Obstrüktif uyku apne sendromlu hastalarda uyku parametreleri ile oksidatif stres arasındaki ilişki
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Modestum Publishing Ltd.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Oksidatif stress reaktif oksijen türevlerinin üretimi ve yıkılması arasındaki dengesizlik ile karakterizedir.
Çalışmamızda Obstrüktif uyku apne sendromu (OUAS)
hastalarında oksidan-antioksidan dengeyi gösteren bazı
biyokimyasal faktörlerle hastalığın şiddetini yansıtan uyku
parametreleri arasındaki ilişkiyi belirlemeyi amaçladık.
Yöntemler: Çalışmaya Dicle Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Uyku merkezinde Polisomnografi
kaydı yapılan toplam 93 hasta alındı. Her olgu tüm gece
polisomnografi işlemine tabi tutuldu. Serum total oksidan
seviyesi (TOS) ve total antioksidan seviyesi (TAS) düzeyleri ölçüldü.
Bulgular: Hastaların yaş ortalaması 47,4 ± 7,2 yıldı. Hasta ve kontrol grupları arasında yaş, cins, vücut kitle indeksi ve semptom sıklığı açısından anlamlı fark saptanmadı
(p>0,05).Hastaların apne hipopne indeksi (AHİ) ortalaması 25,1 adet/saat idi. Hasta grubunda kontrol grubuna
göre anlamlı olarak farklı bulunan parametreler; apne-hipopne indeksi, arrousal indeksi, oksijen desatürasyon indeksi, serum TOS ve serum TAS idi (p<0,05).
Hasta grubunda TOS ve TAS ortalaması sırasıyla 34,2
mmol /L ve 1,18mmol /L olarak saptandı. Kontrol grubunda ise TOS ve TAS ortalaması sırasıyla 21,7 mmol /L ve
1,54 mmol /L olarak saptandı. Aralarındaki farklar anlamlı
idi (p<0,05).
Sonuç: OUAS hastalarında oksidatif stres düzeyi artarken antioksidan düzeyinin azaldığını saptadık.
Objective: Oxidative stress is characterized byan imbalance between production and destruction of reactive oxygen species. In our study, we aimed to determine the relationship between the oxidant-antioxidant balance in patients with showing some biochemical factors reflecting the severity of the disease and sleep parameters in patients with Obstructive Sleep Apnea Syndrome (OSAS). Methods: 93 patients were included to the study at the sleep centre, Department of Chest Diseases, Dicle University Hospital. All patients were subjected to all night polysomnography. Serum TOS and TAS levels were measured. Results: The mean age of patients was 47.4±7.2 years. There was not significant between patient and control groups in terms of age, gender, body mass index and frequency of symptoms (p> 0.05).The mean apnea-hypopnea index (AHI) was 25.1units/hour. We found these parameters significant compared with the control group; apnea-hypopnea index, arousal index, oxygen desaturation index, serum total oxidant and serum total antioxidant level (p<0.05). The mean serum levels TOS and TAS in patients with OSAS were found 34.2 mmol/L and 1.18 mmol/L, respectively. The mean serum levels TOS and TAS in control group were found 21.7 mmol/L and 1.54 mmol/L, respectively. Differences between two groups were significant (p<0.05). Conclusion: We observed that increased level of oxidative stress and decreased antioxidant levels in patients with OSAS. J Clin Exp Invest 2014; 5 (2): 271-275.
Objective: Oxidative stress is characterized byan imbalance between production and destruction of reactive oxygen species. In our study, we aimed to determine the relationship between the oxidant-antioxidant balance in patients with showing some biochemical factors reflecting the severity of the disease and sleep parameters in patients with Obstructive Sleep Apnea Syndrome (OSAS). Methods: 93 patients were included to the study at the sleep centre, Department of Chest Diseases, Dicle University Hospital. All patients were subjected to all night polysomnography. Serum TOS and TAS levels were measured. Results: The mean age of patients was 47.4±7.2 years. There was not significant between patient and control groups in terms of age, gender, body mass index and frequency of symptoms (p> 0.05).The mean apnea-hypopnea index (AHI) was 25.1units/hour. We found these parameters significant compared with the control group; apnea-hypopnea index, arousal index, oxygen desaturation index, serum total oxidant and serum total antioxidant level (p<0.05). The mean serum levels TOS and TAS in patients with OSAS were found 34.2 mmol/L and 1.18 mmol/L, respectively. The mean serum levels TOS and TAS in control group were found 21.7 mmol/L and 1.54 mmol/L, respectively. Differences between two groups were significant (p<0.05). Conclusion: We observed that increased level of oxidative stress and decreased antioxidant levels in patients with OSAS. J Clin Exp Invest 2014; 5 (2): 271-275.
Açıklama
Anahtar Kelimeler
Obstrüktif uyku apne sendromu, Oksidatif stres, TAS, TOS, Obstructive sleep apnea syndrome, Oxidative stress
Kaynak
Journal of Clinical and Experimental Investigations
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
2
Künye
Abakay, Ö., Şen, H. S., Yüksel, H., Palancı, Y., Yılmaz, S., Tanrıkulu, A. Ç. ve diğerleri. (2014). Obstrüktif uyku apne sendromlu hastalarda uyku parametreleri ile oksidatif stres arasındaki ilişki. Journal of Clinical and Experimental Investigations, 5(2), 271-275.
