Yazar "Çelen M.K." seçeneğine göre listele

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    Anti-tuberculosis drug resistance in southeast of turkey
    (Acta Medica Mediterranea, 2013) Dal T.; Özcan N.; Tekin R.; Tekin A.; Çelen M.K.; Özekinci T.
    Objective: Tuberculosis is a globally prevalent life-threatening infectious disease. In this study we aimed to evaluate antibiotic suscebtibility rates of Mycobacterium tuberculosis complex strains. Materials and methods: A total of 150 culture-positive samples were included in. Among culture positive samples 86 were Mycobacterium tuberculosis complex and 64 were non-tuberculous mycobacterium. Of Mycobacterium tuberculosis complex isolated samples 45 were Ziehl-Neelsen positive. Of 64 non-tuberculous mycobacterium isolated samples 15 were Ziehl-Neelsen positive. Mean age of the patients with tuberculosis was 37.74±20.53 and non-tuberculous mycobacterium isolated patients was 46.80±23.32. Antibiotic susceptibility testing was performed for the four first-line anti-tuberculosis drugs by BACTEC MGIT-960 instrument (Becton Dickinson). Of M. tuberculosis strains 41 % was resistant to at least one or more of the drugs (isoniasid 27.9%, ethambutol 8.13%, streptomycin 12.79 %, rifampicine 9.3 %). Of the strains 5.8 % was resistant to two, 3.4 % to three and 3.4 % to four drugs. Conclusion: Mycobacterium tuberculosis complex and drug resistance of this microorganism continued to be a problem for our country and non-tuberculous mycobacterium species may become a problem in the future. We thought that a strong and costeffective tuberculosis control programme contributes to reduce the incidence of drug resistance in the community.
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    Effectiveness of "media mediated information and awareness project of hepatitis b" on diagnosis, monitoring and treatment of hepatitis B
    (Acta Medica Mediterranea, 2013) Dal T.; Çelen M.K.; Ulaş S.; Çelik Y.
    Background: Incidence of hepatitis B is 8-12% in Southeastern Anatolia Region of Turkey. In Diyarbakir, Batman, Siirt, Mardin, which are residential areas with a population of 2.2 million, 95000-144000 persons are suffering from this infectious disease. We aimed to increase the awareness of the public about Hepatitis B through the media, to monitor the impact of this disease on patients, and to determine prevention and treatment strategy. Methods: In four cities, 12 television programs lasting about 60-90 minutes, have been broadcasted 60 days apart between 01.01.2010-31.12.2011. At the same time, in a local newspaper, which was read in the whole region, a corner of hepatitis B formed and different topics, opinions, problems, and wrong treatment methods were discussed in, one day a week. Results: Admission of Diyarbakir patients to Dicle University Hospital was increased by 19% and Batman patients was increased by 23%. A significant difference (p <0.028) was observed in the number of patients admitted to the infectious diseases clinic for hepatitis B, between the years 2009-2011. Conclusion: Continuous media programs, especially in areas with low levels of socioeconomic status will be effective in diagnosis of new cases, monitoring and treatment, preventing of disease, and preventing of the spread.
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    Efficiency of treatment of long period pegile-interferon in delta hepatitis
    (2010) Tekin R.; Ayaz C.; Çelen M.K.
    Despite all, it's treatment is still uneffective and has few alternatives. There is no more alternative utility treatment way except interferons in hepatitis delta infection. Twenty one naive patients with chronic hepatitis delta were included to this study. The patients were arranged in two groups. First group contains 11 patients who received PEG-IFN-?-2a for 1 year, and second group contains 10 patients who received PEG-IFN-?-2a for 2 years. We ascertained the effects of the treatment on liver function tests, virologic parameters and changes in liver histopathology. HDV-RNA became negative in 2 patients in first group (18%), and 3 patients in second group (30%). This negativeness continued up to 24th week after treatment had ended both of two groups. Post-treatment serological response, biochemical response, and histological response was no significant differences in statistically (p>0.05). In conclusion, PEG-IFN-?-2a treatment for two years has more superiority than one year treatment. Limitted number of patients in our study suggests other studies and treatment options for large series in the future.
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    The evaluation of cultures of endotracheal aspirates and isolated bacteria in the diagnosis of ventilator-associated pneumonia
    (Duzce University Medical School, 2011) Uluğ M.; Çelen M.K.; Geyík M.F.; Hoşoğlu S.; Ayaz C.
    Aim: The aim of this study was to determine the ventilator-associated pneumonia (VAP) agents in isolates from endotracheal aspirate samples obtained from patients in intensive care unit (ICU) on mechanical ventilation and their susceptibility to several antibiotics. Material and Methods: Patients that received mechanical ventilation for longer than 48 hours in the ICU were diagnosed as VAP with the clinical and microbiological criteria, were enrolled in this study. Bacteria isolated from the endotracheal aspiration samples of them were identified by conventional methods and Sceptor systems, and their antibiotic susceptibilities were investigated by the National Committee for Clinical Laboratory Standards (NCCLS). Findings: A total of 72 patients were involved in this study and 84 strains were isolated. Among these patients, 12 (14.3%) had polymicrobial etiologic agent. Most commonly encountered microorganisms were Pseudomonas aeruginosa, Staphylococcus aureus and Acinetobacter spp., respectively. Most of the Gram-negative bacteria were susceptible to imipenem, amikacin and ciprofloxacin. Although methicillin resistant S. aureus rate was found %100, glycopeptides resistance was not found. It was determined that 58 (92%) of the Gram-negative bacteria produced ESBL. Results: As a result, VAP is an important and frequently seen infection in ICU. High resistance rates for antibiotics suggested that the treatment of the empirical antibiotics recommended for VAP cases should be updated according to the surveillance data. © 2011 Düzce Medical Journal.
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    The evaluation of geriatric infections: Dicle experience
    (2010) Ulu? M.; Çelen M.K.; Geyik M.F.; Hoşo?lu S.; Ayaz C.
    • Objective: Although successes have been achieved in the treatment of the infectious diseases with antibiotics in nowadays, infectious diseases are still serious problem in the elderly. This study was conducted in order to determine the pattern of clinical infectious diseases in hospitalized elderly patients. • Material and Method: In this study, the data of all elderly patients aged 65 and older, were hospitalized to our clinic between May 2000 and May 2005 were evaluated retrospectively. We reviewed 301 patients for diagnostic studies, risk factors, isolated microorganisms and morbidity and mortality rates. • Results: Infections as a cause of hospitalization were identified as the following frequency; sepsis (19.2%), pneumonia (17.9%), acute gastroenteritis (16.9%), acute bacterial meningitis (5.3%) and urinary tract infection (3.6%), respectively. E. coli was the most isolated microorganism in these patients. Hypertension, chronic obstructive pulmonary disease and diabetes were seen as risk factors in our patients. Seventy-three patients died during hospital stay due to their infection and chronic diseases. • Conclusion: Under diagnosis of the elderly diseases is very common due to many factors related to elderly, family members and health workers. Prognosis is rather worse especially in sepsis due to pneumonia and urinary tract infections.
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    The evaluation of gram negative bacilli isolated from inpatiens and its antibiotic resistance
    (2010) Özmen E.; Geyik M.F.; Ulu? M.; Çelen M.K.; Hoşo?lu S.; Ayaz C.
    Aim: Resistance to gram negative bacilli is increasing all over the world. In this study, the resistance of gram negative bacilli, which were isolated from inpatients, was evaluated for selected antibiotics. The aim of this study was to acquire the significant results for empiric therapy. Material and Method: Eight hundered ninety eight strains which were isolated from inpatients were investigated between May 2003 and April 2005 from clinical speciments at Dicle University Hospital, Diyarbakir. The microdiluation test was used to determine for antibiotics resistance. Findings: Escherichia coli (n=282), Enterobacter spp. (n=215), Pseudomonas aeruginosa (n=101), Klebsiella spp. (n=95), Stenotrophomanas maltophilia (n=69) and Acinetobacter spp. (n=52) were the most frequent isolates. The resistance ratio among whole isolates against ceftriaxone was 73%, cefotaxime 68%, ceftazidime 63%, trimetoprim/sulfamethoxazole 60%, ciprofloksasin 51%, amikasin 20%, imipenem 3% and meropenem 2%. The resistance to the third generation cephalosporins, trimetoprim/sulfamethoxazole and ciprofloxacin was found higher than other antibiotics in this study. Results: In conclusion, antimicrobial resistance must be monitored for each hospital for a reasonable empirical antibiotic therapy. Surveillance studies might be useful for empirical treatment approach. © 2010 Düzce Medical Journal.
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    The importance of fusidic acid in the treatment of chronic osteomyelitis
    (2009) Ulu? M.; Ayaz C.; Çelen M.K.
    In recent years, high resistance to antibiotics used for staphylococci infections causes problems in the treatment. The aim of this study was to investigate the susceptibilities of staphylococcus strains which were isolated in bone tissue and sinus-tract specimens of chronic osteomyelitis (COM) that were seen in our hospital against fusidic acid, vancomycin and teicoplanin that were also recommended as treatment of staphylococci infections. Disk diffusion method was used for in vitro susceptibility testing. In this study, 41 Staphylococcus aureus and 12 coagulase-negative staphylococci strains isolated from bone tissue and sinus-tract were investigated. The rates of resistance to fusidic acid were 4.3% in methicillin-sensitive S. aureus, 16.7% in methicillin-resistant S. aureus, 0% in methicillin-sensitive coagulase-negative staphylococci and 36% in methicillin-resistant coagulase-negative staphylococci. There were no resistance to vancomycin and teicoplanin in none of the strains. The high sensitivity of staphylococci strains to fusidic acid indicates that fusidic acid is a good alternative for the treatment of COM caused by staphylococci.
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    Nasopharyngeal carcinoma in the etiology of fever of unknown origin
    (2010) Ulu? M.; Çelen M.K.; Geyik M.F.; Tekin R.; Ayaz C.
    Fever of unknown origin is defined as a temperature higher than 38.3°C lasting three weeks or longer and not beind diagnosed even after one week of study in-hospital settings. Infections and malignancies had been the most common causes of fever of unknown origin overall. Nasopharyngeal carcinoma, constituting less than 0.03% of all malignant tumors and only 2% of all head and neck cancer. Ebstein Barr virus infection consumption of smoked and salted fish and vitamin-C deficient diet have been blamed in its etiology. In this study,we present two cases who were admitted to our clinic with fever of unknown origin initially and later diagnosed with nasopharyngeal carcinoma atypically progressing.
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    The prevalence and epidemiological characteristics of hepatitis B virus and hepatitis C virus coinfection in Turkey
    (Turkiye Klinikleri, 2013) Aygen B.; Çelen M.K.; Köksal I.; Tosun S.; Karabay O.; Yamazhan T.; Yildiz O.
    We aimed to determine prevalence and epidemiological characteristics of cases coinfected with hepatitis B virus (HBV)/hepatitis C virus (HCV) in Turkey. Material and Methods: The data for this study was obtained from Turk-Hepatitis Registry (HEP-NET) Project, which includes real-life cohort of hepatitis patients from 15 centers in Turkey, and is supported by Viral Hepatitis Society. In the project, 10,165 hepatitis cases were evaluated in 10 hospitals. Results: According to initial visit results, HBV/HCV coinfection was detected in 99 patients. The ratio was 974/100 000. The mean age of the cases was 40.9+21.7 years, 56.6% of them were males and 43.4% were females,. The major risk factors were dental therapy, any surgical procedure, hemodialysis and blood transfusion. The mean alanine aminotransferase (ALT) levels were 70.9±49.1 IU/L in coinfected patients. In 12% of cases HBeAg was positive. The median HCV RNA level was found 0 IU/mL (minimum: 50-maximum: 2.18x107 IU/mL), and the median HBV DNA level was found 2.50x102 IU/mL (minimum: 12-maximum: 1.70x108 IU/mL). In 8.1% of the patients both HCV RNA and HBV DNA were positive, and in 87.5% of cases HCV infection was dominant. The most important risk factor was hemodialysis (25%) in this group. Conclusion: This is the most detailed study which evaluates the prevalence of HBV/HCV coinfection in Turkey. HBV/HCV coinfection prevalence was not higher than HBV or HCV monoinfections. In cases where both HCV RNA and HBV DNA were positive, HCV was predominant. © 2013 by Türkiye Klinikleri.
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    Tenofovir disoproxil fumarate treatment in HbeAg-positive patients
    (EDIMES Edizioni Medico Scientifiche, 2015) Ayaz C.; Çelen M.K.; Dal T.; Deveci Ö.; Bayan K.; Mert D.; Oruç E.
    Tenofovir disoproxil fumarate (Tenofovir DF) is a nucleotide analogue. This multicentre study reports retrospectively the long-term efficacy and safety data with tenofovir DF treatment in nucleosid(t)e-naive, hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients. Thirty-one patients (11 females, 20 males) received 245 mg tenofovir DF per diem. All patients’ initial serum hepatitis B virus (HBV) DNA levels were over 2,000 IU/ml. Serum alanine aminotransferase (ALT) levels, HBeAg, hepatitis B e antibodies (anti-HBe), hepatitis B surface antigen (HBsAg), hepatitis B surface antibodies (Anti-HBs), HBV DNA, creatinine and urea levels were evaluated at baseline, and at weeks 12, 24, 48 and 96 during therapy. Thirtyone patients completed 96 weeks of treatment. Mean age was 37.6±9.4 years. The initial mean value of ALT was 79±39.9 IU/L. At baseline, mean of fibrosis (Ishak) of liver biopsies was 2.3±0.7. Two of the patients (5.9%) achieved HBV DNA<300 copy at week 12 of treatment and 97.1% at week 96. HBeAg loss was observed in 6.7% of patients. At week 96, HBsAg loss was not observed in any of the patients. Mean ALT at week 48 was 32.7 U/L, at week 96 32.6 U/L. Renal safety was good. Creatinine remained stable. Tenofovir DF was well tolerated and produced potent, continuous viral suppression with increasing HBeAg loss. © 2015, EDIMES Edizioni Medico Scientifiche. All rights reserved.