Effects of melatonin and N-acetylcysteine on lung ischemia reperfusion injury

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dc.authorid0000-0001-5708-3431en_US
dc.authorid0000-0002-0645-8755en_US
dc.contributor.authorDurkan, Atilla
dc.contributor.authorÇakmak, Muharrem
dc.contributor.authorÜlkü, Refik
dc.contributor.authorÖzekinci, Selver
dc.contributor.authorKale, Ebru
dc.date.accessioned2023-03-29T12:58:08Z
dc.date.available2023-03-29T12:58:08Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractAim: In our study, we aimed to determine the effects of using melatonin, N-acetyl cysteine, and low potassium dextran solution (LPDS) as a preservative solution on ischemia/reperfusion injury. Material and Methods: A total of 48 male Sprague-Downey rats were used. Rats were divided into 8 groups: group 1: ischemia, group 2: ischemia+melatonin, group 3: ischemia + N-acetylcysteine, group 4: ischemia+melatonin + N-acetylcysteine, group 5: ischemia + reperfusion, group 6: ischemia + reperfusion + melatonin, group 7; ischemia + reperfusion + N-acetyl cysteine, and group 8; ischemia+reperfusion+melatonin+N-acetyl cysteine. Total antioxidant capacity (TAOC), malondialdehyde (MDA) and neutrophil values of each group were determined. The TAOC was obtained by spectrophotometric measurement of the absorption level of the color formed by the hydroxylion formed by the Fenton reaction with orthodianisidine. The MDA value was obtained spectrophotometrically using the thiobarbituric acid method, and the Neutrophil count was obtained as cell count using Papanicolau Stain stain. Results: While the highest TAOC values were in groups 4, 2, 3, 1, the lowest TAOC values were in groups 5,7,6,8. The highest MDA values were in groups 5, 7, 6, 1, 8, whereas the lowest MDA were in groups 4, 2, 3 (p<0.05). Neutrophil in bronchoalveolar lavage increased in groups 5,7,6,3,2,8,4. Discussion: In lung ischemia reperfusion, the use of melatonin and/or N-acetyl cysteine, and LPDS decreases plasma MDA levels and increases TAOC values. Additionally, the use of these antioxidants and preservation solutions decreases cell damage immunohistochemically, the cytokines mediating inflammation, the PMNL, and the inflammatory response associated with them.en_US
dc.identifier.citationDurkan, A., Çakmak, M., Ülkü, R., Özekinci, S. ve Kale, E. (2022). Effects of melatonin and N-acetylcysteine on lung ischemia reperfusion injury. Annals of Clinical and Analytical Medicine, 13(4), 379-383.en_US
dc.identifier.doi10.4328/ACAM.20935
dc.identifier.endpage383en_US
dc.identifier.issn2667-663X
dc.identifier.issue4en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://hdl.handle.net/11468/11561
dc.identifier.volume13en_US
dc.identifier.wosWOS:000782138400007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorÜlkü, Refik
dc.institutionauthorÖzekinci, Selver
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemiaen_US
dc.subjectMelatoninen_US
dc.subjectN-acetylcysteineen_US
dc.subjectReperfusionen_US
dc.titleEffects of melatonin and N-acetylcysteine on lung ischemia reperfusion injuryen_US
dc.titleEffects of melatonin and N-acetylcysteine on lung ischemia reperfusion injury
dc.typeArticleen_US

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