Dynamic contrast-enhanced mammography and breast MRI in the diagnosis of breast cancer and detection of tumor size

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dc.authorid0000-0002-3240-6991en_US
dc.authorid0000-0002-3412-7355en_US
dc.authorid0000-0001-7697-9305en_US
dc.authorid0000-0002-1309-0805en_US
dc.authorid0000-0002-8614-5387en_US
dc.contributor.authorTekinhatun, Muhammed
dc.contributor.authorSabir, Nuran
dc.contributor.authorErdem, Ergün
dc.contributor.authorYılmaz, Sevda
dc.contributor.authorUfuk, Furkan
dc.date.accessioned2024-04-18T11:32:10Z
dc.date.available2024-04-18T11:32:10Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalıen_US
dc.description.abstractBackground/aim: The aim of this study is to evaluate the performance of contrast-enhanced mammography (CEM) and dynamic breast MRI techniques for diagnosing breast lesions, assess the diagnostic accuracy of CEM’s using histopathological findings, and compare lesion size measurements obtained from both methods with pathological size. Materials and methods: This prospective study included 120 lesions, of which 70 were malignant, in 104 patients who underwent CEM and MRI within a week. Two radiologists independently evaluated the MR and CEM images in separate sessions, using the BI-RADS classification system. Additionally, the maximum sizes of lesion were measured. Diagnostic accuracy parameters and the receiver operating characteristics (ROC) curves were constructed for the two modalities. The correlation between the maximum diameter of breast lesions observed in MRI, CEM, and pathology was analyzed. Results: The overall diagnostic values for MRI were as follows: sensitivity 97.1%, specificity 60%, positive predictive value (PPV) 77.3%, negative predictive value (NPV) 93.8%, and accuracy 81.7%. Correspondingly, for CEM, the sensitivity, accuracy, specificity, PPV, and NPV were 97.14%, 81.67%, 60%, 77.27%, and 93.75%, respectively. The ROC analysis of CEM revealed an area under the curve (AUC) of 0.907 for observer 1 and 0.857 for observer 2, whereas MRI exhibited an AUC of 0.910 for observer 1 and 0.914 for observer 2. Notably, CEM showed the highest correlation with pathological lesion size (r = 0.660 for observer 1 and r = 0.693 for observer 2, p < 0.001 for both). Conclusion: CEM can be used with high sensitivity and similar diagnostic performance comparable to MRI for diagnosing breast cancer. CEM proves to be a successful diagnostic method for precisely determining tumor size.en_US
dc.identifier.citationTekinhatun, M., Sabir, N., Erdem, E., Yılmaz, S. ve Ufuk, F. (2024). Dynamic contrast-enhanced mammography and breast MRI in the diagnosis of breast cancer and detection of tumor size. Turkish Journal of Medical Sciences, 54(1), 249-261.en_US
dc.identifier.doi10.55730/1300-0144.5786
dc.identifier.endpage261en_US
dc.identifier.issn1300-0144
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85185685276
dc.identifier.scopusqualityQ1
dc.identifier.startpage249en_US
dc.identifier.urihttps://journals.tubitak.gov.tr/medical/vol54/iss1/28/
dc.identifier.urihttps://hdl.handle.net/11468/13912
dc.identifier.volume54en_US
dc.indekslendigikaynakScopus
dc.institutionauthorTekinhatun, Muhammed
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectContrast-enhanced spectral mammographyen_US
dc.subjectDynamic breast magnetic resonance imagingen_US
dc.titleDynamic contrast-enhanced mammography and breast MRI in the diagnosis of breast cancer and detection of tumor sizeen_US
dc.titleDynamic contrast-enhanced mammography and breast MRI in the diagnosis of breast cancer and detection of tumor size
dc.typeArticleen_US

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