HOXA1 expression in placentas of woman with fetal growth restriction

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dc.contributor.authorAydeniz Acar, Gül Ebru
dc.contributor.authorSevinç Akdeniz, Ayşenur
dc.contributor.authorTüre, Zeynep
dc.contributor.authorAşır, Ayşegül
dc.contributor.authorAcar, Mesut
dc.contributor.authorAşır, Fırat
dc.contributor.authorKorak, Tuğcan
dc.date.accessioned2025-02-22T14:10:57Z
dc.date.available2025-02-22T14:10:57Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In this study, we examined the HOXA1 expression in the placentas of women diagnosed with fetal growth restriction (IUGR) by immunoexpression and in silico analysis. Methods: Placenta samples from 40 control (healthy) and 40 pregnant women diagnosed with IUGR were included in the study. The samples were fixed in zinc-formal and embedded in paraffin. Demographic information of the patients was recorded. Sections taken from paraffin blo-cks were analyzed by Hematoxylin-Eosin and HOXA1 immunostaining. The protein-protein interaction network of HOXA1 was constructed using the STRING database and analyzed with Cytoscape. The route description was made with the DAVID web tool. Results: In histopathological examination, intense fibrin accumulation, structural degeneration of placental components, congestion, dilatation and increased syncytial nodes were observed in the IUGR group compared to the control group. HOXA1 gene expression was significantly increased in the IUGR group. The HOXA1 PPI network contained 201 nodes and 3876 edges. MCODE analysis identified 8 modules, the highest scoring module was related to the “Systemic lupus erythematosus”, “Alcoholism” and “Neutrophil extracellular trap formation” pathways. Conclusion: With immunoexpression and in silico analysis, we showed HOXA1 is a player of immune pathways, tissue development, and placental regulation, suggesting potential research avenues in understanding IUGR mechanisms. © 2024 Perinatal Medicine Foundation.en_US
dc.identifier.doi10.59215/prn.24.0322012
dc.identifier.endpage172en_US
dc.identifier.issn1305-3124
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85207268242en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage166en_US
dc.identifier.urihttps://doi.org/10.59215/prn.24.0322012
dc.identifier.urihttps://hdl.handle.net/11468/29925
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPerinatal Medicine Foundationen_US
dc.relation.ispartofPerinatal Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250222
dc.subjectfetal growth restrictionen_US
dc.subjectHomeobox genesen_US
dc.subjectHOXA1en_US
dc.subjectplacentaen_US
dc.titleHOXA1 expression in placentas of woman with fetal growth restrictionen_US
dc.typeArticleen_US

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