Multiple sclerosis: Relationships between cytokines, MRI lesion burden, visual evoked potentials and disability scores

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dc.contributor.authorTaşdemir, Nebahat
dc.contributor.authorKaraca, Erdal Eren
dc.contributor.authorEce, Aydın
dc.contributor.authorYücel, Yavuz
dc.contributor.authorDikici, Süber
dc.contributor.authorTaşdemir, Mehmet Serhan
dc.date.accessioned2024-04-24T17:58:14Z
dc.date.available2024-04-24T17:58:14Z
dc.date.issued2010
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.description.abstractAim: The aim of this study was to investigate the relationships between the disability (EDSS) scores, magnetic resonance imaging (MRI) lesion burden, the visual evoked potential (VEP) latencies and the cytokine levels in patients with multiple sclerosis (MS) that previously not studied. Method: Study group consisted of 40 MS patients with either relapsing-remitting (RR) (n=29) or secondary progressive course (n=11) and control group comprised 35 matched healthy subjects. Student's t test, Mann-Whitney U, Chi-squared and correlation analyses were used for statistical analyses. Result: In patient group EDSS scores varied from 1.5 to 8.5, all had abnormal MRI T2 plaque burden and 65.0% had abnormal VEP latencies. Serum levels of tumor necrosis factor-alpha (TNF-a{cyrillic}) and interleukin-2 receptor (IL-2R) were significantly higher in patients compared to controls (P<0.001 and P<0.001, respectively). Serum levels of IL-6 and IL-10 were similar in patients and controls (P>0.05). The total EDSS scores significantly correlated with the T2 plaque counts (r=0.637, P<0.001). Among all measured cytokines, only IL-8 levels were significantly correlated with the total EDSS scores and MRI lesion burden (r=0.590, P<0.001 and r=0.535, P<0.001, respectively). Other cytokine levels did not correlate with the disability scores, the amount of MRI lesions or the VEP latencies (P>0.05). Conclusion: Our data indicate that despite clinical stability, immunological activity is not interrrupted in MS and the production of different cytokines were not uniformly affected by the immunomodulator medication. New therapeutic strategies correcting cytokine balance may be useful in MS.en_US
dc.identifier.citationTaşdemir, N., Karaca, E. E., Ece, A., Yücel, Y., Dikici, S. ve Taşdemir, M. S. (2010). Multiple sclerosis: Relationships between cytokines, MRI lesion burden, visual evoked potentials and disability scores. European Journal of General Medicine, 7(2), 167-173.
dc.identifier.doi10.29333/ejgm/82845
dc.identifier.endpage173en_US
dc.identifier.issn1304-3889
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-78650183081en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage167en_US
dc.identifier.urihttps://doi.org/10.29333/ejgm/82845
dc.identifier.urihttps://hdl.handle.net/11468/23743
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTıp Araştırmaları Derneğien_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytokinesen_US
dc.subjectDisabilityen_US
dc.subjectMrien_US
dc.subjectMultiple sclerosisen_US
dc.subjectVisual evoked potentialsen_US
dc.titleMultiple sclerosis: Relationships between cytokines, MRI lesion burden, visual evoked potentials and disability scoresen_US
dc.title.alternativeMultipl skleroz: Sitokinler, MR lezyon yükü, görsel uyarılmış potensiyeller ve sakatlık puanları arasındaki ilişkileren_US
dc.typeArticleen_US

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