Effects of cafeic acid phenethyl ester, ellagic acid, sulforaphane and curcumin on diazinon induced damage to the lungs, liver and kidneys in an acute toxicity rat model

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dc.contributor.authorAlp H.
dc.contributor.authorAytekin I.
dc.contributor.authorEsen H.
dc.contributor.authorBasarali K.
dc.contributor.authorKul S.
dc.date.accessioned2024-04-24T18:43:44Z
dc.date.available2024-04-24T18:43:44Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible protective efects of cafeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphane (SFN) and curcumin (CUR) against the toxic efects of diazinon (DI). Sixty Sprague Dawley rats were randomly divided into 10 groups. Five groups were allocated as control groups comprising unmedicated control, CAPE, EA, SFN and CUR control groups. The remaining five groups were the study groups comprising DI, DI + CAPE, DI + EA, DI + SFN, and DI + CUR groups. The animals were sacrified 24 h after drug administrations. DI caused a decrease in acetyl cholinesterase (AChE) activity (P<0.05) and increases in ?-glutamyltransferase (GGT) and amylase activities. It also damaged the kidney, liver, and lung tissues. The negative efects of DI on these enzymes were confirmed histopathologically. Also, CAPE, EA, SFN and CUR reduced amylase and GGT activities and caused an increase in the AChE activities that were increased due to the toxic efects of DI. Thus, it was determined biochemically and histopathologically that these medication reduced the degenerative toxic efects created by DI in the lung, liver and kidney tissues. These findings led us to believe that CAPE, EA, SFN and CUR may be used as protective medicines in acute DI intoxication.en_US
dc.identifier.endpage933en_US
dc.identifier.issn1300-6045
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-80053615533
dc.identifier.scopusqualityQ3
dc.identifier.startpage927en_US
dc.identifier.urihttps://hdl.handle.net/11468/24337
dc.identifier.volume17en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherVeteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCafeic Acid Phenethyl Esteren_US
dc.subjectCurcuminen_US
dc.subjectDiazinonen_US
dc.subjectEllagic Aciden_US
dc.subjectSulforaphanen_US
dc.titleEffects of cafeic acid phenethyl ester, ellagic acid, sulforaphane and curcumin on diazinon induced damage to the lungs, liver and kidneys in an acute toxicity rat modelen_US
dc.titleEffects of cafeic acid phenethyl ester, ellagic acid, sulforaphane and curcumin on diazinon induced damage to the lungs, liver and kidneys in an acute toxicity rat model
dc.title.alternativeAkut toksisite sıçan modelinde diazinonun neden olduğu akciğer, karaciğer ve böbrek hasarı üzerine kafeik asit fenetil ester, elajik asit, sulforafan ve kurkumin'in etkilerien_US
dc.title.alternativeAkut toksisite sıçan modelinde diazinonun neden olduğu akciğer, karaciğer ve böbrek hasarı üzerine kafeik asit fenetil ester, elajik asit, sulforafan ve kurkumin'in etkileri
dc.typeArticleen_US

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