The importance of fusidic acid in the treatment of chronic osteomyelitis
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Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In recent years, high resistance to antibiotics used for staphylococci infections causes problems in the treatment. The aim of this study was to investigate the susceptibilities of staphylococcus strains which were isolated in bone tissue and sinus-tract specimens of chronic osteomyelitis (COM) that were seen in our hospital against fusidic acid, vancomycin and teicoplanin that were also recommended as treatment of staphylococci infections. Disk diffusion method was used for in vitro susceptibility testing. In this study, 41 Staphylococcus aureus and 12 coagulase-negative staphylococci strains isolated from bone tissue and sinus-tract were investigated. The rates of resistance to fusidic acid were 4.3% in methicillin-sensitive S. aureus, 16.7% in methicillin-resistant S. aureus, 0% in methicillin-sensitive coagulase-negative staphylococci and 36% in methicillin-resistant coagulase-negative staphylococci. There were no resistance to vancomycin and teicoplanin in none of the strains. The high sensitivity of staphylococci strains to fusidic acid indicates that fusidic acid is a good alternative for the treatment of COM caused by staphylococci.
Açıklama
Anahtar Kelimeler
Kaynak
Anatolian Journal of Clinical Investigation
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
3
Sayı
4
