Blood-based biomarkers of frailty in older patients with cancer

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dc.contributor.authorAkagunduz, Baran
dc.contributor.authorErgun, Yakup
dc.contributor.authorAkagunduz, Digdem Dogan
dc.contributor.authorAkbas, Nergis
dc.contributor.authorAkagunduz, Dilara
dc.contributor.authorKaraoglu, Aziz
dc.contributor.authorSoysal, Pinar
dc.date.accessioned2025-02-22T14:09:15Z
dc.date.available2025-02-22T14:09:15Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose of reviewThis review aims to evaluate the current evidence on blood-based biomarkers for frailty detection in older cancer patients. It explores the potential of various biomarkers, including inflammatory markers and microRNAs (miRNAs), to serve as indicators of frailty and examines the limitations of existing studies. The review also highlights the need for further research to validate these biomarkers and improve their clinical applicability.Recent findingsRecent studies have examined blood biomarkers associated with frailty in older cancer patients. Findings suggest that elevated granulocyte levels and lower macrophage-derived stem cells and regulatory T cells are linked to frailty. Inflammatory biomarkers such as interleukin-6 and specific miRNAs, as well as higher neutrophil-to-lymphocyte ratios, have also been identified as potential indicators of frailty. While these biomarkers show promise, no single marker has proven sufficient, and combining them may improve frailty detection. Further research is needed to validate their clinical usefulness in this population.SummaryBlood-based biomarkers show potential for detecting frailty in older patients with cancer, but further research is needed, particularly beyond an inflammatory focus and with more robust study designs.en_US
dc.identifier.doi10.1097/SPC.0000000000000747
dc.identifier.endpage32en_US
dc.identifier.issn1751-4258
dc.identifier.issn1751-4266
dc.identifier.issue1en_US
dc.identifier.pmid39888831en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://hdl.handle.net/11468/29849
dc.identifier.volume19en_US
dc.identifier.wosWOS:001411688200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofCURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CAREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectblood-based biomarkeren_US
dc.subjectfrailtyen_US
dc.subjectolder patients with canceren_US
dc.titleBlood-based biomarkers of frailty in older patients with canceren_US
dc.typeArticleen_US

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