Rosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity

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dc.contributor.authorYildizhan, Eda
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorAkkuş, Murat
dc.contributor.authorKatanalp, Ömer Faruk
dc.contributor.authorÖzkorkmaz, Ebru Gökalp
dc.contributor.authorYıldızhan, İbrahim
dc.date.accessioned2025-02-22T14:13:31Z
dc.date.available2025-02-22T14:13:31Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Deltamethrin (DM) is an insecticide and is widely used around the world. Rosmarinic acid (RA) is found in herbs and spices in the Lamiaceae (mint) family and has antioxidant, antiinflammatory and antiapoptotic effects. We objective to examine the protecting efficacy of Rosmarinic acid in preventing the toxic effects of Deltamethrin. Material and Methods: In ours study we used 28 male rats. Group 1: Control group, Group 2: RA group, RA was given 20 mg/kg peroral (p.o.) for 7 days, Group 3: DM group, 35 mg/kg/dose of DM was given 24 hours before sacrification as a single dose by gavage, Group 4: RA+ DM group. Results: BUN, creatinine, AST and ALT values of the RA+DM group were lower than the DM group. TAS and TOS grades were higher in the DM group matched to the RA+DM group. The damage scores of the DM group were higher aacording as those of the RA+DM group. Conclusion: RA has been shown to have predicative influence in the therapy of deltamethrin-induced nephrotoxicity and hepatotoxicity.en_US
dc.identifier.doi10.37990/medr.1197782
dc.identifier.endpage405en_US
dc.identifier.issn2687-4555
dc.identifier.issue2en_US
dc.identifier.startpage400en_US
dc.identifier.trdizinid1263490en_US
dc.identifier.urihttps://doi.org/10.37990/medr.1197782
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263490
dc.identifier.urihttps://hdl.handle.net/11468/30041
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofMedical records-international medical journal (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectRosmarinic aciden_US
dc.subjecthepatotoxicityen_US
dc.subjectnephrotoxicityen_US
dc.subjectDeltamethrinen_US
dc.titleRosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicityen_US
dc.typeArticleen_US

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