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Öğe Analysis of lumbar disc degeneration: 82 cases(İnönü Üniversitesi Tıp Fakültesi, 2019) Özevren, Hüseyin; Çetin, Abdurrahman; Baloğlu, MuratAim: The purpose of this study was to investigate if the grade of lumbar disc degeneration. Intervertebral disc degeneration is a common degenerative disease. Material and Methods: A retrospective analysis on 34 males and 48 females with intervertebral discs degeneration and a mean age of 51.5 years. Using MRI, the grade of lumbar intervertebral discs degeneration was assessed according to the Pfirrmann classification. Results: There was a high correlation (R =0.385) and significant association (pearson correlation, p < 0.01) between L3/L4 disc degeneration and the aging. There was also a high correlation (R =0.56) and significant association (pearson correlation, p <0.001) between the L3/L4 disc degeneration and the L4/L5. Conclusion: For many years, excessive or abnormal mechanical load was thought to be the main cause of disk degeneration. Rates of aging and lumbar disc degeneration have gradually increased over the years. It is important to note that there is a significant relationship between aging and L3 / L4 disc degeneration and that L4 / L5 disc degeneration may also be present in patients with L3 / L4 disc degeneration.Öğe Assessment relationship between the femoral artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: an experimental study(Springernature, 2022) Çetin, Abdurrahman; Özevren, Hüseyin; Arslan, Remzi; Yektaş, Abdulkadir; Aydın, Mehmet DumluStudy design Animal proof of principle study. Objectives To investigate neurodegeneration in rabbit L4-dorsal root ganglion (DRG) cells by creating experimental spinal subarachnoid hemorrhage (SAH), we aimed to show the neuronal pathway between L-4-DRG and femoral artery. Setting Ataturk University, Medical Faculty, Animal Laboratory, Erzurum, Turkey. Methods This study was designed on 20 rabbits, which were randomly divided into three groups: Spinal SAH (n = 8), SHAM (n = 6), and control (n = 6) groups. Animals were followed for 20 days and then killed. Vasospasm index values of the femoral artery and neuron density of L-4-DRG were analyzed. Results The number of degenerated neurons in DRG was higher in the spinal SAH than the control and SHAM groups (p < 0.001). But, the difference between the control group and the SHAM group was not significant. Normal neuron densities were significantly lower in the spine SAH group compared to the SHAM and the control groups. There was a statistically significant increase in vasospasm index values of the spinal SAH group compared to the other two groups (p < 0.001). Conclusions Decreased volume of the femoral artery lumen was showed in animals with spinal SAH compared with control and SHAM groups. Increased degeneration of the L-4 dorsal root ganglion in animals with spinal SAH was also demonstrated. Our findings might shed light on the planning of future experimental studies and evaluating the clinical relevance of such studies.Öğe Clinical and morphological evaluation of odontoid fractures of C2 vertebra(Society of TURAZ BİLİM, 2020) Çetin, Abdurrahman; Hattapoğlu, Salih; Özevren, HüseyinThere have not been enough studies on cervical vertebra-2 (C2) odontoid fracture and their clinical and radiological evaluation. This study was designed to determinethe proportions of the C2 odontoid fracture types and to determine the specific incidence of fracture types according to age and gender and to evaluate them clinicallyand with cervical spine computed tomography (CT) sections of each case. We retrospectively reviewed 32 cases of C2 odontoid fractures admitted to our clinic betweenJanuary 2013 and March 2017. There were C2 odontoid fracture [15 (46.9%) male and 17 (53.1%) female] who were referred to the neurosurgical clinic. The mean agewas 38.5 (2-87). The most frequent reasons for application were in-vehicle traffic accidents 18 (56.3%), fall 6 (18.8%), outside-vehicle traffic accidents 4 (12.5%), assault3 (9.4%), breast Ca. 1 (3.1%) due to metastasis. In terms of odontoid fracture types; Type I 4 (12.5%), Type II 23 (71.9%), Type III was 5 (15.6%). 13 (40.6%) anterior, 7(21.9%) posterior and 12 (37.5%) nondeplase were applied for odontoid fracture displacement in our cases. Pain and tenderness in the neck region of 29 patients (90.6%)were present in C2 odontoid fractured patients who applied to our clinic, while 3 (9.4%) patients presented with hemiparesia. The Frankel scale of these patients; 1 patient(3.1%) applied with B, 2 (6.3%) with D, 29 (90.6%) with E scale. Odontoid fractures do not always come to us with spinal cord damage, often the initial sign may beonly neck pain. In such cases, odontoid fractures can be easily misdiagnosed and can result in morbidity and mortality, which is a major problem. The aim of our studyis to draw attention to the importance of this issue by evaluating the existing data on odontoid fractures in many aspects, which are not enough studies in the literature.Öğe Deneysel omurilik yaralanmasında metilprednizolon ve eritropoetin birlikteliğinin etkinliği(2016) Çetin, Abdurrahman; Ceviz, Adnanİskeminin sonrası dokuda serbest radikaller birikerek omurilikte hasarının oluşmasında önemli rol oynamaktadır. Metilprednizolon potent bir fipidperoxidasyon inhibitörüdür, ama Braughler ve arkadaşlarının yaptıkları çalışmada travmatik spinal kord da metilprednizolonun yeterli doku konsantrasyonuna ulaşamadığı görülmüştür p?). Yapılan çalışmalarda Eritropoietin'in antioksidan, antienflamatuvar(io7,i25) ve vazodilatatör (us) etkisinin olduğu görülmüştür. Biz yaptığımız çalışmada Eritropoietin ile metilprednizolon'un biyoyararlanımını arttırabilir miyiz sorusuna cevap aradık. Çalışmamızda iki parametreye baktık 1 -Ratlarm nöromotor(swimming testi ile) yanıtı 2- Histopatolojik inceleme yapıldı. Yaptığımız çalışmada 48 adet rat kullanıldı. Nörolojik fonksiyon tesetlerinden sonra histopatolojik inceleme yapıldı. OY, anevrizma küp modeli ile oluşturuldu. İşlem sonunda bütün ratlarm paraplejik olduğu gözlendi. Kör olarak, kontrolgrubu, metilprednizolon grubu, EritropoietinlOOOi.ü./kg tek doz, Eritropoietin 1 000i. ü./kg üç doz, Eritropoietin 1 000i. ü./kg tek doz + Metilprednizolon, ve Eritropoietin 1000i. ü./kg üç doz + Metilprednizolon grupları oluşturuldu. Yaptığımız çalışmada Eritropoietin 1 000i. ü./kg tek dozda intraperitoneal Eritropoietin 1 000i. ü./kg üç dozda intraperitoneal olarak verildi. Metilprednizolon 30 mg / kg bolus, 5.4 mg / kg sekiz saat boyunca verildi. İşlem sonucunda diğer dört grubun skorları, kontrol grubundan istatiksel olarak anlamlı olduğu gözlendi.. Yaptığımız çalışmada kontrol grubu ile Metilprednizolon grubunu değelendirdiğimizde ortaya çıkan fark istatiksel açıdan anlamlı bulunmuştur. ( P<0,01 )Nöromotor fonksiyon testleri (swimming testi ile)sonuçlarma göre; Kontrol grubu ile Eritropoetin 1000 ünite grubunu değerlendirdiğimizde ortaya çıkan fark istatiksel olarak anlamlı bulunmuştur. ( P<0,01 ) Kontrol grubu ile Eritropoetin 3000 ünite grubunu değerlendirdiğimizde ortaya çıkan fark istatiksel olarak anlamlı bulunmuştur. ( P<0,01 ) Kontrol grubu ile Eritropoetin 1000 ünite + Metilprednizolon grubunu 51 değerlendirdiğimizde ortaya çıkan fark istatiksel olarak anlamlı bulunmuştur. (P<0,01) Kontrol grubu ile Eritropoetin 3000 ünite + Metilprednizolon grubunu değerlendirdiğimizde ortaya çıkan fark diğer gruplardan istatiksel olarak anlamlı bulunmuştur. (P<0,01) Bu durum, Eritropoetin 3000 ünite+ metilprednizolon birlikteliğinin omurilik zedelenmesi sonucu oluşan nörolojik fonksiyon kaybının anlamlı derecede düzeldiğini gözlemledik., mevcut çalışmamızın devam edecek çalışmalar ile desteklenmesi gerektiğini düşünmekteyiz.Öğe Effects of lumbosacral angles on development of low back pain(Journal Of Musculoskeletal Pain, 2014) Çağlayan, Mehmet; Tacar, Orhan; Demirant, Ayda; Oktayoğlu, Pelin; Karakoç, Mehmet; Çetin, Abdurrahman; Em, Serda; Bozkurt, Mehtap; Uçar, Demet; Nas, KemalObjective: Low back pain [LBP] is an important health issue due the diagnosis and treatment expenses and loss of workforce it leads to. Biomechanical changes in the vertebral column caused by changes in the lumbosacral angles [LSAs] may lead to LBP. The purpose of this study was to assess body mass index [BMI] and LSAs in patients with LBP and investigate the association between LBP, LSAs and BMI. Methods: Lumbar lordotic angle [LLA], LSA, sacro-horizontal angle [SHA] and sacral inclination angle [SIA] were measured in 117 patients with chronic LBP and 85 healthy normal controls [HNCs] by means of lumbosacral radiography. In addition, association between LSAs, BMI and LBP was investigated. Results: There were no significant differences between patients and HNCs regarding LSAs and BMI. LLA was lower in male patients with LBP compared to male HNCs without LBP [p = 0.013]. In addition, SIA [p = 0.002] and BMI [p = 0.006] were higher in female patients with LBP compared to male patients with LBP. It was found that an increase in LLA increased the risk of having LPB by approximately 1.04-folds [ranging from 1.01 to 1.08; p = 0.045]. On the other hand, no association was found between LSAs and BMI. Conclusion: Changes in LSAs may cause LBP. An increase in LLA may be influential in increasing the risk of LBP. Therefore, measurement of LSAs may guide the physician who is to make clinical decisions in examination of patients with LBP.Öğe Evaluation of PECAM-1 and p38 MAPK expressions in cerebellum tissue of rats treated with caffeic acid phenethyl ester: A biochemical and immunohistochemical study(Via Medica, 2019) Çetin, Abdurrahman; Deveci, EnginBackground: This study aimed to investigate the antioxidative and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on damage caused to cerebellum tissue by diffuse traumatic head trauma via biochemical, histopathologic, and immuno-histochemical methods. Materials and methods: Male Sprague-Dawley (300–350 g) rats were subjected to traumatic brain injury with a weight-drop device (300 g/1 m weight-height impact). Twenty-four adult rats were randomly divided into three equal groups of 8, including a control group, traumatic brain injury (TBI) group, and TBI + CAPE treatment group (10 μmoL/kg/i.p.). Cerebellum tissue samples taken from anterior lobe from all rats were taken 7 days after traumatic injury and were subjected to biochemical and histopathological analysis, as well as immunohistochemical analysis for platelet endothelial cell adhesion molecule-1 (PECAM-1) and phosphate 38-mitogen-activated protein kinase (p38 MAPK). Results: In the TBI group, the granular layer had dilatation and haemorrhage in the capillary vessels and inflammatory cell infiltration around the periphery of the blood vessels. In the TBI + CAPE group, the small capillaries in the white matter were slightly dilated, there were no inflammatory cells, and dense chromatin/ granular cells were observed in the granular layer. Also in the TBI + CAPE group, the Purkinje cells of the ganglion cell layer had ovoid nuclei, were chromatin-rich, and their extensions protruded to the molecular layer. CAPE is thought to regulate inflammation, cell damage, and angiogenetic development by affecting the PECAM-1 and p38 MAPK proteins. Conclusions: These proteins are key modulators of endothelial integrity and neuroinflammation in vessels in response to endothelial damage as well as of the proinflammatory response in the cerebellum in response to traumatic damage.Öğe Expression of vascular endothelial growth factor and glial fibrillary acidic protein in a rat model of traumatic brain injury treated with honokiol: A biochemical and immunohistochemical study(Via Medica, 2019) Çetin, Abdurrahman; Deveci, Enginackground: Traumatic brain injury (TBI) leads to neuronal damage and neurological dysfunction. The aim of our study was to investigate the antioxidative effect of honokiol on TBI in rats with biochemical, histopathological and immunohistochemical methods. Materials and methods: Sprague-Dawley rats were subjected to TBI with a weight-drop device using 300 g/1 m weight/height impact. Forty-five rats were divided into three groups as control group, TBI group and TBI + honokiol group (5 mg/kg/day, i.p.). Honokiol (5 mg/kg) dissolved in dimethyl sulfoxide (DMSO) was intraperitoneally administered to rats for 7 days after the trauma. At the end of experiment, blood samples were taken from the animals and analysed with various biochemical markers. Results: Histopathological examination of the trauma group revealed some degenerated pyramidal cells, dilatation and congestion in blood vessels, hyperplasia in endothelial cells, inflammatory cell infiltration around the vein and disruptions in glial extensions. In TBI + honokiol group, pyramidal neurons showed a decrease in degeneration, slight dilatation in blood vessels, improvement of endothelial cells towards the lumen, and reduction of inflammatory cells in the vessel. In TBI + honokiol group, vascular endothelial growth factor expression was positive in the endothelial and few inflammatory cells of the mildly dilated blood vessels. In the blood brain barrier deteriorated after trauma, it was observed that the glial foot processes were positive expression and extended to the endothelial cells in the TBI + honokiol group. Conclusions: Glial fibrillary acidic protein expression showed a positive reaction in these processes. Considering the important role of antioxidants and inflammatory responses in cerebral damage induced by traumatic head injury, honokiol is thought to be important in decreasing lipid peroxidation, protecting the membrane structure of blood brain barrier, degeneration of neurons and glial cells. CopyrightÖğe Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis(Via Medica, 2019) Baloǧlu, Murat; Çetin, Abdurrahman; Tuncer, Cudi MehmetBackground: This examination was performed to research the advantage of the antioxidant impact of Potentilla fulgens on spinal cord injury (SCI) in rats. Materials and methods: In the SCI model of this examination, the tolerably serious lesion was performed at the L1–L2 spinal segmental level. SCI animals were given P. fulgens 400 mg/kg/day, intraperitoneally. At 7 days post-lesion, exploratory rats were executed after intraperitoneal administration 7 ketamine HCL (0.15 mL/100 g body weight). Spinal cord specimens were taken for histological examination or assurance of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) action. SCI caused a remarkable decline in spinal cord GSH content, trailed by noteworthy increments in MDA levels and MPO action. Results: Degenerative changes in some multipolar and bipolar nerve cells and pyknotic changes in the nuclei of glial cells were likewise noticed. Remarkable development was seen in cells and vascular structures of P. fulgens treated groups when contrasted with untreated groups. Conclusions: Potentilla fulgens application may influence angiogenetic improvement in vein endothelial cells, reduce inflammatory cell aggregation by influencing cytokine system and may make apoptotic nerve cells and neuroprotective component in glial cells.Öğe Relation of neural tube defects with folic acid use during pregnancy(İnönü Üniversitesi Tıp Fakültesi, 2019) Çetin, Abdurrahman; Gökdemir, Mehmet Tahir; Nas, Cemal; Gökdemir, Gül ŞahikaAim: The objective of this study was to investigate the rate of neural tube defects (NTD) and the clinical features of newborns of mothers who did not use folic acid (FA) in their pregnancies. Material and methods: The data of a total of 82 newborns, who were diagnosed with meningomyelocele were operated and examined, retrospectively. The newborns were divided into two groups depending on whether their mothers used FA during pregnancy or not. Results: The mothers of 37 (45.1%) newborns used FA during the antenatal period, whereas those of 45 (54.9%) newborns did not. The mean birth weight of the newborns whose mothers did not use FA were lower. Furthermore 9 (25%) newborns whose mothers did not use FA were delivered via cesarean section.The incidence of meningomyelocele was 80% for 45 newborns with NTDs whose mothers did not use FA. Conclusion: Our results revealed that the mean birth weight was lower while the incidence of meningomyelocele was significantly higher in newborn infants whose mothers did not use FA.
