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    Crevicular fluid level of elastase in type i and type ii diabetes mellitus patients
    (2006) Doğru, Arzum; Çağlayan, Feriha; Dağ, Ahmet; Doğru, Mehmet; Kaya, Filiz Acun
    Elastase activity in pocket fluid samples was taken from 120 patients divided into 4 groups. The groups were identified as Type I DM (Diabetes mellitus) metabolic uncontrolled, Type I metabolic controlled, Type II metabolic uncontrolled, and Type II metabolic controlled groups. The samples were evaluated with spectrophotometry. In our study we found that, in addition to the clinical data, elastase enzyme activity level and elastase enzyme concentration were found to be significantly higher in metabolic uncontrolled diabetic groups than in metabolic controlled groups (p<0.05). Furthermore, we found a relationship between total elastase enzyme activity and enzyme concentration in all of the four groups. The findings of the study support the relationship between elastase activity and the periodontal disease. We may further draw inferences regarding the effects of metabolic control levels on the periodontal tissues in diabetics patients.
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    The investigation of gingival crevicular fluid prosthoglandin e2 level of the type ii diabetes mellitus patients with periodontitis
    (2006) Kaya, Filiz Acun; Çağlayan, Feriha; Dağ, Ahmet; Kaya, Halil; Kaya, Can Ayhan; 0000-0003-2005-6100
    Diabetes mellitus (DM) is a risk factor for periodontal diseases and oral complications are frequently encountered in diabetic patients. In recent studies it was hypothesed that, the gingival crevicular fluid (GCF) prostoglandin E2 (PGE2) levels are higher in type I diabetic individuals than non diabetics. The aim of our study is to determine the GCF PGE2 levels of the individuals with type II dibetes mellitus and periodontitis. In addition it is aimed to investigate to correlation between the GCF PGE2 levels, the clinical parameters and the severity of the disease. 20 type II diabetes mellitus patient (group I), and 20 systhemic healthy (group II), a total of 40 individual with periodontiis were examined. All individuals pocket depth (PD), plaque index (PI), gingival index (GI), and gingival bleeding index (GBI) scores were recorded to determine their clinical status. In addition to these, the volume of GCF was also determined from the same sampling side. The GCF PGE2 levels were determined by radioimmunoassay (RIA) method. The GCF PGE2 levels of I. andII. groups were determined sequentally as 61.88±28.71 and 13.30±4.953pg/nm. The level of PGE2 level was determined significantly higher (p<0.001) in the group of diabetes mellitus patients than systhemic healthy group. Any correlation was not determined between the GCF PGE2 level and clinical parameters among both of the groups. By comparing all oral clinical parameters it was established that there was significiant differences between the groups (P<0.001). The PD and GCF amount of sampling site was also statistically different among the groups (p<0.05), but the difference of other parameter scores were not statistically important (p>0.05). The findings of this study confirms that diabetes mellitus is a risk factor for periodontal diseases and the correlation between GCF PGE2 level and the severity of the periodontal disease. Attracts attention for the GCF PGE2 level which could be used as a marker to determine the perodontal disease severity among type II diabetes mellitus patients.
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    The investigation of the gingival crevicular fluid prostaglandin e2 level of the pregnant individuals with type ii diabetes mellitus and peridontitis
    (2006) Kaya, Filiz Acun; Çağlayan, Feriha; Dağ, Ahmet; Kaya, Can; Doğru, Arzum
    Systhemic diseases and hormonal changes are risk factors for periodontal diseases. In diabetes mellitus patients periodontal destruction is more severe than systhemic healthy patients. The increase of hormones during pregnancy causes more gingival inflammation and gestational gingivitis. In recent studies it was hypothesed that the increase of the level of progesteron in circulation stimulates the release of prostaglandin E2 (PGE2) which causes to gestational gingivitis. The aim of our study is to determine the level of PGE2 in gingival crevicular fluid (GCF) of the pregnant individuals with type II diabetes mellitus and periodontitis. In addition it is aimed to investigate the probable correlations between GCF PGE2 level and the clical parameters and periodontal disease severity. A total of 40 pregnant individual in 24–32 weeks with periodontitis (20 pregnant individual with type II diabetes mellitus, 20 pregnat individual systhemically healthy) were examined. To determine all the individuals periodontal status pocket depth (PD), plaque index (PI), gingival index (GI) and gingival bleeding index (GBI) scores were recorded. The volume of the GCF was also measured from the sampling site in addition to the other measurements. GCF PGE2 level was determined by radioimmunoassy (RIA) method. The GCF PGE2 level was determined as 38.27±26.08 pg/ml in type II diabetic pregnant group and 39.13±23.19 pg/ml in systhemic healthy pregnant group. There was no important difference of GCF PGE2 level among the groups (p>0.05). When the probable correlations between clinical parameters and GCF PGE2 levels were investigated there was found no correlation in healthy pregnant group, but there was correlation determined in type II diabetic pregnant group. When the full mouth clinical parameters were compared there was important differnces determined in the case of GI and GBI among the groups (p<0.01), but there was no important differences determined in the case of PD and PI (p>0.05). This study results establishes that there is no difference between type II diabetes mellitus pregnant patients with peiodontitis and sythemic healthy pregnants with periodontitis in the cases of GCF PGE2 level and periodontal disease severity. Pays attention that GCF PGE2 level can be used as a marker for determining the periodontal disease severity among type II diabetes mellitus pregnant patients as sythemic healthy pregnants.