Teratogenic effect of trimethobenzamide: An experimental study

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dc.contributor.authorBayhan, Gökhan
dc.contributor.authorAşkar, İbrahim
dc.contributor.authorKetani, Muzaffer Aydın
dc.date.accessioned2024-04-24T17:56:18Z
dc.date.available2024-04-24T17:56:18Z
dc.date.issued2005
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractIn the experimental and clinical studies, it was reported that many pharmacological agents had teratogenic effects. There has been no sufficient explanation about the effect of trimethobenzamide, which is an antinauseant agent commonly used in Turkey. Thirty Wistar albino female rats, 3-month-old, weighing 200–250 g, were used to search the teratogenic effect of trimethobenzamide. In estrus, female rats were bred to singly housed males overnight. On the morning, the female rats with positive vaginal lavage for sperm were accepted as in the first gestational day (gd) 0. Sperm-positive females were divided into five groups, including six rats, by collecting randomly. In the first trimester (gd 6–15), in the control group (n=6), normal saline 0.5 ml was given subcutaneously; in the experimental groups, trimethobenzamide (Emedur®) was given subcutaneously, in dose of 17, 34, and 51 mg/kg/day, respectively. At death (gd 20), all live fetuses were evaluated for external, visceral, and skeletal abnormalities. No congenital abnormality was macroscopically seen. There was no developmental abnormality. However, a dose dependent developmental retardation was seen in bone and cartilage tissue, and a dose reduction in fetal body weight. The developmental retardation was prominent especially in vertebrae, and extremities.en_US
dc.identifier.citationBayhan, G., Aşkar, İ. ve Ketani, M. A. (2005). Teratogenic effect of trimethobenzamide: An experimental study. Biotechnology and Biotechnological Equipment, 19(1), 134-137.
dc.identifier.doi10.1080/13102818.2005.10817168
dc.identifier.endpage137en_US
dc.identifier.issn1310-2818
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-13844297024
dc.identifier.scopusqualityQ3
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2005.10817168
dc.identifier.urihttps://hdl.handle.net/11468/23441
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/13102818.2005.10817168
dc.identifier.volume19en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofBiotechnology and Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleTeratogenic effect of trimethobenzamide: An experimental studyen_US
dc.titleTeratogenic effect of trimethobenzamide: An experimental study
dc.typeArticleen_US

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