Protective Effect of Potentilla fulgens on Changes in Cerebellum Following Traumatic Head Injury

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dc.contributor.authorOzevren, Huseyin
dc.contributor.authorIrtegun, Sevgi
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:44:37Z
dc.date.available2024-04-24T17:44:37Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To examine protective effects of Potentilla fulgens (P. fulgens) extract on cerebellar tissue damage of head-traumatized rats with respect to biochemical, histopathological, immunohistochemical, and ultrastructural analysis. STUDY DESIGN: Sprague-Dawley rats were subjected to traumatic head injury with a weight-drop device using 300 g-1 m weight-height impact. In our study the occipital lobe region was subjected to moderate trauma. Sixty-four rats were divided into 4 groups: group 1 (control group), group 2 (P. fulgens group [400 mg/kg/day i.p.]), group 3 (trauma group), and group 4 (trauma +P. fulgens [400 mg/kg/day i.p.]). Distilled water was used as vehicle. All rats were decapitated 5 days after the induction of trauma, and the protective effects of P. fulgens were evaluated by histological, immunohistochemical, and biochemical analyses. RESULTS: After trauma, degenerative changes and congestion were observed in Purkinje and glial cells. Elevated expression of E-cadherin in synaptic junctions, increased tumor necrosis factor alpha expression in Purkinje and glial cells, and elevated endothelin-1 expression in vessel endothelium were observed. Ultra-structural analysis showed loss of mitochondrial crista, and dilation of endoplasmic reticulum of Purkinje cells was observed. CONCLUSION: Although further studies are necessary to evaluate the time- and dose-dependent neuroprotective effects of P. fulgens, it may be a beneficial therapeutic agent for prevention of cerebellar damage following diffuse traumatic head injury.en_US
dc.identifier.endpage42en_US
dc.identifier.issn0884-6812
dc.identifier.issue1en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://hdl.handle.net/11468/22191
dc.identifier.volume40en_US
dc.identifier.wosWOS:000444014900005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCerebellumen_US
dc.subjectCinquefoilen_US
dc.subjectHead Injuryen_US
dc.subjectBlunten_US
dc.subjectHead Traumaen_US
dc.subjectPotentillaen_US
dc.subjectRaten_US
dc.subjectSilverweeden_US
dc.titleProtective Effect of Potentilla fulgens on Changes in Cerebellum Following Traumatic Head Injuryen_US
dc.titleProtective Effect of Potentilla fulgens on Changes in Cerebellum Following Traumatic Head Injury
dc.typeArticleen_US

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