PROTECTIVE EFFECT OF OKUZGOZU (VITIS VINIFERA L. CV.) SEED EXTRACT AGAINST HYDROXYL RADICAL INDUCED DNA DAMAGE

Grape is one of the most commonly consumed fruits in the world. It has various biological functions, due to its potential of rich polyphenol ingredients, most of which are contained in its seeds (70%) and skin (30%). The aim of this study was to investigate the protective role of Okuzgozu cv. grape seed extracts against hydroxyl radical that induced oxidative DNA damage. The results revealed that the presence of various concentrations of grape seed extract in the reaction mixture significantly inhibited DNA damage induced by reactive oxygen species (ROS). In conclusion, the results demonstrated that Okuzgozu cv. grape seed extracts protected DNA against hydroxyl radical that induced oxidative damage and the extract could be used as a valuable food supplement or a nutraceutical product.