA uygulanmayan grupta ise DÇY 4.6?1.3 mm’den 1.3?1.2 mm’ye gerilerken, KDG ise 0.9?0.7 mm’den 5.4?1.5 mm’ye yükseldi. Ortalama kök yüzey örtülmesi EDTA uygulanan grupta %69.25, EDTA uygulanmayan grupta ise %74.12 olarak tespit edildi. Gruplar arasında DÇY ve KDG kıyaslanmasında istatistiksel olarak anlamlı bir fark görülmedi. Gruplar arasında creeping ataşman, KAS ve SCD değerleri açısından anlamlı bir fark tespit edilemedi. Elde edilen bu veriler ışığında kök yüzey modifikasyon ajanı olan EDTA’nın kök yüzeyin örtülmesine katkısı olmadığı sonucu elde edilmiştir. Anahtar kelime; Dişeti çekilmesi, serbest dişeti grefti, EDTA, kök yüzeyinin örtülmesi
