Immunohistochemical Analysis of Hypoxia-Inducible Factor 1-Alpha and Ki-67 Expression in Placenta Previa and Accreta

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dc.contributor.authorOtcu, Serap
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:47:29Z
dc.date.available2024-04-24T17:47:29Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the immunohistochemical staining of hypoxia-inducible factor 1-alpha (HIF-1 alpha) and Ki-67 expression in the placenta of pregnant women with placenta previa and placenta accreta. STUDY DESIGN: Thirty placentas (10 normotensive, 10 placenta previa, and 10 placenta accreta) were processed for routine histological tissue processing. The biochemical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and HIF-1 alpha and Ki-67 immunostaining. RESULTS: Normal histology was observed in placentas of normotensive pregnant women. Placenta previa sections showed increased syncytial knots, intervillous hemorrhage, fibrin accumulation, and hyalinization. In placenta accreta sections, increased syncytial nodes, vascular dilation/congestion, fibrin accumulation, and hyalinization were observed. Normotensive placentas showed no HIF-1 alpha expression. In placenta previa tissues, high HIF-1 alpha expression was observed in vascular endothelial cells, villous stromal cells, and syncytial knots. High HIF-1 alpha expression was recorded in villous stromal cells and cytotrophoblast cells in placenta accreta. In normotensive placental tissues, no Ki-67 expression was observed. In placenta previa sections, high Ki-67 expression was observed mostly in root villi stromal cells and some endothelial cells. High Ki-67 expression was observed mostly in villi stromal cells of placenta accreta. CONCLUSION: It is thought that HIF-1 alpha is an important regulatory gene in the development of villus in trophoblast invasion such as placenta accreta and previa, while Ki-67 will play a key role in the development of abnormal placenta with its stimulating effect on inflammatory cell development and angiogenesis in accreta and preeclampsia.en_US
dc.identifier.endpage149en_US
dc.identifier.issn0884-6812
dc.identifier.issue3en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://hdl.handle.net/11468/22539
dc.identifier.volume43en_US
dc.identifier.wosWOS:000691771000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFemaleen_US
dc.subjectHypoxiaen_US
dc.subjectHypoxia-Inducible Factor 1en_US
dc.subjectAlpha Subuniten_US
dc.subjectPlacentaen_US
dc.subjectPlacenta Accretaen_US
dc.subjectPlacenta Previaen_US
dc.subjectPlacental Lactogenen_US
dc.subjectPregnancyen_US
dc.subjectPhysiologyen_US
dc.subjectPreeclampsiaen_US
dc.titleImmunohistochemical Analysis of Hypoxia-Inducible Factor 1-Alpha and Ki-67 Expression in Placenta Previa and Accretaen_US
dc.titleImmunohistochemical Analysis of Hypoxia-Inducible Factor 1-Alpha and Ki-67 Expression in Placenta Previa and Accreta
dc.typeArticleen_US

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