Radio-protective effects of melatonin on the skin histology in the rat

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dc.contributor.authorCakir Z.U.
dc.contributor.authorDemirel C.
dc.contributor.authorUgurlu P.
dc.contributor.authorSaruhan B.G.
dc.contributor.authorKetani S.
dc.contributor.authorSeker U.
dc.contributor.authorZincircioglu S.B.
dc.date.accessioned2024-04-24T18:46:08Z
dc.date.available2024-04-24T18:46:08Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, the protective effect of melatonin on the radiation-damaged skin was investigated and effectiveness of the protective effect of melatonin was compared with amifostine. Fort this purpose, 40 female Sparague Dawley rats were used. Animals were divided into 5 groups. Control group (C), radiation group (R), and 2 experimental groups (radiation + melatonin 25 mg/kg (R+M) and radiation + amifostin 200 mg/kg (R+WR). A single dose of 20 gy gamma radiation were exposed to the left legs of the rat groups of R, R+M,and R+WR. At the end of a four-week of experiment period, the skin on the left femur of each rat was dissected and routine histological procedures were applied. Nikon Eclipse 400 research microscopy was used for histological observations. All histological structures of the skin were found to be normal in the control group. However, we observed that reduction in thickness of the epidermis and the dermal papillae have disappeared, sweat glands, sebaceous glands and hair follicles atrophy was observed in radiation groups. Our findings showed that R+M group, the thickness of the epidermis, collagen synthesis, R and R+WR group was better with histological structure. As a result, the histological abnormalities of radiation is shaped to protect in the skin, it has been found that melatonin has a significant effect compared to Amifostine (WR2721).en_US
dc.identifier.endpage77en_US
dc.identifier.issn1309-100X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84921669525
dc.identifier.scopusqualityQ3
dc.identifier.startpage73en_US
dc.identifier.urihttps://hdl.handle.net/11468/25074
dc.identifier.volume7en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherUniversity of Dicleen_US
dc.relation.ispartofJournal of International Dental and Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectMelatoninen_US
dc.subjectRadio-Protectiveen_US
dc.subjectRaten_US
dc.titleRadio-protective effects of melatonin on the skin histology in the raten_US
dc.titleRadio-protective effects of melatonin on the skin histology in the rat
dc.typeArticleen_US

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