Intravesical oxybutynin application: Ultrastructural effects on bladder epithelium.

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dc.contributor.authorErsay, A
dc.contributor.authorKetani, MA
dc.contributor.authorNergiz, Y
dc.contributor.authorDemirtas, OC
dc.contributor.authorAkkus, M
dc.contributor.authorOtludil, B
dc.date.accessioned2024-04-24T17:44:30Z
dc.date.available2024-04-24T17:44:30Z
dc.date.issued1999
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntravesically applied oxybutynin, rapidly absorbs into the bloodstream, additional to profound local effect. Currently morphologic effects of oxybutynin on local bladder tissue relatively well established at light microscopic level, but not ultrastructural level. Thirty New Zealand White female rabbits were catheterized daily and intravesical instillation were performed with whether 1mg/kg oxybutynin solution or saline for 30 days. The local effects of the drug on bladder epithelium at electron microscopic level were examined comparing with saline administration. Urinary tract infection (UTI) incidence were similar in both saline and oxybutynin groups (9 vs. 10 of 15 animals respectively) (p>0.05). Interestingly, in 4 of 5 animals that received oxybutynin and never had UTI during the study, separation of zonula occludens intercellular junction was determinated by Jeol electron microscope. This observation can explain rapid absorption of oxybutynin through the bladder into the blood stream. Oxybutynin can damage bladder surface epithelium at ultrastructural level. This effect may lead to increase absorption of it, but not result in higher incidence of bacterial infection.en_US
dc.identifier.endpage156en_US
dc.identifier.issn0749-5331
dc.identifier.issue2en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://hdl.handle.net/11468/22119
dc.identifier.volume15en_US
dc.identifier.wosWOS:000080896300005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherMbr Press Incen_US
dc.relation.ispartofBiochemical Archives
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleIntravesical oxybutynin application: Ultrastructural effects on bladder epithelium.en_US
dc.titleIntravesical oxybutynin application: Ultrastructural effects on bladder epithelium.
dc.typeArticleen_US

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