Efficiency of treatment of long period pegile-interferon in delta hepatitis
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Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Despite all, it's treatment is still uneffective and has few alternatives. There is no more alternative utility treatment way except interferons in hepatitis delta infection. Twenty one naive patients with chronic hepatitis delta were included to this study. The patients were arranged in two groups. First group contains 11 patients who received PEG-IFN-?-2a for 1 year, and second group contains 10 patients who received PEG-IFN-?-2a for 2 years. We ascertained the effects of the treatment on liver function tests, virologic parameters and changes in liver histopathology. HDV-RNA became negative in 2 patients in first group (18%), and 3 patients in second group (30%). This negativeness continued up to 24th week after treatment had ended both of two groups. Post-treatment serological response, biochemical response, and histological response was no significant differences in statistically (p>0.05). In conclusion, PEG-IFN-?-2a treatment for two years has more superiority than one year treatment. Limitted number of patients in our study suggests other studies and treatment options for large series in the future.
Açıklama
Anahtar Kelimeler
Hdv, Peginterferon, Treatment
Kaynak
Anatolian Journal of Clinical Investigation
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
4
Sayı
4
