The evaluation of the prevalence of extrahepatic findings in chronic hepatitis-C virus infection
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Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate the prevalence of clinical and biological extrahepatic findings in HCV infection. Material and Methods: Forty anti-HCV (+) patients and 40 HbsAg (+) patients were evaluated in the study. In the anti-HCV (+) group, 35 of 40 (87.5%) manifested chronic liver disease and 5 of 40 (12.5%) had liver cirrhosis. In the HbsAg (+) group, 33 of 40 (82.5%) were seen to have chronic liver disease and 7 of 40 (17.5%) liver cirrhosis. HCV and HBV infections were confirmed by ELISA and polymerase chain reaction (PCR). Biochemical, hematological and immunological tests were performed for both anti-HCV (+) and HbsAg (+) groups. They were as well evaluated for other clinical presentations, such as rheumatological, dermatological, neurological, and psychiatric symptoms. Results: In the anti-HCV (+) group, the mean age was 49.0 ± 15.7 years, the mean duration of disease was 38.1 ± 51.8 months. In the HbsAg (+) group, they were, respectively, 36.4 ± 13.2 years and 35.3 ± 42.1 months. Extrahepatic clinical presentations in the anti-HCV (+) group versus HbsAg (+) group were as follows: 25% arthralgia and 5% arthritis versus 5% arthralgia (p= 0.031); 10% paresthesia and 12.5% peripheral neuropathy versus 5% paresthesia (p= 0.041); 10% pruritus versus 5% pruritus (p= 0.045); 50% depression and 2.5% anxiety versus 7.5% depression (p= 0.000); 25% ANA (+), 2.5% ASMA (+) and 7.5% [ANA + ASMA + AMA] (+) versus only 5% ANA (+). A positive correlation was found between clinic status and age (r = 0.429, p= 0.006, r= 0.461, p= 0.003), between clinic status and duration of disease (r= 0.516, p= 0.001, r= 0.517, D= 0.001) and between serum albumin and hct levels (r= 0.561, p= 0.000, r= 0.649, p= 0.000) in the anti-HCV (+) and HbsAg (+) groups, respectively. The relative risk values of each of the extrahepatic findings were established in both groups. Conclusion: Extrahepatic findings such as rheumatological, neurological, psychiatric and dermatological clinical presentations, as well as autoantibody positivity, were more frequently observed in the anti-HCV (+) group. It was also observed that the prevalence of extrahepatic findings in this clinical setting was more increased in variable ratio in those with chronic HCV infection rather than in normal individuals. Copyright © 2005 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Hepatitis, Infection, Prevalence
Kaynak
Turkiye Klinikleri Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
25
Sayı
5
