The effects of octreotide on gastric lesions and gastric mucosal barrier in rats which applied stress

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dc.contributor.authorGuzel C.
dc.contributor.authorKanay Z.
dc.contributor.authorOnen A.
dc.contributor.authorKurt D.
dc.contributor.authorDenli O.
dc.contributor.authorCanoruc F.
dc.date.accessioned2024-04-24T17:58:51Z
dc.date.available2024-04-24T17:58:51Z
dc.date.issued1999
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this research was to investigate the effects of octreatide on gastric lesions and mucosal barrier in rats exposed cold +immobilisation stress. Twenty four Swiss Albino rats (approx 150-200 g) were used for this study. Feeds were witheld from to rats for 24 hours, after which they were divided in to three groups. Each group consisted of seven rats; I (n=7) non/stress-induced control group, 2 (n=7): cold and immobilisation stress was induced, 3 (n=7): 100 ?g/kg octreatide was administered subcutaneously one hour prior to stress induction. The rats were then killed and their stomachs examined for ulcerative lesions and ulcer indexes considered. The amounts of mucus and phospholipid, important components of the gastric mucosal barrier, were then rated using Corn and Baur methods and were found to be significantly decreased (p<0.05, p>0.05) in rats exposed to stress. In the third group given sandostatin, it was found that gastric lesions had been prevented. Moreover, mucus and phospholipid levels were higher in this group than the stress exposed control group. (p<0.05, p<0.05 respectively). According to our findings, octreatide is effective in preventing acute hemorrhagic gastric lesions caused by stress and in maintaining gastric mucosal barrier parameters.en_US
dc.identifier.endpage114en_US
dc.identifier.issn1300-4948
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0032764711en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://hdl.handle.net/11468/24126
dc.identifier.volume10en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric Mucosal Barrieren_US
dc.subjectOctreatideen_US
dc.subjectStressen_US
dc.titleThe effects of octreotide on gastric lesions and gastric mucosal barrier in rats which applied stressen_US
dc.title.alternativeOctreotide'nin stres uygulanan sicanlarda mide lezyonlari ve mide mukozal bariyeri uzerindeki etkilerien_US
dc.typeArticleen_US

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