Clinical and epidemiological characteristics of hepatocellular carcinoma cases in east and Southeastern region of Turkey: A multicenter retrospective study

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dc.contributor.authorYalçin K.
dc.contributor.authorYakut M.
dc.contributor.authorDe?ertekin H.
dc.contributor.authorTürkdo?an K.
dc.contributor.authorHarputluo?lu M.
dc.contributor.authorBahçecio?lu I.H.
dc.contributor.authorKadayifçi A.
dc.date.accessioned2024-04-24T17:58:24Z
dc.date.available2024-04-24T17:58:24Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In this multicenter retrospective study, we aimed to investigate the epidemiological and clinical characteristics of patients with hepatocellular cancer (HCC) in the Eastern and Southeastern Anatolian regions of Turkey. Material and Methods: This study included 218 patients from 7 centers-Dicle University (n=96), Yüzüncü Yi{dotless}l University (n=30), İnönü University (n=28), Fi{dotless}rat University (n=24), Gaziantep University (n=20), Atatürk University (n=19), and Harran University (n=1) hospitals. Information about patients was obtained through pre-prepared forms. Diagnosis of HCC was made histologically or with a combination of clinical, radiological, and laboratory findings. Results: The mean age of the patients was 57.67±12.03 with a male-to-female ratio of 5.8:1. Etiologically, 45% of the study group had HBV infection alone, 29% had HDV co-infection, 15% had HCV infection and 10% were idiopathic cases with unknown etiology. Cirrhotic background was present in 94% of the patients and 89% of cases had an advanced stage disease according to the Okuda classification. Alpha-fetoprotein levels were over 300 ng/ml in 81% of the patients. Conclusion: Hepatitis B virus infection followed by hepatitis delta virus infections appeared to be the leading etiological factors for HCC cases in our region. HBsAg carriage continues to be an important risk factor for HCC in Turkey. The fact that most of the HCC cases are in the late stages of disease, makes it necessary to use effective diagnosis and treatment methods with efficient screening and monitoring programs in our country. © 2013 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2012-31667
dc.identifier.endpage813en_US
dc.identifier.issn1300-0292
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84879142021en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage806en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2012-31667
dc.identifier.urihttps://hdl.handle.net/11468/23900
dc.identifier.volume33en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarcinomaen_US
dc.subjectEpidemiologyen_US
dc.subjectHepatitis B Virusen_US
dc.subjectHepatitis Delta Virusen_US
dc.subjectHepatocellularen_US
dc.titleClinical and epidemiological characteristics of hepatocellular carcinoma cases in east and Southeastern region of Turkey: A multicenter retrospective studyen_US
dc.title.alternativeTürkiye'nin do?u ve güneydo?u bölgesinde hepatoselüler karsinomalı vakaların klinik ve epidemiyolojik özellikleri: Çok merkezli retrospektif çalışmaen_US
dc.typeArticleen_US

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